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1kits （10Ibikoresho）
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TesamoreliStructure Imiterere ya
Inkomoko: PubChem |
Urukurikirane: YADAI F TNSY RKVL GQLS A RK L LQDI M SRQ QGE S NQ E RGA R ARL Inzira ya molekulari: C 221H 366N 72O 67S. Uburemere bwa molekuline: 5136 g / mol Numero ya CAS: 218949-48-5 PubChem CID: 16137828 Synonyme: Egrifta |
Research Ubushakashatsi bwa Tesamoreli
Ni ubuhe bushakashatsi bwakozwe na Tesamoreli?
Iyo imisemburo ikura ya recombinant yumuntu (rhGH) ikoreshwa mukuvura imisemburo ikura (GH), nubwo ifite imikorere yubuvuzi, iherekezwa ningaruka mbi zitandukanye. Iki kibazo cyatumye habaho iterambere ryikigereranyo cyo gukura imisemburo ya hormone (GFR), kuko ishobora kwihanganira neza. Tesamoreli ni GFR ikomatanya yakozwe mu rwego rwo kuvura indwara zitandukanye zishobora kuba ziterwa no kubura GH ugereranije, harimo na lipodystrofiya iterwa na virusi itera sida.
Ni ubuhe buryo bwo gukora bwa Tesamoreli?
Uburyo bwibikorwa byindwara ziterwa na virusi itera sida (NAFLD)
Kugena imvugo ya gene:
Muri NAFLD ifitanye isano na virusi itera sida, binyuze mu isesengura ryogukungahaza gene, byagaragaye ko Tesamoreli yongereye imvugo ya gene yashyizweho umukono ijyanye na fosifori yo mu mwijima, mu gihe igabanya imvugo ya gene ijyanye no gutwika, gusana ingirabuzimafatizo, no kugabana selile [1] . By'umwihariko, Tesamoreli yagabanije gene y'umwijima ijyanye no gutwika, gusana ingirangingo, no kugabana ingirabuzimafatizo, byerekana ko igira ingaruka mu kugenzura imiterere y'iyi genes.
Kubuza abunzi b'ingenzi:
Tesamoreli irashobora kubuza angiogenezi yingenzi, fibrosis, hamwe naba medi-inflammatory. Kurugero, irashobora kugabanya cyane urwego rwimitsi ikura ya endoteliyale A (VEGFA), ihindura ibintu bikura β1 (TGFB1), hamwe na macrophage colony-itera ibintu 1 (CSF1). Mu bitabiriye amahugurwa yavuwe na Tesamoreli, igabanuka rya plasma VEGFA na CSF1 ryajyanye no kugabanuka kw amanota y’ibikorwa by’indwara z’umwijima zidafite inzoga, naho kugabanuka kwa TGFB1 na CSF1 byajyanye no kugabanuka kw amanota ya fibrosis yo mu rwego rwa gene [2] . Nkumuyobozi ushinzwe kwinjiza no gukora monocyte, CSF1 irashobora guhinduka intego yo kuvura udushya twanduye NAFLD.
Uburyo bwibikorwa ku gukomeretsa imitsi ya periferique:
Mu kuvura ibikomere bya periferique, Tesamoreli yizera ko byongera imbaraga mu kuvugurura imitsi, kugabanya imitsi, no kunoza imikorere. Ubushakashatsi bugezweho bwerekana ko Tesamoreli ashobora gukoresha imbaraga zayo mugutezimbere inzira yo kuvugurura imitsi no kuyisana. Uburyo bwihariye bwibikorwa ntiburasobanuka neza, ariko bushobora kuba bukubiyemo kugenzura ibintu bikura bikura imitsi, kuzamura imikurire ya axon, na myelination, nibindi [3].
Nubuhe buryo bwihariye Tesamoreli agabanya ibinure byijimye hamwe namavuta yumwijima kubantu banduye virusi itera sida?
Ingaruka igenga imisemburo ikura
Gukangura imisemburo ikura:
Tesamoreli ni imisemburo ikura ya hormone irekura imisemburo (GHRH), ishobora gutera imisemburo ikura. Ku bantu banduye virusi itera sida, gusohora imisemburo ikura bishobora kugira ingaruka, kandi Tesamoreli irashobora guteza imbere irekurwa ry’imisemburo ikura muri glande y’imbere yigana ibikorwa bya GHRH [4-6].
Kugenga ibinure byamavuta:
Imisemburo ikura igira uruhare runini mu guhinduranya ibinure. Irashobora guteza imbere ibinure, kongera okiside ya aside irike, no kugabanya ibinure. Mugukangura imisemburo ikura, Tesamoreli irashobora kugenga mu buryo butaziguye metabolisme y’ibinure no kugabanya ikwirakwizwa ry’amavuta yo mu nda hamwe n’amavuta y’umwijima [4-6].
Ingaruka ku mvugo ya gene y'umwijima
Guhindura inzira ya gene:
Ubushakashatsi bwerekanye ko Tesamoreli ashobora kongera imvugo ya gene yashyizweho umukono ijyanye na fosifori yo mu mwijima, mu gihe igabanya imiterere ya gene zijyanye no gutwika, gusana ingirabuzimafatizo, no kugabana selile [1].
