Tesamoreli miligaramu 20

▎ Tesamoreli ka jɔcogo

Sɔrɔyɔrɔ: PubChem

A kɛcogo: YADAIFTNSYRKVLGQLSARKLLQDIMSRQQGESNQERGARARL Formula molekilɛri: C 221H 366N 72O 67S Molecules girinya: 5136 g/mol CAS nimɔrɔ: 218949-48-5 PubChem ka CID: 16137828. Bamako, Mali Kɔrɔɲɔgɔnmaw: Egrifta

▎ Tesamoreli ka ɲininiw

Tesamoreli ka ɲininiw kɛcogo ye mun ye?

Adamaden ka bonya hormone (rhGH) min bɛ fara ɲɔgɔn kan (rhGH) bɛ se ka kɛ kɛnɛyaso la ka ɲɛsin bonya hormone (GH) dɛsɛ furakɛli ma, nka a bɛ taa ni kɔlɔlɔ suguya caman fana ye. O ko in kɛra sababu ye ka hadamadenw ka bonya hormone-releasing factor (GFR) analogues (GFR) dilan, barisa u bɛ se ka muɲu ka ɲɛ. Tesamoreli ye GFR dilannen ye min dabɔra ka kɛ fura ye min bɛ se ka kɛ bana suguya caman furakɛli ye minnu bɛ se ka kɛ sababu ye ka GH dɛsɛ hakɛ dɔ sɔrɔ, sidabanakisɛ ni farikolojidɛsɛbana fana sen bɛ o la.

Tesamoreli ka baara kɛcogo ye mun ye?

Fɛɛrɛ min bɛ kɛ ka ɲɛsin sidabanakisɛ ma min tɛ dɔlɔ ye sugunɛbilenni na (NAFLD):

Jɛnɛya jiracogo ɲɛnabɔli: 

NAFLD min bɛ tali kɛ sidabanakisɛ la, ni jeninida nafama sɛgɛsɛgɛli ye, a jirala ko Tesamoreli ye dɔ fara jamu siginiden jɛnɛya jirali kan min bɛ tali kɛ oksidan fosforilasi la sugunɛ na, ka sɔrɔ ka dɔ bɔ jeninida kuluw jirali la minnu bɛ tali kɛ funu, farikolo yɔrɔw dilancogo, ani selilɛri ^la tilali Kɛrɛnkɛrɛnnenya la, Tesamoreli ye sugunɛ jamu kuluw jigin minnu ɲɛsinnen bɛ funu, farikolo yɔrɔw dilancogo ani farikolokisɛw tilali ma, o b’a jira ko a b’a nɔ jira ni o jamu ninnu jirali ɲɛnabɔli ye.

Cɛsiribaa jɔnjɔnw balili: 

Tesamoreli bɛ se ka joli-sira-funu, joli-sira-funu ani funu cɛmancɛlafɛn jɔnjɔnw bali. Misali la, a bɛ se ka dɔ bɔ kosɛbɛ joli-sira-funu-kɔnɔ-fɛnw falen-falen A (VEGFA), bonya fɛn caman tigɛli β1 (TGFB1) ani makɔrɔfaga koloni-stimulant 1 (CSF1) hakɛ la. Tesamoreli furakɛli kɛbagaw la, VEGFA ni CSF1 dɔgɔyali joli la, o bɛ tali kɛ sugunɛbilenni tuluma baara hakɛ dɔgɔyali la min tɛ dɔlɔ ye, ani TGFB1 ni CSF1 dɔgɔyali bɛ tali kɛ fibrose hakɛ dɔgɔyali la jeninida ^hakɛ la I n’a fɔ monositɛriw tali ni u baaracogo ɲɛnabɔbaga, CSF1 bɛ se ka kɛ furakɛli laɲini kura ye NAFLD la min bɛ sɔrɔ sidabanakisɛ fɛ.

