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1kits (Ebipipa 10) .
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▎ Enzimba ya Tesamoreli
Ensibuko: PubChem |
Omutendera: YADAIFTNSYRKVLGQLSARKLLQDIMSRQQGESNQERGARARL Ensengekera ya molekyu: C 221H 366N 72O 67S Obuzito bwa molekyu: 5136 g/mol Ennamba ya CAS: 218949-48-5 PubChem CID: 16137828. Enkola y’okukuuma eddagala lino Ebigambo ebifaanagana: Egrifta |
▎ Okunoonyereza ku Tesamoreli
Tesamoreli yali akola ki?
Recombinant human growth hormone (rhGH) erina obusobozi mu bujjanjabi mu kujjanjaba obuzibu bw’obusimu obukula (GH), naye era buwerekerwako ebizibu eby’enjawulo. Embeera eno ereetedde okukola eddagala eriyitibwa human growth hormone-releasing factor (GFR), kubanga liyinza okuba n’okugumira obulungi. Tesamoreli ye GFR ey’obutonde ekoleddwa ng’eddagala eriyinza okujjanjaba endwadde ez’enjawulo eziyinza okuba nga zeekuusa ku bbula lya GH, omuli n’obulwadde bw’amasavu obukwatagana ne siriimu.
Enkola ki Tesamoreli gy’ekola?
Enkola y’okukola ku bulwadde bw’ekibumba obutali bwa masavu obukwatagana ne siriimu (NAFLD):
Okulungamya okwolesebwa kw’obuzaale:
Mu NAFLD ekwatagana ne siriimu, okuyita mu kwekenneenya okugaggawaza ensengekera y’obuzaale, kyazuulibwa nti Tesamoreli yayongera okwolesebwa kw’ensengekera y’obuzaale ey’omukono ekwata ku oxidative phosphorylation mu kibumba, ate ng’akendeeza ku kwolesebwa kw’obuzaale obukwatagana n’okuzimba, okuddaabiriza ebitundu, n’okugabanya obutoffaali [1] . Okusingira ddala, Tesamoreli yakendeeza ku buzaale bw’ekibumba obukwatagana n’okuzimba, okuddaabiriza ebitundu, n’okugabanya obutoffaali, ekiraga nti ekola ekikolwa kyayo nga etereeza okwolesebwa kw’obuzaale buno.
Okuziyiza abatabaganya abakulu:
Tesamoreli esobola okuziyiza abatabaganya abakulu mu kukola emisuwa, fibrosis, n’okuzimba. Okugeza, kiyinza okukendeeza ennyo ku miwendo gy’ensonga y’okukula kw’emisuwa A (VEGFA), ensonga y’okukula kw’emisuwa β1 (TGFB1), n’ensonga 1 (CSF1) esitula ekibinja ky’amazzi amanene. Mu beetabye mu kugezesebwa abafuna obujjanjabi bwa Tesamoreli, okukendeera kwa VEGFA ne CSF1 mu plasma kwakwatagana n’okukendeera mu bubonero bw’emirimu gy’obulwadde bw’ekibumba egy’amasavu obutali bwa mwenge, ate okukendeera mu TGFB1 ne CSF1 kwakwatagana n’okukendeera mu bubonero bwa fibrosis ku ddaala ly’obuzaale [1] . Nga omulungamya okuwandiika n’okukola kwa monocyte, CSF1 eyinza okufuuka ekigendererwa eky’obujjanjabi ekiyiiya eri NAFLD ekwatagana ne siriimu.
Enkola y’okukola ku buvune bw’obusimu obw’okumpi:
Mu kujjanjaba obuvune bw’obusimu obw’okumpi, Tesamoreli kirowoozebwa nti ayongera ku kuzzaawo obusimu obuyitibwa axonal regeneration, okukendeeza ku kukendeera kw’ebinywa, n’okulongoosa ebiva mu nkola. Okunoonyereza okuliwo kati kulaga nti Tesamoreli eyinza okukozesa ekikolwa kyayo ng’etumbula enkola y’okuddamu okukola n’okuddaabiriza obusimu. Enkola entongole ey’okukola tennategeerekeka bulungi, naye eyinza okuzingiramu okulungamya ensonga z’okukula kw’obusimu, okutumbula okukula kw’obusimu, n’okukola myelination [2]..
