Tesamoreli 20mg

▎ Ọdịdị Tesamoreli

Isi mmalite: PubChem

Usoro: YADAIFTNSYRKVLGQLSARKLLQDIMSRQQGESNQERGARARL Ụdị mkpụrụ ndụ: C 221H 366N 72O 67S Arọ molekụla: 5136 g/mol Nọmba CAS: 218949-48-5 PubChem CID: 16137828 Ụdị okwu: Egrifta

▎ Tesamoreli Research

Kedu ihe ndabere nyocha nke Tesamoreli?

Recombinant hormone na-eto eto (rhGH) na-arụ ọrụ nke ọma n'ịgwọ ụkọ hormone na-eto eto (GH), mana ọ na-esonyere ya na mmetụta ọjọọ dị iche iche. Ọnọdụ a akpalitela mmepe nke analogues nke na-ewepụta homonụ na-eto mmadụ (GFR), n'ihi na ha nwere ike ịnwe nnabata ka mma. Tesamoreli bụ GFR sịntetik nke emepụtara dị ka ọgwụgwọ nwere ike ịgwọ ọrịa dị iche iche nwere ike jikọta ya na ụkọ GH, gụnyere lipodystrophy metụtara HIV.

Kedu usoro nke Tesamoreli si arụ ọrụ?

Usoro nke ime ihe na ọrịa imeju abụba na-abụghị nke mmanya na-egbu nje HIV (NAFLD):

Iwu nke okwu mkpụrụ ndụ ihe nketa: 

Na NAFLD metụtara nje HIV, site na nyocha mkpụrụ ndụ ihe nketa, a chọpụtara na Tesamoreli mụbara okwu nke mkpụrụ ndụ mbinye aka nke metụtara phosphorylation oxidative na imeju, ebe ọ na-ebelata ngosipụta nke mkpụrụ ndụ ihe nketa metụtara mbufụt, nrụzi anụ ahụ, na nkewa sel ^[1] . Kpọmkwem, Tesamoreli gbadara usoro mkpụrụ ndụ imeju metụtara mbufụt, nrụzi anụ ahụ, na nkewa sel, na-egosi na ọ na-arụ ọrụ ya site n'ịhazi ngosipụta nke mkpụrụ ndụ ihe nketa ndị a.

Mgbochi nke ndị ogbugbo: 

Tesamoreli nwere ike igbochi ndị isi ogbugbo nke angiogenesis, fibrosis, na mbufụt. Dịka ọmụmaatụ, ọ nwere ike belata ọkwa nke vascular endothelial growth factor A (VEGFA), na-agbanwe ihe na-eto eto β1 (TGFB1), na macrophage colony-stimulating factor 1 (CSF1). N'ime ndị na-anata ọgwụgwọ Tesamoreli, mbelata nke VEGFA na CSF1 na plasma jikọtara ya na mbelata nke ọrịa imeju na-adịghị egbu egbu na-aba n'anya, na mbelata na TGFB1 na CSF1 jikọtara ya na mbelata nke akara fibrosis nke mkpụrụ ndụ ihe nketa ^[1] . Dị ka onye na-achịkwa mbanye na mbanye monocyte, CSF1 nwere ike bụrụ ebumnuche ọgwụgwọ ọhụrụ maka NAFLD metụtara HIV.

Usoro nke ime ihe na mmerụ ahụ dị n'akụkụ:

N'ime ọgwụgwọ nke mmerụ ahụ akwara dị n'akụkụ, Tesamoreli kwenyere na ọ na-eme ka mmụba axonal dịkwuo elu, belata atrophy muscle, ma melite nsonaazụ ọrụ. Ọmụmụ ihe dị ugbu a na-egosi na Tesamoreli nwere ike ịrụ ọrụ ya site n'ịkwalite usoro nke ịmaliteghachi akwara na nrụzi. Aghọtabeghị usoro ihe omume a kapịrị ọnụ, mana ọ nwere ike ịgụnye nhazi nke ihe uto akwara, nkwalite uto axonal, na myelination ^[2].

