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▎ HCG ka baarakɛcogo
Sɔrɔyɔrɔ: PubChem |
IUPAC Kɔrɔlen: N(1)Cys-Gly-OH.H-Aad(1)-OH Formula molekilɛri: C 11H 19N 3O 6S Molecules girinya:321,35g/mol CAS nimɔrɔ: 9002-61-3 PubChem ka CID: 4369448 ye Kɔrɔɲɔgɔnmaw: Gonadotrophine chorionic;CHEMBL1233255 |
▎ HCG ka ɲininiw
HCG ka ɲininiw kɛcogo ye mun ye?
Adamaden ka Gonadotropin (HCG) ye fɛn ye min bɛ baara nafama caman kɛ, wa a jɔyɔrɔ ka bon kosɛbɛ fan dɔw la i n’a fɔ kɔnɔmaya ani hadamaden ka kansɛri. A fɔlɔ, HCG ye fɛnɲɛnamafagalan ye min ka jugu kosɛbɛ. O ye glycoprotéine ye min ka asidi ka ca, wa sukaro hakɛ ka ca a la. , HCG bɛ sɔrɔ cogo caman na, i n’a fɔ HCG basigilen, HCG sulfaté, HCG hyperglycosylé, β-HCG hɔrɔnma, ani β-HCG libre hyperglycosylé, a ɲɔgɔnnaw Filanan .
Kɔnɔmaya siratigɛ la, HCG nafa ka bon hadamaden ka kalolabɔ ni hadamaden ka kɔnɔmaya la. HCG min bɛ kɛ tuma bɛɛ, o jɔyɔrɔ ka bon farikolojidɛsɛbanakisɛ sɔrɔli la, wa a bɛ baara nafamaw fana kɛ trofoblaste selilɛriw danfara la ani den balocogo la. Misali la, a bɛ den balo sɔrɔli dɔn joli-sira-funu fɛ miometri (miometrium) joli siraw la minnu bɛ wele ko spiral [1] . HCG hyperglycosylé fana jɔyɔrɔ ka bon kɔnɔmaya daminɛ na. O ye HCG isoformi kunba ye kɔnɔmaya daminɛ na, min bɛ se ka apoptose bali, ka selilɛriw ka don, ka bonya, ani ka fɛn juguw caman cili sabati, ani ka denso doncogo ni denso bonya kunbɛn.
Kansɛri siratigɛ la, tumu juguman minnu tɛ trofoblasitiki ye, olu bɛ HCG ka β hɔrɔnyalen hyperglycosylated (hyperglycosylated free β subunit) bɔ, o min, i n’a fɔ autocrine factor, a bɛ kansɛribanakisɛw falenni ni u jiginni jugumanba sabati ka taa a fɛ, a kɛtɔ ka apoptose kɛlɛ.
Ka fara o kan, HCG sɔrɔli fana bɛ kɛ ka caya kɛnɛyaso baara la, i n’a fɔ kɔnɔmaya sɛgɛsɛgɛli, kɔnɔmaya kɔlɔlɔw kɔlɔsili, den minnu bɛ ni Down syndrome ye, olu farati dɔnni, kɔnɔmaya ɲɛfɛla sɔrɔli kofɔli, HCG sɔrɔli ka kɔn kɔnɔmaya ɲɛ, kɔnɔmaya kɔnɔbara basigilen banaw dɔnni n’u ɲɛnabɔli, kɔnɔmaya tumobanaw sɔrɔli minnu bɛ lafiya, denso yɔrɔ trophoblastic banaw sɛgɛsɛgɛli, ka cɛya banakisɛw kunbɛnni, ani ka hadamadenw ka bana juguman wɛrɛw kɔlɔsi, a ɲɔgɔnnaw [1] ..
HCG ka baarakɛcogo ye mun ye?