Ingaruka kuri gen zijyanye no guhanura kanseri ya hepatocellular:
Tesamoreli irashobora kandi kugena imiterere ya gene ijyanye no guhanura kanseri ya hepatocellular, kugenzura imiterere ya gene ijyanye no guhanura neza no kugabanya imiterere ya gene ijyanye no kutamenya neza, [1] . Izi mpinduka mumagambo ya gene zishobora kuba zifitanye isano n'ingaruka za Tesamoreli mukugabanya amavuta y'umwijima.
Isano n'amanota ya gene ya fibrosis:
Mu bitabiriye amahugurwa bavuwe na Tesamoreli, izi mpinduka mu mvugo y’umwijima zajyanye no kunoza amanota ya gene ya fibrosis. Ibi byerekana ko Tesamoreli ashobora kuzamura fibrotic yumwijima muguhindura imiterere yumwijima, bityo bikagabanya amavuta yumwijima [1].
Ingaruka kuri poroteyine za plasma
Kubuza abunzi b'ingenzi:
Tesamoreli irashobora kugabanya cyane urwego rwa poroteyine za plasma nkimikurire yimitsi iva mu mitsi A (VEGFA), guhindura ibintu bikura beta 1 (TGFB1), hamwe na macrophage colony-itera ibintu 1 (CSF1) [1] . Izi poroteyine zifitanye isano na angiogenez, fibrosis, hamwe n’umuriro, kandi kubuzwa na Tesamoreli birashobora gufasha kugabanya amavuta y’umwijima no gutwika.
Isano n'amanota y'indwara:
Mu bitabiriye amahugurwa bavuwe na Tesamoreli, igabanuka rya plasma VEGFA na CSF1 ryajyanye no kugabanuka kw amanota y’ibikorwa by’umwijima w’umwijima utarimo inzoga (NAFLD), kandi kugabanuka kwa TGFB1 na CSF1 byajyanye no kugabanuka kw amanota ya fibrosis yo mu rwego rwa gene [1] . Ibi byerekana ko amabwiriza ya poroteyine ya plasma na Tesamoreli ashobora kuba afitanye isano no kuzamura indwara zumwijima.
Inkomoko: Byatangajwe [1]
Ni ubuhe buryo bukoreshwa na Tesamoreli?
Ingaruka ku bantu banduye virusi itera SIDA
Kugabanya ibinure bya visceral hamwe namavuta yumwijima:
Ubushakashatsi bumwe bwerekanye ko ku bantu banduye virusi itera SIDA bahabwa imiti ivura integase (INSTIs), kwiyongera kwa tipusi adipose tissue (VAT) biteye impungenge, kubera ko umusoro ku nyongeragaciro ujyanye n’ingaruka ziterwa n’indwara z’umwijima zidafite inzoga (NAFLD). Tesamoreli, imisemburo ikura itanga imisemburo ikura ya hormone, byagaragaye ko igabanya umusoro ku nyongeragaciro ku bantu banduye virusi itera SIDA bafite lipohypertrophyi irenga 15% mu mezi 6 [7] . Mu igeragezwa ryagenzuwe na platbo ry’abitabiriye 61 banduye virusi itera sida NAFLD, isesengura ryakozwe nyuma y’abantu bahabwa ubuvuzi bwa INSTI ryerekanye ko nyuma y’amezi 12, umusoro ku nyongeragaciro mu itsinda rya placebo wiyongereyeho 10.8%, mu gihe umusoro ku nyongeragaciro mu itsinda ry’ubuvuzi wa Tesamoreli wagabanutseho 8.3% muri rusange. Byongeye kandi, agace k’amavuta y’umwijima (HFF) mu itsinda ry’ubuvuzi rya Tesamoreli kagabanutseho 31% ugereranije n’ibanze, ibyo bikaba byari hejuru cyane ugereranije n’itsinda rishinzwe kuvura ibibanza [7].
Kunoza ubwiza bwibinure:
Ku bantu banduye virusi itera sida, ku barwayi bafite umubyibuho ukabije wakoresheje Tesamoreli, ubwinshi bw’amavuta yo mu mitsi (VAT) hamwe n’ibinure byo munsi (SAT) byiyongereye, kandi uku kwiyongera ntikwatewe n’imihindagurikire y’ibinure, byerekana ko Tesamoreli ashobora no kuzamura ireme rya TVA na SAT muri iri tsinda ry’abarwayi [8].
Ingaruka kumikorere yubudahangarwa:
Gukoresha igihe kirekire Tesamoreli birashobora kugabanya ibimenyetso bya selile T na monocyte / macrophage ibikorwa mukuzenguruka kwanduye virusi itera sida kandi bikagabanya inzira z'umubiri ziri mu mwijima. By'umwihariko, ugereranije na placebo, Tesamoreli yagabanije kuzenguruka kwa poroteyine 13, harimo chemokine enye, cytokine ebyiri, molekile enye zifitanye isano na selile, hamwe na arginase-1, galectine-9, hamwe n’ikura rya hepatocyte. Isesengura ry’urusobe ryerekanye ko hari imikoranire ya hafi hagati yinzira ya gene ishinzwe kugabanya izo poroteyine, kandi inyandiko-mvugo yerekana ibimenyetso byerekana ko igabanuka ry’inzira z'umubiri ziri mu mwijima [9].
