Bya Cocer Peptides 
omwezi gumu emabega
EBINTU BYONNNA N’AMAWULIRE GW’EBINTU EBIweereddwa KU MUTINDO GUNO BIKOZESEBWA KU KUSASANYA AMAWULIRE N’EBIKOLWA BY’OKUSOMESA.
Ebintu ebiweereddwa ku mukutu guno bigendereddwamu kunoonyereza mu kisenge (in vitro research) byokka. Okunoonyereza mu vitro (Olulattini: *mu ndabirwamu*, ekitegeeza mu bikozesebwa mu ndabirwamu) kukolebwa ebweru w’omubiri gw’omuntu. Ebintu bino si bya ddagala, tebikkiriziddwa kitongole kya Amerika ekivunaanyizibwa ku by’emmere n’eddagala (FDA), era tebirina kukozesebwa kuziyiza, kujjanjaba oba kuwonya mbeera yonna ya bujjanjabi, bulwadde oba bulwadde. Kikugirwa nnyo mu mateeka okuyingiza ebintu bino mu mubiri gw’omuntu oba ebisolo mu ngeri yonna.
Okutwalira awamu
Okuva lwe yazuulibwa mu 1999, ghrelin ezze evaayo ng’ekifo ekikulu eky’okunoonyereza mu sayansi w’obulamu olw’emirimu gyayo egy’enjawulo egy’omubiri n’ebikolwa byayo ebigazi mu biramu. Ghrelin akola kinene nnyo mu kulungamya okufuluma kw’obusimu obukula (GH) era era yeenyigira mu nkola eziwerako ezikulu ez’omubiri, omuli okutebenkeza amaanyi, okulungamya okwagala okulya, enkola y’olubuto, okuziyiza emisuwa gy’omutima, n’okukuuma obusimu.
Ekifaananyi 1 Obusimu bwa ghrelin mu ngeri yaayo etakola (desacyl ghrelin) bukyusibwa ne bufuuka mu ngeri yaayo ekola (acyl ghrelin).
Enzimba n’Ensaasaanya ya Ghrelin
(1) Enzimba y’ebintu
Ebirungo by’eddagala: Ghrelin ye polypeptide erimu amino acids 28, nga ensengekera yaayo enkulu eraga okukuuma okw’amaanyi mu bika eby’enjawulo. Mu bantu, ensengekera ya amino asidi ya ghrelin ye GSSFLSPEHQRVQQRKESKKPPAKLQPR. Ekintu kyayo eky’enjawulo kwe kukyusa octanoylation ku bisigalira bya serine ku kifo 3, ekikulu ennyo mu kusiba kwa ghrelin ku kirungo ekifulumya obusimu obukula (GHS-R) n’okukozesa emirimu gyayo egy’ebiramu.
Isomers: Ng’oggyeeko Ghrelin eya classic octanoylated, waliwo ne deacetylated Ghrelin ne isomer endala. Newankubadde nga Ghrelin eya deacetylated terina nkyukakyuka ya octanoylation era terina busobozi kusiba ku GHS-R n’enkolagana ey’amaanyi, okunoonyereza kulaga nti esobola okukola ebikolwa by’ebiramu okuyita mu bikwata oba enkola endala ezitamanyiddwa.
(2) Okugabanya
Ensaasaanya y’ebitundu by’omubiri: Ghrelin okusinga ekolebwa era n’efulumizibwa obutoffaali obufulumya asidi mu nseke z’omu lubuto era era yeeyolekera mu bitundu n’ebitundu by’omubiri ebingi, omuli ekyenda ekitono, olubuto, hypothalamus, ne pituitary gland. Mu nkola y’olubuto, emiwendo gy’okwolesebwa kwa ghrelin gikendeera mpolampola okuva mu lubuto okutuuka mu kyenda ekitono. Mu nkola y’obusimu obw’omu makkati, ghrelin yeeyolekera nnyo mu bitundu nga arcuate nucleus ne paraventricular nucleus of the hypothalamus, ebikwatagana ennyo n’okulungamya okwagala okulya, okukyusakyusa amaanyi, n’okulungamya neuroendocrine.
Okubeera mu butoffaali: Mu lubuto, Ghrelin okusinga yeeyolekera mu butoffaali bw’endocrine mu lubuto, obusobola okuzuula embeera y’emmere munda mu nkola y’olubuto n’okutambuza obubonero eri obusimu obw’omu makkati okuyita mu kufulumya Ghrelin. Mu nseke z’omubiri (pituitary gland), Ghrelin eyinza okukola butereevu ku butoffaali bw’obusimu obukula okulung’amya okufuluma kw’obusimu obukula.
