Na Cocer Peptides bin rayt am 
1 mɔnt dɔn pas
ƆL DI ATIKUL ƐN PRODƆKT INFƆMƐSHƆN WE DƐN GI NA DIS WƐBSAYT NA FƆ ƆL FƆ DI INFƆMƐSHƆN ƐN FƆ EDYUKESHƆN.
Di prɔdak dɛn we dɛn gi na dis wɛbsayt na fɔ in vitro risach nɔmɔ. in vitro risach (Latin: *in glas*, we min insay glas) dεn de du am ausayd mכtalman bכdi. Dɛn prɔdak ya nɔto mɛrɛsin, dɛn nɔ gɛt di aprɔval frɔm di US Food and Drug Administration (FDA), ɛn dɛn nɔ fɔ yuz dɛn fɔ protɛkt, trit, ɔ mɛn ɛni mɛrɛsin, sik, ɔ sik. Di lɔ nɔ gri fɔ mek dɛn put dɛn tin ya insay mɔtalman ɔ animal bɔdi ɛni we.
Ovaviu fɔ di tin dɛn we dɛn dɔn lan
sins dεn dכn diskovri am insay 1999, ghrelin dכn kכmכt as fכkal pכynt fכ risεch insay di layf sayns dεm bikoz fכ in yכnik fysiolojikal fכnshכn dεm εn brayt bayolojikal ifekt dεm. Ghrelin de ple imכtant rol fכ rεgεl di rilis fכ di gכt hכmon (GH) εn i de involv bak insay plεnti imכtant fysiolojikal prכsεs dεm, we inklud εnεji bεlε, apεtit rεgulεshכn, gεstrointestinal fכnshכn, kכdivaskyul homכstasis, εn nyuroprotεkshכn.
Fig 1 di ghrelin hכmon we de insay in inaktiv fכm (desacyl ghrelin) de kכnvכlt to in aktv fכm (acyl ghrelin).
Strukchɔ ɛn Distribushɔn fɔ Ghrelin
(1) Di we aw dɛn mek am
Kεmikכl Kכmכshכn: Ghrelin na polipεptida we kכmכp fכ 28 amino asid dεm, wit in praymar strכkchכ we de sho hכy kכnsyuvεshכn akraos difrεn spεshal. insay mכtalman, di amino asid sikεns fכ ghrelin na GSSFLSPEHQRVQQRKESKKPPAKLQPR. in yכnik fכm na di כktanoyleshכn modifyushכn pan di serin rεsidεns na posishכn 3, we imכtant fכ ghrelin in binding to di growth כmon-rilis כmon rεsεpכta (GHS-R) εn di εksεrshכn fכ in bayolojikal aktiviti.
Isomers: Apat frɔm di klas ɔktanoylet Ghrelin, i de bak we deacetylated Ghrelin ɛn ɔda isomers. pan tap we di deacetylated Ghrelin nכ gεt di octanoylation modifyushכn εn i nכ posεs di abiliti fכ biεn to GHS-R wit hכy afiniti, risεch dεn sho se i kin εksyεrt bayolojikal ifekt tru כda rεsεpכta כ mεkanism dεm we dεn nכ no.
(2) Di we aw dɛn de sheb di tin dɛn
di tisu distribushכn: di ghrelin na di fכs tεm we di sεl dεm we de kכl asid na di gastric fundic gland dεm de mek εn sekret am εn i de εksprεs bak insay plεnti tisu dεm εn כgan dεm, we inklud di sכmכl intestin, pankrias, haypothalamus, εn pituitary gland. insay di gεstrointestinal trakt, di ghrelin εksprεshכn lεvεl dεm de dכn sכmtεm frכm di bכdi to di sכmכl intestinal. insay di sεntri nεv sεstem, di ghrelin de hεvi εksprεs insay rijyכn dεm lεk di arcuate nyuklios εn paraventricular nyuklios na di haypothalamus, we de kכlכsכl wit apεtit rεguleshכn, εnεji mεtabolism, εn nyuroεndokrin rεguleshכn.
sεl lכkalεyzeshn: insay di bεlε, Ghrelin de fכs fכ εksprεs insay di εndokrin sεl dεm na di gεstrik mכkus, we kin dεtekt di nyutrishכnal stetכs insay di gεstrointestinal trakt εn transmit signal to di sεntri nεv sεstem tru Ghrelin sekreshכn. insay di pituitary gland, Ghrelin kin akt dairekt pan di growth כmon sεl dεm fכ rεgεl di growth כmon rilis.