Fɛɛrɛ min bɛ kɛ ka ɲɛsin farikolo yɔrɔw joginni ma:

Nɛrɛmuguma joginni furakɛli la, a dalen b’a la ko Tesamoreli bɛ axonal regeneration (axonal regeneration) sabati, ka farikolojidɛsɛ dɔgɔya, ani ka baarakɛcogo ɲɛ. Sisan sɛgɛsɛgɛliw y’a jira ko Tesamoreli bɛ se k’a nɔ bila a kɛtɔ ka farikolo yɔrɔw labɛncogo kura ni u dilancogo ɲɛ. A kɛcogo kɛrɛnkɛrɛnnen ma faamuya ka ɲɛ fɔlɔ, nka a bɛ se ka kɛ ko a bɛ kɛ ni farikolojidɛsɛ furaw labɛnni ye, ka axonal falenni sabati, ani ka myelination ^{[2] .}.

Tesamoreli ka fɛɛrɛ kɛrɛnkɛrɛnnen ye mun ye ka kɔnɔnatumu ni sugunɛ tulu dɔgɔya sidabanakisɛ bɛ mɔgɔ minnu na?

Labɛnni nɔ min bɛ kɛ ka ɲɛsin bonya hormone ma:

Bonya hormone bɔli lawulili: 

Tesamoreli ye GHRH dilannen ye min bɛ se ka bonya hormone bɔli lawuli. Sidabanakisɛ bɛ mɔgɔ minnu na, o bɛ se ka nɔ bila bonya hormone bɔli la, wa Tesamoreli bɛ se ka ɲɛgɛnɛsira ɲɛfɛla bila ka bonya hormone bɔ ni GHRH ka baara ladege ^ye.

Tulumafɛnw falen-falencogo ɲɛnabɔli: 

Bonya hormone jɔyɔrɔ ka bon tulumafɛnw falenni na. A bɛ se ka tulumafɛnw bɔli sabati, ka dɔ fara asidi tulumafɛnw ka oksidan kan, ani ka tulumafɛnw dalajɛli dɔgɔya. Ni Tesamoreli bɛ bonya hormone bɔli lawuli, a bɛ se ka tulumafɛnw falen-falencogo ɲɛnabɔ cogo la min tɛ ɲɛ ani ka dɔ bɔ kɔnɔnatumu ni sugunɛ tulu dalajɛli la ^[3-5]..

A nɔ bɛ sɔrɔ sugunɛ ka jeninida jiracogo la:

Jɛnɛya siraw caman cili: 

Kɔlɔsiliw y’a jira ko Tesamoreli bɛ se ka dɔ fara siginiden jɛnɛya kulu jirali kan min bɛ tali kɛ oksidan fosforilasi la sugunɛ na, ka sɔrɔ ka dɔ bɔ jɛnɛya kuluw jirali la minnu bɛ tali kɛ funu, farikolo yɔrɔw dilancogo ani selilɛri tilali ^la.

Jɛnɛya minnu bɛ nɔ bila sugunɛbilenni kansɛri ɲɛfɔli la: 

Tesamoreli bɛ se fana ka jamu kuluw labɛn minnu bɛ tali kɛ sugunɛbilenni kansɛri ɲɛfɔli la, ka jamu kuluw labɛn sanfɛ minnu bɛ tali kɛ ɲɛfɔli ɲuman na ani ka jamu kuluw labɛn minnu bɛ tali kɛ ɲɛfɔli jugu la, o cogo ^na kelen Nin fɛn caman Changements dans la gènes (Jɛnɛya jiracogo) bɛ se ka kɛ sababu ye ka Tesamoreli nɔ bila sugunɛ tulu dɔgɔyali la.

Jɛɲɔgɔnya ni fibrose bɛ tali kɛ jeninida hakɛw la: 

Mɔgɔ minnu furakɛra ni Tesamoreli ye, o fɛn caman yeli sugunɛ kɛcogo la, olu tun bɛ tali kɛ fibrose ni fɛnɲɛnamafagalanw ka jeninida hakɛw ɲɛnabɔli la. O b’a jira ko Tesamoreli bɛ se ka sugunɛ tulu dɔgɔya ni a bɛ sugunɛ jamu jiracogo ɲɛnabɔ ani ka sugunɛ fibrotic cogoya ɲɛ ^{[1] .}.