Enkola y’okukola kw’ekirungo kya Peptide ekifulumya obusimu bw’okukula
(1) Okusiba ku Receptors
GHS-R-mediated signaling pathway: Ebikulu ebiva mu biramu ebya Ghrelin bituukibwako nga biyita mu kusiba ku kirungo ekifulumya obusimu obukula 1a (GHS-R1a). GHS-R1a ye G protein-coupled receptor esaasaanidde nnyo mu pituitary gland, hypothalamus, n’ebitundu ebirala eby’okumpi. Nga yeesibye ku GHS-R1a, ghrelin ekola puloteyina za G, nga zino zikola ekkubo ly’obubonero erya phospholipase C (PLC)-inositol trisphosphate (IP3)-calcium ion (Ca⊃2;+), ekivaako okweyongera kw’obungi bwa Ca⊃2;+ mu butoffaali era okukkakkana nga zitumbula okufulumya obusimu obukula n’okulungamya eby’omubiri ebirala emirimu.
Enkola ezitali za GHS-R: Ng’oggyeeko GHS-R1a, okunoonyereza kulaga nti ghrelin era eyinza okukola ebikolwa by’ebiramu okuyita mu nkolagana n’ebikwata ebirala oba puloteyina z’olususu.
Ekifaananyi 2 Ghrelin ekola ebikolwa byayo mu hypothalamus ng’eyita mu makubo asatu ag’enjawulo.
(2) Okulungamya okwolesebwa kw’obuzaale
Ensengekera z’obuzaale ezikwatagana n’ekisiki kya hypothalamic-pituitary: Ghrelin esobola okulungamya okwolesebwa kw’obuzaale obuwera mu kisenge kya hypothalamic-pituitary. Ku ddaala lya pituitary, ghrelin esobola okulinnyisa okuwandiika kw’obusimu obukula, okutumbula okusengejja n’okufulumya obusimu obukula. Mu hypothalamus, ghrelin esobola okukwata ku kwolesebwa kw’obusimu obufulumya obusimu bw’okukula (GHRH) ne somatostatin (SS), mu ngeri etali butereevu n’etereeza okufulumya obusimu bw’okukula ng’ekyusakyusa okufulumya kwa GHRH ne SS. Okusingira ddala, ghrelin esobola okusitula okufulumya kwa GHRH ate ng’eziyiza okufulumya kwa SS, bwe kityo mu ngeri ey’okukwatagana n’etumbula okufulumya obusimu bw’okukula.
Ensengekera z’obuzaale ezikwatagana n’enkyukakyuka y’amasoboza: Mu bitundu by’amasavu n’ekibumba, ghrelin etereeza okwolesebwa kw’obuzaale obukwatagana n’enkyukakyuka y’amasoboza. Okugeza, ghrelin esobola okulinnyisa okwolesebwa kwa peroxisome proliferator-activated receptor γ (PPARγ), okutumbula okwawukana kw’obutoffaali bw’amasavu n’okutondebwa kw’amasavu; mu kiseera kye kimu, mu kibumba, ghrelin etereeza okwolesebwa kw’obuzaale obukwatagana ne gluconeogenesis, ekikwata ku homeostasis y’emiwendo gya glucose mu musaayi.
Ebikolwa by’omubiri ebya peptide efulumya obusimu bw’okukula
(1) Okutumbula okufulumya obusimu bw’okukula
Okukola obutereevu ku nseke: Ghrelin kirungo kya maanyi ekifulumya obusimu bw’okukula ekikola butereevu ku butoffaali bw’obusimu obukula mu nseke y’omu maaso, okutumbula okusengejja n’okufulumya obusimu bw’okukula okuyita mu kkubo ly’obubonero eritambulizibwa GHS-R1a. Bw’ogeraageranya n’obusimu obufulumya obusimu bw’okukula (GHRH), ghrelin eyamba okufulumya obusimu bw’okukula amangu, era byombi birina ebikolwa ebikwatagana. Mu mbeera z’omubiri, ghrelin, GHRH, ne somatostatin awamu zitereeza okufulumya kw’obusimu bw’okukula mu ngeri ey’okukuba, ne zikuuma emiwendo gy’obusimu bw’okukula egya bulijjo.
