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1 kits (10 Vials)
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▎ Tsarin Tesamoreli
Source: PubChem |
Sequence: YADAI F TNSY RKVL GQLS A RK L LQDI M SRQ QGE S NQ E RGA R ARL Tsarin Halitta: C 221H 366N 72O 67S Nauyin Kwayoyin: 5136 g/mol Lambar CAS: 218949-48-5 Saukewa: 16137828 Synonyms: Egrifta |
▎ Binciken Tesamoreli
Menene asalin bincike na Tesamoreli?
Lokacin da aka yi amfani da recombinant hormone girma na mutum (rhGH) a cikin maganin raunin hormone girma (GH), ko da yake yana da tasiri na asibiti, yana kuma tare da cututtuka daban-daban. Wannan yanayin ya haifar da haɓakar haɓakar haɓakar haɓakar haɓakar ɗan adam analogs factor-releaseing factor (GFR), saboda suna iya samun mafi kyawun jurewa. Tesamoreli wani GFR ne na roba wanda aka haɓaka azaman yuwuwar magani ga cututtuka iri-iri da ke da alaƙa da ƙarancin dangi na GH, gami da lipodystrophy mai alaƙa da HIV.
Menene tsarin aikin Tesamoreli?
Hanyar aiki akan cutar hanta mai ƙiba mai alaƙa da HIV (NAFLD)
Sarrafa maganganun kwayoyin halitta:
A cikin NAFLD da ke da alaƙa da HIV, ta hanyar nazarin haɓakar haɓakar ƙwayoyin cuta, an gano cewa Tesamoreli ya ƙara yawan maganganun sa hannu na sa hannu da ke da alaƙa da oxidative phosphorylation a cikin hanta, yayin da rage bayyanar cututtukan cututtukan da ke da alaƙa da kumburi, gyaran nama, da rarraba tantanin halitta [1] . Musamman, Tesamoreli ya rage tsarin tsarin hanta da ke da alaƙa da kumburi, gyaran nama, da rarraba tantanin halitta, wanda ke nuna cewa yana aiwatar da tasirinsa ta hanyar daidaita maganganun waɗannan kwayoyin halitta.
Hana masu shiga tsakani masu mahimmanci:
Tesamoreli na iya hana maɓalli angiogenesis, fibrosis, da masu shiga tsakani masu kumburi. Alal misali, yana iya rage yawan matakan haɓakar haɓakar haɓakar jijiyoyi A (VEGFA), canza yanayin girma β1 (TGFB1), da macrophage colony-stimulating factor 1 (CSF1). A cikin mahalarta da ke karɓar maganin Tesamoreli, raguwa a cikin plasma VEGFA da CSF1 an haɗa su tare da raguwa a cikin ƙwayar cutar hanta mai ƙwayar cuta ba tare da barasa ba, kuma raguwa a cikin TGFB1 da CSF1 an haɗa su tare da raguwa a cikin matakin fibrosis na jinsin [2] . A matsayin mai kula da daukar ma'aikata da kunnawa monocyte, CSF1 na iya zama sabuwar manufa ta warkewa ga NAFLD mai alaƙa da HIV.
Hanyar aiki akan raunin jijiya na gefe:
A cikin maganin raunin jijiya na gefe, an yi imanin Tesamoreli don haɓaka farfadowa na axonal, rage atrophy na tsoka, da inganta sakamakon aiki. Binciken na yanzu ya nuna cewa Tesamoreli na iya yin tasiri ta hanyar inganta tsarin farfadowa da gyaran jijiyoyi. Ba a fahimci takamaiman tsarin aikin ba tukuna, amma yana iya haɗawa da daidaita abubuwan haɓaka jijiya, haɓaka haɓakar axonal, da myelation, da sauransu [3]..
Menene takamaiman hanyar da Tesamoreli ke rage kitsen visceral da kitsen hanta a cikin masu kamuwa da cutar HIV?
Tasirin tsari akan hormone girma
Ƙarfafa haɓakar haɓakar hormone:
Tesamoreli shine hormone mai sakin hormone (GHRH), wanda zai iya tayar da ƙwayar girma. A cikin mutane masu kamuwa da kwayar cutar HIV, ana iya shafar siginar hormone girma, kuma Tesamoreli na iya inganta sakin hormone girma daga glandan pituitary na baya ta hanyar yin kwaikwayon aikin GHRH [4-6]..
Gudanar da metabolism na fats:
Girman hormone yana taka muhimmiyar rawa a cikin metabolism mai. Yana iya inganta rushewar kitse, ƙara yawan iskar oxygen na fatty acid, da rage yawan kitse. Ta hanyar haɓaka siginar hormone girma, Tesamoreli na iya daidaita tsarin metabolism a kaikaice kuma ya rage tarin kitsen visceral da kitsen hanta [4-6].
