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1kits (10Vials) .
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▎ Melanotan-2 ƒe Dɔwɔɖoɖo
Dzɔtsoƒe: PubChem |
Tsitretsitsi: Ac-Nle-cyclo (Asp-His-D-Phe-Arg-Trp-Lys)-NH2 Molekyulãwo ƒe Mɔfiame: C 50H 69N 15O9 Molekyulã ƒe Kpekpeme: 1024.2 g/mol CAS ƒe xexlẽdzesi: 121062-08-6 PubChem ƒe CID: 92432 Nya siwo sɔ kple wo nɔewo: MT-II |
▎ Melanotan-2 Numekuku
Nukae nye numekuku si me Melanota wɔ ?
Melanota nye atike si wotsɔ lãnuwo wɔe si sɔ kple wo nɔewo. Enye α-melanocyte-stimulating hormone (α-MSH) ƒe kpeɖeŋutɔ si wowɔ, si wotsɔa atikewo wɔwɔ ƒe mɔnuwo dzrana ɖo [1] . α-MSH nye lãmetsi si le dzɔdzɔme nu si wɔa ŋutilã ƒe dɔwɔwɔ vovovowo le amegbetɔ ƒe ŋutilã me, siwo dometɔ aɖewoe nye ŋutigbalẽ ƒe amadede dzi kpɔkpɔ. Wotrɔ asi le melanota ŋu be wòasrɔ̃ α-MSH ƒe ŋusẽkpɔɖeamedzi aɖewo gake eƒe dɔwɔwɔ sẽ wu eye taɖodzinu tɔxɛwo le eŋudɔwɔwɔ. Woto melanota vɛ gbã be wòanye nusi ado ŋutigbalẽ ƒe amadede ɖe ŋgɔ, si fia be enye nusi woyɔna be ŋutigbalẽ ƒe amadede. Esi amewo va le ŋutigbalẽ ƒe amadede didi geɖe wu dim la, ame aɖewo te didi be yewoakpɔ ŋutigbalẽ ƒe viviti dodo kabakaba to Melanota dodo me. Numekuku si wowɔ le go sia me ku ɖe eƒe dɔwɔwɔ kple ŋusẽ si wòkpɔna ɖe ŋutigbalẽ ƒe amadede dzi ŋu koŋ. Le kpɔɖeŋu me, numekukuwo ɖee fia be Melanota ate ŋu abla ɖe lãmenugbagbevi tɔxɛ siwo le melanocytes dzi ŋu be wòana melanin nawɔ, si wɔnɛ be ŋutigbalẽa nado viviti [2, 3]..
Nukae nye Melanota ?
Melanota nye lãmenugbagbevi si wotsɔ wɔe si do ƒome kple α-melanocyte-stimulating hormone (α-MSH). Eƒe dɔ vevitɔe nye be wòana ŋutigbalẽ ƒe amadede nadzi ɖe edzi eye wòana amegbetɔ ƒe ŋutigbalẽ nado viviti. Melanota wɔa eƒe ŋusẽkpɔɖeamedzi koŋ to nuwɔwɔ kple melanocortin xɔlawo me. Etɔxɛe la, abe melanocortin receptor agonist si metiaa ame o ene la, ate ŋu ana melanin nawɔ le ŋutigbalẽa me, si ana ŋutigbalẽa nawɔ amadede, si fia be ŋutigbalẽa ƒe amadede nadze. Tsɔ kpe ɖe eŋu la, ate ŋu ana ŋutsu ƒe vidzinu natsi tre le eɖokui si kple gbɔdɔdɔ ƒe dzodzro hã.
Nuka koŋue nye Melanota ƒe dɔwɔwɔ le lãgbalẽ ɖeɖe me?
