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1 kits (10 Vials)
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▎ Tsarin HCG
Source: PubChem |
IUPAC Condensed: N (1)Cys-Gly-OH.H-Aad(1)-OH Tsarin Halitta: C 11H 19N 3O 6S Nauyin Kwayoyin Halitta: 321.35g/mol Lambar CAS: 9002-61-3 Kamfanin CID na PubChem: 4369448 Synonyms: Chorionic gonadotrophin; CHEMBL1233255 |
▎ Binciken HCG
Menene asalin bincike na HCG?
Gonadotropin Chorionic Human (HCG) kwayar halitta ce tare da ayyuka masu mahimmanci da yawa kuma yana taka muhimmiyar rawa a fannoni kamar ciki da kansar ɗan adam. Da fari dai, HCG matsananci kwayoyin halitta. Shi ne mafi yawan acidic glycoprotein kuma ya ƙunshi mafi girman adadin sukari. Na biyu, HCG ya wanzu ta nau'i daban-daban, ciki har da HCG na yau da kullum, HCG sulfated, HCG hyperglycosylated, β-HCG kyauta, da hyperglycosylated free β-HCG, da dai sauransu [1]..
Dangane da ciki, HCG yana da mahimmanci ga yanayin hailar ɗan adam da ciki na ɗan adam. HCG na yau da kullun yana taka rawa wajen haɓaka samar da corpus luteum progesterone kuma yana da ayyuka masu mahimmanci a cikin bambance-bambancen cell trophoblast da abinci mai gina jiki na tayi. Misali, yana fahimtar samar da abinci mai gina jiki na tayi ta hanyar angiogenesis a cikin jijiyoyin karkace na myometrium [1] . Hyperglycosylated HCG kuma yana taka muhimmiyar rawa a farkon matakan ciki. Yana da babban isoform na HCG a farkon matakan ciki, wanda zai iya hana apoptosis, inganta mamayewar kwayar halitta, girma, da kuma mummunan canji, da sarrafa dasawa da haɓakar mahaifa [1]..
Dangane da ciwon daji, cututtukan cututtukan da ba na trophoblastic ba suna haifar da sashin β na kyauta na hyperglycosylated na HCG, wanda, a matsayin abu na autocrine, yana ƙara haɓaka haɓakawa da mummunan canjin ƙwayoyin cutar kansa ta hanyar adawa da apoptosis [1]..
Bugu da ƙari, ana amfani da gano HCG sosai a cikin aikace-aikacen asibiti, ciki har da gwajin ciki, saka idanu sakamakon ciki, ƙayyade haɗarin tayin tare da Down syndrome, tsinkayar preeclampsia, gano HCG pituitary, ganowa da sarrafa cututtuka na trophoblastic gestational, bincikar cututtukan cututtuka na huhu na gestational trophoblastic, bincikar cututtuka na huhu na huhu, bincikar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta malignancies, da kuma lura da sauran mutane malignancies, da dai sauransu [1]..
Menene tsarin aikin HCG?
1. Tasiri kan karɓar endometrium
Wasu nazarin sun nuna cewa HCG na iya shafar karbuwar endometrium ta hanyar miR-126-3p/PIK3R2/PI3K/Akt/eNOS axis kuma yana taka muhimmiyar rawa a cikin tsarin dasa amfrayo (Wang W, 2023). Takamammen bayyanar da su sune kamar haka:
Inganta aikin masu karɓa na endometrial: Ta hanyar kafa samfurin linzamin kwamfuta na rashin aikin mahaifa (EID) da kuma magance shi tare da mifepristone, da kuma gudanar da gwaje-gwaje a lokaci guda akan kwayoyin epithelial na jikin mutum (EECs), an gano cewa bayan maganin HCG, karɓar endometrium a cikin mice EID ya inganta. Misali, matakin magana na CD105 a cikin berayen da matakan furotin na cadherins CD144 da CD146 sun karu kamar yadda aka ƙaddara ta immunohistochemistry da Western blotting.