Tasiri kan bayyanar kwayar halittar hanta
Canza hanyoyin gado:
Nazarin ya gano cewa Tesamoreli na iya ƙara bayyanar sa hannu akan saitin sa hannu wanda ke da alaƙa da oxidative phosphorylation a cikin hanta, yayin da yake rage maganganun ƙwayoyin halittar da ke da alaƙa da kumburi, gyaran nama, da rarraba tantanin halitta [1].
Tasirin kwayoyin halittar da ke da alaƙa da tsinkayar cutar sankara na hepatocellular:
Tesamoreli kuma na iya daidaita tsarin kwayoyin halittar da ke da alaƙa da tsinkayen cututtukan cututtukan hanta, haɓaka tsarin ƙwayoyin halittar da ke da alaƙa da kyakkyawan tsinkaye da rage ƙayyadaddun ƙwayoyin halittar da ke da alaƙa da ƙarancin tsinkaye, bi da bi [1] . Wadannan canje-canje a cikin maganganun kwayoyin halitta na iya kasancewa da alaka da tasirin Tesamoreli akan rage kitsen hanta.
Dangantaka da maki masu alaƙa da fibrosis:
A cikin mahalarta da aka bi da Tesamoreli, waɗannan canje-canje a cikin maganganun hanta suna da alaƙa da ingantattun ƙididdiga masu alaƙa da fibrosis. Wannan yana nuna cewa Tesamoreli na iya inganta yanayin fibrotic na hanta ta hanyar daidaita maganganun kwayoyin hanta, don haka rage kitsen hanta [1].
Tasiri kan sunadaran plasma
Hana masu shiga tsakani masu mahimmanci:
Tesamoreli na iya rage yawan matakan sunadarai na plasma irin su jijiyar endothelial girma factor A (VEGFA), canza girma factor beta 1 (TGFB1), da macrophage colony-stimulating factor 1 (CSF1) [1] . Wadannan sunadaran suna da alaƙa da angiogenesis, fibrosis, da kumburi, kuma hana su ta hanyar Tesamoreli na iya taimakawa wajen rage kitsen hanta da kumburi.
Daidaita da maki na cututtuka:
A cikin mahalarta da aka yi tare da Tesamoreli, raguwa a cikin plasma VEGFA da CSF1 an haɗa su tare da raguwa a cikin ƙwayar cutar hanta mai haɗari (NAFLD), kuma raguwa a cikin TGFB1 da CSF1 an haɗa su tare da raguwa a cikin matakin fibrosis na jinsin [1] . Wannan yana nuna cewa ka'idodin waɗannan sunadaran plasma ta Tesamoreli na iya kasancewa da alaƙa da haɓaka yanayin cututtukan hanta.
Source:PubMed [1]
Menene aikace-aikacen Tesamoreli?
Tasiri kan masu cutar HIV
Rage kitsen visceral da kitsen hanta:
Wasu nazarin sun nuna cewa a cikin mutanen da ke dauke da kwayar cutar HIV da ke karbar maganin integrase inhibitor (INSTIs), karuwa a cikin visceral adipose tissue (VAT) yana da damuwa, saboda VAT yana da alaƙa da ƙananan cututtuka irin su cututtukan hanta maras barasa (NAFLD). Tesamoreli, analog na hormone mai sakin hormone girma, an nuna shi don rage VAT a cikin mutanen da ke dauke da kwayar cutar HIV tare da lipohypertrophy fiye da 15% a cikin watanni 6 [7] . A cikin gwajin gwajin da aka yi amfani da shi na mahalarta 61 tare da NAFLD mai cutar HIV, wani bincike na baya-bayan nan na mutanen da ke karbar maganin INSTI ya gano cewa bayan watanni 12, VAT a cikin rukunin placebo ya karu da 10.8%, yayin da VAT a cikin ƙungiyar kulawa ta Tesamoreli ya ragu da 8.3% gaba ɗaya. Bugu da ƙari, ɓangaren ƙwayar hanta (HFF) a cikin rukunin jiyya na Tesamoreli ya ragu da 31% dangane da tushe, wanda ya fi girma fiye da wannan a cikin rukunin jiyya na placebo [7].
Inganta ingancin mai:
A cikin mutane masu kamuwa da kwayar cutar HIV, a cikin marasa lafiya masu kiba na tsakiya waɗanda suka yi amfani da Tesamoreli, yawan kitse na visceral (VAT) da mai mai subcutaneous (SAT) ya karu, kuma wannan haɓaka ya kasance mai zaman kansa ga canje-canje a cikin kitse mai yawa, yana nuna cewa Tesamoreli kuma na iya haɓaka ingancin VAT da SAT a cikin wannan rukunin marasa lafiya [8].
