|
1kits (10Vials) .
| Agbɔsɔsɔ: | |
|---|---|
▎ HCG ƒe Dɔwɔɖoɖo
Dzɔtsoƒe: PubChem |
IUPAC Nusiwo wotsɔ ƒo ƒui: N (1) Cys-Gly-OH.H-Aad (1)-OH Molekyulãwo ƒe Mɔfiame: C 11H 19N 3O 6S Molekyul ƒe kpekpeme:321.35g/mol CAS ƒe Xexlẽdzesi: 9002-61-3 PubChem ƒe CID: 4369448 Nya siwo sɔ kple wo nɔewo: Chorionic gonadotrophin;CHEMBL1233255 |
▎ HCG Ŋuti Numekuku
Nukae nye numekuku si wowɔ le HCG ŋu?
Human Chorionic Gonadotropin (HCG) nye molecule si si dɔ vevi geɖewo le eye wòwɔa akpa vevi aɖe le akpa aɖewo abe fufɔfɔ kple amegbetɔ ƒe kansa ene me. Gbã la, HCG nye molecule si gbɔ eme. Enye glycoprotein si me acid le wu eye sukli sɔ gbɔ wu le eme. Evelia, HCG li le nɔnɔme vovovowo me, siwo dometɔ aɖewoe nye HCG si wozãna edziedzi, HCG si me sulfat le, HCG si me sukli sɔ gbɔ ɖo, β-HCG si me sukli sɔ gbɔ ɖo, β-HCG si me sukli sɔ gbɔ ɖo, kple β-HCG si me sukli sɔ gbɔ ɖo, kple bubuawo [1] ..
Le fufɔfɔ gome la, HCG le vevie na amegbetɔ ƒe dzinukpɔkpɔ kple amegbetɔ ƒe fufɔfɔ. HCG si wozãna edziedzi wɔa akpa aɖe le corpus luteum progesterone ƒe wɔwɔ dodo ɖe ŋgɔ me eye wòwɔa dɔ veviwo hã le trophoblast cell ƒe vovototodedeameme kple fugboe ƒe nunyiame me. Le kpɔɖeŋu me, ekpɔa fugboe ƒe nunyiame nana to ʋukawo ƒe dzɔdzɔ me le ʋuka siwo le ʋuka me ƒe ʋuka siwo le tsatsam me la dzea sii [1] . Hyperglycosylated HCG hã wɔa akpa vevi aɖe le fufɔfɔ ƒe gɔmedzedze. Enye HCG isoform vevitɔ le fufɔfɔ ƒe gɔmedzedze, si ate ŋu axe mɔ ɖe apoptosis nu, ado lãmenugbagbeviwo ƒe amedzidzedze, tsitsi, kple tɔtrɔ vɔ̃ɖi ɖe ŋgɔ, eye wòakpɔ vidzidɔa dede kple vidzidɔ ƒe tsitsi dzi [1]..
Le kansa gome la, dɔdzẽ vɔ̃ɖi siwo menye trophoblastic o la wɔa HCG ƒe hyperglycosylated free β subunit, si, abe autocrine factor ene la, gadoa kansa lãmenugbagbeviwo ƒe tsitsi kple woƒe tɔtrɔ vɔ̃ɖi ɖe ŋgɔ to tsitretsitsi ɖe apoptosis ŋu me [1]..
Tsɔ kpe ɖe eŋu la, wozãa HCG didi hã le dɔdamɔnu me geɖe, siwo dometɔ aɖewoe nye fufɔfɔ dodokpɔ, ŋkuléle ɖe fufɔfɔ me tsonu ŋu, nyanya afɔku si le fugboe siwo ŋu Down ƒe dɔlélea le ŋu, nyagblɔɖi le preeclampsia ŋu, de dzesi pituitary HCG, deteksi kple edzikpɔkpɔ, fufɔfɔ ƒe trophoblastic dɔlélewo didi kple wo dzi kpɔkpɔ, fufɔfɔ ƒe dɔdzẽ ƒe dɔléle siwo le ɖoɖoezizi me didi, vidzidɔ ƒe teƒe si trophoblastic dɔlélewo didi, aɖuɖɔtoe me dɔlékui ƒe lãmenugbagbeviwo ƒe dɔléle vɔ̃ɖiwo dzi kpɔkpɔ, kple ŋkuléle ɖe amegbetɔ ƒe dɔléle vɔ̃ɖi bubuwo ŋu, kple bubuawo [1] ..