1. A bɛ nɔ bila kɔnɔbara basigilen ka jaabi la
Kalan dɔw y’a jira ko HCG bɛ se ka nɔ bila kɔnɔbara basigilen na ka tɛmɛ miR-126-3p/PIK3R2/PI3K/Akt/eNOS axis fɛ ani ka jɔyɔrɔba ta denw doncogo la (Wang W, 2023). A jiracogo kɛrɛnkɛrɛnnenw ye ninnu ye:
Kɔnɔbara basigilenw ka baara kɛcogo ɲɛnabɔli : Ni sosow ye denso doncogo jugumanba (EID) misali dɔ sigi sen kan ani k’a furakɛ ni mifepristone ye, ani ka kɔrɔbɔliw kɛ o waati kelen na hadamadenw ka kɔnɔbara basigilenw (EECs) kan, a jirala ko HCG furakɛli kɔfɛ, kɔnɔbara basigilen minɛcogo ɲɛna EID sogow la. Misali la, CD105 jiracogo hakɛ cayara sosow la ani kadɛrɛni CD144 ni CD146 farikolojɔli hakɛ cayara i n’a fɔ a ɲɛfɔra cogo min na immunohistochimie ni Western blotting fɛ.
Jɛnɛya jirali ɲɛnabɔli : HCG bɛ se ka miR-126-3p jirali sabati ani ka PIK3R2 jirali bali, ani miR-126-3p bɛ PIK3R2 laɲini. Kɔrɔbɔli minnu kɛra in vivo ani in vitro fila bɛɛ la, olu y’a jira ko HCG bɛ PI3K/Akt/eNOS sira baara ka tɛmɛ miR-126-3p/PIK3R2 axis fɛ, o bɛ kɔnɔbara basigilen jaabicogo ɲɛ.
2. Jɔrɔ min bɛ kɔnɔmaya sabatili la
HCG bɛ sɔrɔ kosɛbɛ sinsitiyotrofoblasi selilɛriw fɛ minnu bɛ danfara bɔ, wa a ye den taamasiɲɛ nafamaba ye min nafa ka bon kɔnɔmaya sabatili la [2] ..
Siginiden caman ka cascade reactions activation : HCG bɛ se ka siri luteinizing hormone/chorionic gonadotropin receptor (LHCGR) la ani ka se ka signal cascade reactions caman kɛ, o la, denbaw bɛ decapentaplegic homolog 2 (Smad2) kɛlɛli la denba minnu bɛ se caman na, protein kinase C (PKC), ani/walima protein kinase A (PKA), ka tɛmɛ jɛɲɔgɔnya tilennen/ɲɛnamaya fɛ ni fɛn caman tigɛli ye bonya facteur β minɛbaga (TGFβR).
Ka joli-sira-funu sabati denso kɔnɔ : HCG jɔyɔrɔ ka bon kosɛbɛ joli-sira-funu sabatili la denso kɔnɔ, ka bonya sigida ɲuman di den ma.Miometrium (miometrium) lafiyali sabatili: A bɛ dɛmɛ ka denso sabatilen sabati ani ka sigida bɛnnen di den ka yiriwali ma.Ka farikolo tangacogo sabati denso la denba ni den cɛsira : A jɔyɔrɔ ka bon farikolo tangacogo la denba ni den cɛsira la ani ka denba farikolo tangacogo jaabi balan denw ma.
3. Jɔrɔ min bɛ denw jiginni na minnu bɛ sumaya
Kɔlɔsiliw y’a jira ko kuran fɛ farikolojidɛsɛ furakɛli (TEAS) ni HCG furakɛli faralen ɲɔgɔn kan, o bɛ se ka banabagatɔw ka kɔnɔmaya kɔlɔlɔw ɲɛ ka taa a fɛ minnu bɛ denw bilali kɛ nɛnɛ na.
Ka dɔ fara kɔnɔbara basigilen kan : TEAS furakɛli bɛ dɛmɛ kosɛbɛ ka kɔnɔbara girinya caya banabagatɔw la minnu bɛ denw bilali kɛ ni nɛnɛ ye. HCG ni TEAS furakɛli faralen ɲɔgɔn kan, o fana bɛ dɛmɛ ka kɔnɔbara basigilen bonya o banabagatɔ ninnu na.
Denso joli bolicogo hakɛ dɔgɔyali : Denso kɔnɔ joli bolicogo hakɛ PI ni RI hakɛ minnu bɛ TEAS faralen ɲɔgɔn kan ni HCG kulu ni TEAS kulu ye, olu tun ka dɔgɔn kosɛbɛ ka tɛmɛ kɔrɔsili kulu ta kan, o b’a jira ko HCG ni TEAS furakɛli faralen ɲɔgɔn kan, o bɛ se ka dɔ bɔ denso joli bolicogo hakɛ PI ni RI la banabagatɔw la.