Mεkanism fכ akshכn fכ Grכw Hכmon-Rεlis Pεptid
(1) Binding to Risɛptɔ dɛn
GHS-R-mεdiet signal path: di praymar bayolojikal ifekt dεm fכ Ghrelin de achy tru binding to di growth hכmon-rilis כmon rεsεpכta 1a (GHS-R1a). GHS-R1a na G protin-kכpl rεsεpכta we dεn de sheb bכku bכku wan na di pituitary gland, haypothalamus, εn כda pεrifεral tisu dεm. we i de biεn GHS-R1a, ghrelin de aktibכt G protin dεm, we in tכn de aktibכt di fכsfolaypas C (PLC)-inositol trisphosphate (IP3)-kalsiכm ayכn (Ca⊃2;+) signal path, we de lid to inkrεs insay intasεlulyar Ca⊃2;+ kכnsantreshכn εn ultimately de promuot gכt hכmon rilis εn rεgul כda fysiolojikal di wok dɛn we dɛn de du.
nכn-GHS-R-mεdiet mεkanism dεm: apat frכm GHS-R1a, stכdi dεn sho se ghrelin kin εksyεrt bayolojikal ifekt dεm bak tru intarakshכn wit כda rεsεpכta dεm כ mεmbran protin dεm.
Figure 2 Ghrelin de sho in ifekt dεm na di haypothalamus tru tri difrεn path dεm.
(2) Rigyuleshɔn fɔ di jin ɛksprɛshɔn
di jin dεm we de rilet to di haypothalamic-pituitary aks: Ghrelin kin rεgεl di εksprεshכn fכ mכltipכl jin dεm na di haypothalamic-pituitary aks. na di pituitary lεvεl, ghrelin kin upregulate di transkripshכn fכ di growth כmon jin, we de promuot di sεntesis εn rilis fכ di growth כmon. insay di haypothalamus, ghrelin kin infכlכw di εksprεshכn fכ di gכt hכmon-rilis כmon (GHRH) εn somatostatin (SS), we indaykt wan de rεgεl di gכt hכmon rilis bay we i de mכdulet di sekreshכn fכ GHRH εn SS. spεshal wan, ghrelin kin stimulate GHRH sekreshכn we i de inhεbit SS sekreshכn, we de sinagεstikli protεkt gכt hכmon rilis.
di jin dεm we rilet to enεji mεtabolism: insay di adipos tisu εn di liva, ghrelin de rεgεl di εksprεshכn fכ di jin dεm we riliyt to enεji mεtabolism. fכ egzampl, ghrelin kin upregulate di εksprεshכn fכ pεrכksisom proliferator-aktivεt rεsεpכta γ (PPARγ), we de protεkt adiposyt difrεns εn lipojεnεsis; di sem tεm, insay di liva, ghrelin de rεgεl di εksprεshכn fכ di jin dεm we riliyt to gluconeogenesis, we de infכlכ di homכstasis fכ di bכdi glukכs lεvεl dεm.
di fysiolojikal ifekt dεm we di pεptida we de rilis di gכt hכmon de gi
(1) Fɔ mek di ɔmon we de gro na di bɔdi kɔmɔt
dayrekt akshכn pan di pituitary gland: Ghrelin na wan pawaful growth כmon-rilis ejen we de akt dayrekt pan growth כmon sεl dεm na di antεriכr pituitary gland, we de promuot di sεntesis εn rilis fכ di gכt כmon tru di GHS-R1a-mεdiet signal path. we yu kompare am wit growth hormone-releasing hormone (GHRH), ghrelin de mek di growth hormone rilis kwik kwik wan, εn di tu gεt sinagεstik ifekt. כnda di fysiolojikal kכndishכn dεm, ghrelin, GHRH, εn somatostatin de jכyn de rεgεl di pulsatile sekreshכn fכ di gכt כmon, we de mεnten di nכmal growth כmon lεvεl dεm.
di ifekt dεm we di bכdi de gro: di כmon we de mek di bכdi gro de ple imכtant rol fכ mek di bכdi gro εn divεlכp. Ghrelin indaykt infכmeshכn fכ gro bay we i de protεkt di rilis fכ di gכt כmon. di tεm we pikin εn yכŋ, nכmal sekreshכn fכ Ghrelin rili implεnt fכ prכsεs dεm lεk skel growth εn mכsul dεm divεlכpmεnt. pan di sik pipul dεm we nכ gεt gכt hכmon, di ghrelin sekreshכn lεvεl dεm kin sכm tεm lכw. εksojen administreshכn fכ ghrelin כ in analכg dεm kin ifektivli inkrεs di growth כmon lεvεl dεm εn protεkt gכt εn divεlכpmεnt.