Nukae nye HCG ƒe dɔwɔwɔ ƒe mɔnu?
1. Ŋusẽkpɔɖeamedzi ɖe vidzidɔa ƒe xɔxlɔ̃ dzi
Numekuku aɖewo ɖee fia be HCG ateŋu akpɔ ŋusẽ ɖe vidzidɔa ƒe xɔxlɔ̃ dzi to miR-126-3p/PIK3R2/PI3K/Akt/eNOS axis dzi eye wòawɔ akpa vevi aɖe le fugboe dede ƒe ɖoɖoa me (Wang W, 2023). Nusiwo koŋ woɖena fianae nye esiawo:
Vidzidɔ me dɔlékuiwo ƒe dɔwɔwɔ nyuie wu: To fugboe ƒe dɔmawɔmawɔ nyuie (EID) ƒe kpɔɖeŋu si wowɔ ɖe sisiblisi ŋu ɖoɖo anyi eye wotsɔ mifepristone da dɔe, eye le ɣeyiɣi ma ke me la, wowɔ dodokpɔwo ɖe amegbetɔ ƒe vidzidɔ me lãmenugbagbeviwo (EECs) ŋu me la, wokpɔe be le HCG dɔdamɔnu megbe la, vidzidɔa ƒe xɔxlɔ̃ le EID sisiblisiwo me nyo ɖe edzi. Le kpɔɖeŋu me, wodzi CD105 ƒe ɖeɖefia ƒe agbɔsɔsɔ ɖe edzi le sisiblisiwo me kple protein ƒe agbɔsɔsɔ si le cadherins CD144 kple CD146 me abe alesi wokpɔe to dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ kple Western blotting me ene.
Domenyiŋusẽfianu ƒe ɖeɖefia dzi kpɔkpɔ: HCG ate ŋu ado miR-126-3p ƒe ɖeɖefia ɖe ŋgɔ eye wòaxe mɔ ɖe PIK3R2 ƒe ɖeɖefia nu, eye miR-126-3p tɔa ŋku PIK3R2. Dodokpɔ siwo wowɔ le vivo kple vitro siaa ɖo kpe edzi be HCG naa PI3K/Akt/eNOS mɔa wɔa dɔ to miR-126-3p/PIK3R2 axis dzi, si wɔnɛ be vidzidɔa ƒe xɔxlɔ̃ nyona ɖe edzi.
2. Akpa si wòwɔna le fufɔfɔ me léle ɖe asi me
Syncytiotrophoblast lãmenugbagbevi siwo to vovo koŋue wɔa HCG eye wònye fugboe ƒe dzesi vevi aɖe si hiã vevie na fufɔfɔ me léle ɖe asi [2] ..
Dzesi geɖewo ƒe dɔwɔwɔ ƒe dɔwɔwɔ: HCG ate ŋu abla ɖe luteinizing hormone/chorionic gonadotropin receptor (LHCGR) ŋu eye wòate ŋu awɔ dzesi ƒe cascade ƒe dɔwɔwɔ geɖe ŋudɔ, siwo dometɔ aɖewoe nye vidada siwo tsi tre ɖe decapentaplegic homolog 2 (Smad2) ŋu na vidada siwo si ŋutete geɖe le, protein kinase C (PKC), kple/alo protein kinase A (PKA), to kadodo tẽ/si mele tẽ o kple tɔtrɔa me tsitsi ƒe nuwɔna β xɔla (TGFβR).
Ʋukawo ƒe dzɔdzɔ dodo ɖe ŋgɔ le vidzidɔ ƒe ʋuka me: HCG wɔa akpa tɔxɛ aɖe le ʋukawo ƒe dzɔdzɔ dodo ɖe ŋgɔ le vidzidɔ ƒe ʋuka me, si naa tsitsi ƒe nɔnɔme nyui aɖe fugboea.Maintaining the quiescence of the myometrium: Ekpena ɖe vidzidɔa ƒe nɔnɔme si li ke ŋu eye wònaa nɔnɔme si sɔ na fugboea ƒe tsitsi.Promoting immunomodulation at the vidada kple fugboe ƒe ƒomedodo: Ewɔa akpa vevi aɖe le dɔlélenutsiŋutete ƒe tɔtrɔ le vidada kple fugboe ƒe ƒomedodo me eye wòdaa asɔ le vidada ƒe dɔlélenutsiŋutete ƒe ŋuɖoɖo ɖe fugboea ŋu me.