Fɛn minnu bɛ tali kɛ kɔnɔmaya ladonni na, olu hakɛ caya joli la: HCG furakɛli bɛ dɛmɛ kosɛbɛ ka dɔ fara joli la P ni jolidɛsɛ balilan (LIF) hakɛ kan banabagatɔw la minnu bɛ denw bilali kɛ nɛnɛ na. LIF hakɛ minnu bɛ joli la TEAS kulu la, HCG kulu la, ani TEAS faralen ɲɔgɔn kan ni HCG kulu la, olu bɛɛ tun ka ca kosɛbɛ ka tɛmɛ kɔrɔsili kulu ta kan. Denw doncogo hakɛ min tun bɛ kulu faralen ɲɔgɔn kan, o tun ka ca kosɛbɛ ka tɛmɛ kulu min tun bɛ kɛlɛ la, o b’a jira ko TEAS ni HCG furakɛli faralen ɲɔgɔn kan, o bɛ se ka banabagatɔw ka kɔnɔmaya kɔlɔlɔw ɲɛ ka taa a fɛ minnu bɛ denw bilali kɛ nɛnɛ na.
4. Cɛw ka sɔgɔsɔgɔninjɛ furakɛli
Gonadisimu dɔgɔyali min bɛ sɔrɔ gonadotropin bɔli fɛ cɛw la, o bɛ nɔba bila banabagatɔw ka bangekɔlɔsi kɛnɛya ni u ka ɲɛnamaya kɛcogo la. Hadamaden ka Gonadotropin (HCG) jɔyɔrɔ ka bon o bana suguw furakɛli la. HCG bɛ siri fɛnw minɛbagaw la minnu bɛ Leydig selilɛriw sanfɛ cɛya la, ka selilu kɔnɔ taamasiɲɛw sira baara, ka kolosinsinnan jiginni sabati ka kɛ tetarasikilini ye. Testosterone caya bɛ se ka kɛ sababu ye ka cɛya bonya ni a yiriwa ani ka dɔ fara cɛya hakɛ kan. O waati kelen na, tetarasikilini fana bɛ se ka bangekɔlɔsi fɛɛrɛw yiriwali lawuli i n’a fɔ epididymis ani vas deferens. Testosterone jɔyɔrɔ ka bon cɛw ka cɛnimusoya kɛcogo filananw yiriwali la. Ni dɔ farala tetarasikilini hakɛ kan, HCG furakɛli bɛ se ka kunsigi ni Hadama ka pɔmi falen, ka farikolo fanga bonya, ka cɛnimusoya nege caya, a ɲɔgɔnnaw
Kɔnɔnatumuw sɔrɔyɔrɔw, laɲiniw, taamasiɲɛw jiginni minnu bɛ tali kɛ ɲɔgɔn na, ani HCG isofɔmu suguya caman baarakɛcogo musokɔnɔma tɛ minnu na ani musokɔnɔmaw.
Soso:PubMed [2] Ɲɛjirali dɔw.
HCG kɛcogo kunbabaw ye jumɛnw ye?
1. A bɛ kɛ kɔnɔmaya daminɛ na
Nafa min bɛ joli T-HCG ni β-HCG kɔnɔfɛnw sumani na kɔnɔmaya daminɛ na: Aw bɛ kɔnɔmaya daminɛ na minnu tɛ cogo la, aw bɛ T-HCG suman ni kemiluminisɛnsi ye, ka joli la β-HCG suman ni radioimmunoassay ye, ani ka kɔlɔsili fangamaw kɛ. Jateminɛw y’a jira ko T-HCG ni β-HCG joli la, kɔnɔmaya kɔkanna kulu la, olu hakɛ ka dɔgɔn kosɛbɛ ka tɛmɛ kɔnɔtiɲɛ kulu ni kɔnɔmaya kɔnɔmaya kulu ta kan. O b’a jira ko joli la T-HCG ni β-HCG kɔnɔfɛnw sumani bɛ ni kɛrɛnkɛrɛnnenya ni a sɛgɛsɛgɛli hakɛ ɲuman ye walasa ka kɔnɔta kɔkanna ni kɔnɔmaya kɔnɔta danfara bɔ, wa T-HCG ka sɛgɛsɛgɛli ni dannaya ka bon.