Melanota nana ŋutigbalẽ ƒe ŋutigbalẽ biã to nuwɔwɔ kple melanocortin 1 xɔla si le melanocytes dzi me. Woxɔe se be Melanota srɔ̃a ŋusẽ si melanocortin α-melanocyte-stimulating hormone (α-MSH) kpɔna ɖe melanocytes ƒe MC1 xɔla dzi, si wɔnɛ be agouti signaling protein ƒe ɖeɖefia dzina ɖe edzi. Melanota ʋãa melanocytes be woawɔ melanin ahaɖee ɖa, si wɔnɛ be ŋutigbalẽ ƒe amadede dzina ɖe edzi [4] . Ate ŋu ado eumelanin ƒe wɔwɔ ɖe ŋgɔ le ŋutigbalẽa me be ŋutigbalẽa nazu amadede. Numekukuwo ɖee fia be α-melanocyte-stimulating hormone (α-MSH) analogue cyclic -[Ac-Nle(4), Asp(5), D-Phe(7), Lys(10)] alpha-MSH-(4 - 10) amide (Melanota ), si nye melanocortin receptor agonist sesẽ aɖe, ate ŋu aʋã eumelanin ƒe wɔwɔ be ŋutigbalẽ ƒe amadede nadze [5] . .
Nukae nye mɔnu tɔxɛ si Melanota wɔna le ŋutsu ƒe vidzinu ƒe tsitretsitsi kple gbɔdɔdɔ ƒe dzodzro dodo ɖe ŋgɔ me?
Tsitretsitsi ƒe ʋuʋu:
Le sisiblisi siwo wofa alɔ̃ na gome la, Melanota —si nye melanocortin receptor agonist si menye tẽ o—ɖe tsitretsitsi ƒe ʋuʋu si nɔa te ɖe agbɔsɔsɔme dzi fia ne wodoe to ʋuka me dodo (0.1–1 mg/kg) alo hypothalamic paraventricular nucleus infusion (0.1–1 μg) dzi. Dɔwɔwɔ sia he ŋutsu ƒe vidzinu ƒe tsitretsitsi vɛ eye wòɖe tsitretsitsi ƒe nudzɔdzɔ gbãtɔwo ƒe ɣeyiɣi didi dzi kpɔtɔ [6] .Eƒe ŋusẽkpɔɖeamedzi ate ŋu abia be wòana melanocortin xɔlawo nawɔ dɔ le titina lãmekawo me, si ana ahɔhɔ̃mekawo ƒe mɔ siwo do ƒome kple tsitretsitsi la naɖɔ ɖo. Ne wodo Melanota ɖe dɔgboa me (0.2 μg) le L6 - S1 ƒe seƒe la, tsitretsitsi ƒe nudzɔdzɔwo ƒe sesẽme lolona wu. Esia ɖee fia be ahɔhɔ̃meka siwo le aklã ƒe ɖoɖo nu hã ate ŋu akpɔ gome le Melanota ƒe tsitretsitsi ƒe ʋuʋu me [6]..
Tsitretsitsi dodo ɖe ŋgɔ:
Ne wodo Melanota (1 mg/kg) ɖe ʋuka me vɔ la, tsitretsitsi ƒe ŋuɖoɖo si doa me lãmekawo ƒe ʋuʋu hena vɛ dzina ɖe edzi, si wɔnɛ be wòwɔa akpa si doa tsitretsitsi ɖe ŋgɔ [6] . Ne woɖe akɔta ƒe paravertebral sympathetic chain ɖa kpata vɔ la, woɖea Melanota ƒe ŋusẽ si doa ŋusẽ ame la ɖa. Esia ɖee fia be Melanota ƒe ŋusẽkpɔɖeamedzi si doa ŋusẽ ŋutsu ƒe tsitretsitsi nɔ te ɖe akɔta ƒe paravertebral sympathetic chain ƒe blibonyenye dzi. To vovo na ema la, Melanota si wodo ɖe corpus cavernosum (1 μg) me meɖe promoter ƒe dɔwɔwɔ aɖeke fia o. Aklã ƒe ʋuʋu alo akɔta ƒe lãmeka ƒe akpa eve ɖeɖe alo ŋutsu ƒe akɔta ƒe lãmeka megblẽ Melanota si wodona ɖe ʋuka me (1 mg/kg) ƒe dɔwɔwɔ dodo ɖe ŋgɔ me o, si gaɖee fia be Melanota ƒe ŋusẽ si doa ŋusẽ tsitretsitsi ɖe tsitretsitsi ŋu la toa veveseseɖeamenu ƒe lãmeka ƒe mɔ dzi koŋ tsɔ wu be wòato akɔta ƒe lãmeka alo ŋutsu ƒe akɔta ƒe lãmeka dzi [6] ..