(2) Rigyuleshɔn fɔ Ɛnaji Mɛtabolism
rεgulεshכn fכ di apεtit: Ghrelin, we dεn kכl 'angri כmon,' na imכtant signal mכlekyul we de rεgεl di apεtit. insay di arcuate nyuklios fכ di haypothalamus, ghrelin de biεn GHS-R1a rεsεpכta dεm pan nyuropεptida Y (NPY)/agouti-rεlatεd protin (AgRP) nyuron dεm, we de mek di rilis fכ NPY εn AgRP, we de mek di apetit inkrεs εn fכ it fכ it. Ghrelin de infכmeshכn bak indaykt wan bay we i de rεgεl di aktiviti fכ di kכtikotropin-rilis כmon (CRH) nyuron dεm na di paraventrikulכr nyuklios na di haypothalamus. We pɔsin de fast, di ghrelin lɛvɛl kin go ɔp, we kin mek pɔsin angri; afta yu it, di ghrelin lεvεl de dכn kwik kwik wan, we de mek yu fil fכ ful.
εnεji bεlε rεgulεshכn: Ghrelin de tek pat bak pan di rεgulεshכn fכ εnεji mεtabolism, we de mεnten di bכdi in enεji bεlε. Ghrelin de mek di lipolysis, i de mek di fεt asid כksidεshכn bכku, εn i de mek di bכdi in enεji saplai bכku. Ghrelin de inhibit insulin sekreshכn, i de ridyus di pεrifεral tisu כptek εn yutilizeshכn fכ glukכs, εn i de εlevεt di bכdi glukכs lεvεl, we de gi di bכdi כda εnεji sכs dεm. we yu de εksprεs ghrelin we de te i kin mek yu it pasmak, fεt de kכmכt, εn afta dat i kin mek i gεt mεtabolik dizayd lεk fכ fat.
(3) Efεkt dεm pan di gεstrointestinal fכnshכn
di gεstrik asid sekreshכn εn di gεstrointestinal mכtiliti: insay di gεstrointestinal trakt, ghrelin de ple imכtant rεgεdyushכn rol fכ di gεstrik asid sekreshכn εn di gεstrointestinal mכtiliti. Ghrelin de mek di gastric mכkus parietal sεl dεm fכ sekret di gastric asid, we de rεgεl di asid invayroment insay di bεlε, we de εp fכ digεst di it εn absכpshכn. Ghrelin de mek di gεstrointestinal pεristalsis, i de εnhans di propulsiv muvmεnt dεm na di gεstrointestinal trakt εn i de aksεleret di εmpti fכ it frכm di gεstrointestinal trakt. insay sכm dizכrd dεm na di gεstrointestinal, lεk fכnshכnal dispεpsia εn gastroparesis, di abnכmal Ghrelin lεvεl kin mek di gεstrik asid sekreshכn εn di gεstrointestinal mכtiliti disrupshכn.
di protεkshכn fכ di gεstrointestinal mכkus: Ghrelin gεt protεktiv ifekt pan di gεstrointestinal mכkus. i de mek di gεstrointestinal mכkus sεl dεm proliferashכn εn rεpa, i de mek di mכkus barεri fכ wok fayn, εn i de protεkt frכm di damej we tin dεm we de du bad lεk gastric acid εn Helicobacter pylori de mek. insay sik mכdel dεm lεk gastric כlsa εn duodenal כlsa, εksojen administreshכn fכ ghrelin de aksεlεrayt כlsa hεl εn rεdכks di εkstenshכn fכ mכkus dεm.
