Cocer Peptides fɛ 
a bɛ kalo 1 bɔ
BƐƐRƐ KUNNAFONIW NI FƐRƐW KUNNAFONIW BƐƐ MIN BƐ NI WEBSITE KAN NA, U BƐ KUNNAFONIW FƆLƆ DƆRƆN NI KALANSENW YE.
Fɛn minnu bɛ di nin siti in kan, olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *glasi kɔnɔ*, o kɔrɔ ye gilasi kɔnɔ) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki ka dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.
Kuma bɛɛ lajɛlen
Kabini a sɔrɔla san 1999, grelin bɔra kɛnɛ kan i n’a fɔ ɲininikɛyɔrɔba ɲɛnamaya dɔnniyaw la k’a sababu kɛ a farikolo baara kɛrɛnkɛrɛnnenw ye ani a ka ɲɛnamayako nɔba. Ghrelin jɔyɔrɔ ka bon kosɛbɛ bonya hormone (GH) bɔli labɛnni na, wa a sen bɛ farikoloɲɛnajɛ nafama caman fana na, i n’a fɔ fanga balansi, dumuni nege labɛnni, kɔnɔbara baara, dusukun ni jolisiraw ka homeostasis, ani neuroprotection.
Jaa 1 Ghrelin hormone min bɛ a cogo la min tɛ baara kɛ (desacyl ghrelin) o bɛ wuli ka kɛ a cogo la min tɛ baara kɛ (acyl ghrelin).
Ghrelin ka sigicogo n’a jɛnsɛnni
(1) Jateminɛ kɛcogo
Furakɛcogo : Ghrelin ye polipɛtidi ye min dilannen don ni asidi aminiki 28 ye, a jɔcogo fɔlɔ bɛ lakananiba jira suguya wɛrɛw la. Hadamadenw na, grelin ka asidi aminiki sinsinni ye GSSFLSPEHQRVQQRKESKKPPAKLQPR ye. A ka fɛn kɛrɛnkɛrɛnnen ye ɔkitanoyili caman cili ye serini tolen kan yɔrɔ 3nan na, o min nafa ka bon kosɛbɛ grelini sirili la ni bonya hormone-releasing hormone receptor (GHS-R) ye ani a ka ɲɛnamaya kɛcogo cɛsiri.
Izomɛriw : Ka fara Ghrelin octanoylé klasiki kan, Ghrelin deacetylé ni izomɛri wɛrɛw fana bɛ yen. Hali ni Ghrelin deacetylé tɛ ni octanoylation modification ye, wa se tɛ a la ka siri GHS-R la ni affinité caman ye, ɲininiw y’a jira ko a bɛ se ka biologiki nɔw bila a sɔrɔyɔrɔ wɛrɛw fɛ walima a kɛcogo dɔnnen wɛrɛw fɛ.
(2) Tila-tilacogo
Farikolo yɔrɔw tilatilali : Ghrelin bɛ sɔrɔ fɔlɔ ani ka bɔ asidi bɔli selilɛriw fɛ kɔnɔbara basigilenw na ani a bɛ sɔrɔ fana farikolo yɔrɔw ni farikolo yɔrɔ caman na, i n’a fɔ banakɔtaa fitini, kɔnɔbara, hipotalamus ani pituitaire gland. Kɔnɔbara basigilen na, grelin jiracogo hakɛ bɛ dɔgɔya dɔɔni dɔɔni ka bɔ kɔnɔbara la ka taa banakɔtaa fitini na. Farikoloɲɛnajɛ cɛmancɛ la, grelini bɛ sɔrɔ kosɛbɛ yɔrɔw la i n’a fɔ hipotalamus nucleus arcuate ani nucleus paraventriculaire, olu ni dumuni nege labɛnni, fanga sɛnɛcogo ani neuroendocrine ɲɛnabɔli bɛ tali kɛ ɲɔgɔn na kosɛbɛ.