Sarrafa maganganun kwayoyin halitta: HCG na iya haɓaka furcin miR-126-3p kuma ya hana furcin PIK3R2, da miR-126-3p suna hari PIK3R2. Duka a cikin vivo da gwaje-gwajen in vitro sun tabbatar da cewa HCG tana kunna hanyar PI3K/Akt/eNOS ta hanyar miR-126-3p/PIK3R2, don haka inganta karbuwar endometrium.
2. Gudunmawa wajen kiyaye ciki
HCG ana samar da shi ne ta bambance-bambancen sel syncytiotrophoblast kuma shine siginar amfrayo mai mahimmanci don kiyaye ciki [2].
Kunna halayen halayen sigina da yawa: HCG na iya ɗaure zuwa ga mai karɓa na luteinizing hormone / chorionic gonadotropin receptor (LHCGR) kuma mai yuwuwar kunna halayen siginar siginar da yawa, gami da uwaye akan decapentaplegic homolog 2 (Smad2) ga uwaye masu iyawa da yawa, furotin kinase C (PKC), da / ko furotin kinase C (PKC), da / ko haɓaka haɓakar furotin ta hanyar haɓakawar kai tsaye tare da β-increasing. (TGFβR).
Ƙaddamar da angiogenesis a cikin mahaifa endothelium: HCG taka muhimmiyar rawa wajen inganta angiogenesis a cikin mahaifa endothelium, samar da kyakkyawan yanayin girma ga amfrayo.Maining da quiescence na myometrium: Yana taimaka wajen kula da barga jihar na mahaifa da kuma samar da yanayi mai dacewa ga ci gaban amfrayo.Promoting da mamofe rawar da wani tasiri mai mahimmanci a cikin aikin rigakafi yana taka muhimmiyar rawa a cikin aikin rigakafi. immunomodulation a wajen uwa- tayin da kuma daidaita martanin tsarin rigakafi na uwa zuwa amfrayo.
3. Matsayin canja wurin tayin daskararre
Nazarin ya gano cewa motsa jiki na acupoint na lantarki (TEAS) tare da jiyya na HCG na iya inganta sakamakon ciki na marasa lafiya da ke jurewa daskarar da amfrayo [3].
Ƙara kauri daga cikin endometrium: TEAS magani ya fi taimakawa wajen ƙara kauri na endometrium a cikin marasa lafiya da ke jurewa daskararren amfrayo. Haɗin maganin HCG da TEAS kuma yana taimakawa wajen ƙara kauri na endometrium a cikin waɗannan marasa lafiya.
Rage ma'auni na jini na jini na mahaifa: Ma'auni na jinin jini na endometrial PI da RI a cikin TEAS hade tare da ƙungiyar HCG da ƙungiyar TEAS sun kasance ƙasa da ƙasa fiye da waɗanda ke cikin ƙungiyar kulawa, yana nuna cewa haɗin haɗin HCG da TEAS zai iya rage ma'aunin jini na PI da RI na ƙwayar mahaifa a cikin marasa lafiya.
Haɓaka matakan abubuwan da ke da alaƙa da kula da ciki a cikin jini: Jiyya na HCG galibi yana taimakawa wajen haɓaka matakan ƙwayar cutar sankarar jini P da cutar sankarar bargo (LIF) a cikin marasa lafiya da ke jujjuya canjin amfrayo. Matakan LIF na jini a cikin ƙungiyar TEAS, ƙungiyar HCG, da TEAS da aka haɗa tare da ƙungiyar HCG duk sun fi girma fiye da waɗanda ke cikin ƙungiyar kulawa. Yawan dasa amfrayo a cikin rukunin da aka haɗa ya kasance mafi girma fiye da wanda ke cikin ƙungiyar kulawa, yana nuna cewa haɗin gwiwar TEAS da HCG zai iya inganta sakamakon ciki na marasa lafiya da ke jurewa daskararren amfrayo.