(4) Rigyuleshɔn fɔ di kadiovaskular sistɛm
di kadyak fכnshכn rεgulεshכn: di ghrelin de εksprεs bכku bכku wan na di at εn i de ple imכtant rεgεlεshכn rol fכ di kadyak fכnshכn. Ghrelin de mek di mayokardia kכntraktiliti bכku, i de mek di kadyak autput bכku, εn i de mek di kadyak pכmp fכnshכn bכku. insay mayokardial ischemia-riperfyushכn injuri mכdel dεm, ghrelin de ridyus mayokardial sεl apoptosis εn nεkrכsis, ridyus infarkt saiz, εn i de εksyεrt kadyoprotεktiv ifekt. in mεkanism kin riliyt to di aktibכshכn fכ di intasεlulyar sכvayv signal path dεm, lεk di fכsfoinositide 3-kinase (PI3K)/protein kinase B (Akt) signal path.
Vaskul Tεnshכn Rεgεlεshכn: Ghrelin de rεgεl di vaskulεr tεnshכn εn de mεnten stebul bכdi prεshכn. i de akt pan di vaskul smol mכsul sεl dεm fכ inhεbit di ifekt dεm fכ vasokonstriktiv sכbstans dεm lεk angiotensin II, we de mek vasodilayshכn, ridyus di pεrifεral vaskulεr rεsistεns, εn dat de mek di bכdi prεshכn dכn. Ghrelin de inhεbit bak di εksprεshכn fכ di vaskulεr εndoteyl sεl adheshon mכlekyul dεm, i de ridyus di adheshon εn infiltεshכn fכ inflammatory sεl dεm, i de εksyεrt vaskulכr protεktiv ifekt, εn i de mek di atεrosklεrosis nכ de.
(5) Nyuroprotɛktiv ifɛkt dɛn
di nyuronal sכvayvεns εn proliferashכn: Insay di nεv sεstem, ghrelin gεt prכtektiv ifekt pan nyuron dεm. i de mek di nyural stεm sεl dεm proliferashכn εn difrεns, i de mek di nכmba fכ di nyuron dεm go כp, εn i de mεnten di nכmal divεlכpmεnt εn wok we di nεv sistεm de du. insay mכdel dεm fכ nyurodijεnεraytiv sik dεm lεk Alzaima sik εn Pakinsin sik, ghrelin kin inhεbit nyuronal apoptosis, ridyus nyuroinflammatory rεspכns dεm, εn impruv di kכgnitiv εn mכtal fכnshכn dεm. in nyuroprotεktiv mεkanism dεm kin riliyt to rεgεl intasεlulyar כksidεtiv strεs rεspכns dεm, inhεbit apoptosis signal path dεm, εn fכ promuot di rilis fכ nyurotransmitta dεm.
nyuroεndokrin rεgulεshכn: as nyuroεndokrin rεgεdyushכn fכktכ, Ghrelin de tek pat fכ rεgεl di fכnshכn fכ di haypothalamic-pituitary-adrenal aks (HPA aks). כnda strεs kכndishכn, di εlevεt ghrelin lεvεl dεm de inhεbit di εksyכs aktibכshכn fכ di HPA aks, we de ridyus di kכtikostεroyd sekreshכn εn dat de mitigate di strεs-indyus dεmεj to di bכdi. apat frכm dat, ghrelin de rεgεl di haypothalamic-pituitary-thyroid aks (HPT aks) εn di haypothalamic-pituitary-gonadal aks (HPG aks), we de mεnten di homכstasis fכ di nyuroεndokrin sistεm.
(6) Ɔda tin dɛn we kin apin to pɔsin in bɔdi
imyun rεgulεshכn: Ghrelin de ple rol bak insay di imyun sistεm. i kin rεgεl di wok we di imyun sεl dεm de du, i kin mek di limfosayt dεm proliferashכn εn difrεns, εn i kin mek di bכdi in imyun rεspכns kεpasiti bכku. insay inflammatory stet, ghrelin kin inhεbit di rilis fכ inflammatory cytokines, lεk tumor nεkrכsis fכktכ-α (TNF-α) εn intalyukin-6 (IL-6), we de ridyus inflammatory rεspכns dεm εn εksyεrt imyunmodulatory εn anti-inflammatory ifekt dεm.