A nɔ bɛ bila joli la farikolojɔli dumuniw na:

Cɛsiribaa jɔnjɔnw balili: 

Tesamoreli bɛ se ka joli la farikolojɔli dumuniw hakɛ dɔgɔya kosɛbɛ i n’a fɔ siraw kɔnɔfɛnw falenfalen A (VEGFA), bonya fɛn caman tigɛli β1 (TGFB1), ani makɔrɔfaga koloni wulilan 1 (CSF1 ⁾ joli Nin farikolojɔli dumuni ninnu bɛ tali kɛ joli-sira-funu, fiɲɛbana (fibrose) ani funu na, wa ni Tesamoreli ye u bali, o bɛ se ka kɛ sababu ye ka sugunɛ tulu ni funu dɔgɔya.

Soso:PubMed ^{[1] Ɲɛjirali dɔw.}

Tesamoreli baarakɛcogo ye mun ye?

A bɛ se ka kɛ sidabanakisɛ bɛ mɔgɔ minnu na:

Kɔnɔnatumu tulu ni sugunɛ tulu dɔgɔyali: 

Kalan dɔw y’a jira ko sidabanakisɛ bɛ mɔgɔ minnu na, ni u bɛ furakɛli kɛ ni integrase inhibiteur (INSTI) ye, kɔnɔbara basigilen (VAT) caya ye haminanko ye barisa PIB bɛ tali kɛ bana wɛrɛw la minnu bɛ duguma i n’a fɔ sugunɛbilenni min tɛ dɔlɔ ye (NAFLD). A jirala ko tesamoreli bɛ dɔ bɔ PIB la sidabanakisɛ bɛ mɔgɔ minnu na, farikolojidɛsɛ bɛ minnu na, ni u ka ca ni 15% ye kalo 6 kɔnɔ ^[6] . Kɔrɔbɔli min kɛra ni furakisɛ ye, n’o kɛra mɔgɔ 61 kan minnu bɛ ni NAFLD ye min bɛ tali kɛ sidabanakisɛ la, mɔgɔ minnu ye INSTI furakɛli kɛ, olu ka sɛgɛsɛgɛli kɔfɛ, o y’a jira ko kalo 12 kɔfɛ, PIB min bɛ furakisɛ ta kulu la, o cayara ni 10,8% ye, ka sɔrɔ PIB min bɛ Tesamoreli furakɛli kulu la, o dɔgɔyara ni 8,3% ye u bɛɛ lajɛlen na. Ka fara o kan, sugunɛ tulu hakɛ (HFF) min bɛ Tesamoreli furakɛli kulu la, o dɔgɔyara ni 31% ye ni a kɛra a daminɛ na, o hakɛ tun ka ca kosɛbɛ ni furakisɛ furakɛli kulu ta ^ye.

Ka tulumafɛnw jogo ɲɛ: 

Sidabanakisɛ bɛ mɔgɔ minnu na, banabagatɔ minnu ka fasa cɛmancɛ la, ni u ye Tesamoreli ta, kɔnɔnatumu (VAT) ni farikolo jukɔrɔla tulu (SAT) hakɛ cayara, wa o caya in tun tɛ tulumafɛnw caman yeli ye, o b’a jira ko Tesamoreli fana bɛ se ka PIB ni SAT jogo ɲɛ ka taa a fɛ nin banabagatɔ kulu in ^na.