4. Maganin hypogonadism na namiji
Hypogonadism lalacewa ta hanyar rashin isasshen ƙwayar gonadotropin a cikin maza yana da tasiri mai mahimmanci akan lafiyar haihuwa da ingancin rayuwar marasa lafiya. Human Chorionic Gonadotropin (HCG) yana taka muhimmiyar rawa wajen magance irin waɗannan cututtuka. HCG yana ɗaure ga masu karɓa a saman sel Leydig a cikin gwajin jini, yana kunna hanyar siginar intracellular, kuma yana haɓaka canjin cholesterol zuwa testosterone. Haɓakawa a cikin testosterone na iya haɓaka haɓakawa da haɓakar ƙwayar cuta da haɓaka ƙarar ƙwayar cuta. A lokaci guda kuma, testosterone na iya haɓaka haɓakar gabobin haihuwa kamar epididymis da vas deferens. Testosterone yana taka muhimmiyar rawa wajen haɓaka halayen halayen jima'i na maza. Ta hanyar haɓaka matakin testosterone, maganin HCG na iya haɓaka haɓakar gemu da apples ɗin Adam, haɓaka ƙarfin tsoka, da haɓaka sha'awar jima'i, da sauransu.
Maɓuɓɓugar salula, maƙasudi, haɗaɗɗun sigina, da ayyuka na daban-daban isoforms na HCG a cikin marasa ciki da mata masu juna biyu.
Source:PubMed [2]
Menene babban aikace-aikacen HCG?
1. An yi amfani da shi don gano farkon ciki
Darajar auna abin da ke cikin jini T-HCG da β-HCG a farkon ciki: Tattara lokuta na farkon ciki mara kyau, auna T-HCG ta amfani da chemiluminescence, auna ma'aunin β-HCG ta amfani da radioimmunoassay, da gudanar da lura mai tsauri. Sakamakon ya nuna cewa abubuwan da ke cikin jini T-HCG da β-HCG a cikin rukunin ciki na ectopic sun kasance ƙasa da ƙasa fiye da waɗanda ke cikin ƙungiyar zubar da ciki da ƙungiyar ciki na ciki. Wannan yana nuna cewa auna abubuwan da ke cikin jini T-HCG da β-HCG yana da ƙayyadaddun ƙayyadaddun ƙayyadaddun ƙayyadaddun ƙayyadaddun ƙwayar cuta da ƙimar ganowa don bambance ciki ectopic ciki da ciki na ciki, kuma T-HCG yana da hankali da aminci [4].
Ganewar ciki na ectopic ciki ta hanyar haɗuwa da maganin HCG, β-HCG, da progesterone: Gano maganin HCG, β-HCG, da progesterone a cikin mata masu juna biyu na al'ada da mata masu ciki tare da ciki na ectopic. Sakamakon ya nuna cewa matakan jini HCG, β-HCG, da progesterone a cikin mata masu ciki na al'ada sun fi na mata masu ciki masu ciki na ectopic ciki. Lokacin da aka gano shi kadai, daidaitattun adadin HCG na jini a cikin ganewar asali na ciki ectopic shine 70.83%; daidaiton ƙimar β-HCG shine 66.7%; Matsakaicin adadin progesterone shine 54.17%. Haɗin gano ƙwayar cutar HCG, β-HCG, da progesterone yana da daidaiton adadin har zuwa 95.8% a cikin ganewar asali na ciki ectopic [5]..
2. Aikace-aikace a cikin fasahar haihuwa taimako
Haɓaka balaga na follicular: A cikin ƙarfafawar ovarian, gonadotropin menopause na ɗan adam (hMG) na iya haɓaka maturation na follicular bayan rashin jin daɗin pituitary wanda aka haifar da analogues na sakin hormone na gonadotropin (Gn-RH-analogue). Wannan shi ne yafi saboda yana guje wa amsawar luteinizing hormone (LG) mara kyau wanda ke faruwa yayin jiyya na hMG a kusan kashi ɗaya bisa uku na zagayowar jiyya. A cikin binciken da yawa ta amfani da buserelin ko degarelix azaman analogues na Gn-RH, marasa lafiya 282 sun karɓi hadi a cikin vitro, canja wurin intrafallopian gamete, ko a matsayin wani ɓangare na maganin 'in vivo'. Haɗin jiyya na analog na GnRH / hMG/HCG yana haɓaka ƙimar ciki sosai a duk ƙungiyoyi. Yawan ciki na marasa lafiya da aka yi musu magani tare da HMG/HCG ya kasance 17%, yayin da haɗin gwiwar ya sanya kashi 25% na marasa lafiya masu ciki [6].