Nyɔnuwo ƒe gbɔdɔdɔ ƒe dzodzro ƒe nuwɔna ƒe nyonyo:
Numekukuwo ɖee fia be Melanota kpɔa ŋusẽ ɖe nyɔnuwo ƒe gbɔdɔdɔ ƒe nuwɔna hã dzi. Le sisiblisi nyɔnuwo gome la, sisiblisi siwo woɖe azigolo siwo wotsɔ estradiol benzoate (EB) kple progesterone (P) da dɔ na do ŋgɔ, Melanota (1 kple 3 mg/kg) dodo ɖe ʋuka me na titri, duƒuƒu, kple to ʋuʋu ƒe xexlẽme dzi ɖe edzi, si ɖee fia be progesterone ate ŋu awɔ nu kple Melanota atsɔ adzi nyɔnuwo ƒe gbɔdɔdɔ ƒe dzodzro ɖe edzi [7] ..
Ŋusẽ si MTII kpɔna ɖe melanoma lãmenugbagbeviwo ƒe tumorigenicity dzi.
Dzɔtsoƒe:PubMed [1] .
Melanota nye nusi ƒe dɔwɔwɔ kple numekuku ƒe mɔfiamewo le vovovo. Nusiwo gbɔna aƒo nu tso numekuku bubu siwo do ƒome kplii le Melanota ŋu me .
Tsitretsitsi ƒe ʋuʋu:
Le numekuku aɖewo me la, wokpɔe be Melanota kpɔa ŋusẽ ɖe vidzidzi ƒe ɖoɖoa hã dzi. Le kpɔɖeŋu me, Melanota ate ŋu ana ŋutsu ƒe vidzinu natsi tre le mɔ si mesɔ o nu. Dɔnɔ aɖewo kpɔ tsitretsitsi vevesesetɔe le Melanota dodo ɖe ŋutigbalẽ te megbe, eye woɖe veveseseɖeamenu ƒe lãmekawo ƒe dzodzo ƒe dzesiwo hã fia, abe dzi ƒe tsotso ƒe dzidziɖedzi, ʋu ƒe sisi ƒe dzidziɖedzi, dzimaɖitsitsi, kple fifia fũ [8] .Esia ɖee fia be Melanota ate ŋu akpɔ ŋusẽ ɖe ʋu ƒe sisi kple ahɔhɔ̃mekawo ƒe ɖoɖowɔwɔ dzi le vidzidzi ŋutinuwo me to dɔwɔwɔ ɖe nu tɔxɛ aɖewo dzi ahɔhɔ̃mekawo kple xɔla ƒe ɖoɖowo, si wɔnɛ be tɔtrɔwo vaa ŋutsu ƒe tsitretsitsi ƒe dɔwɔwɔ me. Tsɔ kpe ɖe eŋu la, le numekuku siwo wowɔ le lãklewo ŋu me la, melanocortin ƒe atikewo ateŋu ahe lordosis ƒe nɔnɔme vɛ, si gɔme woɖe be enye kpeɖodzi be gbɔdɔdɔ ƒe dzodzro dzi ɖe edzi [8] , si gaɖee fia be ŋusẽ si Melanota kpɔna ɖe vidzidzi ƒe ɖoɖoa dzi ateŋu atso gbɔdɔdɔ ƒe dzodzro kple gbɔdɔdɔ ƒe nuwɔna ƒe ɖoɖowɔwɔ gbɔ.
Melanin wɔwɔ dodo ɖe ŋgɔ:
Abe melanocortin ƒe nɔnɔmetata si wowɔ ene la, Melanota ateŋu abla ɖe melanocortin I xɔla (MC1R) ŋu atsɔ ado melanin wɔwɔ ɖe ŋgɔ [9] .Ewɔa esia koŋ to melanocytes ƒe dzidziɖedzi dodo ɖe ŋgɔ kple tyrosinase ƒe dɔwɔwɔ dzi kpɔkpɔ me. Dɔwɔwɔ sia si doa melanin wɔwɔ ɖe ŋgɔ naa Melanota ƒe asixɔxɔ si woate ŋu azã le ŋutigbalẽ ƒe akpa dzi, le kpɔɖeŋu me, ate ŋu awɔ akpa aɖe le ŋutigbalẽ ƒe dɔléle aɖewo dada kple wo nu tsitsi me.
