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1 kits (10 Vials)
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▎ Tsarin Tesamoreli
Source: PubChem |
Jeri: YADAIFTNSYRKVLGQLSARKLLQDIMSRQQGESNQERGARARL Tsarin Halitta: C 221H 366N 72O 67S Nauyin Kwayoyin: 5136 g/mol Lambar CAS: 218949-48-5 Saukewa: 16137828 Synonyms: Egrifta |
▎ Binciken Tesamoreli
Menene asalin bincike na Tesamoreli?
Recombinant mutum girma hormone (rhGH) yana da asibiti tasiri a cikin lura da girma hormone rashi (GH), amma kuma yana tare da daban-daban m illa. Wannan yanayin ya haifar da haɓakar haɓakar haɓakar haɓakar haɓakar ɗan adam analogs factor-releaseing factor (GFR), saboda suna iya samun mafi kyawun jurewa. Tesamoreli wani GFR ne na roba wanda aka haɓaka azaman yuwuwar magani ga cututtuka iri-iri waɗanda zasu iya alaƙa da ƙarancin dangi na GH, gami da lipodystrophy mai alaƙa da HIV.
Menene hanyoyin aiwatar da Tesamoreli?
Hanyar aiki akan cutar hanta mai ƙiba mai alaƙa da HIV (NAFLD):
Ka'idar bayyanar cututtuka:
A cikin NAFLD da ke da alaƙa da HIV, ta hanyar nazarin haɓakar haɓakar ƙwayoyin cuta, an gano cewa Tesamoreli ya ƙara yawan maganganun sa hannu na sa hannu da ke da alaƙa da oxidative phosphorylation a cikin hanta, yayin da rage bayyanar cututtukan cututtukan da ke da alaƙa da kumburi, gyaran nama, da rarraba tantanin halitta [1] . Musamman, Tesamoreli ya ƙaddamar da tsarin tsarin hanta da ke da alaƙa da kumburi, gyaran nama, da rarraba tantanin halitta, wanda ke nuna cewa yana yin tasirinsa ta hanyar daidaita maganganun waɗannan kwayoyin halitta.
Hana manyan masu shiga tsakani:
Tesamoreli na iya hana masu shiga tsakani masu mahimmanci na angiogenesis, fibrosis, da kumburi. Alal misali, yana iya rage yawan matakan haɓakar haɓakar haɓakar jijiyoyi A (VEGFA), canza yanayin girma β1 (TGFB1), da macrophage colony-stimulating factor 1 (CSF1). A cikin mahalarta da ke karɓar maganin Tesamoreli, raguwa a cikin VEGFA da CSF1 a cikin plasma an haɗa su tare da raguwa a cikin aikin cututtukan hanta maras barasa, kuma raguwa a cikin TGFB1 da CSF1 an haɗa su tare da raguwa a cikin matakin fibrosis na jinsin [1] . A matsayin mai kula da daukar ma'aikata da kunnawa monocyte, CSF1 na iya zama sabuwar manufa ta warkewa ga NAFLD mai alaƙa da HIV.
Hanyar aiki akan raunin jijiya na gefe:
A cikin maganin raunin jijiya na gefe, an yi imanin Tesamoreli don haɓaka farfadowa na axonal, rage atrophy na tsoka, da inganta sakamakon aiki. Binciken na yanzu yana nuna cewa Tesamoreli na iya yin tasiri ta hanyar inganta tsarin farfadowa da gyaran jijiyoyi. Ba a fahimci takamaiman tsarin aikin ba tukuna, amma yana iya haɗawa da daidaita abubuwan haɓaka jijiya, haɓaka haɓakar axonal, da myelation [2].
Menene takamaiman hanyar Tesamoreli don rage kitsen visceral da kitsen hanta a cikin masu kamuwa da cutar HIV?
Tasirin tsari akan hormone girma:
Ƙarfafa haɓakar haɓakar hormone:
Tesamoreli wani GHRH ne na roba wanda zai iya motsa siginar hormone girma. A cikin mutane masu kamuwa da kwayar cutar HIV, za a iya shafar siginar hormone girma, kuma Tesamoreli na iya inganta glandar pituitary na baya don saki hormone girma ta hanyar kwaikwayon aikin GHRH [3-5].
Gudanar da metabolism na fats:
Girman hormone yana taka muhimmiyar rawa a cikin metabolism mai. Yana iya inganta lipolysis, ƙara oxidation na fatty acid, da kuma rage yawan kitse. Ta hanyar haɓaka siginar hormone girma, Tesamoreli na iya daidaita tsarin metabolism a kaikaice kuma ya rage tarin kitsen visceral da kitsen hanta [3-5].