Kɔnɔmaya kɔkanna sɛgɛsɛgɛli ni joli la HCG, β-HCG ani porojɛsitɛri sɔrɔli faralen ɲɔgɔn kan: Aw bɛ joli la HCG, β-HCG ani porojɛsitɛri sɔrɔ musokɔnɔma kɛnɛmanw na ani musokɔnɔma minnu kɔnɔma don. Jateminɛw y’a jira ko HCG, β-HCG ani porojɛsitɛri hakɛ bɛ musokɔnɔma minnu na, olu ka fisa ni musokɔnɔmaw ta ye minnu kɔnɔbara tɛ kɔnɔbara la. Ni a kɔlɔsira a kelen na, serum HCG tiɲɛni hakɛ bɛ kɔnɔbara kɔkanna sɛgɛsɛgɛli la, o ye 70,83% ye; β-HCG ka tiɲɛni hakɛ ye 66,7% ye; porojɛsitɛri ka tiɲɛni hakɛ ye 54,17% ye. Serum HCG, β-HCG ani progesterone sɔrɔli faralen ɲɔgɔn kan, o bɛ se ka kɛ 95,8% ye kɔnɔbara kɔkanna sɛgɛsɛgɛli la [5] ..
2. A kɛcogo bangekɔlɔsi fɛɛrɛ dɛmɛnanw na
Folikiliw kɔgɔcogo ɲuman : Ovarie lawulili la, hadamaden ka kalolabɔ gonadotropin (hMG) bɛ se ka folikili kɔgɔcogo ɲuman kɛ pituitaire desensitisation kɔfɛ min bɛ sɔrɔ gonadotropin-releasing hormone analogues (Gn-RH-analogue) fɛ. O bɛ kɛ kɛrɛnkɛrɛnnenya la barisa a bɛ a yɛrɛ tanga endogène luteinizing hormone (LG) jaabi basigilen ma min bɛ kɛ hMG furakɛli senfɛ furakɛli kɛcogo tilancɛ kelen ɲɔgɔn na. Kalan caman na minnu kɛra ni busɛrilini walima degarelikisi ye i n’a fɔ Gn-RH analoziw, banabagatɔ 282 ye kɔnɔtiɲɛ sɔrɔ in vitro, ka gamete intrafallopian transfert sɔrɔ, walima ka kɛ 'in vivo' furakɛli dɔ ye. GnRH analogue/hMG/HCG furakɛli faralen ɲɔgɔn kan, o ye dɔ fara kɔnɔmaya hakɛ kan kosɛbɛ kulu bɛɛ la. Banabagatɔ minnu furakɛra ni HMG/HCG ye, olu ka kɔnɔmaya hakɛ kɛra 17% ye, ka sɔrɔ furakɛli faralen ɲɔgɔn kan, o ye banabagatɔ 25% kɔnɔ ta [6] ..
Kɔnɔbara basigilen jaabicogo ɲɛ : Hadamaden ka Gonadotropin (HCG) ye taamasiɲɛ nafama dɔ ye sani den ka don a kɔnɔ. Sɛgɛsɛgɛli minnu kɛra ni kɔnɔbara basigilenw sɛgɛsɛgɛli ye, olu y’a jira ko HCG tali kɔfɛ denso kɔnɔ, farikolokisɛ minnu bɛ endoteliyali selilɛriw nɔrɔli mɔlikulu VE-cadherin (CD144) ani S-Endo-1 (CD146) jira, olu hakɛ cayara kosɛbɛ, o b’a jira ko kɔnɔnatumuw nɔrɔli mɔlikuluw bɛ se ka kɛ fɛɛrɛ ye min bɛ se ka kɛ sababu ye HCG bɛ denw doncogo ni kɔnɔmaya hakɛ ɲɛ.
2. Luteal insufficience furakɛli
San tan fila tɛmɛnenw kɔnɔ, porojɛsitɛri tali kɛnɛma bɛ kɛ i n’a fɔ luteal phase support (LPS) ka fara kɔnɔbara lawulili kɔrɔsilen kan ni hadamaden ka Chorionic Gonadotropin (HCG) ye walasa ka folikɛlanw kɔgɔli laban daminɛ. GnRHa donli walasa ka kɔnɔbara basigilen daminɛ, o b’a jira ko porojɛsitɛri tali kɛnɛma tɛ se ka kɔnɔta hakɛ wasa sɔrɔ ni HCG faralen tɛ a kan.