Ebikosa enkula: Obusimu obuyamba okukula bukola kinene mu kutumbula enkula n’enkula y’omubiri. Ghrelin mu ngeri etali butereevu ekwata ku kukula ng’etumbula okufulumya obusimu bw’okukula. Mu buto n’obuvubuka, okufulumya okwa bulijjo okwa Ghrelin kikulu nnyo mu nkola ng’okukula kw’amagumba n’okukula kw’ebinywa. Mu balwadde abalina obuzibu bw’obusimu bw’okukula, emiwendo gy’okufulumya ghrelin gitera okuba wansi. Okugaba ghrelin oba analogues zaayo okuva ebweru kiyinza bulungi okwongera ku busimu obukula n’okutumbula okukula n’okukula.
(2) Okulungamya Enkyukakyuka y’Amaaso
Okutereeza okwagala okulya: Ghrelin, amanyiddwa nga 'obusimu bw'enjala,' molekyu nkulu eraga obubonero etereeza okwagala okulya. Mu kitundu ekiyitibwa arcuate nucleus ekya hypothalamus, ghrelin yeekwata ku GHS-R1a receptors ku neuropeptide Y (NPY)/agouti-related protein (AgRP) neurons, n’esitula okufulumya NPY ne AgRP, bwe kityo n’eyongera okwagala okulya n’okutumbula okulya emmere. Ghrelin era mu ngeri etali butereevu ekwata ku njagala y’okulya ng’etereeza emirimu gy’obusimu obufulumya obusimu obuyitibwa corticotropin-releasing hormone (CRH) mu kitundu ekiyitibwa paraventricular nucleus ekya hypothalamus. Mu kiseera ky’okusiiba, emiwendo gya ghrelin girinnya, ekivaako enjala; oluvannyuma lw’okulya, omuwendo gwa ghrelin gukendeera mangu, ne kyongera okuwulira ng’ojjudde.
Okulungamya bbalansi y’amasoboza: Ghrelin era yeetaba mu kulungamya enkyukakyuka y’amasoboza, okukuuma bbalansi y’amasoboza g’omubiri. Ghrelin atumbula lipolysis, ayongera ku fatty acid oxidation, n’okutumbula amaanyi g’omubiri. Ghrelin aziyiza okufulumya insulini, akendeeza ku kukwatibwa kw’ebitundu by’omubiri ebiriraanyewo n’okukozesa glucose, n’okulinnyisa emiwendo gya glucose mu musaayi, n’awa omubiri ensibuko z’amaanyi endala. Okwolesebwa kwa ghrelin okungi okutambula obutasalako kuyinza okuvaako okunywa amaanyi agasukkiridde, okukuŋŋaanyizibwa kw’amasavu, n’oluvannyuma obuzibu mu nkyukakyuka y’emmere ng’omugejjo.
(3) Ebikosa enkola y’olubuto n’ekyenda
Okufulumya asidi mu lubuto n’okutambula kw’olubuto: Mu nkola y’olubuto, ghrelin akola kinene nnyo mu kulungamya mu kufulumya asidi mu lubuto n’okutambula kw’olubuto. Ghrelin asitula obutoffaali bw’omu lubuto obuyitibwa gastric mucosal parietal cells okufulumya asidi w’olubuto, n’atereeza embeera ya asidi munda mu lubuto, ekiyamba mu kugaaya emmere n’okuginyiga. Ghrelin etumbula okuzimba olubuto n’ekyenda, okutumbula entambula z’okusitula mu nkola y’olubuto n’okwanguyiza okufulumya emmere okuva mu nkola y’olubuto. Mu buzibu obumu obw’omu lubuto, gamba ng’obutakola bulungi mu lubuto n’okuzimba olubuto, emiwendo gya Ghrelin egitaali gya bulijjo giyinza okuvaako okutaataaganyizibwa mu kufulumya asidi mu lubuto n’okutambula kw’olubuto.
Okukuuma Omusuwa gw’Olubuto: Ghrelin alina ekikolwa eky’obukuumi ku nnywanto y’omu lubuto. Kitumbula okukula n’okuddaabiriza obutoffaali bw’omu lubuto, kyongera ku nkola y’ekiziyiza ky’omu lubuto, n’okukuuma obutayonoonebwa ebintu eby’obulabe nga asidi w’olubuto ne Helicobacter pylori. Mu bikolwa by’endwadde nga amabwa g’omu lubuto n’amabwa g’omu lubuto, okugaba ghrelin okuva ebweru kwanguyiza amabwa okuwona era kikendeeza ku bunene bw’okwonooneka kw’omubiri.
