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1kits （10Ibikoresho）
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TesamoreliStructure Imiterere ya
Inkomoko: PubChem |
Urukurikirane: YADAIFTNSYRKVLGQLSARKLLQDIMSRQQGESNQERGARARL Inzira ya molekulari: C 221H 366N 72O 67S. Uburemere bwa molekuline: 5136 g / mol Numero ya CAS: 218949-48-5 PubChem CID: 16137828 Synonyme: Egrifta |
Research Ubushakashatsi bwa Tesamoreli
Ni ubuhe bushakashatsi bwakozwe na Tesamoreli?
Imisemburo ikura ya recombinant yumuntu (rhGH) igira ingaruka nziza mubuvuzi bwo kuvura imisemburo ikura (GH), ariko kandi iherekejwe ningaruka mbi zitandukanye. Iki kibazo cyatumye habaho iterambere ryikigereranyo cyo gukura imisemburo ya hormone (GFR), kuko ishobora kwihanganira neza. Tesamoreli ni GFR ikomatanya yakozwe mu rwego rwo kuvura indwara zitandukanye zishobora kuba ziterwa no kubura GH ugereranije, harimo na lipodystrofiya iterwa na virusi itera sida.
Ni ubuhe buryo bwo gukora bwa Tesamoreli?
Uburyo bwibikorwa byindwara ziterwa na virusi itera sida (NAFLD):
Kugena imvugo ya gene:
Muri NAFLD ifitanye isano na virusi itera sida, binyuze mu isesengura ryogukungahaza gene, byagaragaye ko Tesamoreli yongereye imvugo ya gene yashyizweho umukono ijyanye na fosifori yo mu mwijima, mu gihe igabanya imvugo ya gene ijyanye no gutwika, gusana ingirabuzimafatizo, no kugabana selile [1] . By'umwihariko, Tesamoreli yagabanije igenamigambi rya gene y'umwijima ijyanye no gutwika, gusana ingirangingo, no kugabana ingirabuzimafatizo, byerekana ko igira ingaruka mu kugenzura imiterere y'iyi genes.
Kubuza abunzi b'ingenzi:
Tesamoreli irashobora kubuza abunzi b'ingenzi ba angiogenez, fibrosis, no gutwika. Kurugero, irashobora kugabanya cyane urwego rwimitsi ikura ya endoteliyale A (VEGFA), ihindura ibintu bikura β1 (TGFB1), hamwe na macrophage colony-itera ibintu 1 (CSF1). Abitabiriye amahugurwa bahabwa ubuvuzi bwa Tesamoreli, igabanuka rya VEGFA na CSF1 muri plasma ryajyanye no kugabanuka kw'amanota y'ibikorwa by'indwara y'umwijima itari inzoga, kandi kugabanuka kwa TGFB1 na CSF1 byajyanye no kugabanuka kw'amanota ya fibrosis yo mu rwego rwa gene [1] . Nkumuyobozi ushinzwe kwinjiza no gukora monocyte, CSF1 irashobora guhinduka intego yo kuvura udushya twanduye NAFLD.
Uburyo bwibikorwa ku gukomeretsa imitsi ya periferique:
Mu kuvura ibikomere bya periferique, Tesamoreli yizera ko byongera imbaraga mu kuvugurura imitsi, kugabanya imitsi, no kunoza imikorere. Ubushakashatsi bugezweho bwerekana ko Tesamoreli ashobora gukoresha ingaruka zayo mugutezimbere inzira yo kuvugurura imitsi no kuyisana. Uburyo bwihariye bwibikorwa ntiburasobanuka neza, ariko birashobora kuba bikubiyemo kugenzura ibintu bikura bikura imitsi, kuzamura imikurire ya axon, na myelination [2].
Nubuhe buryo bwihariye bwa Tesamoreli mukugabanya ibinure byijimye hamwe namavuta yumwijima kubantu banduye virusi itera sida?
Ingaruka igenga imisemburo ikura:
Gukangura imisemburo ikura:
Tesamoreli ni GHRH ikora neza ishobora gutera imisemburo ikura. Ku bantu banduye virusi itera sida, ururenda rwa hormone yo gukura rushobora kugira ingaruka, kandi Tesamoreli irashobora guteza imbere glande ya pitoito imbere kugirango irekure imisemburo ikura yigana ibikorwa bya GHRH [3-5].
Kugenga ibinure byamavuta:
Imisemburo ikura igira uruhare runini mu guhinduranya ibinure. Irashobora guteza imbere lipolysis, kongera okiside ya aside irike, no kugabanya ibinure. Mugukangura imisemburo ikura, Tesamoreli irashobora kugenga mu buryo butaziguye metabolisme y’ibinure no kugabanya ikwirakwizwa ry’amavuta yo mu nda hamwe n’amavuta y’umwijima [3-5].