O kɛra sababu ye ka fɛɛrɛ wɛrɛw labɛn luteal phase dɛmɛni kama. Ka dɔ fara sigida kɔnɔna na porojɛsitɛri sɔrɔli kan farikolo yɔrɔ caman na, o ye ko jɔnjɔn ye, fan dɔ fɛ, walasa ka kɔnɔbara basigilen banakisɛ sɔrɔli bali, ani fan wɛrɛ fɛ, ka porojɛsitɛri hakɛ bɛnnen di walasa ka a doncogo sabati.
Sisan ɲininiw ye HCG hakɛ fitinin jɔyɔrɔ jateminɛ luteal phase dɛmɛni na ani ka a nafa ni a dɛsɛ minnu bɛ se ka sɔrɔ, olu sɛgɛsɛgɛ. Ka da HCG furakɛlicogo kan, jatebɔ misali dɔ kɛra HCG hakɛ tilatilali kan luteal phase waati la ni HCG tali fɛɛrɛ suguya caman faralen ye ɲɔgɔn kan i n’a fɔ luteal phase dɛmɛni. A jirala ko sisan luteal fasa dɛmɛni min bɛ di ka fara GnRHa triggering kan (o kɔrɔ ye ko 1500IU) barika ka bon kojugu, wa don o don HCG hakɛ fitinin tali bɛ se ka luteal fasa dɛmɛ ɲuman di furaw ma minnu bɛ sɔrɔ sisan. HCG hakɛ fitinin furakɛli jaabi fɔlɔw fana bɛ di [8] ..
3. Kɔnɔbara kɔnɔ cɛya min ma jigin fan kelen fɛ, o furakɛli
Sɛgɛsɛgɛli dɔ kɛra banabagatɔw kan minnu ye orchidopexy kɛ kɔnɔbara kɔnɔ cɛya min ma jigin fan kelen fɛ, k’a ta sɛtanburukalo san 2010 la ka se sɛtanburukalo san 2016. Dɔgɔkun fila opereli kɔfɛ, banabagatɔ minnu ye furakɛli kɛ ni ɔrimɔni ye, olu bangebagaw tun ka kan ka dɔgɔkun 6 kɛcogo dɔ labato. Banabagatɔw tun bɛ pikiri kɛ farikolo jukɔrɔ, o ye UI 500 (Gonasi-HP) ye dɔgɔkun kɔnɔ. Kuntilenna kɛra furakɛli laban na ani kalo 6 o kɔfɛ.
Tɔgɔtɔgɔnin hakɛ jateminɛna ni ultrasound ni ultrasonic elastography ye tuguni kelen-kelen bɛɛ la, ka a suma ni banabagatɔw ta ye minnu ma furakɛli kɛ. Jateminɛw y’a jira ko banabagatɔ 45 ye furakɛli kɛ, u si hakɛ cayalenba ye kalo 18,0±9,7 ye. Banabagatɔ 32 ye furakɛli kɛ ni ɔrimɔni ye opereli kɔfɛ, wa a kɔlɔlɔ si ma sɔrɔ walima ni a tali dabilacogo si ma sɔrɔ.
Banabagatɔ bɛɛ ye tuguni kɛ ka ban. Kɔnɔbara basigilen si ma sɔrɔ kulu fila bɛɛ la. Furakɛli kulu la, banabagatɔ 81% sera cɛya hakɛ bɛnnen ma kalo 6 kɔnɔ, ka sɔrɔ banabagatɔ tɔw ka cɛya hakɛ tun ka dɔgɔ hali bi. Jɛkulu min ma furakɛ, banabagatɔ 46% sera cɛya hakɛ bɛnnen ma. Adamaden ka Chorionic Gonadotropin (u-HCG) tali opereli kɔfɛ, o bɛ se ka cɛya bonya ni a baara ɲɛ ka kɛɲɛ ni cɛya bonya ni a yiriwali ye [9] ..