(4) Okulungamya enkola y’emisuwa gy’omutima
Okulungamya enkola y’omutima: Ghrelin yeeyolekera nnyo mu mutima era akola kinene mu kulungamya enkola y’omutima. Ghrelin ayongera ku kukwatagana kw’emisuwa gy’omutima, ayongera ku bifuluma mu mutima, n’okulongoosa enkola y’okupampagira omutima. Mu bikolwa by’obuvune mu myocardial ischemia-reperfusion, ghrelin ekendeeza ku myocardial cell apoptosis ne necrosis, ekendeeza ku sayizi y’okusannyalala, era ekola ekikolwa eky’okukuuma omutima. Enkola yaayo eyinza okuba nga yeekuusa ku kukola kw’amakubo g’obubonero bw’okuwangaala mu butoffaali, gamba nga ekkubo ly’obubonero erya phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt).
Okulungamya okusika omuguwa kw’emisuwa: Ghrelin etereeza okusika omuguwa kw’emisuwa n’okukuuma puleesa nga tekyukakyuka. Kikola ku butoffaali bw’ebinywa ebiseeneekerevu eby’emisuwa okuziyiza ebikolwa by’ebintu ebiziyiza emisuwa nga angiotensin II, ekivaako emisuwa okugaziwa, okukendeeza ku buziyiza bw’emisuwa egy’okumpi, era bwe kityo ne kikendeeza puleesa. Ghrelin era aziyiza okulaga molekyu z’okunyweza obutoffaali bw’emisuwa, n’ekendeeza ku kwekwata n’okuyingira kw’obutoffaali obuzimba, n’ekola ekikolwa eky’okukuuma emisuwa, n’okuziyiza okukula kw’okuzimba emisuwa.
(5) Ebikolwa eby’okukuuma obusimu
Obulamu bw’obusimu n’okukula: Mu nkola y’obusimu, ghrelin erina ekikolwa eky’obukuumi ku busimu obuyitibwa neurons. Kitumbula okukula n’okwawukana kw’obutoffaali obusibuka mu busimu, kyongera ku muwendo gw’obusimu obuyitibwa neurons, era kikuuma enkula ya bulijjo n’enkola y’obusimu. Mu bikolwa by’endwadde ezikendeeza ku busimu ng’obulwadde bwa Alzheimer n’obulwadde bwa Parkinson, ghrelin esobola okuziyiza okufa kw’obusimu, okukendeeza ku kuddamu kw’obusimu obuzimba, n’okulongoosa emirimu gy’okutegeera n’enkola y’emirimu. Enkola zaayo ez’okukuuma obusimu ziyinza okuba nga zeekuusa ku kulungamya eby’okuddamu by’okunyigirizibwa mu butoffaali (intracellular oxidative stress responses), okuziyiza amakubo agalaga obubonero bwa apoptosis, n’okutumbula okufulumya obusimu obutambuza obusimu.
Okulungamya obusimu: Ng’ensonga efugira obusimu obukola omubiri, Ghrelin yeetaba mu kulungamya enkola y’ekitundu ky’omubiri ekiyitibwa hypothalamic-pituitary-adrenal axis (HPA axis). Mu mbeera z’okunyigirizibwa, emiwendo gya ghrelin egy’okulinnya giziyiza okukola ennyo kw’ekisiki kya HPA, ne kikendeeza ku kufulumya corticosteroid era bwe kityo ne kikendeeza ku kwonooneka kw’omubiri okuva ku situleesi. Okugatta ku ekyo, ghrelin etereeza ekitundu kya hypothalamic-pituitary-thyroid axis (HPT axis) ne hypothalamic-pituitary-gonadal axis (HPG axis), okukuuma homeostasis y’enkola y’obusimu.
(6) Ebintu ebirala ebiva mu mubiri
Okutereeza abaserikale b’omubiri: Ghrelin nayo ekola kinene mu baserikale b’omubiri. Kisobola okulung’amya enkola y’obutoffaali bw’abaserikale b’omubiri, okutumbula okukula n’okwawukana kw’obutoffaali obukola omusaayi, n’okutumbula obusobozi bw’abaserikale b’omubiri okuddamu. Mu mbeera z’okuzimba, ghrelin esobola okuziyiza okufulumya obutoffaali obuzimba, gamba nga tumor necrosis factor-α (TNF-α) ne interleukin-6 (IL-6), bwe kityo n’ekendeeza ku kuddamu kw’okuzimba n’okukola ebikolwa eby’okukyusa obusimu n’okuziyiza okuzimba.