Enkola ki entongole eya Tesamoreli mu kukendeeza amasavu mu bitundu by’omubiri n’amasavu mu kibumba mu bantu abalina akawuka ka siriimu?
Enkola y’okulungamya ku busimu bw’okukula:
Okusitula okufulumya obusimu bw’okukula:
Tesamoreli ye GHRH ekoleddwa mu ngeri ey’ekikugu esobola okusitula okufulumya obusimu bw’okukula. Mu bantu abalina akawuka ka siriimu, okufulumya obusimu bw’okukula kuyinza okukosebwa, era Tesamoreli esobola okutumbula enseke y’omu maaso okufulumya obusimu bw’okukula ng’akoppa ekikolwa kya GHRH [3-5]..
Okulungamya enkyukakyuka y’amasavu:
Obusimu obuyamba okukula bukola kinene mu nkyukakyuka y’amasavu. Kiyinza okutumbula lipolysis, okwongera ku oxidation ya fatty acids, n’okukendeeza ku kukuŋŋaanyizibwa kw’amasavu. Nga asitula okufulumya obusimu bw’okukula, Tesamoreli ayinza okulung’amya mu ngeri etali butereevu enkyukakyuka y’amasavu n’okukendeeza ku kukuŋŋaanyizibwa kw’amasavu mu bitundu by’omubiri n’amasavu mu kibumba [3-5]..
Enkola ku kwolesebwa kw’obuzaale bw’ekibumba:
Okukyusa amakubo g’obuzaale:
Okunoonyereza kuzudde nti Tesamoreli asobola okwongera ku kwolesebwa kw’ekibinja ky’obuzaale eky’omukono ekikwatagana n’okufuuka oxidative phosphorylation mu kibumba, ate nga akendeeza ku kwolesebwa kw’ensengekera z’obuzaale ezikwatagana n’okuzimba, okuddaabiriza ebitundu, n’okugabanya obutoffaali [1]..
Okukosa obuzaale obukwatagana n’okuteebereza kookolo w’obutoffaali bw’ekibumba:
Tesamoreli era esobola okulungamya ensengekera z’obuzaale ezikwatagana n’okuteebereza kookolo w’ekibumba, okulinnyisa ensengekera z’obuzaale ezikwatagana n’okuteebereza okulungi n’okukkakkanya ensengekera z’obuzaale ezikwatagana n’okuteebereza okubi, okusinziira ku [1] . Enkyukakyuka zino mu kwolesebwa kw’obuzaale ziyinza okuba nga zeekuusa ku ngeri Tesamoreli gy’ekola ku kukendeeza amasavu mu kibumba.
Enkolagana n’obubonero bw’obuzaale obukwata ku fibrosis:
Mu beetabye mu kugezesebwa abajjanjabwa ne Tesamoreli, enkyukakyuka zino mu kwolesebwa kw’ekibumba zaali zikwatagana n’okulongoosa mu bubonero bw’obuzaale obukwata ku fibrosis. Kino kiraga nti Tesamoreli ayinza okukendeeza amasavu mu kibumba ng’atereeza okulaga kw’obuzaale bw’ekibumba n’okulongoosa embeera y’ekibumba ey’obuwuzi [1] ..
Enkola ku puloteyina za plasma:
Okuziyiza abatabaganya abakulu:
Tesamoreli esobola okukendeeza ennyo ku miwendo gya puloteyina za plasma nga vascular endothelial growth factor A (VEGFA), transforming growth factor β1 (TGFB1), ne macrophage colony-stimulating factor 1 (CSF1) [1] . Proteins zino zeekuusa ku angiogenesis, fibrosis, n’okuzimba, era okuziziyiza Tesamoreli kiyinza okuyamba okukendeeza amasavu mu kibumba n’okuzimba.
Ensibuko:PubMed [1] .
Tesamoreli ekozesebwa ki?