Inganta karbuwar endometrium: Human Chorionic Gonadotropin (HCG) na daya daga cikin muhimman sigina kafin dasa amfrayo. Binciken da aka yi amfani da nazarin nama na endometrial ya gano cewa bayan gudanarwar intrauterine na HCG, adadin sel da ke bayyana kwayoyin endothelial cell adhesion VE-cadherin (CD144) da S-Endo-1 (CD146) sun karu sosai, suna nuna cewa kwayoyin endothelial cell adhesion na iya zama wata hanya mai yuwuwar hanyar da HCG ke inganta haɓakar ciki [7] embryo..
2. Maganin rashin lafiyar luteal
A cikin shekaru ashirin da suka gabata, an yi amfani da gwamnatin progesterone exogenous azaman tallafin lokaci na luteal (LPS) a hade tare da sarrafa kuzarin ovarian ta amfani da Chorionic Gonadotropin (HCG) don haifar da maturation na ƙarshe na follicles. Gabatarwar GnRHa don haifar da ovulation yana nuna cewa gudanarwar progesterone na waje bai isa ba don cimma ƙimar ciki mai gamsarwa ba tare da ƙarin HCG ba.
Wannan ya haifar da samar da wasu dabaru don tallafawa lokaci na luteal. Ƙara yawan samar da progesterone na gida na ƙananan corpora lutea shine mahimmin mahimmanci, a gefe guda, don kauce wa ci gaban ciwon hyperstimulation na ovarian, kuma a gefe guda, don samar da isasshen matakin progesterone don kula da dasawa.
Binciken na yanzu ya kimanta rawar ƙaramin adadin HCG don tallafin lokaci na luteal kuma yayi nazarin yuwuwar fa'ida da rashin amfaninsa. Dangane da halaye na pharmacokinetic na HCG, an ƙididdige samfurin lissafi na rarraba tattarawar HCG a lokacin lokacin luteal ta hanyar haɗa hanyoyin gudanarwa daban-daban na HCG a matsayin tallafin lokaci na luteal. Ana ba da shawarar cewa tallafin lokaci na luteal na yanzu da aka bayar tare da haifar da GnRHa (watau 1500IU) yana da ƙarfi sosai, kuma gwamnatin micro-dose HCG na yau da kullun na iya ba da ingantaccen tallafin lokaci na luteal don samun magunguna a halin yanzu. Hakanan ana ba da sakamakon farko na asibiti na hanyar micro-dose HCG [8].
3. Maganin gwajin da ba a yi ba a ciki
An gudanar da bincike a kan marasa lafiya da suka yi amfani da orchidopexy don gwajin ciki na ciki wanda ba a kwance ba daga Satumba 2010 zuwa Satumba 2016. Makonni biyu bayan aikin, iyayen marasa lafiya da suka karbi maganin hormone suna buƙatar bin tsarin tsarin makonni 6. Marasa lafiya sun sami allurar subcutaneous na 500 UI (Gonasi-HP) a mako guda. An gudanar da bibiya a ƙarshen jiyya da watanni 6 bayan haka.
An auna girman gwajin ta hanyar duban dan tayi da ultrasonic elastography a kowane biyo baya kuma idan aka kwatanta da na marasa lafiya da ba su karbi magani ba. Sakamakon ya nuna cewa marasa lafiya 45 sun sami magani, tare da matsakaicin shekarun watanni 18.0 ± 9.7. 32 marasa lafiya sun sami maganin hormone bayan tiyata, kuma babu wani mummunan halayen ko lokuta na janyewa.