A bɛ nɔ bila farikolo tangalanw ka baara la: 

Tesamoreli tali kuntaalajan bɛ se ka T-cell ni monositɛri/makɔrɔfaga baara taamasiɲɛw dɔgɔya sidabanakisɛ bɛ mɔgɔ minnu na, olu ka joli la ani ka farikolo tangacogo siraw dɔgɔya sugunɛ na. Kɛrɛnkɛrɛnnenya la, ni i ye a suma ni furakisɛ ye, Tesamoreli ye farikolojɔli dumuni 13 hakɛ dɔgɔya farikolo la, i n’a fɔ kemokini naani, sitokini fila, T-cell ni ɲɔgɔn cɛ fɛnɲɛnamafagalan naani, ka fara arginase-1, galectin-9 ani hepatocyte growth factor kan. Réseau sɛgɛsɛgɛli y’a jira ko jɛɲɔgɔnya gɛlɛn bɛ jeninida siraw ni ɲɔgɔn cɛ minnu bɛ o farikolojɔli dumuniw dɔgɔya, wa transcriptomics laɲinitaw ye farikolo tangalanw ka jigin taamasiɲɛ dafa sugunɛ ^kɔnɔ.

A nɔ bɛ sɔrɔ sugunɛbilenni na min tɛ dɔlɔ ye:

Sugunɛ tulu dɔgɔyali ani ka fiɲɛbana bali ka taa ɲɛ: 

Sugunɛbilenni min tɛ dɔlɔ ye, o min bɛ sɔrɔ sidabana fɛ, a jirala ko Tesamoreli bɛ sugunɛ tulu dɔgɔya ani ka fiɲɛbana bali. Ɲininikalaw ye jateminɛ sinsinnen kɛ joli la farikolojɔlifɛn 9 kan minnu bɛ bɛn sanfɛla ɲɛmɔgɔba jamu ma jamu kuluw kɔnɔ minnu bɛ labɛn cogo wɛrɛ la, wa u y’a ye ko Tesamoreli kɛra sababu ye ka dɔ bɔ kosɛbɛ joli siraw ka endoteliyali bonya factor A (VEGFA), transforming growth factor β1 (TGFB1), ani macrophage colony-stimulating factor 1 (CSF1) la. Mɔgɔ minnu furakɛra ni Tesamoreli ye, VEGFA ni CSF1 dɔgɔyali joli la, o bɛ tali kɛ sugunɛbilenni tuluma baara hakɛ dɔgɔyali la min tɛ dɔlɔ ye, ani TGFB1 ni CSF1 dɔgɔyali bɛ tali kɛ fibrose hakɛ dɔgɔyali la jeninida hakɛ la. I n’a fɔ monositɛriw tali ni u baaracogo ɲɛnabɔbaga, CSF1 bɛ se ka kɛ furakɛli laɲini kura ye sugunɛ tulumabana na min tɛ dɔlɔ ye sidabanakisɛ la ^{[1] .}.

A nɔ bɛ sɔrɔ sugunɛ transcriptome siginiden kan:

Ni an kɛra baara kɛ ni jeninida nafama sɛgɛsɛgɛli ye, a jirala ko Tesamoreli ye dɔ fara jamu siginiden jɛnɛya jiracogo kan sugunɛ na min bɛ tali kɛ fosforilasi oksidan na ani ka dɔ bɔ jamu suguya jirali la sugunɛ na min bɛ tali kɛ funu, farikolo yɔrɔw dilancogo ani selilu tilali la. Ka fara o kan, Tesamoreli fana ye jɛnɛya sugandilenw kɔrɔta ani ka jigin minnu bɛ tali kɛ sugunɛbilenni kansɛri ɲɛfɔli ɲuman ni a ɲɛfɔcogo jugu la. Mɔgɔ minnu furakɛra ni Tesamoreli ye, o fɛn caman yeli sugunɛ jiracogo la, olu tun bɛ tali kɛ fibrose ni fɛnɲɛnamafagalanw ka jeninida hakɛw ɲɛnabɔli la ^[9]..