Okulungamya enkyukakyuka y’amagumba: Ghrelin alina ebikolwa ebilung’amya ku nkyukakyuka y’amagumba. Kitumbula okukula n’okwawukana kw’amagumba, kiziyiza emirimu gy’amagumba, bwe kityo ne kyongera ku bunene bw’amagumba n’okutumbula okutondebwa kw’amagumba. Mu balwadde abalina obulwadde bw’amagumba, emiwendo gya ghrelin gitera okukendeera, ekiraga nti ghrelin eyinza okuba nga ekwatagana n’okukula kw’obulwadde bw’amagumba. Okugaba ghrelin oba analogues ebweru kiyinza okuwa enkola empya ez’obujjanjabi ku bulwadde bw’amagumba.
Okukozesa eddagala erifulumya obusimu bw’okukula (Growth Hormone-Releasing Peptide).
(1) Enkozesa y’obujjanjabi mu bujjanjabi
Obutabeera na busimu bw’okukula: Ku balwadde abalina obuzibu mu busimu bw’okukula, Ghrelin ne analogues zaayo bisobola okukola ng’ebirungo ebijjanjaba. Nga zisitula okufulumya obusimu bw’okukula, zitumbula okukula n’okukula mu balwadde. Bw’ogeraageranya n’obujjanjabi obw’ekinnansi obw’okukyusa obusimu bw’okukula, Ghrelin ne analogues zaayo ziwa obukuumi obulungi n’okugumiikiriza, era ziyinza okutumbula okukula mu ngeri esaanira mu mubiri nga zitereeza okufulumya obusimu bw’okukula obw’omunda.
Ekifaananyi 3 Endocrine regulation ya GH n’okuziyiza obujjanjabi.
Endwadde z’enkyukakyuka mu mubiri
Omugejjo ne Ssukaali: Mu kujjanjaba omugejjo, wadde nga Ghrelin ayogerwako nga 'obusimu bw'enjala,' okulungamya emiwendo gya Ghrelin oba amakubo gaayo agalaga obubonero kiyinza okulongoosa enkyukakyuka y'amaanyi, okukendeeza ku njagala y'okulya, n'okutuuka ku kugejja. Okukola ebiziyiza Ghrelin receptor okuziyiza Ghrelin okusiba ku receptors kiyinza okuziyiza apetite n’okukendeeza ku mmere gye balya. Ku balwadde ba ssukaali, Ghrelin eyinza okukola ebirungi ku miwendo gya glucose mu musaayi ng’ayita mu nkola nga okulungamya okufulumya insulini n’okulongoosa obuziyiza bwa insulini. Okugaba Ghrelin okuva ebweru kiyamba okufuga glucose mu musaayi n’okuwulira insulin mu nvunza ezirina ssukaali, ne kiwa amagezi amapya ku bujjanjabi bwa sukaali.
Obulwadde bwa Metabolic syndrome: Obulwadde bwa Metabolic syndrome kibinja kya ndwadde ezimanyiddwa nga omugejjo, puleesa, sukaali mu musaayi n’obutaba na masavu mu musaayi. Olw’omulimu gwayo mu kukyusa amaanyi n’okulungamya emisuwa gy’omutima, ghrelin eyinza okufuuka ekigendererwa ekiyinza okujjanjaba obulwadde bw’okukyusakyusa emmere. Nga tutereeza emiwendo gya ghrelin, kiyinza okusoboka okulongoosa mu kiseera kye kimu ebiraga obuzibu bw’enkyukakyuka mu mubiri mu balwadde abalina obulwadde bw’enkyukakyuka mu mubiri, gamba ng’okugejja, okukendeeza puleesa, n’okulongoosa mu glucose mu musaayi n’amasavu agatali ga bulijjo.