Ingaruka ku mvugo ya gene y'umwijima:
Guhindura inzira ya gene:
Ubushakashatsi bwerekanye ko Tesamoreli ashobora kongera imvugo ya gene yashyizweho umukono ijyanye na fosifori yo mu mwijima, mu gihe igabanya imiterere ya gene zijyanye no gutwika, gusana ingirabuzimafatizo, no kugabana selile [1].
Ingaruka kuri gen zijyanye no guhanura kanseri ya hepatocellular:
Tesamoreli irashobora kandi kugena imiterere ya gene ijyanye no guhanura kanseri ya hepatocellular, igenga imiterere ya gene ijyanye no guhanura neza no kugabanya imiterere ya gene ijyanye no guhanura nabi, kimwe [1] . Izi mpinduka mumagambo ya gene zishobora kuba zifitanye isano n'ingaruka za Tesamoreli mukugabanya amavuta y'umwijima.
Isano n'amanota ya fibrosis ajyanye na gene:
Mu bitabiriye amahugurwa bavuwe na Tesamoreli, izi mpinduka mu mvugo y’umwijima zajyanye no kunoza amanota ya gene ya fibrosis. Ibi byerekana ko Tesamoreli ashobora kugabanya ibinure byumwijima muguhindura imiterere yumwijima no kunoza fibrotic yumwijima [1].
Ingaruka kuri poroteyine za plasma:
Kubuza abunzi b'ingenzi:
Tesamoreli irashobora kugabanya cyane urwego rwa poroteyine za plasma nkimikurire yimitsi iva mu maraso A (VEGFA), ihindura ibintu bikura β1 (TGFB1), hamwe na macrophage colony-itera ibintu 1 (CSF1) [1] . Izi poroteyine zifitanye isano na angiogenezi, fibrosis, hamwe no gutwika, kandi kubuzwa na Tesamoreli birashobora kugabanya ibinure byumwijima no gutwika.
Inkomoko: Byatangajwe [1]
Ni ubuhe buryo bukoreshwa na Tesamoreli?
Ingaruka ku bantu banduye virusi itera sida:
Kugabanya ibinure byijimye hamwe namavuta yumwijima:
Ubushakashatsi bumwe bwerekanye ko ku bantu banduye virusi itera sida bahabwa imiti igabanya ubukana (INSTIs), kwiyongera kw'imitsi ya adipose ya visceral adipose (VAT) biteye impungenge kuko umusoro ku nyongeragaciro ufitanye isano n'ingaruka ziterwa n'indwara y'umwijima idafite inzoga (NAFLD). Tesamoreli yerekanye ko igabanya umusoro ku nyongeragaciro ku banduye virusi itera sida bafite lipohypertrophy ku gipimo kirenga 15% mu mezi 6 [6] . Mu igeragezwa ryagenzuwe na platbo ry’abantu 61 bitabiriye NAFLD yanduye virusi itera sida, isesengura ryakozwe nyuma y’abantu bahabwa imiti ya INSTI ryerekanye ko nyuma y’amezi 12, TVA mu itsinda rya placebo yiyongereyeho 10.8%, mu gihe umusoro ku nyongeragaciro mu itsinda ry’ubuvuzi wa Tesamoreli wagabanutseho 8.3% muri rusange. Byongeye kandi, agace k’amavuta y’umwijima (HFF) mu itsinda ry’ubuvuzi rya Tesamoreli kagabanutseho 31% ugereranije n’ibanze, ibyo bikaba byari hejuru cyane ugereranije n’itsinda rishinzwe kuvura ibibanza [6].
Kunoza ubwiza bwibinure:
Ku bantu banduye virusi itera sida, ku barwayi bafite umubyibuho ukabije wakoresheje Tesamoreli, ubwinshi bw’amavuta yo mu mitsi (VAT) hamwe n’ibinure byo munsi (SAT) byiyongereye, kandi uku kwiyongera ntikwatewe n’imihindagurikire y’ibinure, byerekana ko Tesamoreli ashobora kandi kuzamura ireme rya TVA na SAT muri iri tsinda ry’abarwayi [7].
Ingaruka kumikorere yubudahangarwa:
Gukoresha igihe kirekire Tesamoreli birashobora kugabanya ibimenyetso bya selile T na monocyte / macrophage ibikorwa mukuzenguruka kwanduye virusi itera sida kandi bikagabanya inzira z'umubiri mu mwijima. By'umwihariko, ugereranije na placebo, Tesamoreli yagabanije kuzenguruka kwa poroteyine 13, harimo chemokine enye, cytokine ebyiri, molekile enye zifitanye isano na selile, hamwe na arginase-1, galectine-9, hamwe n’ikura rya hepatocyte. Isesengura ry’urusobe ryerekanye imikoranire ya hafi hagati yinzira ya gene ishinzwe kugabanya izo poroteyine, kandi inyandiko-mvugo yerekana ibimenyetso byerekana ibimenyetso byerekana inzira y’ubudahangarwa mu mwijima [8].