Kɔnɔnatumuw sigiyɔrɔ : Kɔnɔbara la, Ghrelin bɛ sɔrɔ fɔlɔ kɔnɔbara basigilen kɔnɔnatumuw la, minnu bɛ se ka balocogo dɔn kɔnɔbara basigilen kɔnɔ ani ka taamasiɲɛw lase farikolo cɛmancɛ la Ghrelin bɔli fɛ. Pituitaire glande kɔnɔ, Ghrelin bɛ se ka baara kɛ ka ɲɛsin bonya hormone cellules ma walasa ka growth hormone bɔli ɲɛnabɔ.
Pepitidi min bɛ bonya hormone bɔ, o ka baara kɛcogo
(1) Ka siri Recepteurs (Jaabiw) la
GHS-R-mediated signaling pathway : Ghrelin ka ɲɛnamaya kɛcogo fɔlɔw bɛ sɔrɔ ni a sirili ye bonya hormone-releasing hormone receptor 1a (GHS-R1a) la. GHS-R1a ye G protein-coupled receptor ye min bɛ jɛnsɛn kosɛbɛ pituitaire glande, hypothalamus ani farikolo yɔrɔ wɛrɛw la. Ni a sirilen don GHS-R1a la, grelin bɛ G furakisɛw baara, o minnu bɛ fosifolipazi C (PLC)-inositol trisphosphate (IP3)-calcium ion (Ca⊃2;+) taamasiɲɛ sira baara, o bɛ na ni Ca⊃2;+ hakɛ caya ye selilɛri kɔnɔ ani ka laban ka bonya hormone bɔli sabati ani ka farikoloɲɛnajɛ wɛrɛw labɛn baarakɛcogo minnu bɛ kɛ.
Fɛɛrɛ minnu tɛ GHS-R fɛ : Ka fara GHS-R1a kan, sɛgɛsɛgɛliw y’a jira ko grelin fana bɛ se ka nɔ bila ɲɛnamaya la ni a ni a minɛbaga wɛrɛw walima membrane proteines ka jɛɲɔgɔnya ye.
Jaa 2 Ghrelin b’a nɔ bila hypothalamus la sira saba fɛ minnu tɛ kelen ye.
(2) Jɛnɛya jiracogo ɲɛnabɔli
Hypothalamic-pituitary axis ni ɲɔgɔn cɛ jɛnɛya : Ghrelin bɛ se ka jɛnɛya caman jirali labɛn hipotalamu-pituitaire axis kɔnɔ. Pituitaire ta fan fɛ, ghrelin bɛ se ka bonya hormone gène sɛbɛnni wuli ka taa sanfɛ, ka bonya hormone synthèse ni a bɔli sabati. Hypothalamus kɔnɔ, grelin bɛ se ka nɔ bila bonya hormone bɔli hormone (GHRH) ni somatostatin (SS) jirali la, ka bonya hormone bɔli ɲɛnabɔ cogo la min tɛ ɲɛ, a kɛtɔ ka GHRH ni SS bɔli sɛmɛntiya. Kɛrɛnkɛrɛnnenya la, grelini bɛ se ka GHRH bɔli lawuli ka sɔrɔ a bɛ SS bɔli bali, o la, a bɛ kɛ sababu ye ka bonya hormone bɔli sabati ɲɔgɔn fɛ.
Jɛnɛya minnu bɛ tali kɛ fanga sɛnɛcogo la : Fasa ni sugunɛ na, grelini bɛ jɛnɛya minnu bɛ tali kɛ fanga sɛnɛcogo la, olu jiracogo ɲɛnabɔ. Misali la, grelin bɛ se ka peroxisome proliferator-activated receptor γ (PPARγ) jiracogo kɔrɔta, ka farikolo tulumafɛnw danfara ni tulumafɛnw bɔli sabati; o waati kelen na, sugunɛ na, grelini bɛ jamu jiracogo ɲɛnabɔ min bɛ tali kɛ sukaro sɔrɔli la, o bɛ nɔ bila joli sukaro hakɛ homeostase la.