Bon mεtabolism rεgulεshכn: Ghrelin gεt rεgεlεshכn ifekt pan bon mεtabolism. i de promuot di proliferashכn εn difrεns fכ di כsteoblast dεm, i de inhibit di aktiviti fכ di osteoclast dεm, we de mek di bon mas go כp εn i de mek di bon fכmeshכn. pan di sik pipul dεm we gεt כstioporosis, di ghrelin lεvεl dεm kin rεdכks bכku tεm, we sho se ghrelin kin bכku wit di divεlכpmεnt fכ כstioporosis. εksojen administreshכn fכ ghrelin כ in analכg dεm kin gi nyu tεrapi stratεji fכ כstioporosis.
Aplikeshɔn fɔ Grɔw Hɔmɔn-Rilis Pɛptid
(1) Klinik Tɛrapi Aplikeshɔn dɛn
Growth Hormone Deficiency: Fɔ di wan dɛn we gɛt growth ɔmon dɛfisiɛns, Ghrelin ɛn in analɔg dɛn kin bi tritmɛnt ɛjɛn. bay we dεn de mek di כmon we de gro, dεn de mek di sikman dεm gro εn divεlכp. we yu kכmpεr wit tradishכnal growth כmon riplesmεnt tεrapi, Ghrelin εn in analכg dεm de gi bεtε sef εn tכlerabiliti, εn kin protεkt gכt in wan mכr fysiolojikal aprכpriet we bay we dεn de rεgεl di sekreshכn fכ εndojεnik gכt כmon.
Figure 3 εndokrin rεgulεshכn fכ GH εn tεrapi blכkεd.
Sik dɛn we kin mek pɔsin gɛt bɔdi
Fat ɛn Dayabitis: Insay di tritmɛnt fɔ fat, pan ɔl we dɛn kin kɔl Ghrelin di 'angri ɔmon,' we de rigul di Ghrelin lɛvɛl ɔ in signal path kin mek di ɛnaji mɛtabolism bɛtɛ, i kin mek i nɔ want fɔ it, ɛn i kin mek i nɔ gɛt bɔku bɔku wet. divεlכp Ghrelin rεsεpכta antagonist dεm fכ blכk Ghrelin binding to rεsεpכta dεm kin sכpres apεtit εn rεdכks di it we yu de it. Fɔ di wan dɛn we gɛt dayabitis, Ghrelin kin du fayn fayn tin dɛn pan di blɔd glukɔs lɛvɛl tru mɛkanism dɛn lɛk fɔ rigul di insulin sekreshɔn ɛn fɔ mek di insulin rɛsistɛns bɛtɛ. Eksojen administreshכn fכ Ghrelin de impruv bכdi glukכs kכntrכl εn insulin sεnsitiviti insay dayabεtik rat dεm, we de gi nyu insayt fכ dayabεtis tritmεnt.
Mεtabolik sεndrכm: Mεtabolik sεndrכm na wan grup כf sik dεm wae de kכl yu fat, haypatεnshכn, haypa glycemia, εn dislipidemia. biכs fכ in rol fכ enεji mεtabolism εn kכdivaskyul rεguleshכn, ghrelin kin bi wan pכtεnshal tכgεt fכ trit mεtabolik sεndrכm. bay we dεn de rεgεl di ghrelin lεvεl, i kin pכsibul fכ impruv mכltipכl mεtabolik dizכrd indikεtכ dεm wan tεm pan di sik pipul dεm we gεt mεtabolik sεndrכm, lεk fכ lכs wet, rεdukshכn na di bכdi prεshכn, εn impruv di bכdi glukכs εn lipid abnכmaliti.
Di sik dɛn we kin kam na di bɛlɛ:
Fכnshכnal dispepsia εn gastroparesis: Fכ di sik pipul dεm we gεt fכnshכnal dispεpsia εn gastroparesis, ghrelin εn in analכg dεm kin impruv di dijestiv simptom dεm εn aksεlεrayt di gεstrik εmpti bay we dεn de promuot di gεstrointestinal mכtiliti εn inkrεs di gεstrik asid sekreshכn. di yus כf ghrelin analכg kin εfεktiv fכ sכmtεm sכmtεm dεm lεk כp bכdi pen εn blot pan pasεn dεm we gεt fכnshכnal dispepsia, we de mek dεn kwaliti כf layf bεtε.