3. Akpa si wòwɔna le fugboe siwo wofa tsikpe me ƒe asitɔtrɔ me
Numekukuwo ɖee fia be elektrik-ŋusẽ ƒe ʋuʋu to ŋutigbalẽ me (TEAS) si wotsɔ kpe ɖe HCG zazã ŋu ate ŋu ana dɔnɔ siwo wotsɔ fugboe si wofa tsikpe me la ƒe fufɔfɔ me tsonu nanyo ɖe edzi [3]..
Vidzidɔa ƒe titrime dzi ɖeɖe kpɔtɔ: TEAS zazã koŋ kpena ɖe vidzidɔa ƒe titrime dzina ɖe edzi le dɔnɔ siwo wotsɔ fugboe si wofa tsikpe me la me. HCG kple TEAS zazã ɖekae hã kpena ɖe dɔnɔ siawo ƒe vidzidɔa ƒe titrime ŋu.
Vidzidɔ ƒe ʋuka ƒe ʋu ƒe sisi ƒe dzesi dzi ɖeɖe kpɔtɔ: Vidzidɔ me ʋu ƒe sisi ƒe dzesi PI kple RI ƒe asixɔxɔ siwo le TEAS siwo wotsɔ ƒo ƒu kple HCG ƒuƒoƒoa kple TEAS ƒuƒoƒoa me ɖiɖi ŋutɔ wu esiwo le ƒuƒoƒo si me wokpɔa wo gbɔ le, si ɖee fia be HCG kple TEAS ƒe atikewɔwɔ ƒokpli ate ŋu aɖe ʋu ƒe sisi ƒe dzesi PI kple RI si le vidzidɔa me dzi akpɔtɔ le dɔnɔwo me.
Nusiwo ku ɖe fufɔfɔ dzi kpɔkpɔ ŋu ƒe agbɔsɔsɔ dzi ɖeɖe kpɔtɔ le ʋumenugbagbeviɣi me: HCG zazã koŋ kpena ɖe ame ŋu be ʋumenugbagbeviɣi P kple ʋumenugbagbeviɣidɔ mɔxenu (LIF) ƒe agbɔsɔsɔ dzina ɖe edzi le dɔnɔ siwo wotsɔ fugboe si wotu ɖe tsikpe me la me. LIF ƒe agbɔsɔsɔ si le ʋumenu me le TEAS ƒuƒoƒoa, HCG ƒuƒoƒoa, kple TEAS si wotsɔ ƒo ƒu kple HCG ƒuƒoƒoa me katã sɔ gbɔ ŋutɔ wu esiwo le ƒuƒoƒo si me wokpɔa wo gbɔ le me. Fugboe si wodona le ƒuƒoƒo si woƒo ƒu me sɔ gbɔ ŋutɔ wu esi le ƒuƒoƒo si me wokpɔa wo gbɔ le me, si fia be TEAS kple HCG zazã ɖekae ate ŋu ana dɔnɔ siwo wotsɔ fugboe si wofa tsikpe me la ƒe fufɔfɔ me tsonu nanyo ɖe edzi.