4. A kɛcogo β-HCG boloci ɲinini na
Aw bɛ HCG lawulili sɛgɛsɛgɛli kɛ musow kan minnu bolocilen don ni NII beta-HCG boloci ye nka u tun tɛ ni HCG kɛlɛli farikolojidɛsɛ hakɛ ye, ani ka porojɛsitɛri bɔli lawulili kɛ joli la ka kɛ farikolojidɛsɛ taamasiɲɛ ye HCG jolisira fɛ. Jateminɛw y’a jira ko kɔrɔsili kulu la, muso fanba ka porojɛsitɛri bɔli hakɛ tun ka ca kosɛbɛ HCG lawulili kɔfɛ ka tɛmɛ basigi hakɛ kan, ka sɔrɔ porojɛsitɛri hakɛ dantɛmɛnen musow la bolocilen kulu la, o ma tɛmɛ basigi hakɛ kan boloci kɔfɛ, o b’a jira ko boloci bɛ farikolo tangalan minnu bɔ, olu bɛ se ka HCG kɔkanna nɔ bali.
Kuncɛli la, HCG jɔyɔrɔ ka bon furakɛli siratigɛ la min tɛ se ka bila a nɔ na, kɛrɛnkɛrɛnnenya la, yɔrɔ minnu ɲɛsinnen bɛ bangeko ma. Bangekɔlɔsi furakɛli la, a bɛ se ka kɔnɔmaya bila mɔgɔ la ka ɲɛ, ka jigiya lase banabagatɔw ma minnu ka bangebaliya bɛ sɔrɔ kɔnɔmaya banaw fɛ. Ni a sirilen don LH minɛbagaw la farikolo la, a bɛ se ka LH hakɛ dafabaliya kunbɛn antagoniste protocole kɔnɔ ani ka dɛmɛ don folikɛlanw kɔgɔli la. Ni luteal dɛsɛ don, HCG bɛ se ka corpus luteum lawuli ka porojɛsitɛri bɔ ani ka ɔrimɔni sigida bɛnnen mara walasa ka kɔnɔmaya dɛmɛ.
Cɛw ka sɔgɔsɔgɔninjɛ min bɛ sɔrɔ gonadotropin bɔli dafalen fɛ, HCG bɛ se ka Leydig selilɛriw lawuli cɛya la walasa ka tetarasikilini sɔrɔ ani ka a bɔ, ka cɛya yiriwali sabati, ka cɛnimusoya kɛcogo filananw ɲɛ, ani ka banabagatɔw ka bangeko baara ni u ka ɲɛnamaya kɛcogo ɲɛ. O waati kelen na, HCG jɔyɔrɔ ka bon kɔnɔmaya daminɛ na, a bɛ farikolojidɛsɛ bila ka to ka porojɛsitɛri bɔ walasa den ka don a la ani ka a yiriwa. Dɔgɔtɔrɔso sɛgɛsɛgɛli la, HCG hakɛ dɔnni ye basigi nafama ye kɔnɔmaya daminɛ na ani ka kɔnɔmaya jugumanw dɔn i n’a fɔ kɔnɔmaya kɔkanna, o bɛ dɛmɛ barikama di a ma walasa ka a sen don a la ani ka a furakɛ waati bɛnnen na.
A sɛbɛnbaga ko la
Fɛn minnu kofɔlen dòn san fɛ, olu bɛɛ ɲinini Kɛra, k’u Labɛn ani k’u Lajɛ Cocer Peptides fɛ.
Dɔnniya gafe sɛbɛnbaga
Chinedu Nwabuobi ye ɲininikɛla ye min ka dɔnniya bɛ Obstetrics & Gynecology, Reproductive Biology, Biochimistry & Molecular Biology, Chemistry, ani Oncology baarabolow la. A ni baarada tɔgɔba caman jɛra, i n’a fɔ Floride Saheli Iniwɛrisite, Rochester Iniwɛrisite ani Memorial Sloan Kettering Cancer Center. A ka ɲininiw sinsinnen bɛ barokunw kan i n’a fɔ hadamadenw ka gonadotropin (HCG) ka baarakɛcogo ɲɛnamaw n’a baarakɛcogo kɛnɛyaso la, ni dɛmɛ ye walasa k’a jɔyɔrɔ faamuya bangekɔlɔsi kɛnɛyako la ani bana minnu bɛ tali kɛ a la. Chinedu Nwabuobi tɔgɔ sɛbɛnnen bɛ citation (citation) kɔnɔ [2].