Ebikosa abantu abalina akawuka ka siriimu:
Okukendeeza amasavu mu bitundu by’omubiri n’amasavu mu kibumba:
Okunoonyereza okumu kulaga nti mu bantu abalina akawuka ka siriimu abafuna obujjanjabi bwa integrase inhibitor (INSTIs), okweyongera kw’ebitundu by’amasavu eby’omu lubuto (VAT) nsonga yeeraliikiriza kubanga VAT ekwatagana n’endwadde ezikwatagana wansi ng’obulwadde bw’ekibumba obutali bwa masavu (NAFLD). Tesamoreli eragiddwa okukendeeza ku VAT mu bantu abalina akawuka ka siriimu abalina lipohypertrophy ebitundu ebisukka mu 15% mu myezi 6 [6] . Mu kugezesebwa okwafugibwa placebo ku bantu 61 abalina NAFLD ekwatagana ne siriimu, okwekenneenya okwakolebwa oluvannyuma lw’abantu ssekinnoomu abafuna obujjanjabi bwa INSTIs kwazuula nti oluvannyuma lw’emyezi 12, VAT mu kibinja kya placebo yeeyongera ebitundu 10.8%, ate VAT mu kibinja ky’abajjanjabi Tesamoreli yakendeera ebitundu 8.3% okutwalira awamu. Okugatta ku ekyo, ekitundu ky’amasavu mu kibumba (HFF) mu kibinja ekyajjanjabwa Tesamoreli kyakendeera ebitundu 31% okusinziira ku ntandikwa, nga kino kyali kisinga nnyo ku ekyo mu kibinja eky’obujjanjabi bwa placebo [6]..
Okulongoosa omutindo gw’amasavu:
Mu bantu abalina akawuka ka siriimu, mu balwadde abalina omugejjo ogw’omu makkati abakozesa Tesamoreli, obungi bw’amasavu mu bitundu by’omubiri (VAT) n’amasavu agali wansi w’olususu (SAT) bweyongera, era okweyongera kuno kwali kwetongodde ku nkyukakyuka mu bungi bw’amasavu, ekiraga nti Tesamoreli era esobola okulongoosa omutindo gwa VAT ne SAT mu kibinja ky’abalwadde kino [7]..
Ebikosa enkola y’abaserikale b’omubiri:
Okukozesa Tesamoreli okumala ebbanga eddene kiyinza okukendeeza ku bubonero bw’emirimu gy’obutoffaali bwa T ne monocyte/macrophage mu ntambula y’omusaayi gw’abantu abalina akawuka ka siriimu n’okukendeeza ku makubo g’abaserikale b’omubiri mu kibumba. Okusingira ddala, bw’ogeraageranya n’eddagala eriyitibwa placebo, Tesamoreli yakendeeza ku bungi bw’obutoffaali 13 obutambula, omuli chemokines nnya, cytokines bbiri, molekyu nnya ezikwatagana n’obutoffaali bwa T, awamu ne arginase-1, galectin-9, ne hepatocyte growth factor. Okwekenenya emikutu kwalaga enkolagana ey’okumpi wakati w’amakubo g’obuzaale agavunaanyizibwa ku kukendeeza ku puloteyina zino, era targeted transcriptomics yakakasa down-regulation signal y’amakubo g’abaserikale b’omubiri mu kibumba [8]..
Effect mu bulwadde bw’ekibumba obw’amasavu obutali bwa mwenge:
Okukendeeza amasavu mu kibumba n’okuziyiza fibrosis okukula:
Mu bulwadde bw’ekibumba obutali bwa masavu obukwatagana ne siriimu, Tesamoreli eragiddwa okukendeeza amasavu mu kibumba n’okuziyiza okukula kw’obusimu obuyitibwa fibrosis. Abanoonyereza baakola okwekenneenya okussa essira ku puloteyina za plasma 9 ezikwatagana n’obuzaale obukulembedde waggulu mu buzaale obulung’amibwa mu ngeri ey’enjawulo era ne bakizuula nti Tesamoreli yaleetawo okukendeera okw’amaanyi mu nsonga y’okukula kw’emisuwa A (VEGFA), ensonga y’okukula ekyusa β1 (TGFB1), ne macrophage colony-stimulating factor 1 (CSF1). Mu beetabye mu kujjanjabwa ne Tesamoreli, okukendeera kwa VEGFA ne CSF1 mu plasma kwakwatagana n’okukendeera mu bubonero bw’emirimu gy’obulwadde bw’ekibumba obw’amasavu obutali bwa mwenge, ate okukendeera mu TGFB1 ne CSF1 kwakwatagana n’okukendeera mu bubonero bwa fibrosis ku ddaala ly’obuzaale. Nga omulungamya okuwandiika n’okukola kwa monocyte, CSF1 eyinza okufuuka ekigendererwa eky’obujjanjabi ekiyiiya eri obulwadde bw’ekibumba obw’amasavu obutali bwa mwenge mu siriimu [1]..