4. Ŋutsuwo ƒe ʋumenugbagbeviɣidɔ dada
Hipogonadism si tsoa gonadotropin ƒe dodo nyuie le ŋutsuwo me kpɔa ŋusẽ gã aɖe ɖe vidzidzi ƒe lãmesẽ kple dɔnɔwo ƒe agbenɔnɔ ƒe nyonyome dzi. Amegbetɔ ƒe Chorionic Gonadotropin (HCG) wɔa akpa vevi aɖe le dɔléle mawo dada me. HCG blana ɖe lãmenugbagbevi siwo le Leydig lãmenugbagbeviwo ƒe anyime le vidzidɔa me ŋu, enaa lãmenugbagbeviwo me dzesimɔa wɔa dɔ, eye wòdoa ʋumemi ƒe tɔtrɔ wòzua testosterone ɖe ŋgɔ. Testosterone ƒe dzidziɖedzi ate ŋu ado vidzidɔa ƒe tsitsi kple tsitsi ɖe ŋgɔ eye wòana vidzidɔa ƒe lolome nadzi ɖe edzi. Le ɣeyiɣi ma ke me la, testosterone ate ŋu ana vidzidzi ŋutinuwo abe epididymis kple vas deferens ene hã natsi. Testosterone wɔa akpa vevi aɖe le ŋutsu ƒe gbɔdɔdɔ ƒe nɔnɔme evelia ƒe dzɔdzɔ me. To testosterone ƒe agbɔsɔsɔ dzi ɖeɖe kpɔtɔ me la, HCG zazã ate ŋu ado ɖa kple Adam ƒe akɔɖuwo ƒe tsitsi ɖe ŋgɔ, ana lãmekawo nasẽ ɖe edzi, eye wòana gbɔdɔdɔ ƒe dzodzro nadzi ɖe edzi, kple bubuawo
Lãmenugbagbeviwo ƒe dzɔtsoƒewo, taɖodzinuwo, dzesiwo ƒe ƒuƒoƒo siwo do ƒome kplii, kple HCG isoform vovovowo ƒe dɔwɔwɔ le nyɔnu siwo mefɔ fu o kple funɔwo me.
Dzɔtsoƒe:PubMed [2] .
Nukawoe nye HCG zazã veviwo?
1. Wozãnɛ tsɔ dea dzesi fufɔfɔ ƒe gɔmedzedze
Asixɔxɔ si le serum T-HCG kple β-HCG ƒe nusiwo le eme dzidzedze ŋu le fufɔfɔ ƒe gɔmedzedze: Ƒo fufɔfɔ ƒe gɔmedzedze ƒe nɔnɔme siwo mesɔ o nu ƒu, dzidze serum T-HCG to chemiluminescence zazã me, dzidze serum β-HCG to radioimmunoassay zazã me, eye nàwɔ ŋkuléle ɖe nu ŋu le mɔ si trɔna nu. Nusiwo do tso eme ɖee fia be serum T-HCG kple β-HCG si le fufɔfɔ ƒe ƒuƒoƒo si le vidzidɔa godo me ɖiɖi ŋutɔ wu esiwo le fufɔfɔ ƒe ƒuƒoƒoa kple fufɔfɔ le vidzidɔ me ƒe ƒuƒoƒoa me. Esia ɖee fia be serum T-HCG kple β-HCG ƒe nusiwo le eme dzidzedze la ƒe tẽnyenye kple dɔlélewo didi ƒe agbɔsɔsɔme nyo hena vovototodede fufɔfɔ si le vidzidɔa godo kple fufɔfɔ le vidzidɔ me, eye T-HCG ƒe seselelãme kple kakaɖedzi le eŋu wu [4]..
Fufɔfɔ le vidzidɔa godo ƒe dzesi to ʋumenugbagbeviɣi me HCG, β-HCG, kple progesterone didi ɖekae me: De dzesi serum HCG, β-HCG, kple progesterone le funɔ siwo sɔ kple funɔ siwo fɔ fu le vidzidɔa godo me. Nusiwo do tso eme ɖee fia be serum HCG, β-HCG, kple progesterone ƒe agbɔsɔsɔ le funɔ siwo sɔ me nyo wu esiwo le funɔ siwo fɔ fu le vidzidɔa godo me. Ne wokpɔe ɖeɖeko la, serum HCG ƒe nyateƒetoto le fufɔfɔ si le vidzidɔa godo ƒe dɔléle didi me nye 70.83%; β-HCG ƒe nyateƒetoto ƒe agbɔsɔsɔme nye 66.7%; progesterone ƒe nyateƒetoto ƒe agbɔsɔsɔme nye 54.17%. Serum HCG, β-HCG, kple progesterone ƒe dzedzeme ƒokpli ƒe nyateƒetoto dea 95.8% le fufɔfɔ si le vidzidɔa godo ƒe dɔléle didi me [5]..