Kuncɛli la, i n’a fɔ bonya hormone bɔli hormone synthétique analogue, Tesamoreli ye furakɛli seko jira fan caman na. Kalan caman y’a jira ko a bɛ se ka bonya hormone bɔli ɲɛnabɔ ka ɲɛ ani ka hadamadenw ka farikoloɲɛnajɛ kɛcogo ɲɛ. Sidabanakisɛw furakɛli la, a bɛ nɔba bila kɔnɔbara tulumafɛnw dalajɛli dɔgɔyali la. Ni a bɛ bonya hormone bɔli lawuli ani ka tulumafɛnw sɛnɛcogo ɲuman kɛ, a bɛ dɔ bɔ kɔnɔnatumu hakɛ la k’a sɔrɔ a ma nɔ bila farikolo nɔgɔlen na, wa a jɔyɔrɔ ka ɲi banabagatɔw farikolo labɛncogo ladilanni na. Sugunɛbilenni min tɛ dɔlɔ ye, o furakɛli la, sɛgɛsɛgɛli dɔw y’a jira fana ko a bɛ se ka dɔ bɔ tulu hakɛ la sugunɛ na. Tesamoreli nafa ka bon kosɛbɛ. Sidabanakisɛ bɛ banabagatɔ minnu na, a bɛ fɛɛrɛ ɲuman di walasa ka tulumafɛnw falenfalenbaliya min bɛ sɔrɔ bana ni furakɛli fɛ, o ɲɛ, ka banabagatɔw ka ɲɛnamaya kɛcogo ɲɛ, ka dɛmɛ don ka hakili degunw lajɔ minnu bɛ sɔrɔ u ɲɛda cogoya caman yeli fɛ, ani ka dɔ fara u ka jɛɲɔgɔnya hakilina kan sigida la. Unit daminɛcogo

A sɛbɛnbaga ko la

Fɛn minnu kofɔlen dòn san fɛ, olu bɛɛ ɲinini Kɛra, k’u Labɛn ani k’u Lajɛ Cocer Peptides fɛ.

Dɔnniya gafe sɛbɛnbaga

Stanley TL ye dɔnnikɛla ye Harvard Iniwɛrisite la, a bɛ ɲinini ni kalan kɛ baaradaw la i n’a fɔ Harvard dɔgɔtɔrɔso ani Masasi dɔgɔtɔrɔsoba. A ka ɲininiw ye kɔnɔboli ni farikoloɲɛnajɛ, banakisɛfagalanw, farikolo tangacogo, fɛnɲɛnamafagalanw, ani balo ni dumunikɛcogo ye. A ye ɲinini kunbabaw Kɛ o ko ninnu na, ka hakilinata-jɔ-yɔrɔw Di banaw sɛgɛsɛgɛli, u furakɛli ani u kunbɛnni ma minnu bɛ tali Kɛ ɲɔgɔn na. O waati kelen na, a ni jɛkuluw bɛ jɛ kosɛbɛ i n’a fɔ Harvard dɔgɔtɔrɔso ani Masasi denmisɛnw ka dɔgɔtɔrɔsoba, ka teori ni kɛnɛyaso baarakɛcogo fara ɲɔgɔn kan ani ka dɛmɛ don furakɛli ko la. Stanley TL tɔgɔ sɛbɛnnen bɛ citation (citation) ɲɛfɔli sɛbɛn kɔnɔ [5].

▎ Sɛbɛn minnu bɛ tali kɛ o la

[1] Fourman L. T., Billingsley J. M., Agyapong G., ani a ɲɔgɔnnaw. Tesamorelin nɔ minnu bɛ sugunɛbilenni taamasiɲɛw la NAFLD la min bɛ sɔrɔ sidabanakisɛ fɛ[J]. Jci Hakilila, 2020,5(16).DOI:10.1172/jci.hakilila.140134.

[2] Jaimie T S. Tesamoreli furakɛli walasa ka Axonal Regeneration (Axonal Regeneration) sabati, ka farikolo-ɲɛnajɛ dɔgɔya ani ka baarakɛcogo ɲɛ ka tugu peripheral nerve injury and repair kɔfɛ[J]. 2015 sàn.