Kedu usoro a kapịrị ọnụ nke Tesamoreli na mbenata abụba visceral na abụba imeju na ndị bu nje HIV?

Mmetụta nchịkwa na hormone uto:

Na-akpali mmepụta nke hormone uto: 

Tesamoreli bụ GHRH sịntetịt nke nwere ike ịkpalite nzuzo nke hormone uto. N'ime ndị bu nje HIV, ihe nzuzo nke hormone na-eto eto nwere ike imetụta, Tesamoreli nwere ike ịkwalite ụbụrụ pituitary nke dị n'ihu iji hapụ hormone na-eto eto site n'iṅomi omume GHRH ^[3-5]..

Na-achịkwa metabolism abụba: 

Hormone uto na-arụ ọrụ dị mkpa na metabolism abụba. Ọ nwere ike ịkwalite lipolysis, mụbaa oxidation nke fatty acids, ma belata mkpokọta abụba. Site n'ịkwalite nzuzo nke homonụ na-eto eto, Tesamoreli nwere ike ịhazi metabolism abụba n'ụzọ na-edoghị anya ma belata mkpokọta abụba visceral na abụba imeju ^[3-5]..

Mmetụta na okwu mkpụrụ ndụ imeju:

Ụzọ mkpụrụ ndụ ihe nketa na-agbanwe: 

Nnyocha achọpụtala na Tesamoreli nwere ike ịbawanye okwu nke mkpụrụ ndụ mbinye aka nke metụtara oxidative phosphorylation na imeju, ebe ọ na-ebelata okwu mkpụrụ ndụ ihe nketa metụtara mbufụt, nrụzi anụ ahụ, na nkewa sel ^[1]..

Na-emetụta mkpụrụ ndụ ihe nketa metụtara prognosis nke carcinoma hepatocellular: 

Tesamoreli nwekwara ike ịhazi usoro mkpụrụ ndụ ihe nketa metụtara prognosis nke carcinoma hepatocellular, na-achịkwa usoro mkpụrụ ndụ ihe nketa metụtara ezigbo prognosis na ala-na-achịkwa usoro mkpụrụ ndụ ihe nketa metụtara prognosis na-adịghị mma, n'otu n'otu ^[1] . Mgbanwe ndị a na okwu mkpụrụ ndụ ihe nketa nwere ike jikọta na mmetụta Tesamoreli na ibelata abụba imeju.

Mmekọrịta na akara mkpụrụ ndụ fibrosis: 

N'ime ndị sonyere na Tesamoreli, mgbanwe ndị a na nkwupụta imeju jikọtara ya na ọnụọgụ mkpụrụ ndụ ihe metụtara fibrosis ka mma. Nke a na-egosi na Tesamoreli nwere ike belata abụba imeju site n'ịhazi okwu mkpụrụ ndụ imeju na imeziwanye ọnọdụ fibrotic nke imeju ^[1].

Mmetụta na protein plasma:

Na-egbochi ndị ogbugbo isi: 

Tesamoreli nwere ike ibelata ọkwa nke proteins plasma dị ka vascular endothelial growth factor A (VEGFA), na-agbanwe ihe na-eto eto β1 (TGFB1), na macrophage colony-stimulating factor 1 (CSF1) ^[1] . Protein ndị a metụtara angiogenesis, fibrosis, na mbufụt, na mgbochi nke Tesamoreli nke ha nwere ike inye aka belata abụba imeju na mbufụt.

Isi mmalite: PubMed ^[1]

Kedu ihe bụ ngwa Tesamoreli?