2. Dɔwɔwɔ le vidzidzi mɔ̃ɖaŋununya si ŋu wokpena ɖo me
Azigolo ƒe tsitsi nyuie wu: Le azigolo ƒe ʋuʋu me la, amegbetɔ ƒe dzinukpɔkpɔ ƒe gonadotropin (hMG) ate ŋu ana lãkusi ƒe tsitsi nanyo ɖe edzi le pituitary desensitization si gonadotropin-releasing hormone analogues (Gn-RH-analogue) hena vɛ megbe. Esia le alea koŋ elabena eƒoa asa na lãmetsi si woyɔna be endogenous luteinizing hormone (LG) ƒe ŋuɖoɖo si mesɔ o si dzɔna le hMG dɔdamɔnu me le atikewɔwɔ ƒe tsatsam siwo ade akpa etɔ̃lia me ta. Le numekuku geɖe siwo wozã buserelin alo degarelix abe Gn-RH analogues ene me la, dɔnɔ 282 xɔ vidzidzi le vitro, gamete intrafallopian transfer, alo abe 'in vivo' atikewɔwɔ ƒe akpa aɖe ene. GnRH analogue/hMG/HCG zazã ɖekae na fufɔfɔ ƒe agbɔsɔsɔme dzi ɖe edzi ŋutɔ le ƒuƒoƒoawo katã me. Dɔnɔ siwo wotsɔ HMG/HCG da dɔe ƒe fufɔfɔ nye 17%, gake atikewɔwɔ ƒokpli na dɔnɔawo ƒe 25% fɔ fu [6]..
Vidzidɔa ƒe dɔwɔwɔ nyuie wu: Amegbetɔ ƒe Chorionic Gonadotropin (HCG) nye dzesi vevi siwo dona hafi dea fugboe la dometɔ ɖeka. Numekuku siwo wowɔ tsɔ zã vidzidɔ me lãmenugbagbeviwo me dzodzro ɖee fia be le HCG dodo le vidzidɔ me megbe la, lãmenugbagbevi siwo ɖea lãmenugbagbevi siwo le lãkusi me ƒe molecule siwo nye VE-cadherin (CD144) kple S-Endo-1 (CD146) fiana ƒe xexlẽme dzina ɖe edzi ŋutɔ, si fia be lãmenugbagbeviwo ƒe lãmenugbagbeviwo ƒe adhesion molecules ate ŋu anye mɔnu si ate ŋu ato HCG ana fugboe ƒe dodo kple fufɔfɔ ƒe agbɔsɔsɔme nanyo ɖe edzi [7] ..
2. Luteal ƒe dɔmawɔmawɔ nyuie dada
Ƒe blaeve enye sia la, wozãa progesterone si wodona le gota abe luteal phase support (LPS) ene tsɔ kpe ɖe azigolo ƒe ʋuʋu si dzi wokpɔna ŋu to amegbetɔ ƒe Chorionic Gonadotropin (HCG) zazã me tsɔ hea azigolowo ƒe tsitsi mamlɛtɔ vɛ. GnRHa ƒe dodo be wòaʋã azigolo ƒe dodo ɖee fia be progesterone si wodona le egodo mesɔ gbɔ be woakpɔ fufɔfɔ ƒe agbɔsɔsɔ si ana dzidzeme ame ne wometsɔ HCG kpe ɖe eŋu o.
Esia na woto mɔnu bubuwo vɛ na luteal phase support. Progesterone si le nutoa me ƒe dzidziɖedzi le corpora lutea geɖe me nye nya vevi aɖe, le go ɖeka me, be woaƒo asa na azigolo ƒe ʋuʋu fũu akpa ƒe dɔléle ƒe dzɔdzɔ, eye le go bubu me la, be woana progesterone ƒe agbɔsɔsɔ si sɔ be woalé azigoloa me ɖe te.
Numekuku siwo wowɔ fifia da akpa si micro-dose HCG wɔna hena luteal phase support kpɔ eye wosrɔ̃ nu tso eƒe viɖe kple kuxi siwo ate ŋu ado tso eme ŋu. Wonɔ te ɖe HCG ƒe atike ƒe dɔwɔwɔ ƒe nɔnɔmewo dzi da akɔntabubu ƒe kpɔɖeŋu aɖe si ku ɖe HCG ƒe agbɔsɔsɔme mama le luteal phase me ŋu to HCG dodo ƒe mɔnu vovovo geɖewo ƒoƒo ƒu abe luteal phase ƒe kpekpeɖeŋu ene me. Wodo susua ɖa be fifia luteal phase support si wona kpe ɖe GnRHa triggering (si nye, 1500IU) ŋu la nu sẽ akpa, eye gbesiagbe micro-dose HCG dodo ate ŋu ana luteal phase ƒe kpekpeɖeŋu nyuitɔ kekeake na atike siwo li fifia. Wogblɔ dɔdamɔnu gbãtɔ siwo do tso micro-dose HCG mɔnu hã me [8]..