[3] Rahman F, McLaughlin T, Mesquita P, ani a ɲɔgɔnnaw. Tesamɔrilini nɔ bɛ se ka kɛ sidabanakisɛ bɛ mɔgɔ minnu na, ni kɔkolo tulu bɛ u la ani ni u tɛ u la: Sɛgɛsɛgɛli kɔfɛ, min kɛra fasa III fila-fiyentɔ ye ni furakisɛ ye[J]. Dɔgɔtɔrɔso ni bamanankan dɔnniya gafe, 2022,7(1).DOI:10.1017/cts.2022.515.

[4] Mateo MG, Gutierrez MDM, Domingo P. Tesamoreli ka ɲɛsin kɔnɔbara tuluma tɛmɛnen furakɛli ma sidabanakisɛ 1 banakisɛ bɛ banabagatɔ minnu na, ni farikolojidɛsɛ bɛ u la.[J]. Endocrinologie & Metabolisme dɔnnikɛlaw ka seginkanni, 2011,6(1):21-30.DOI:10.1586/eem.10.83.

[5] Stanley T. L., Falutz J., Marsolais C., ani a ɲɔgɔnnaw. Fasa dɔgɔyali bɛ tali kɛ farikoloɲɛnajɛ kɛcogo ɲuman na sidabanakisɛ bɛ banabagatɔ minnu na minnu bɛ Tesamoreli ta[J]. Bana minnu bɛ sɔrɔ kɛnɛyaso la, 2012,54(11):1642-1651.DOI:10.1093/cid/cis251.

[6] McLaughlin T, Grinspoon S. K., Stanley T., ani mɔgɔ wɛrɛw. 1499. Tesamoreli bɛ farikolo tulumafɛnw ni sugunɛ tulu dɔgɔya INSTI furakɛli la sidabanakisɛ bɛ mɔgɔ minnu na[J]. Forum da wulilen banakisɛw, 2023,10(2):500-1334.DOI:10.1093/ofid/ofad500.1334.

[7] Lake JE, La K, Erlandson K. M., ani mɔgɔ wɛrɛw. Tesamoreli bɛ tulu hakɛ ɲɛ ka bɔ tulu hakɛ caman yeli la[J]. Sida, 2021,35(9):1395-1402.DOI:10.1097/QAD.0000000000002897. Bamako, Mali.

[8] Stanley T. L., Fourman L. T., Wong L. P., ani a ɲɔgɔnnaw. Bonya ɔrimɔni min bɛ ɔrimɔni bɔ, o bɛ farikolo tangalanw ka baarakɛcogo taamasiɲɛw dɔgɔya ka kɛɲɛ ni a nɔ ye sugunɛ farikolo tangacogo siraw la mɔgɔ minnu na sidabanakisɛ bɛ mɔgɔ minnu na ani sugunɛbilenni min tɛ dɔlɔ ye[J Bana minnu bɛ sɔrɔ kɛnɛyaso la, 2021,73(4):621-630.DOI:10.1093/cid/ciab019.

[9] Fourman L. T., Stanley T. L., Billingsley J. M., ani a ɲɔgɔnnaw. Tesamɔrilini jaabi siraw dantigɛli NAFLD la min bɛ sɔrɔ sidabanakisɛ fɛ ni protéomic ni transcriptomic fɛɛrɛ laɲininen ye[J]. Dɔnniya kunnafoniw, 2021,11(1).DOI:10.1038/s41598-021-89966-y.

BƐƐRƐ KUNNAFONIW NI FƐRƐW KUNNAFONIW BƐƐ MIN BƐ NI WEBSITE KAN NA, U BƐ KUNNAFONIW FƆLƆ DƆRƆN NI KALANSENW YE.  

Fɛn minnu bɛ di nin siti in kan, olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *glasi kɔnɔ*, o kɔrɔ ye gilasi kɔnɔ) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki ka dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.