Pepitiri min bɛ bonya hormone bɔ, o nɔw farikolo ta fan fɛ
(1) Ka bonya hormones bɔli sabati
Baara tilennen min bɛ kɛ ɲɛgɛnɛsira la : Ghrelin ye bonyalan ye min bɛ se ka bonya hormone bɔ, min bɛ baara kɛ ka ɲɛsin bonya hormone selilɛriw ma minnu bɛ ɲɛgɛnɛsira ɲɛfɛla la, ka bonya hormone sɔrɔli ni a bɔli sabati GHS-R1a fɛ taamasiɲɛw sira fɛ. Ni aw ye a suma ni bonya hormone (GHRH) ye, grelin bɛ bonya hormone bɔli lawuli joona, wa o fila bɛ ɲɔgɔn sɔrɔ. Farikoloɲɛnajɛw la, grelin, GHRH ani somatostatin bɛ jɛ ka bonya hormone bɔli labɛn ni wulikan ye, ka bonya hormone hakɛ sabati.
A nɔ minnu bɛ bonya la: Bonya hormone jɔyɔrɔ ka bon farikolo bonya ni a yiriwali sabatili la. Ghrelin bɛ nɔ bila bonya la cogo la min tɛ ɲɛ, a kɛtɔ ka bonya hormone bɔli sabati. Denmisɛnninw ni funankɛya waatiw la, Ghrelin bɔli cogo bɛnnen na, o nafa ka bon kosɛbɛ walew la i n’a fɔ kolotugudaw falenni ani farikolo yiriwali. Banabagatɔ minnu ka bonya hormone dɛsɛ bɛ u la, a ka ca a la, grelin bɔli hakɛ bɛ dɔgɔya. Grelin walima a ɲɔgɔnnaw tali kɛnɛma, o bɛ se ka dɔ fara bonya hormones hakɛ kan kosɛbɛ ani ka bonya ni yiriwali sabati.
(2) Kuwame ka fɛnw falen-falencogo ɲɛnabɔli
Dumuni nege ɲɛnabɔli : Ghrelin, min bɛ wele ko 'kɔngɔ hormone,' ye taamasiɲɛ nafama ye min bɛ dumuni nege ɲɛnabɔ. Hypothalamus nucleus arcuate kɔnɔ, grelin bɛ siri GHS-R1a minɛbagaw la neuropeptide Y (NPY)/agouti-related protein (AgRP) senkɔniw kan, o bɛ NPY ni AgRP bɔli lawuli, o bɛ dɔ fara dumuni nege kan ani ka dumuni dunta sabati. Ghrelin fana bɛ nɔ bila dumuni nege la cogo la min tɛ ɲɛ, a kɛtɔ ka kɔritikotropini bɔli ɔrimɔni (CRH) senkɔniw ka baara ɲɛnabɔ hipotalamus paraventriculaire nucléaire kɔnɔ. Sunɔgɔ waati, ghrelin hakɛ bɛ wuli, o bɛ kɔngɔ bila mɔgɔ la; dumuni kɛlen kɔfɛ, grelin hakɛ bɛ dɔgɔya joona, o bɛ dɔ fara a fasa dusukunnata kan.
Fanga balansi labɛnni : Ghrelin fana bɛ a sen don fanga sɛnɛcogo labɛnni na, ka farikolo fanga balansi mara. Ghrelin bɛ lipolyse sabati, ka asidi fatɔw ka oksidan caya, ani ka farikolo fanga bonya. Ghrelin bɛ insuline bɔli bali, ka dɔ bɔ farikolo yɔrɔw la ka sukaro tali ni a baara, ani ka sukaro hakɛ caya joli la, o bɛ fanga sɔrɔyɔrɔ wɛrɛw di farikolo ma. Gɛrɛlini caman tali kuntaalajan bɛ se ka kɛ sababu ye ka fanga dunta kojugu, ka tulumafɛnw lajɛ, ani o kɔfɛ farikoloɲɛnajɛ gɛlɛyaw i n’a fɔ fasa.