3. Atikewɔwɔ na akpa ɖeka ƒe ƒodo me vidzidɔ si meɖiɖi o
Wowɔ numekuku aɖe le dɔnɔ siwo wowɔ orchidopexy na wo hena akpa ɖeka ƒe vidzidɔ si meɖiɖi o le ƒodo me tso September 2010 va ɖo September 2016. Le dɔwɔwɔ nɛ kwasiɖa eve megbe la, ehiã be dɔnɔ siwo wotsɔ lãmetsiŋusẽ da dɔ na la dzilawo nawɔ ɖe kwasiɖa 6 ƒe ɖoɖoa dzi. Wodoa UI 500 (Gonasi-HP) na dɔnɔawo le ŋutigbalẽ te kwasiɖa sia kwasiɖa. Wowɔ kplɔkplɔ ɖo le atikewɔwɔa ƒe nuwuwu kple ɣleti 6 megbe.
Wotsɔ ultrasound kple ultrasonic elastography dzidze vidzidɔa ƒe lolome le kplɔkplɔ ɖesiaɖe me eye wotsɔe sɔ kple dɔnɔ siwo womewɔ atike na o tɔ. Nusiwo do tso eme ɖee fia be dɔnɔ 45 xɔ atike, eye ƒe si woxɔ le mama dedie nu nye ɣleti 18.0±9.7. Wotsɔ lãmetsiŋusẽtike na dɔnɔ 32 le dɔwɔwɔ nɛ vɔ megbe, eye womekpɔ nu gbegblẽ aɖeke le wo ŋu alo woɖe asi le wo ŋu o.
Dɔnɔawo katã wu kplɔkplɔ ɖo nu. Womekpɔ vidzidɔ ƒe dɔmawɔmawɔ nyuie le hatsotso eveawo siaa me o. Le atikewɔwɔ ƒe ƒuƒoƒoa me la, dɔnɔawo ƒe 81% ɖo vidzidɔ ƒe lolome si sɔ gbɔ le ɣleti 6 me, esime dɔnɔ bubuwo ƒe vidzidɔ ƒe lolome gakpɔtɔ le sue. Le ƒuƒoƒo si womewɔ atike na o me la, dɔnɔawo ƒe 46% ɖo vidzidɔ ƒe lolome si sɔ gbɔ. Amegbetɔ ƒe Chorionic Gonadotropin (u-HCG) zazã le dɔwɔwɔ vɔ megbe ate ŋu ana vidzidɔa ƒe lolome kple dɔwɔwɔ nanyo ɖe edzi to vidzidɔa ƒe tsitsi kple tsitsi dodo ɖe ŋgɔ me [9]..
4. Dɔwɔwɔ le β-HCG atikewɔmɔnu ŋuti numekuku me
Wɔ HCG ƒe dzodzo dodokpɔ na nyɔnu siwo wodo atike na kple NII beta-HCG atike gake womekpɔ anti-HCG dɔlékuiwutike ƒe agbɔsɔsɔme aɖeke o, eye nàzã serum progesterone ƒe dodo ƒe ʋuʋu abe nusi afia alesi corpus luteum wɔa nui ɖe HCG si wodona ɖe ʋuka me ŋu ene. Nusiwo do tso eme ɖee fia be le ƒuƒoƒo si me wokpɔa wo gbɔ le me la, nyɔnu akpa gãtɔ ƒe progesterone ƒe dodo le HCG ƒe ʋuʋu megbe sɔ gbɔ ŋutɔ wu esi le gɔmedzedzea me, gake progesterone ƒe agbɔsɔsɔ si sɔ gbɔ wu le nyɔnu siwo le ƒuƒoƒo si me wodo atike na me la mewu basal ƒe agbɔsɔsɔ le atikewɔmɔnu megbe o, si ɖee fia be dɔlékuiwutike siwo atikewɔmɔnua wɔ ate ŋu axe mɔ ɖe HCG si tso gota ƒe ŋusẽkpɔɖeamedzi nu [10]..