Mmetụta na ndị mmadụ bu nje HIV:

Mbelata abụba visceral na abụba imeju: 

Ụfọdụ nnyocha egosila na n'ime ndị bu nje HIV na-anata ọgwụgwọ integrase inhibitor (INSTIs), mmụba nke anụ ahụ adipose visceral (VAT) bụ ihe na-echegbu onwe ya n'ihi na VAT na-ejikọta ya na nsogbu ndị dị n'okpuru ala dị ka ọrịa imeju na-adịghị egbu egbu (NAFLD). E gosipụtara Tesamoreli iji belata VAT na ndị bu nje HIV nwere lipohypertrophy karịa 15% n'ime ọnwa 6 ^[6] . N'ime nnwale a na-achịkwa placebo nke ndị sonyere 61 nwere NAFLD metụtara HIV, nyocha post-hoc nke ndị mmadụ na-anata ọgwụgwọ INSTIs chọpụtara na mgbe ọnwa iri na abụọ gachara, VAT na otu placebo mụbara site na 10.8%, ebe VAT na otu ọgwụgwọ Tesamoreli belatara site na 8.3% n'ozuzu ya. Na mgbakwunye, akụkụ abụba imeju (HFF) na otu ọgwụgwọ Tesamoreli belatara site na 31% n'ihe metụtara ntọala, nke dị elu karịa nke ahụ na otu ọgwụgwọ placebo ^[6]..

Na-akwalite ogo abụba: 

N'ime ndị bu nje HIV, na ndị ọrịa nwere oke oke ibu bụ ndị ji Tesamoreli, njupụta nke abụba visceral (VAT) na abụba subcutaneous (SAT) mụbara, mmụba a enweghịkwa mgbanwe na oke abụba, na-egosi na Tesamoreli nwekwara ike melite ogo VAT na SAT n'ime otu ndị ọrịa a ^[7]..

Mmetụta na ọrụ mgbochi ọrịa: 

Ogologo oge iji Tesamoreli mee ihe nwere ike ibelata ihe nrịbama nke cell T na monocyte / macrophage na mgbasa ozi nke ndị bu nje HIV na-achịkwa ụzọ mgbochi na imeju. Kpọmkwem, ma e jiri ya tụnyere placebo, Tesamoreli belatara mkpokọta na-ekesa nke protein 13, gụnyere chemokines anọ, cytokines abụọ, ụmụ irighiri mkpụrụ ndụ T anọ metụtara, yana arginase-1, galectin-9, na ihe na-eto eto hepatocyte. Nyocha netwọkụ gosipụtara mmekọrịta chiri anya n'etiti ụzọ mkpụrụ ndụ ihe nke na-ahụ maka ibelata protein ndị a, yana transcriptomics ezubere iche gosipụtara akara nrịbama nke ụzọ mgbochi na imeju ^[8]..

Mmetụta na ọrịa imeju abụba na-abụghị mmanya:

Mbelata abụba imeju na igbochi ọganihu fibrosis: 

N'ọrịa imeju na-adịghị egbu egbu nke nje HIV, egosila Tesamoreli iji belata abụba imeju ma gbochie ọganihu fibrosis. Ndị nchọpụta mere nyocha lekwasịrị anya nke proteins plasma 9 kwekọrọ na mkpụrụ ndụ ihe nketa kachasị elu na usoro mkpụrụ ndụ dị iche iche na-achịkwa wee chọpụta na Tesamoreli butere mbelata dị ukwuu na vaskụla endothelial growth factor A (VEGFA), na-agbanwe ihe uto β1 (TGFB1), na macrophage colony-stimulating factor 1 (CSF1). N'ime ndị sonyere na Tesamoreli, mbelata nke VEGFA na CSF1 na plasma jikọtara ya na mbelata akara ọrụ ọrịa imeju na-adịghị egbu egbu, yana mbelata TGFB1 na CSF1 jikọtara ya na mbelata akara fibrosis nke mkpụrụ ndụ ihe nketa. Dị ka onye na-achịkwa mbanye na ọrụ monocyte, CSF1 nwere ike bụrụ ebumnuche ọgwụgwọ ọhụrụ maka ọrịa imeju na-adịghị egbu egbu na HIV ^[1].