(3) A bɛ nɔ bila kɔnɔbara baara la
Kɔnɔbara basigilen ni kɔnɔbara lamagacogo : Kɔnɔbara basigilen na, grelin jɔyɔrɔ ka bon kosɛbɛ kɔnɔbara basigilen bɔli ni kɔnɔbara lamagacogo ɲɛnabɔli la. Ghrelin bɛ kɔnɔbara basigilenw bila ka kɔnɔbara asidi bɔ, ka asidi sigida labɛn kɔnɔbara kɔnɔ, o bɛ dumuni toli ni a minɛcogo dɛmɛ. Ghrelin bɛ kɔnɔbara basigilen (peristalsis) sabati, ka fɛnɲɛnamafagalanw lamagacogo ɲɛ kɔnɔbara la ani ka dumuni lankolonya teliya ka bɔ kɔnɔbara la. Kɔnɔnatumu dɔw la, i n’a fɔ dumunikɛbaliya baarakɛbaliya ani kɔnɔboli, Ghrelin hakɛ min tɛ bɛn, o bɛ se ka kɛ sababu ye ka kɔnɔbara asidi bɔli ni kɔnɔbara lamagacogo tiɲɛ.
Kɔnɔnatumuw lakanani : Ghrelin bɛ kɔnɔboli tanga. A bɛ kɔnɔbara basigilenw caya ani k’u dilan, ka ɲɛgɛnɛsiralabanaw bali ka baara kɛ ka ɲɛ, ani ka a tanga tiɲɛni ma min bɛ sɔrɔ fɛn juguw fɛ i n’a fɔ kɔnɔbara asidi ni Helicobacter pylori. Bana misaliw la i n’a fɔ kɔnɔbara basigilenw ni kɔnɔbara basigilenw, grelin tali kɛnɛma bɛ kirinni kɛnɛyali teliya ani ka dɔ bɔ ɲɛgɛnɛsira tiɲɛni hakɛ la.
(4) Dusukun ni jolisiraw labɛncogo
Dusukun baarakɛcogo ɲɛnabɔli : Ghrelin bɛ sɔrɔ kosɛbɛ dusukun na, wa a jɔyɔrɔ ka bon kosɛbɛ dusukun baarakɛcogo ɲɛnabɔli la. Ghrelin bɛ dusukun tantanni sabati, ka dusukun bɔli caya, ani ka dusukun pɔnpe baara ɲɛ. Mikorokaridi ischemie-reperfusion jogincogo misaliw la, grelin bɛ dusukun tantanni selilɛriw ka apoptose ni necrosis dɔgɔya, ka infarct hakɛ dɔgɔya, ani ka dusukun lakanani nɔ bila. A kɛcogo bɛ se ka tali kɛ farikolo kɔnɔ ɲɛnamaya taamasiɲɛw siraw baara la, i n’a fɔ fosfoinositide 3-kinase (PI3K)/protéine kinase B (Akt) taamasiɲɛw sira.
Jolisiraw tansiyɔn ɲɛnabɔli : Ghrelin bɛ joli siraw tansiyɔn ɲɛnabɔ ani ka tansiyɔn sabatili sabati. A bɛ baara kɛ joli-sira-funu-kɔnɔ-fɛnw kan walasa ka joli-sira-funu-fɛnw nɔw bali i n’a fɔ angiotensin II, ka joli-sira-funu-yɔrɔw bonya, ka joli-sira-funu lamini joli-sira-funu-kɛlɛli dɔgɔya, o la ka tansiyɔn jigin. Ghrelin fana bɛ joli siraw kɔnɔnatumuw nɔrɔli mɔlikuluw jirali bali, ka funubanakisɛw nɔrɔli ni u doncogo dɔgɔya, ka joli siraw lakanani nɔ bila, ani ka joli siraw sɔgɔsɔgɔli bali.
(5) A bɛ se ka kɛ sababu ye ka farikolo tanga
Senfagabana ka ɲɛnamaya ni u caya : Farikoloɲɛnajɛ la, ghrelin bɛ se ka farikolo tanga. A bɛ farikolojidɛsɛbanakisɛw caya ni u danfara sabati, ka dɔ fara senfagabana hakɛ kan, ani ka farikolojidɛsɛ yiriwali n’a baara kɛcogo ɲuman sabati. Farikoloɲɛnajɛbanaw misaliw la i n’a fɔ Alzheimer bana ani Parkinson ka bana, grelin bɛ se ka senfagabana apoptose bali, ka farikolojidɛsɛ jaabiw dɔgɔya, ani ka hakili ni farikoloɲɛnajɛ baara ɲɛ. A ka farikolo tangacogo bɛ se ka kɛ sababu ye ka farikolo kɔnɔ oksidan degun jaabiw labɛn, ka apoptose taamasiɲɛw siraw bali, ani ka farikolojidɛsɛ furaw bɔli sabati.