Endwadde z’omu lubuto:
Functional dyspepsia and gastroparesis: Ku balwadde abalina functional dyspepsia ne gastroparesis, ghrelin ne analogues zaayo zisobola okulongoosa obubonero bw’okugaaya emmere n’okwanguyiza okufulumya amazzi mu lubuto nga zitumbula okutambula kw’olubuto n’okwongera ku kufulumya asidi mu lubuto. Okukozesa ghrelin analogues kiyinza bulungi okukendeeza ku bubonero ng’obulumi mu lubuto olwa waggulu n’okuzimba mu balwadde abalina obulwadde bw’okubulwa emmere obukola, bwe kityo ne kitereeza omutindo gw’obulamu bwabwe.
Amabwa g’omu lubuto: Olw’engeri Ghrelin gy’ekuuma ku nnywanto z’omu lubuto, esobola okutumbula okuwona kw’amabwa era bwe kityo erina omugaso oguyinza okukozesebwa mu kujjanjaba amabwa g’omu lubuto. Okuweebwa Ghrelin oba analogues zaayo okuva ebweru kiyinza okwanguya enkola y’okuddaabiriza amabwa n’okukendeeza ku kuddamu kw’amabwa.
Endwadde z’emisuwa n’emisuwa:
Myocardial ischemia-reperfusion injury: Mu kujjanjaba myocardial ischemia-reperfusion injury, Ghrelin, olw’ebikolwa byayo eby’okukuuma omutima, esuubiza ng’ekirungo ekipya eky’obujjanjabi. Nga ogaba Ghrelin oba analogues zaayo nga tonnaba oba nga myocardial ischemia-reperfusion, esobola okukendeeza ku myocardial cell okwonooneka, okukendeeza ku bunene bwa infarct, n’okulongoosa enkola y’omutima. Okugezesa ebisolo n’ebyava mu kugezesebwa mu malwaliro biraga ebisuubiza ebivaamu, nga biwa obukodyo obupya obw’okujjanjaba obuvune bw’okusannyalala kw’omusaayi (myocardial ischemia-reperfusion injury).
Omutima okulemererwa: Mu balwadde abalina omutima okulemererwa, emiwendo gya Ghrelin gitera okukendeera era gikwatagana n’obuzibu bw’okulemererwa kw’omutima. Okwongera ku Ghrelin oba analogues zaayo kiyinza okulongoosa enkola y’omutima mu balwadde abalemererwa omutima nga kyongera ku myocardial contractility, okulongoosa cardiac energy metabolism, n’okuziyiza myocardial cell apoptosis, bwe kityo ne kyongera ku mutindo gw’obulamu bw’abalwadde n’emiwendo gy’okuwangaala.
Endwadde ezikola ku busimu:
Obulwadde bwa Alzheimer n’obulwadde bwa Parkinson: Okusinziira ku ngeri Ghrelin gy’ekuuma obusimu, erina omugaso oguyinza okukozesebwa mu kujjanjaba endwadde z’obusimu ng’obulwadde bwa Alzheimer n’obulwadde bwa Parkinson. Nga egaba Ghrelin oba analogues zaayo, eyinza okuziyiza neuronal apoptosis, okukendeeza neuroinflammatory responses, n’okulongoosa abalwadde mu kutegeera n’enkola y’enkola y’emirimu.
Stroke and Traumatic Brain Injury: Mu buvune obw’amaanyi obw’obusimu nga stroke n’obuvune ku bwongo obuvune, Ghrelin ayinza okukola ebikolwa eby’okukuuma obusimu ng’ayita mu nkola omuli okukendeeza ku kwonooneka kw’obusimu n’okutumbula okuddamu okukola kw’obusimu. Okunoonyereza kulaga nti mu bikolwa by’ebisolo eby’okusannyalala oba obuvune ku bwongo obuva ku buvune, okukozesa Ghrelin kuyinza okukendeeza ku sayizi y’okusannyalala oba okukendeeza ku bunene bw’okwonooneka kw’obwongo, bwe kityo ne kilongoosa ebiva mu nkola y’obusimu. Ghrelin eyinza okukola ng’obujjanjabi obw’okugatta ku kusannyalala n’obuvune ku bwongo obuva ku buvune, okwongera okutumbula ebiva mu kuddaabiriza abalwadde.
Ebimaliriziddwa
Nga peptide ey’omunda ekola emirimu mingi, Ghrelin ekola kinene nnyo mu nkola ez’enjawulo ez’omubiri, omuli okukula n’okukula, okukyusakyusa amaanyi, enkola y’olubuto, enkola y’emisuwa gy’omutima homeostasis, n’okukuuma obusimu.
Ensonda
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