Mmetụta na mbinye aka transcriptome imeju:

N'iji nyocha mkpụrụ ndụ ihe nketa nke mkpụrụ ndụ ihe nketa, a chọpụtara na Tesamoreli mụbara okwu imeju nke mkpụrụ ndụ mbinye aka nke metụtara phosphorylation oxidative ma belata okwu imeju nke mkpụrụ ndụ ihe nketa metụtara mbufụt, nrụzi anụ ahụ, na nkewa sel. Tụkwasị na nke ahụ, Tesamoreli na-edozikwa ma na-achịkwa usoro mkpụrụ ndụ ihe nketa ahọpụtara nke metụtara ihe dị mma na nke na-adịghị mma nke carcinoma hepatocellular, n'otu n'otu. N'ime ndị sonyere na Tesamoreli, mgbanwe ndị a na nkwupụta imeju na-ejikọta ọnụ ọgụgụ mkpụrụ ndụ fibrosis ka mma ^[9].

N'ikpeazụ, dị ka analọg sịntetik nke hormone na-ewepụta hormone na-eto eto, Tesamoreli egosipụtawo ike ọgwụgwọ n'ọtụtụ akụkụ. Ọnụ ọgụgụ dị ukwuu nke ọmụmụ ekwenyela na ọ nwere ike ịchịkwa ihe nzuzo nke hormone na-eto eto nke ọma ma melite ọrụ metabolic mmadụ. Na ọgwụgwọ ọrịa nje HIV, ọ na-enwe mmetụta dị ukwuu n'ibelata mkpokọta abụba afọ. Site na-akpali akpali nke secretion nke ibu hormone na optimizing abụba metabolism, ọ na-ebelata ọnụ ọgụgụ nke visceral abụba na-enweghị emetụta dabere ahu uka, na-arụ ọrụ dị mma n'igbanwe ahu mejupụtara nke ndị ọrịa. N'ịgwọ ọrịa imeju na-adịghị egbu egbu, ụfọdụ nnyocha egosiwokwa na ọ nwere ike ibelata abụba dị n'imeju. Tesamoreli dị ezigbo mkpa. Maka ndị ọrịa bu nje HIV, ọ na-enye ụzọ dị mma iji kwalite nsogbu metabolism abụba nke ọrịa na ọgwụgwọ na-akpata, na-eme ka ndụ ndị ọrịa dịkwuo mma, na-enyere aka belata nrụgide uche nke mgbanwe ọdịdị ọdịdị ha na-akpata, na-eme ka ha nwee mmetụta nke mmekọrịta mmadụ na ibe ya. Ntinye nkeji

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Onye ode akwụkwọ akụkọ sayensị

Stanley TL bụ ọkà mmụta na Mahadum Harvard, na-etinye aka na nyocha na nkuzi na ụlọ ọrụ dịka Harvard Medical School na Massachusetts General Hospital. Ngalaba nyocha ya gụnyere endocrinology na metabolism, ọrịa na-efe efe, immunology, microbiology, and nutrition and dietetics. O meela nyocha miri emi na mpaghara ndị a, na-enye ntọala usoro maka nyocha, ọgwụgwọ na mgbochi nke ọrịa ndị metụtara ya. N'otu oge ahụ, ọ na-arụkọ ọrụ ọnụ na òtù dị ka Harvard Medical School na Massachusetts General Hospital for Children, na-ejikọta tiori na omume ụlọ ọgwụ na inye onyinye na ahụike. Edere Stanley TL na ntụnye aka nke ntụaka [5].

▎ Okwu ndị dị mkpa

[1] Fourman LT, Billingsley JM, Agyapong G, et al. Mmetụta nke tesamorelin na mbinye aka transcriptomic hepatic na NAFLD[J metụtara HIV]. Jci Insight, 2020,5 (16).DOI:10.1172/jci.insight.140134.