Neuroendocrine Regulation : I n’a fɔ neuroendocrine regulateur factor, Ghrelin bɛ a sen don hypothalamic-pituitary-adrenal axis (HPA axis) baarakɛcogo labɛnni na. Degunw na, grelini hakɛ cayalenba bɛ HPA aksidan baara kojugu bali, o bɛ dɔ bɔ kɔritikositɛri bɔli la ani o la, a bɛ farikolo tiɲɛni nɔgɔya degun fɛ. Ka fara o kan, grelini bɛ hipotalamu-pituitaire-thyroïde axis (HPT axis) ani hypothalamic-pituitaire-gonadal axis (HPG axis) labɛn, ka neuroendocrine system homeostasis mara.
(6) Farikoloɲɛnajɛ nɔ wɛrɛw
Farikolo tangacogo : Ghrelin fana jɔyɔrɔ ka bon farikolo tangacogo la. A bɛ se ka farikolo tangalanw ka baara ɲɛnabɔ, ka farikolojidɛsɛbanakisɛw caya ni u danfara sabati, ani ka farikolo tangacogo fanga bonya. Funu cogoyaw la, grelini bɛ se ka funu sitokiniw bɔli bali, i n’a fɔ tumor necrosis factor-α (TNF-α) ani interleukin-6 (IL-6), o la, a bɛ dɔ bɔ funu jaabiw la ani ka farikolo tangalanw ni funu kɛlɛli nɔ bila.
Kolow falenfalencogo ɲɛnabɔli : Ghrelin bɛ se ka kolotugudaw labɛncogo ɲɛnabɔ. A bɛ kolotugudaw caya ni u danfara sabati, a bɛ kolotugudaw ka baara bali, o la, a bɛ dɔ fara kolo girinya kan ani ka kolo dilancogo sabati. Banabagatɔ minnu koloci bɛ u la, a ka ca a la, grelin hakɛ bɛ dɔgɔya, o b’a jira ko grelin bɛ se ka kɛ sababu ye ka koloci sɔrɔ. Gɛrɛlini walima a ɲɔgɔnnaw tali kɛnɛma, o bɛ se ka kɛ sababu ye ka koloci furakɛli fɛɛrɛ kuraw di.
Peptide min bɛ bonya hormone bɔ, o tali
(1) Furakɛcogo minnu bɛ kɛ kɛnɛyaso la
Bonya hormone dɛsɛ : Banabagatɔ minnu ka bonya hormone dɛsɛ bɛ u la, Ghrelin ni a ɲɔgɔnnaw bɛ se ka kɛ furakɛli furaw ye. Ni u bɛ bonya hormone bɔli lawuli, u bɛ bonya ni yiriwali sabati banabagatɔw la. Ni aw ye a suma ni laadala bonya hormone sinsinni furakɛli ye, Ghrelin n’a ɲɔgɔnnaw bɛ lakana ni muɲuli ɲuman di, wa u bɛ se ka bonya sabati cogo la min bɛnnen don farikolo ta fan fɛ, ni u bɛ bonya hormone kɔnɔna na bɔli labɛn.
Jaa 3 GH ka endocrine régulation ani furakɛli balili.