Uruhare mu ndwara zumwijima zidafite inzoga
Kugabanya ibinure byumwijima no gukumira iterambere rya fibrosis:
Mu ndwara y’umwijima iterwa na virusi itera sida, Tesamoreli byagaragaye ko igabanya amavuta y’umwijima kandi ikarinda fibrosis. Abashakashatsi bakoze isuzuma ryibanze kuri poroteyine 9 za plasma zihuye n’isonga rya mbere ry’imbere mu bice bitandukanye bya genoside kandi basanze Tesamoreli yatumye igabanuka rikabije ry’imikurire y’imitsi y’imitsi A (VEGFA), ihindura ibintu bikura β1 (TGFB1), na macrophage colony-itera 1 (CSF1). Mu bitabiriye amahugurwa bavuwe na Tesamoreli, igabanuka rya plasma VEGFA na CSF1 ryajyanye no kugabanuka kw'amanota y'ibikorwa by'indwara y'umwijima idafite inzoga, kandi kugabanuka kwa TGFB1 na CSF1 byajyanye no kugabanuka kw'amanota ya fibrosis yo mu rwego rwa gene. Nkumuyobozi ushinzwe kwinjiza no kwinjiza monocyte, CSF1 irashobora guhinduka intego yo kuvura indwara zumwijima zidafite inzoga zanduye virusi itera sida [2].
Ingaruka ku mwirondoro wumwijima:
Hifashishijwe isesengura ryitunganyirizwa rya gene, byagaragaye ko Tesamoreli yongereye umwijima kwerekana umwijima wa gene yashyizweho umukono ujyanye na fosifori ya okiside kandi bigabanya umwijima ugaragaza imiterere ya gene zijyanye no gutwika, gusana ingirabuzimafatizo, no kugabana selile. Byongeye kandi, Tesamoreli yanagenzuye kandi agabanya imiterere ya gene yatoranijwe ijyanye no kumenya neza no kutamenya neza kanseri ya hepatocellular. Mu bitabiriye amahugurwa bavuwe na Tesamoreli, izi mpinduka mu mvugo y’umwijima zajyanye no kunoza amanota ya gene ya fibrosis [2].
Nka hormone ikura ya hormone irekura imisemburo igereranya, Tesamoreli yerekanye ubushobozi bwo kuvura mubice byinshi. Mu gusoza, umubare munini w’ubushakashatsi wemeje ko ushobora kugenzura neza imisemburo ya hormone yo gukura no kunoza imikorere yumubiri. Mu kuvura indwara ziterwa na virusi itera sida, igira ingaruka zikomeye mu kugabanya ibinure byo mu nda. Mugutera imbaraga zo gusohora imisemburo ikura no guhindura ibinure byamavuta, bigabanya ibinure byama visceral bitagize ingaruka kumubiri unanutse, bigira uruhare runini muguhindura umubiri wabarwayi. Mu kuvura indwara y’umwijima idafite inzoga, ubushakashatsi bumwe na bumwe bwerekanye ko bushobora kugabanya ibinure by’umwijima. Ubusobanuro bwa Tesamoreli ni bwinshi. Ku barwayi banduye virusi itera sida, itanga uburyo bunoze bwo kunoza imiterere ya metabolisme y’ibinure iterwa n’indwara no kuvurwa, kuzamura imibereho y’abarwayi, bifasha kugabanya umuvuduko w’imitekerereze iterwa n’imihindagurikire y’imiterere, kandi bikongera imyumvire yabo yo kwishyira hamwe.
Ibyerekeye Umwanditsi
Ibikoresho byavuzwe haruguru byose byakorewe ubushakashatsi, byahinduwe kandi byakozwe na Cocer Peptides.
Umwanditsi w'ikinyamakuru
Stanley TL ni intiti muri kaminuza ya Harvard, akora ubushakashatsi no kwigisha mu bigo nk'ishuri ry'ubuvuzi rya Harvard n'ibitaro bikuru bya Massachusetts. Mubushakashatsi yakoze harimo endocrinology na metabolism, indwara zandura, immunologiya, microbiologiya, nimirire nimirire. Yakoze ubushakashatsi bwimbitse muri izi nzego, atanga ishingiro ry’imyumvire yo gusuzuma, kuvura, no kwirinda indwara zifitanye isano. Muri icyo gihe, akorana cyane n’imiryango nk’ishuri ry’ubuvuzi rya Harvard n’ibitaro bikuru by’abana bya Massachusetts, ahuza inyigisho n’ubuvuzi ndetse akanatanga umusanzu mu buvuzi. Stanley TL yanditse kurutonde rwerekana [4].