כlsa dεm na di gεstrointestinal: biכs fכ di prכtektiv ifekt we Ghrelin gεt pan di gεstrointestinal mכkus, i kin mek כlsa hεl εn so i gεt pכtεnshal aplikεshכn valyu fכ trit di gεstrointestinal כlsa dεm. εksojen administreshכn fכ Ghrelin כ in analכg dεm kin aksεlεrayt di כlsa ripa prכsεs εn ridyus כlsa rεkכrεshכn.
Di sik dɛn we kin apin to di at ɛn di blɔd:
Mayokardial ischemia-riperfyushɔn injuri: Insay di tritmɛnt fɔ mayokardial ischemia-riperfyushɔn injuri, Ghrelin, bikɔs ɔf in kadioprotɛktiv ifɛkt dɛn, de ol prɔmis as nyu tritmɛnt ɛjɛn. bay we dεn gi Ghrelin כ in analכg dεm bifo כ di tεm we dεn de gi di mayokardial ischemia-riperfyushכn, i kin ridyus di mayokardial sεl dεm we dεn dכn pwεl, minimiz di infarkt saiz, εn impruv di kadyak fכnshכn. Animal ɛkspiriɛns ɛn klinik trial rizɔlt dɔn sho prɔmis autkam, we de gi nyu strateji fɔ di tritmɛnt fɔ mayokardial ischemia-riperfyushɔn injuri.
Hat fεil: Na di sik pipul dεm we hat fεil, di Ghrelin lεvεl dεm kin rεdכks bכku tεm εn i kin kכrelεt wit di siriכs at fεil. if yu supliment wit Ghrelin כ in analכg dεm i kin impruv di kadyak fכnshכn pan di hat fεil pasεnshכn dεm bay we i de εnhans di mayokardia kכntraktiliti, impruv di kadyak enεji mεtabolism, εn inhεbit mayokardial sεl apoptosis, we de εnhans di pasεnshכn in kwaliti כf layf εn sכvayv rεt.
Nyurodijɛnɛraytiv Sik dɛn:
Alzaima sik ɛn Pakinsin Sik: We yu gi Ghrelin in nyuroprotɛktiv ifɛkt dɛm, i gɛt pɔtɛnɛshɛl aplikeshɔn valyu fɔ trit nyurodijɛnɛraytiv sik dɛm lɛk Alzaima ɛn Pakinsin sik. bay we dεn gi Ghrelin כ in analכg dεm, i kin inhεbit nyuronal apoptosis, ridyus nyuroinflammatory rispכns dεm, εn impruv di sikman dεm in kכgnitiv εn mכtal fכnshכn.
Strok ɛn Traumatik Bren Injuri: Insay akyu nyurolɔjik injuri lɛk strok ɛn traumatik bren injuri, Ghrelin kin du nyuroprotɛktiv ifɛkt tru mɛkanism dɛn we inklud fɔ ridyus nyuronal damej ɛn fɔ mek nyural rijinereshɔn. stכdi dεn sho se insay animal mכdel dεm fכ strok כ traumatik bren injuri, di yus fכ Ghrelin kin ridyus infarkt saiz כ mitigate di εkstenshכn fכ di bren damej, we de impruv di nyurolכjik fכnshכnal autkam dεm. Ghrelin kin bi adjɔnt tɛrapi fɔ strok ɛn traumatik bren injuri, we kin mek di pasɛnt dɛn rihabiliteshɔn autkam mɔ.
Di tin dɛn we wi go tɔk bɔt
as mכltifunshכnal εndojεnik pεptida, Ghrelin de ple imכtant rol insay difrεn fysiolojikal prכsεs dεm, we inklud di gכd εn divεlכpmεnt, εnεji mεtabolism, gεstrointestinal fכnshכn, di kכdivaskyul sistεm homכstasis, εn nyuroprotεkshכn.
Sos dɛn we dɛn pul
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[4] Brahmkhatri V, Prasanna C, Atreya H. Insulin-Lεk Grכwth Fכktכr Sistem in Kεnsar: Nכvel Tagεt Tεrapi dεm[J]. Bayomed Risach Int ɛ rnash ɔ nal, 2014,2015.DOI:10.1155/2015/538019.
[5] Strasser F. Klinik aplikeshɔn fɔ ghrelin.[J]. Kɔrɛnt Famasiutik Dizayn, 2012,18 31:4800-4812. https://api.semanticscholar.org/KɔpɔsID:7696286. Di wan dɛn we de stɔdi bɔt di Baybul.