Enkola ku mukono gwa transcriptome y’ekibumba:
Nga tukozesa okwekenneenya okugaggawaza ensengekera y’obutonde (gene set enrichment analysis), kyazuulibwa nti Tesamoreli yayongera ku kwolesebwa kw’ekibumba kw’ensengekera y’obuzaale ey’omukono (signature gene set) ekwatagana ne oxidative phosphorylation era n’akendeeza ku kwolesebwa kw’ekibumba kw’obuzaale obukwatagana n’okuzimba, okuddaabiriza ebitundu, n’okugabanya obutoffaali. Okugatta ku ekyo, Tesamoreli era yalongoosa n’okukka wansi ensengekera z’obuzaale ezaalondebwa ezikwatagana n’okuteebereza okulungi n’okubi okwa kookolo w’ekibumba, mu kulondako. Mu beetabye mu kugezesebwa abajjanjabwa ne Tesamoreli, enkyukakyuka zino mu kwolesebwa kw’ekibumba zaali zikwatagana n’okulongoosa obubonero bw’obuzaale obukwata ku fibrosis [9]..
Mu kumaliriza, nga synthetic analog of growth hormone-releasing hormone, Tesamoreli alaze obusobozi bw’obujjanjabi mu bintu ebingi. Okunoonyereza kungi kukakasizza nti esobola bulungi okulung’amya okufulumya obusimu bw’okukula n’okulongoosa enkola y’enkyukakyuka y’emmere y’omuntu. Mu kujjanjaba endwadde ezeekuusa ku siriimu, kikola kinene ku kukendeeza amasavu agakuŋŋaanyizibwa mu lubuto. Nga esitula okufulumya obusimu bw’okukula n’okulongoosa enkola y’amasavu, ekendeeza ku bungi bw’amasavu mu bitundu by’omubiri awatali kukosa mubiri omugonvu, era kikola kinene mu kutereeza obutonde bw’omubiri gw’abalwadde. Mu kujjanjaba obulwadde bw’ekibumba obutaliimu masavu, okunoonyereza okumu era kulaga nti busobola okukendeeza ku masavu agali mu kibumba. Tesamoreli ya makulu nnyo. Ku balwadde abalina akawuka ka siriimu, kiwa engeri ennungi ey’okulongoosaamu obuzibu bw’okukyusakyusa amasavu obuva ku bulwadde n’obujjanjabi, kitereeza omutindo gw’obulamu bw’abalwadde, kiyamba okumalawo puleesa y’eby’omwoyo ereetebwa enkyukakyuka mu ndabika, n’okutumbula okuwulira kwabwe okw’okukwatagana n’abantu. Enyanjula y’ekitundu
Ebikwata ku Muwandiisi
Ebintu ebyogeddwako waggulu byonna binoonyerezeddwako, birongooseddwa era ne bikung’aanyizibwa kkampuni ya Cocer Peptides.
Omuwandiisi wa Scientific Journal
Stanley TL mukenkufu mu Harvard University, akola okunoonyereza n’okusomesa mu matendekero nga Harvard Medical School ne Massachusetts General Hospital. Ebintu by’anoonyerezaako mulimu endocrinology ne metabolism, endwadde ezisiigibwa, immunology, microbiology, n’endya n’emmere. Akoze okunoonyereza okw’obwegendereza mu bintu bino, n’awa emisingi gy’enzikiriziganya okuzuula, okujjanjaba, n’okuziyiza endwadde ezikwatagana nabyo. Mu kiseera kye kimu, akolagana nnyo n’ebibiina nga Harvard Medical School ne Massachusetts General Hospital for Children, ng’agatta endowooza n’enkola y’obujjanjabi n’okukola ku nsonga z’obusawo. Stanley TL awandiikiddwa mu kiwandiiko ekijuliziddwa mu kiwandiiko ekijuliziddwa [5].