Le nyataƒoƒo me la, HCG wɔa akpa aɖe si womate ŋu aɖɔli o le atikewɔwɔ me, vevietɔ le akpa siwo ku ɖe vidzidzi ŋu me. Le vidzidzi ƒe atikewɔwɔ me la, ate ŋu ana azigolo nado nyuie, si ana mɔkpɔkpɔ nasu dɔnɔ siwo ƒe vidzidzi mete ŋu tsoa fugboe ƒe dɔlélewo gbɔ o la si. To kadodo kple LH xɔla siwo le ŋutilã me me la, ate ŋu aɖo LH ƒe agbɔsɔsɔ si mesɔ gbɔ le antagonist protocol me o eye wòakpe ɖe follicular maturation ŋu. Le luteal ƒe dɔmawɔmawɔ nyuie gome la, HCG ate ŋu aʋã corpus luteum be wòaɖe progesterone ɖa eye wòalé lãmetsiŋusẽ ƒe nɔnɔme si sɔ me ɖe asi be wòado alɔ fufɔfɔ.
Le ŋutsuwo ƒe ʋuka me ʋu ƒe sisi si tso gonadotropin ƒe dodo mesɔ gbɔ o gome la, HCG ate ŋu aʋã Leydig lãmenugbagbevi siwo le vidzidɔ me be woawɔ testosterone ahaɖee ɖa, ado vidzidɔ ƒe tsitsi ɖe ŋgɔ, ana gbɔdɔdɔ ƒe nɔnɔme evelia nanyo ɖe edzi, eye wòana dɔnɔwo ƒe vidzidzi ƒe dɔwɔwɔ kple agbenɔnɔ nanyo ɖe edzi. Le ɣeyiɣi ma ke me la, HCG wɔa akpa vevi aɖe le fufɔfɔ ƒe gɔmedzedze me léle ɖe asi me, si ʋãa corpus luteum be wòaɖe progesterone ɖe go atraɖii be wòakpɔ egbɔ be wotsɔ fugboe de eme eye wòtsi. Le dɔdaƒe ƒe dɔlélewo didi me la, HCG ƒe agbɔsɔsɔme nyanya nye gɔmeɖoanyi vevi aɖe si dzi woanɔ te ɖo anya fufɔfɔ kaba eye woade dzesi fu siwo mesɔ o abe fufɔfɔ le vidzidɔ godo ene, si naa kpekpeɖeŋu sesẽ na nudede dɔa me le ɣeyiɣi nyuitɔ dzi kple atikewɔwɔ.
Le Agbalẽŋlɔla La Ŋu
Nusiwo míeyɔ ɖe etame la katã nye esiwo ŋu Cocer Peptides wɔ numekuku le, trɔ asi le wo ŋu eye woƒo wo nu ƒu.
Dzɔdzɔmeŋutinunya ƒe Agbalẽŋlɔla
Chinedu Nwabuobi nye numekula si bi ɖe Vidzidzi & Nyɔnuwo ƒe Dɔlélewo, Vidzidzi Ŋuti Nunya, Nu gbagbewo ƒe Dzɔdzɔmeŋusẽŋununya & Molecular Biology, Dzɔdzɔmeŋusẽŋununya, kple Kansaŋutinunya me. Ewɔ ɖeka kple dɔwɔƒe xɔŋkɔ geɖe, siwo dometɔ aɖewoe nye South Florida Yunivɛsiti, Rochester Yunivɛsiti, kple Memorial Sloan Kettering Kansa Dɔwɔƒe. Eƒe numekukuwo ku ɖe nyatiwo abe amegbetɔ ƒe chorionic gonadotropin (HCG) ƒe nugbagbewo ƒe dɔwɔwɔ kple eƒe dɔdamɔnu zazã ŋu, eye wòkpena ɖe akpa si wòwɔna le vidzidzi ƒe lãmesẽ kple dɔléle siwo do ƒome kplii me gɔmesese ŋu. Woŋlɔ Chinedu Nwabuobi ŋkɔ ɖe nyayɔyɔ ƒe nyatakaka me [2].