Bana minnu bɛ sɔrɔ farikolojɔli dumuniw fɛ
Fasa ni sukarodunbana : Fasa furakɛli la, hali ni Ghrelin bɛ wele ko 'kɔngɔ hormone' min bɛ Ghrelin hakɛ walima a taamasiɲɛw ɲɛnabɔ, o bɛ se ka fanga falenfalen ɲɛ, ka dumuni nege dɔgɔya, ani ka se ka farikolo girinya dɔgɔya. Ghrelin tali kunbɛnbagaw labɛnni walasa ka Ghrelin sirili bali minɛbagaw la, o bɛ se ka dumuni nege bali ani ka dumuni dunta dɔgɔya. Jabɛtibanabagatɔw fɛ, Ghrelin bɛ se ka nɔ ɲuman bila joli sukaro hakɛ la fɛɛrɛw fɛ i n’a fɔ ka inisɔndiya bɔli ɲɛnabɔ ani ka inisɔndiya kunbɛncogo ɲɛ. Ghrelin tali kɛnɛma bɛ joli sukaro kɔlɔsili ni inisɔndiya kɛcogo ɲɛ sukarodunbanabagatɔw la, o bɛ hakilina kuraw di sukarodunbana furakɛli ma.
Banakisɛfagalanw (Syndrome métabolique): Banakisɛfagalanw ye banaw kulu ye minnu bɛ sɔrɔ fasa, tansiyɔn jiginni, sukarodunbana, ani jolidɛsɛ. K’a sababu kɛ a jɔyɔrɔ ye fanga sɛnɛcogo la ani dusukun ni jolisiraw labɛnni na, grelin bɛ se ka kɛ laɲini ye min bɛ se ka kɛ farikoloɲɛnajɛ bana furakɛli la. Ni grelini hakɛ bɛ labɛn, a bɛ se ka kɛ ka farikoloɲɛnajɛ bana taamasiɲɛ caman ɲɛ ka ɲɛ waati kelen na banabagatɔw la minnu farikolo ka bana bɛ u la, i n’a fɔ farikolo girinya dɔgɔyali, tansiyɔn dɔgɔyali, ani joli sukaro ni tulumafɛnw tiɲɛni.
Kɔnɔbara basigilen banaw:
Dusukunnabana baarakɛbaliya ni kɔnɔboli : Banabagatɔ minnu ka dumunikɛbaliya ni kɔnɔboli bɛ u la, grelini n’a ɲɔgɔnnaw bɛ se ka dumunikɛcogo taamasiɲɛw ɲɛ ani ka kɔnɔbara lankolonya teliya ni kɔnɔbara lamagacogo sabatili ye ani ka kɔnɔbara asidi bɔli caya. Gɛrɛlini analoziw tali bɛ se ka bana taamasiɲɛw nɔgɔya kosɛbɛ i n’a fɔ kɔnɔbara sanfɛla dimi ni funu banabagatɔw la minnu bɛ ni dumunikɛbaliya baarakɛta ye, o bɛ u ka ɲɛnamaya kɛcogo ɲɛ.
Kɔnɔnatumuw : K’a sababu kɛ Ghrelin ka lakanani fanga ye kɔnɔbara basigilen na, a bɛ se ka kirinni kɛnɛyali sabati, o la, a bɛ se ka kɛ a kɛli la kɔnɔboli furakɛli la. Ghrelin walima a ɲɔgɔnnaw tali kɛnɛma, o bɛ se ka kirinni dilancogo teliya ani ka kirinni seginni dɔgɔya.
Dusukun ni jolisiraw banaw:
Dusukun tantanni-joginni-joli segin-ka-bɔ : Dusukun tantanni-joginni furakɛli la, Ghrelin, ka da a ka dusukun tangacogo kan, a bɛ layidu ta i n’a fɔ furakɛli fɛɛrɛ kura. Ni aw ye Ghrelin walima a ɲɔgɔnnaw di ka kɔn dusukun tantanni-schemie-reperfusion ɲɛ walima a kɛtuma na, a bɛ se ka dɔ bɔ dusukun tantanni selilɛriw tiɲɛni na, ka dusukun tantanni hakɛ dɔgɔya, ani ka dusukun baara ɲɛ. Baganw ka kɔrɔbɔliw ni kɛnɛyaso sɛgɛsɛgɛliw jaabiw ye layidu ta, ka fɛɛrɛ kuraw di dusukun tantanni-schemie-reperfusion jogin furakɛli la.