[2] Jaimie T S. Tesamoreli Therapy na-eme ka Axonal Regeneration, Wedata Atrophy Muscle ma melite nsonaazụ arụ ọrụ na-esochi mmerụ ahụ na mmezi nke akwara dị n'akụkụ. 2015.

[3] Rahman F, McLaughlin T, Mesquita P, et al. Mmetụta nke tesamorelin n'ime ndị nwere nje HIV nwere ma na-enweghị abụba dorsocervical: Nyochaa post hoc nke nkeji III nke na-achịkwa placebo abụọ [J]. Akwụkwọ akụkọ nke Clinical and Translational Science, 2022,7 (1) .DOI: 10.1017/cts.2022.515.

[4] Mateo MG, Gutierrez MDM, Domingo P. Tesamoreli maka ọgwụgwọ nke oke abụba abụba na nje HIV-1 na-ebute ọrịa lipodystrophy.[J]. Nyocha ọkachamara nke Endocrinology & Metabolism, 2011,6 (1): 21-30.DOI: 10.1586 / eem.10.83.

[5] Stanley TL, Falutz J, Marsolais C, et al. Mbelata na Visceral Adiposity Ejikọtara ya na Profaịlụ Metabolic emelitere na ndị ọrịa bu nje HIV na-anata Tesamoreli[J]. Ọrịa na-efe efe nke ụlọ ọgwụ, 2012,54 (11): 1642-1651.DOI: 10.1093/cid/cis251.

[6] McLaughlin T, Grinspoon SK, Stanley T, et al. 1499. Tesamoreli na-ebelata Visceral Adipose Tissue na Fat Fat na INSTI-emeso ndị nwere nje HIV[J]. Mepee Ọrịa Ọrịa Na-efe efe, 2023,10 (2): 500-1334.DOI: 10.1093/ofid/ofad500.1334.

[7] Lake JE, La K, Erlandson KM, et al. Tesamoreli na-akwalite ogo abụba na-adabereghị na mgbanwe na oke abụba[J]. Enyemaka, 2021,35 (9): 1395-1402.DOI:10.1097/QAD.000000000002897.

[8] Stanley TL, Fourman LT, Wong LP, et al. Hormone na-eto eto na-ahapụ homonụ na-ebelata ihe nrịbama nke mgbaka mgbochi ahụ n'otu aka ahụ yana mmetụta dị na ụzọ mgbochi imeju na ndị nwere nje HIV na ọrịa imeju na-adịghị egbu egbu[J]. Ọrịa na-efe efe nke ụlọ ọgwụ, 2021,73 (4): 621-630.DOI: 10.1093/cid/ciab019.

[9] Fourman LT, Stanley TL, Billingsley JM, et al. Na-akọwapụta ụzọ nzaghachi tesamorelin na NAFLD metụtara nje HIV site na iji usoro proteomic na trancriptomic ezubere iche[J]. Akụkọ sayensị, 2021,11 (1).DOI:10.1038/s41598-021-89966-y.

Edemede na ozi ngwaahịa niile enyere na webụsaịtị a bụ naanị maka mgbasa ozi na ebumnuche mmụta.  

Ngwaahịa ndị enyere na webụsaịtị a bụ naanị maka nyocha in vitro. A na-eme nyocha in vitro (Latin: * na iko *, nke pụtara na ihe eji enyo) na mpụga ahụ mmadụ. Ngwaahịa ndị a abụghị ọgwụ, ndị US Food and Drug Administration (FDA) akwadobeghị ya, ha agaghịkwa eji ya gbochie, gwọọ, ma ọ bụ gwọọ ọnọdụ ahụike ọ bụla, ọrịa, ma ọ bụ ọrịa. Iwu amachibidoro nke ọma iwebata ngwaahịa ndị a n'ime ahụ mmadụ ma ọ bụ anụmanụ n'ụdị ọ bụla.