Tasiri kan bayyanar kwayar halittar hanta:
Canza hanyoyin gado:
Nazarin ya gano cewa Tesamoreli na iya ƙara bayyanar sa hannu akan saitin sa hannu wanda ke da alaƙa da oxidative phosphorylation a cikin hanta, yayin da yake rage maganganun ƙwayoyin halittar da ke da alaƙa da kumburi, gyaran nama, da rarraba tantanin halitta [1].
Tasirin kwayoyin halittar da ke da alaƙa da tsinkayar cutar sankara na hepatocellular:
Tesamoreli kuma zai iya daidaita tsarin kwayoyin halittar da ke da alaƙa da tsinkayar cutar sankarau na hepatocellular, haɓaka-kayyade tsarin ƙwayoyin halittar da ke da alaƙa da kyakkyawan tsinkaye da kuma saukar da tsarin ƙwayoyin halittar da ke da alaƙa da rashin tsinkaye mara kyau, bi da bi [1] . Wadannan canje-canje a cikin maganganun kwayoyin halitta na iya kasancewa da alaka da tasirin Tesamoreli akan rage kitsen hanta.
Dangantaka da maki masu alaƙa da fibrosis:
A cikin mahalarta da aka bi da Tesamoreli, waɗannan canje-canje a cikin maganganun hanta suna da alaƙa da ingantattun ƙididdiga masu alaƙa da fibrosis. Wannan yana nuna cewa Tesamoreli na iya rage kitsen hanta ta hanyar daidaita maganganun hanta da inganta yanayin fibrotic na hanta [1].
Tasiri akan sunadaran plasma:
Hana masu shiga tsakani masu mahimmanci:
Tesamoreli na iya rage yawan matakan sunadarai na plasma irin su jijiyar endothelial girma factor A (VEGFA), canza girma factor β1 (TGFB1), da macrophage colony-stimulating factor 1 (CSF1) [1] . Wadannan sunadaran suna da alaƙa da angiogenesis, fibrosis, da kumburi, kuma hana su ta hanyar Tesamoreli na iya taimakawa rage kitsen hanta da kumburi.
Source:PubMed [1]
Menene aikace-aikacen Tesamoreli?
Tasiri kan masu cutar HIV:
Rage kitsen visceral da kitsen hanta:
Wasu nazarin sun nuna cewa a cikin mutanen da ke dauke da kwayar cutar HIV da ke karbar maganin integrase inhibitor (INSTIs), karuwa a cikin visceral adipose tissue (VAT) wani lamari ne na damuwa saboda VAT yana hade da ƙananan cututtuka irin su cututtukan hanta maras barasa (NAFLD). An nuna Tesamoreli don rage VAT a cikin mutanen da ke dauke da kwayar cutar HIV tare da lipohypertrophy fiye da 15% a cikin watanni 6 [6] . A cikin gwajin gwajin da aka yi amfani da shi na mahalarta 61 tare da NAFLD mai cutar HIV, bincike na baya-bayan nan na mutanen da ke karbar maganin INSTI ya gano cewa bayan watanni 12, VAT a cikin rukunin placebo ya karu da 10.8%, yayin da VAT a cikin ƙungiyar kulawa ta Tesamoreli ya ragu da 8.3% gaba ɗaya. Bugu da ƙari, ɓangaren ƙwayar hanta (HFF) a cikin rukunin jiyya na Tesamoreli ya ragu da 31% dangane da tushe, wanda ya fi girma fiye da wannan a cikin rukunin jiyya na placebo [6].
Inganta ingancin mai:
A cikin mutane masu kamuwa da kwayar cutar HIV, a cikin marasa lafiya masu kiba na tsakiya waɗanda suka yi amfani da Tesamoreli, yawan kitse na visceral (VAT) da mai subcutaneous (SAT) ya karu, kuma wannan haɓaka ya kasance mai zaman kansa daga canje-canje a cikin kitse mai yawa, yana nuna cewa Tesamoreli kuma na iya haɓaka ingancin VAT da SAT a cikin wannan rukunin marasa lafiya [7].
Tasiri kan aikin rigakafi:
Yin amfani da dogon lokaci na Tesamoreli zai iya rage alamun T cell da monocyte / macrophage aiki a cikin wurare dabam dabam na mutane masu kamuwa da kwayar cutar HIV da kuma daidaita hanyoyin rigakafi a cikin hanta. Musamman, idan aka kwatanta da placebo, Tesamoreli ya rage yawan adadin sunadaran sunadaran 13, ciki har da chemokines hudu, cytokines guda biyu, kwayoyin kwayoyin T guda hudu, da arginase-1, galectin-9, da haɓakar haɓakar hanta. Binciken cibiyar sadarwa ya nuna kusancin kusanci tsakanin hanyoyin halittar da ke da alhakin rage waɗannan sunadaran, kuma bayanan da aka yi niyya sun tabbatar da siginar ƙasƙanci na hanyoyin rigakafi a cikin hanta [8]..