Numekuku siwo wowɔ le dɔlékuiwutikewo ƒe akpawo ŋu:
Le numekuku si wowɔ tso dɔlékuiwutikewo ŋu me la, numekuku siwo wowɔ to B16-F10 melanoma ƒe kpɔɖeŋua zazã me ɖee fia be togbɔ be Melanota mekpɔa ŋusẽ aɖeke ɖe melanoma lãmenugbagbeviwo ƒe dzidziɖedzi dzi o hã la, ate ŋu axe mɔ ɖe melanoma lãmenugbagbeviwo ƒe ʋuʋu, amedzidzedze, kple ƒuƒoƒo ƒe wɔwɔme nu nyuie. Melanota zazã le teƒea hã ate ŋu aɖe dɔdzẽ ƒe ŋgɔyiyi dzi akpɔtɔ ŋutɔ le sisiblisi siwo ŋu melanoma si woɖo anyi le me. Eƒe dɔwɔwɔ ƒe mɔnu enye be wòana phosphatase kple tensin homolog (PTEN) ƒe dziyiyi to melanocortin 1 receptor (MC1R) dzi, to esia me axe mɔ ɖe melanoma ƒe ŋgɔyiyi nu to cyclooxygenase II (COX-2)/prostaglandin E2 (PGE2) ƒe dzesimɔ dzi ɖeɖe kpɔtɔ me [1]..
Dɔdamɔnu ƒe ŋusẽkpɔɖeamedzi ɖe autism dzi:
Numekuku aɖewo zã vidada ƒe dɔlélenutsiŋutete ƒe dɔwɔwɔ (MIA) sisiblisi ƒe kpɔɖeŋu si nye autism tsɔ da atikewɔwɔ ƒe ŋutete si le melanocortin receptor 4 agonist M Melanota ŋu kpɔ le nɔnɔme siwo le abe autism ene le ŋutsu tsitsi sisiblisiwo me [10] .Ŋutsu MIA mice ɖe nɔnɔme siwo ɖi autism fia, siwo dometɔ aɖewoe nye hadomenuwɔna ƒe dzesi siwo gblẽ, gbeɖiɖi ƒe kadodo dzi ɖeɖe kpɔtɔ, kple nuwɔna siwo gbugbɔ gblɔna ƒe dzidziɖedzi. Melanota dodo na MIA mice ŋutsuwo ŋkeke adre tsiã ɖe enu na be hadomenuwɔna ƒe dzesiwo nyo ɖe edzi. Tɔtrɔ gã aɖeke meva le hadomenuwɔna ƒe dzesiwo me le C57 mice ŋutsu siwo ƒe nɔnɔme sɔ me le Melanota zazã vɔ megbe o . Tsɔ kpe ɖe eŋu la, le C57 mice siwo sɔ me la, tɔtrɔ aɖeke meva le nuwɔna siwo ɖi dzimaɖitsitsi alo esiwo wogbugbɔna wɔna me le Melanota zazã vɔ megbe o, gake woƒe kpekpeme dzi ɖe kpɔtɔ ŋutɔ le subacute atikewɔwɔ vɔ megbe. Nyatakaka siawo ɖee fia be Melanota nye atike nyui aɖe si ate ŋu ana nuwɔna ƒe gbɔdzɔgbɔdzɔ siwo le abe autism ene nanyo ɖe edzi le autism ƒe kpɔɖeŋu si wowɔ le MIA mice ŋutsu tsitsiwo me.