Dusukun tantanni : Dusukun tantanni bɛ banabagatɔ minnu na, a ka ca a la, Ghrelin hakɛ bɛ dɔgɔya, wa a bɛ tali kɛ dusukun tantanni jugumanba la. Ni aw ye Ghrelin walima a ɲɔgɔnnaw fara u kan, o bɛ se ka dusukun baara ɲɛ dusukun tantanni banabagatɔw la, ka dusukun tantanni sabati, ka dusukun fanga sɛnɛcogo ɲɛ, ani ka dusukun tantanni selilɛriw ka apoptose bali, o la, banabagatɔw ka ɲɛnamaya kɛcogo ɲuman ni u ka ɲɛnamaya hakɛ bɛ bonya.
Bana minnu bɛ mɔgɔ farikolo tiɲɛ:
Alzheimer bana ni Parkinson ka bana : Ni an y’a jateminɛ ko Ghrelin bɛ se ka farikolo tanga, a nafa bɛ se ka kɛ a la farikoloɲɛnajɛ banaw furakɛli la i n’a fɔ Alzheimer bana ani Parkinson ka bana. Ni a ye Ghrelin walima a ɲɔgɔnnaw di, a bɛ se ka farikolojidɛsɛ bali, ka farikolojidɛsɛ jaabiw dɔgɔya, ani ka banabagatɔw ka hakili ni u ka farikoloɲɛnajɛ kɛcogo ɲɛ.
Sɔgɔsɔgɔninjɛ ni kunsɛmɛ joginni jugumanw na i n’a fɔ sɔgɔsɔgɔninjɛ ni kunsɛmɛ joginni jugumanba, Ghrelin bɛ se ka farikolo tangacogo kɛ fɛɛrɛw fɛ minnu bɛ senfagabana tiɲɛni dɔgɔya ani ka senfagabana seginni sabati. Kɔlɔsiliw y’a jira ko baganw ka misaliw la, minnu bɛ kɛ ni sɔgɔsɔgɔninjɛ walima kunsɛmɛ joginni ye, Ghrelin tali bɛ se ka dɔ bɔ sɔgɔsɔgɔninjɛ hakɛ la walima ka kunsɛmɛ tiɲɛni hakɛ dɔgɔya, o la, hakiliɲagami baarakɛcogo bɛ ɲɛ. Ghrelin bɛ se ka kɛ furakɛli dɛmɛnan ye jolida ni kunsɛmɛ joginniw na, o bɛ banabagatɔw ka kɛnɛya sabatili nafa bonya ka taa a fɛ.
Kuncɛli minnu bɛ kɛ
I n’a fɔ pepitiri kɔnɔna na min bɛ baara caman kɛ, Ghrelin jɔyɔrɔ ka bon farikolo taabolo suguya caman na, i n’a fɔ bonya ni yiriwali, fanga sɛnɛcogo, kɔnɔbara baara, dusukun ni jolisiraw ka omɛostasi, ani farikolo lakanani.
Sosow (Sɔrɔyɔrɔw).
[1] Basuny A, Aboelainin M, Hamed E. Ghrelin ka sigicogo n’a farikolo baarakɛcogo[J]. Biomedical Journal of Science & Technique Research, 2020,31.DOI:10.26717/BJSTR.2020.31.005080.
[2] Ibrahim A M. Ghrelin - Farikoloɲɛnajɛ baarakɛcogo ni a labɛnni[J]. Eur Endocrinol, 2015,11(2):90-95.DOI:10.17925/EE.2015.11.02.90.. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew.
[3] Khatib N, Gaidhane S, Gaidhane A. M., ani mɔgɔ wɛrɛw. Ghrelin : ghrelin i n’a fɔ Peptide min bɛ a ɲɛnabɔ bonya hormone bɔli la.[J]. Dɔgɔtɔrɔso ni sɛgɛsɛgɛli ɲinini gafe : Jcdr, 2014,8 8:MC13-MC17. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew.
[4] Brahmkhatri V, Prasanna C, Atreya H. Insuline-like growth factor system kansɛri la: Furakɛcogo kura laɲinitaw[J]. Biomed ɲininiw diɲɛ kɔnɔ, 2014,2015.DOI:10.1155/2015/538019.
[5] Strasser F. Gɛrɛlini tali kɛnɛyaso la.[J]. Sisan furakɛlicogo, 2012,18 31:4800-4812. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew.