Tasiri a cikin cututtukan hanta mai kitse mara-giya:
Rage kitsen hanta da hana ci gaban fibrosis:
A cikin cututtukan hanta maras barasa da ke da alaƙa da HIV, an nuna Tesamoreli don rage kitsen hanta da hana ci gaban fibrosis. Masu bincike sun gudanar da kimantawa da aka mayar da hankali kan sunadaran plasma na 9 wanda ya dace da manyan manyan kwayoyin halitta a cikin nau'o'in nau'in nau'in jinsin da aka tsara kuma sun gano cewa Tesamoreli ya haifar da raguwa mai yawa a cikin ƙwayar endothelial girma factor A (VEGFA), canza girma factor β1 (TGFB1), da macrophage colony-stimulating factor 1 (CSF1). A cikin mahalarta da aka bi da Tesamoreli, raguwa a cikin VEGFA da CSF1 a cikin plasma an haɗa su tare da raguwa a cikin aikin cututtukan hanta mai kitse ba tare da barasa ba, kuma raguwa a cikin TGFB1 da CSF1 yana da alaƙa da raguwa a cikin matakin fibrosis na jinsi. A matsayin mai kula da daukar ma'aikata da kunnawa na monocyte, CSF1 na iya zama sabuwar dabarar warkewa don cutar hanta mai kitse mara barasa a cikin HIV [1].
Tasiri kan sa hannun kwafin hanta:
Yin amfani da ƙididdigar haɓakar haɓakar ƙwayoyin halitta, an gano cewa Tesamoreli ya haɓaka hanta bayanin hanta na tsarin sa hannu na sa hannu wanda ke da alaƙa da oxidative phosphorylation kuma ya rage bayyanar hanta na ƙwayoyin halittar da ke da alaƙa da kumburi, gyaran nama, da rarraba tantanin halitta. Bugu da ƙari, Tesamoreli kuma yana haɓaka-sarrafawa da ƙasƙantar da ƙayyadaddun ƙayyadaddun ƙwayoyin halittar da aka zaɓa waɗanda ke da alaƙa mai kyau da ƙarancin hasashen cutar sankarar hanta, bi da bi. A cikin mahalarta da aka bi da Tesamoreli, waɗannan canje-canje a cikin maganganun hanta suna da alaƙa da ingantattun ƙididdiga masu alaƙa da fibrosis [9].
A ƙarshe, a matsayin analog na roba na hormone mai sakin hormone girma, Tesamoreli ya nuna yiwuwar warkewa a fannoni da yawa. Yawancin karatu sun tabbatar da cewa zai iya daidaita tsarin samar da hormone girma da kuma inganta aikin rayuwa na mutum. A cikin maganin cututtukan da ke da alaƙa da cutar kanjamau, yana da tasiri mai mahimmanci wajen rage yawan kitsen ciki. Ta hanyar haɓaka haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar mai, yana rage adadin kitse na visceral ba tare da cutar da kiba ba, kuma yana taka rawa mai kyau wajen daidaita tsarin jikin marasa lafiya. Dangane da cutar hanta mai kitse ba ta barasa ba, wasu bincike sun nuna cewa yana iya rage kitsen da ke cikin hanta. Tesamoreli yana da mahimmanci. Ga masu kamuwa da cutar kanjamau, yana ba da ingantacciyar hanya don inganta ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta da kuma inganta yanayin rayuwar marasa lafiya, yana taimakawa wajen kawar da matsalolin tunanin mutum wanda ya haifar da sauye-sauye a cikin bayyanar, kuma yana inganta haɗin kai na zamantakewa. Gabatarwar naúrar
Game da Marubuci
Abubuwan da aka ambata a sama duk bincike ne, gyara su kuma Cocer Peptides ne suka haɗa su.
Mawallafin Jaridar Kimiyya
Stanley TL masani ne a Jami'ar Harvard, wanda ya tsunduma cikin bincike da koyarwa a cibiyoyi irin su Harvard Medical School da Babban Asibitin Massachusetts. Fannonin bincikensa sun haɗa da endocrinology da metabolism, cututtuka masu yaduwa, rigakafi, ƙwayoyin cuta, da abinci mai gina jiki da abinci. Ya gudanar da bincike mai zurfi a cikin waɗannan fagagen, yana ba da tushe na ka'idar don ganewar asali, magani, da rigakafin cututtuka masu alaƙa. A lokaci guda kuma, yana ba da haɗin kai tare da ƙungiyoyi irin su Harvard Medical School da Babban Asibitin Massachusetts don Yara, yana haɗa ka'idar tare da aikin asibiti da ba da gudummawa ga aikin likita. An jera Stanley TL a cikin ambaton ambaton [5].