Ŋkuɖodzinu ƒe dɔmawɔmawɔ nyuie ƒe tɔtrɔ:
Numekukuwo ɖee fia be wokpɔe be nuɖuɖu si me ami sɔ gbɔ ɖo (HF) dzia lãmekawo ƒe gbegblẽ kple ahɔhɔ̃mekawo ƒe dɔlélewo ƒe afɔku ɖe edzi. Numekuku sia ku ƒomedodo si ate ŋu anɔ nuɖuɖu, Melanota si tɔa ŋku melanocortin xɔlawo, kple zebrafish ƒe nuwɔna dome [11] . Nukutɔe la, ɣeyiɣi kpui aɖe ƒe HF nuɖuɖu si nɔa anyi abe 1% ene le sɔveda ƒe agbenɔƒe gɔ̃ hã kpɔ ŋusẽ gã aɖe ɖe eƒe tsitsi dzi. Ne wotsɔe sɔ kple sɔmelã siwo wona nuɖuɖu si dzi woɖuna la, zebrafish siwo wona HF nuɖuɖu ɖee fia be woƒe ŋkuɖoɖonudzi ƒe dzesidede nu me gblẽ, dzimaɖitsitsi ƒe agbɔsɔsɔ dzi ɖe edzi, eye woƒe didi be yewoaku nu me dzi ɖe kpɔtɔ le kwasiɖa etɔ̃ pɛ ko megbe. Eye Melanota trɔ asi le nusiwo mesɔ o siawo siwo HF nuɖuɖua hena vɛ ŋu . Lã siwo wona HF nuɖuɖu eye wotsɔ Melanota da dɔe la ɖe ŋkuɖoɖo nu dzi, dzimaɖitsitsi, kple numekuku ƒe nuwɔna siwo sɔ kple esiwo le ƒuƒoƒo si me wokpɔa wo gbɔ le la fia. Numekuku sia na kpeɖodzi be HF ɖuɖu ɣeyiɣi kpui aɖe gɔ̃ hã ate ŋu akpɔ ŋusẽ ɖe ŋkuɖoɖonudzi kple seselelãme dzi, eye enye numekuku gbãtɔ si ɖee fia be Melanota ate ŋu atrɔ tɔtrɔ siawo.
Hadomegbenɔnɔ ƒe nuwɔna ŋuti ɖoɖowɔwɔ:
Le ahɔhɔ̃ŋutinunya me numekuku me la, wokpɔe be Melanotan-II ate ŋu aɖɔ hadomenuwɔna ɖo to melanocortin xɔlawo ƒe ʋuʋu me eye emegbe wòana oxytocin ƒe ɖoɖo si le titina la nawɔ dɔ [12] . Etɔxɛe la, le Melanota dodo ɖe ɖoɖo nu megbe la, Melanota dodo ɖe ʋuka me tsɔ wu be woadoe to ŋɔti me ate ŋu ana Fos nadze le magnocellular neurons siwo le supraoptic nucleus (SON) kple paraventricular nucleus (PVN) me le hypothalamus me vevie, eye woate ŋu aɖe ŋuɖoɖo sia dzi akpɔtɔ to melanocortin antagonist zazã do ŋgɔ me SHU-9119 ƒe agbalẽa. Elektrikŋusẽŋutinunya ƒe nuŋlɔɖiwo ɖee fia be Melanota dodo ɖe ʋuka me ate ŋu ana oxytocin ahɔhɔ̃meka siwo le SON me ƒe tudada ƒe agbɔsɔsɔme nadzi ɖe edzi. Esia ɖee fia be Melanota kpɔa ŋusẽ ɖe oxytocin ƒe ɖoɖo si do ƒome kple hadomenuwɔna le lãmekawo me dzi le ɖoɖowɔwɔ me, eye eƒe dɔwɔwɔ ate ŋu anye be wòaɖɔ oxytocin ahɔhɔ̃mekawo ƒe dɔwɔwɔ kple woƒe dodo ɖo to dɔlékuixɔla tɔxɛwo kple dzesimɔwo ƒe dɔwɔwɔ me.