Duk marasa lafiya sun kammala biyan. Babu lokuta na zubar jini na jini a cikin ƙungiyoyin biyu. A cikin rukuni na jiyya, 81% na marasa lafiya sun kai girman gwajin gwaji na yau da kullun a watanni 6, yayin da adadin gwajin sauran marasa lafiya ya kasance kaɗan. A cikin rukunin da ba a kula da su ba, 46% na marasa lafiya sun kai girman gwajin gwaji na yau da kullun. Yin amfani da Gonadotropin Chorionic na mutum bayan aiki (u-HCG) na iya inganta girma da aikin gwajin ta hanyar haɓaka girma da haɓakar gwajin jini [9].
4. Aikace-aikace a cikin bincike na maganin β-HCG
Gudanar da gwajin ƙarfafawa na HCG akan matan da aka yi musu rigakafi da maganin rigakafin beta-HCG na NII amma ba su da anti-HCG antibody titers, kuma a yi amfani da kuzarin siginar progesterone na jini azaman mai nuna martanin corpus luteum ga HCG na ciki. Sakamakon ya nuna cewa a cikin rukunin kulawa, yawancin mata suna da matakin haɓakar haɓakar progesterone mai mahimmanci bayan haɓakawar HCG fiye da matakin basal, yayin da mafi girman matakin progesterone a cikin mata a cikin rukunin rigakafin bai wuce matakin basal ba bayan alurar riga kafi, yana nuna cewa ƙwayoyin rigakafin da allurar ta samar na iya shiga tasirin tasirin HCG na waje [10]..
A ƙarshe, HCG yana taka rawar da ba za a iya maye gurbinsa ba a fannin likitanci, musamman a cikin abubuwan da suka shafi haifuwa. A cikin maganin haihuwa, yana iya haifar da ovulation yadda ya kamata, yana kawo bege ga marasa lafiya da rashin haihuwa da ke haifar da rashin lafiyar ovulation. Ta hanyar ɗaure ga masu karɓar LH a cikin jiki, zai iya daidaita ƙarancin matakin LH a cikin ka'idar antagonist kuma yana taimakawa tare da maturation na follicular. Don rashin isasshen luteal, HCG na iya tayar da corpus luteum don ɓoye progesterone kuma ya kula da yanayin hormonal da ya dace don tallafawa ciki.
Don hypogonadism na namiji wanda ya haifar da rashin isasshen ƙwayar gonadotropin, HCG na iya tayar da kwayoyin Leydig a cikin gwaji don haɗawa da ɓoye testosterone, inganta haɓakar jini, inganta halayen jima'i na biyu, da haɓaka aikin haihuwa da ingancin rayuwar marasa lafiya. A lokaci guda, HCG yana taka muhimmiyar rawa wajen kiyaye ciki da wuri, yana motsa jikin jiki don ci gaba da ɓoye progesterone don tabbatar da dasa amfrayo da haɓakawa. A cikin ganewar asibiti, gano matakin HCG shine muhimmin tushe don ƙayyade farkon ciki da kuma gano ciki mara kyau kamar ciki na ectopic, yana ba da goyon baya mai karfi don shiga tsakani da magani na lokaci.
Game da Marubuci
Abubuwan da aka ambata a sama duk bincike ne, gyara su kuma Cocer Peptides ne suka haɗa su.
Mawallafin Jaridar Kimiyya
Chinedu Nwabuobi kwararre ne a fannonin da suka shafi Ciwon ciki & Gynecology, Biology Reproductive, Biochemistry & Molecular Biology, Chemistry, and Oncology. Yana da alaƙa da manyan cibiyoyi da yawa, gami da Jami'ar Kudancin Florida, Jami'ar Rochester, da Cibiyar Ciwon daji ta Memorial Sloan Kettering. Bincikensa yana mai da hankali kan batutuwa kamar ayyukan nazarin halittu da aikace-aikacen asibiti na gonadotropin chorionic gonadotropin (HCG), tare da gudummawa don fahimtar rawar da take takawa a cikin lafiyar haihuwa da cututtukan da ke da alaƙa. An jera Chinedu Nwabuobi a cikin ambaton ambato [2].