Tasiri kan aikin rigakafi:
Yin amfani da dogon lokaci na Tesamoreli zai iya rage alamun T cell da monocyte / macrophage aiki a cikin wurare dabam dabam na mutane masu kamuwa da kwayar cutar HIV da kuma rage tsarin rigakafi a cikin hanta. Musamman, idan aka kwatanta da placebo, Tesamoreli ya rage yawan adadin sunadaran sunadaran 13, ciki har da chemokines hudu, cytokines guda biyu, kwayoyin kwayoyin T guda hudu, da arginase-1, galectin-9, da haɓakar haɓakar hanta. Binciken cibiyar sadarwa ya nuna cewa akwai kusanci tsakanin hanyoyin halittar da ke da alhakin rage waɗannan sunadaran, kuma bayanan da aka yi niyya sun tabbatar da siginar raguwar hanyoyin rigakafi a cikin hanta [9]..
Matsayi a cikin cututtukan hanta mai kitse mara-giya
Rage kitsen hanta da hana ci gaban fibrosis:
A cikin cututtukan hanta mai haɗari maras amfani da cutar HIV, an tabbatar da Tesamoreli don rage kitsen hanta da hana ci gaban fibrosis. Researchers conducted a focused evaluation of 9 plasma proteins corresponding to the top leading-edge gene sets in the differentially regulated gene sets and found that Tesamoreli led to a significant reduction in vascular endothelial growth factor A (VEGFA), transforming growth factor β1 (TGFB1), and macrophage colony-stimulating factor 1 (CSF1). A cikin mahalarta da aka bi da Tesamoreli, raguwa a cikin plasma VEGFA da CSF1 an haɗa su tare da raguwa a cikin aikin cututtukan hanta maras barasa, kuma raguwa a cikin TGFB1 da CSF1 an haɗa su tare da raguwa a cikin matakin fibrosis na jinsi. A matsayin mai kula da daukar ma'aikata da kunnawa na monocyte, CSF1 na iya zama sabbin dabarun warkewa don cutar hanta mai kitse mara barasa a cikin HIV [2].
Tasiri kan bayanin martabar hanta:
Yin amfani da ƙididdigar haɓakar haɓakar ƙwayoyin halitta, an gano cewa Tesamoreli ya haɓaka hanta bayanin hanta na tsarin sa hannu na sa hannu wanda ke da alaƙa da oxidative phosphorylation kuma ya rage bayyanar hanta na ƙwayoyin halittar da ke da alaƙa da kumburi, gyaran nama, da rarraba tantanin halitta. In addition, Tesamoreli also upregulated and downregulated the selected gene sets related to good and poor prognosis of hepatocellular carcinoma, respectively. A cikin mahalarta da aka bi da Tesamoreli, waɗannan canje-canje a cikin maganganun hanta suna da alaƙa da ingantattun ƙididdiga masu alaƙa da fibrosis [2].
A matsayin analog na haɓakar haɓakar haɓakar ƙwayar cuta, Tesamoreli ya nuna yuwuwar warkewa a fannoni da yawa. A ƙarshe, babban adadin karatu sun tabbatar da cewa zai iya daidaita yadda ake fitar da hormone girma da inganta aikin rayuwa na jiki. A cikin maganin cututtukan da ke da alaƙa da cutar kanjamau, yana da tasiri mai mahimmanci wajen rage yawan kitsen ciki. Ta hanyar haɓaka haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar mai, yana rage adadin kitse na visceral ba tare da cutar da kiba ba, yana taka rawa mai kyau wajen daidaita yanayin jikin marasa lafiya. Dangane da cutar hanta mai kitse ba ta barasa ba, wasu bincike sun nuna cewa yana iya rage kitsen hanta. Muhimmancin Tesamoreli yana da zurfi. Ga masu kamuwa da cutar HIV, yana ba da ingantacciyar hanya don inganta cututtukan ƙwayoyin cuta da cututtukan da ke haifar da kiba da jiyya, inganta yanayin rayuwar marasa lafiya, yana taimakawa wajen kawar da matsin lamba na tunani da canje-canjen kamanni ke haifarwa, da haɓaka fahimtar haɗin kai.
Game da Marubuci
Abubuwan da aka ambata a sama duk bincike ne, gyara su kuma Cocer Peptides ne suka haɗa su.
Mawallafin Jaridar Kimiyya
Stanley TL masani ne a Jami'ar Harvard, wanda ya tsunduma cikin bincike da koyarwa a cibiyoyi irin su Harvard Medical School da Babban Asibitin Massachusetts. Fannonin bincikensa sun haɗa da endocrinology da metabolism, cututtuka masu yaduwa, rigakafi, ƙwayoyin cuta, da abinci mai gina jiki da abinci. Ya gudanar da bincike mai zurfi a cikin waɗannan fagagen, yana ba da tushe na ka'idar don ganewar asali, magani, da rigakafin cututtuka masu alaƙa. A lokaci guda kuma, yana ba da haɗin kai tare da ƙungiyoyi irin su Harvard Medical School da Babban Asibitin Massachusetts don Yara, yana haɗa ka'idar tare da aikin asibiti da ba da gudummawa ga aikin likita. An jera Stanley TL a cikin ambaton ambaton [4].