Numekuku siwo wowɔ tso lolo akpa kple lãmenugbagbeviwo ƒe lãmesẽ ŋu:
Le lolo akpa kple lãmenugbagbeviwo ƒe lãmesẽ gome la, numekuku aɖewo zã domenyiŋusẽfianu ƒe kpɔɖeŋu na mice siwo me pituitary adenylate cyclase-activating polypeptide (PACAP) mele o eye wokpɔe be melanocortin receptor agonist Melanota ate ŋu aɖe dzoxɔxɔ ƒe ŋutete si gblẽ le mice siwo me PACAP mele o ƒe dzoxɔxɔ ƒe ŋutete si gblẽ le vuvɔ ƒe tɔtrɔ ɖe nɔnɔme ŋu ƒe akpa aɖe. Esia ɖee fia be PACAP ate ŋu awɔ akpa aɖe le melanocortin ƒe ɖoɖoa ƒe dzigbe gome, si ana ami dzẽ ƒe veveseseɖeamenu ƒe lãmekawo ƒe dɔwɔwɔ le sisiblisiwo me, si ana wòakpɔ ŋusẽ ɖe lolo akpa kple lãmenugbagbeviwo ƒe lãmesẽ dzi [13]..
Lãmetsiŋusẽ ƒe dɔwɔwɔ kple ŋutilã ƒe dzoxɔxɔ dzi kpɔkpɔ:
Melanota kpɔa ŋusẽ gã aɖe ɖe lãmenugbagbeviwo ƒe dɔwɔwɔ hã dzi. Le kpɔɖeŋu me, Melanota dodo ɖe sisiblisiwo me ateŋu ahe hypometabolism/hypothermia si de to eye wònɔa anyi ɣeyiɣi kpui aɖe [14] .Numekukuwo ɖee fia be le mice siwo si mast cells mele o me la, woɖea dzoxɔxɔ si Melanota hena vɛ la ɖa, si fia be ehiã be mast cells nakpɔ gome le eme. Melanota nana dzoxɔxɔ dzi ɖena kpɔtɔna le sisiblisiwo me to mast cells ƒe dɔwɔwɔ kple histamine 1 xɔla ƒe dɔwɔwɔ me, eye eƒe dɔwɔwɔ ƒe mɔnu lɔ lãmenugbagbeviwo ƒe dɔwɔwɔ kple lãmenugbagbevi geɖe ƒe kadodo ɖe eme.
Le nyataƒoƒo me la, abe nusi wowɔ si he amewo ƒe susu ŋutɔ ene la, Melanota ɖea nɔnɔme tɔxɛwo fiana le go geɖe me. Le ŋutigbalẽ gome la, to kadodo kple lãmenugbagbevi tɔxɛ siwo le melanocytes dzi me la, ate ŋu ado melanin ƒe wɔwɔ ɖe ŋgɔ nyuie, si ana lãgbalẽŋudɔwɔwɔ ƒe mɔnu si menye kɔnyinyi o na amesiwo di be akɔbli ƒe ŋutigbalẽ nanɔ lãmesẽ me. Ne wotsɔ Melanota sɔ kple lãgbalẽ ɖeɖe to keklẽ si me keklẽŋusẽ le ɣeyiɣi didi me la, ate ŋu aƒo asa na keklẽ si nu sẽ ƒe nugbegblẽ le ŋutigbalẽa ŋu tẽ eye wòaɖe afɔku siwo ate ŋu ado tso ɣe ƒe dzoxɔxɔ, ŋutigbalẽ ƒe tsitsi, kple ŋutigbalẽ me kansa gɔ̃ hã me dzi akpɔtɔ.
Le gbɔdɔdɔ ƒe dɔwɔwɔ dzi kpɔkpɔ ƒe nukpɔsusu nu la, Melanota kpɔa ŋusẽ nyui ɖe ŋutsu ƒe vidzinu ƒe tsitretsitsi le eɖokui si ƒe ʋuʋu kple gbɔdɔdɔ ƒe dzodzro dodo ɖe ŋgɔ dzi. Esia nye egbɔkpɔnu nyui aɖe si ate ŋu asu ame aɖewo siwo gbɔdɔdɔ ƒe dɔmawɔmawɔ nyuie le alo amesiwo le mɔ kpɔm be yewoana yewoƒe gbɔdɔdɔ ƒe nuteƒekpɔkpɔ nanyo ɖe edzi. Ate ŋu akpɔ ŋusẽ nyui ɖe gbɔdɔdɔ ƒe dɔwɔwɔ dzi to ahɔhɔ̃mekawo ƒe mɔ tɔxɛ siwo le titina kple gotagome lãmekawo me dɔwɔwɔ kple ahɔhɔ̃meka siwo do ƒome kplii kple esiwo xɔa nyatakaka siwo do ƒome kplii la dzi kpɔkpɔ me, si ana mɔnukpɔkpɔ yeyewo nasu ame si be wòana gbɔdɔdɔ ƒe lãmesẽ nanyo ɖe edzi.