Ingaruka mu ndwara zumwijima zidafite inzoga:
Kugabanya ibinure byumwijima no kwirinda fibrosis gutera imbere:
Mu ndwara y’umwijima iterwa na virusi itera sida, Tesamoreli yerekanwe kugabanya amavuta y’umwijima no kwirinda fibrosis. Abashakashatsi bakoze isuzuma ryibanze kuri poroteyine 9 za plasma zijyanye na gen zo hejuru ziyobora mu bice bitandukanye bya genoside kandi basanze Tesamoreli yatumye igabanuka rikabije ry’imikurire y’imitsi y’imitsi A (VEGFA), ihindura imikurire β1 (TGFB1), na macrophage colony-itera 1 (CSF1). Mu bitabiriye amahugurwa bavuwe na Tesamoreli, igabanuka rya VEGFA na CSF1 muri plasma ryajyanye no kugabanuka kw'amanota y'ibikorwa by'indwara y'umwijima itari inzoga, kandi kugabanuka kwa TGFB1 na CSF1 byajyanye no kugabanuka kw'amanota ya fibrosis yo mu rwego rwa gene. Nkumuyobozi ushinzwe kwinjiza no kwinjiza monocyte, CSF1 irashobora kuba intego yo kuvura udushya tw’umwijima w’umwijima utarimo inzoga muri VIH [1].
Ingaruka ku mwandiko wanditseho umwijima:
Hifashishijwe isesengura ryitunganyirizwa rya gene, byagaragaye ko Tesamoreli yongereye umwijima kwerekana umwijima wa gene yashyizweho umukono ujyanye na fosifori ya okiside kandi bigabanya umwijima ugaragaza imiterere ya gene zijyanye no gutwika, gusana ingirabuzimafatizo, no kugabana selile. Byongeye kandi, Tesamoreli yanagenzuye kandi agenga imiterere ya gene yatoranijwe ijyanye no kumenya neza no kutamenya neza kanseri ya hepatocellular. Mu bitabiriye amahugurwa bavuwe na Tesamoreli, izi mpinduka mu mvugo y’umwijima zajyanye no kunoza amanota ya gene ya fibrosis [9].
Mu gusoza, nk'ikigereranyo cyo guhuza imisemburo ikura imisemburo ikura, Tesamoreli yerekanye ubushobozi bwo kuvura mubice byinshi. Umubare munini wubushakashatsi wemeje ko ushobora kugenzura neza imisemburo ya hormone ikura no kunoza imikorere yumuntu. Mu kuvura indwara ziterwa na virusi itera sida, igira ingaruka zikomeye mu kugabanya ibinure byo munda. Mugukangura imisemburo ya hormone yo gukura no guhindura metabolisme yibinure, bigabanya ingano yibinure byumubiri bitagize ingaruka kumubiri wumubiri unanutse, kandi bigira uruhare runini muguhindura umubiri wabarwayi. Mu kuvura indwara y’umwijima idafite inzoga, ubushakashatsi bumwe na bumwe bwerekanye kandi ko bushobora kugabanya ibinure biri mu mwijima. Tesamoreli ifite akamaro kanini. Ku barwayi banduye virusi itera sida, itanga uburyo bunoze bwo kunoza ikibazo cy’ibinure byatewe n’indwara no kuvurwa, kuzamura imibereho y’abarwayi, bifasha kugabanya umuvuduko w’imitekerereze iterwa n’imihindagurikire y’imiterere, kandi bikongerera imyumvire yo kwishyira hamwe. Intangiriro
Ibyerekeye Umwanditsi
Ibikoresho byavuzwe haruguru byose byakorewe ubushakashatsi, byahinduwe kandi byakozwe na Cocer Peptides.
Umwanditsi w'ikinyamakuru
Stanley TL ni intiti muri kaminuza ya Harvard, akora ubushakashatsi no kwigisha mu bigo nk'ishuri ry'ubuvuzi rya Harvard n'ibitaro bikuru bya Massachusetts. Mubushakashatsi yakoze harimo endocrinology na metabolism, indwara zandura, immunologiya, microbiologiya, nimirire nimirire. Yakoze ubushakashatsi bwimbitse muri izi nzego, atanga ishingiro ry’imyumvire yo gusuzuma, kuvura, no kwirinda indwara zifitanye isano. Muri icyo gihe, akorana cyane n’imiryango nk’ishuri ry’ubuvuzi rya Harvard n’ibitaro bikuru by’abana bya Massachusetts, ahuza inyigisho n’ubuvuzi ndetse akanatanga umusanzu mu buvuzi. Stanley TL iri kurutonde rwibisobanuro [5].