Le numekuku si wowɔ tso lolo akpa kple lãmenugbagbeviwo ƒe lãmesẽ ŋu me la, Melanota ɖe viɖe siwo ate ŋu anɔ eme hã fia. Ate ŋu aɖɔ ŋusẽ ƒe asitɔtrɔ kple ŋutilã ƒe dzoxɔxɔ ɖo eye wòakpɔ ŋusẽ aɖe ɖe ami ƒe dɔwɔwɔ ƒe gbegblẽ dzi le lolo akpa me. Enaa numekuku ƒe mɔfiame yeye aɖe le lolo akpa dada kple lãmenugbagbeviwo ƒe lãmesẽ dzi kpɔkpɔ ŋu, si kpena ɖe ame ŋu le atikewɔwɔmɔnu yeyewo toto vɛ kple dɔnɔ siwo lolo akpa ƒe lãmesẽ ƒe nyonyo me.
Le Agbalẽŋlɔla La Ŋu
Nusiwo míeyɔ ɖe etame la katã nye esiwo ŋu Cocer Peptides wɔ numekuku le, trɔ asi le wo ŋu eye woƒo wo nu ƒu.
Dzɔdzɔmeŋutinunya ƒe Agbalẽŋlɔla
Cousen, P nye numekula si ƒe susu koŋ le Ŋutilãŋutinunya ƒe Nulɔdɔ ƒe akpa dzi. Eƒe dɔwɔwɔ le domenyinyi sia me do ƒome kple habɔbɔ geɖewo, siwo dometɔ aɖewoe nye South Tees Hosp NHS Fdn Trust, James Cook Yunivɛsiti Kɔdzi, Royal Cornwall Kɔdzi, Sheffield Yunivɛsiti, kple Chesterfield Royal Hosp. Le eƒe dɔ tɔxɛ vevitɔ si wòwɔ le Lãmesẽŋutinunya me la, Cousen godo la, anɔ eme be P ƒe numekuku ƒe didiwo kple dɔwɔnawo keke ta ɖo nuto siwo do ƒome kplii abe dɔlélenutsiŋutete ene me, le kadodo si le nusiwo ŋu dɔlélenutsiŋutete le kple dɔlélenutsiŋutete dome ta. Esia ate ŋu abia be woasrɔ̃ nu tso dɔlélenutsiŋutete ƒe ŋuɖoɖo siwo hea ŋutigbalẽ ƒe nɔnɔme siwo me nulɔdɔwo vɛ ŋu eye woaku atikewɔwɔmɔnu yeye siwo dzi woato atrɔ asi le ŋuɖoɖo siawo ŋu.
Tsɔ kpe ɖe eŋu la, eƒe numekukua ate ŋu alɔ dɔdamɔnu dodokpɔwo wɔwɔ ɖe ŋutigbalẽŋutinunya ƒe atike yeyewo ŋu, ŋutigbalẽ ƒe mɔxenu ƒe dɔwɔwɔ kple akpa si wòwɔna le mɔxexe ɖe nulɔdɔwo nu me dzodzro, kple domenyiŋusẽfianu siwo nana ame ɖekaɖekawo te ŋu xɔa ŋutigbalẽ ƒe nulɔdɔwo me dzodzro. Gakpe ɖe eŋu la, ne míebu alesi lãmesẽnyawo ŋuti numekukuwo wɔa dɔ vovovowoe ŋu la, ate ŋu awɔ dɔ aduadu kple eŋutinunyala siwo tso dɔ bubuwo abe atikeŋutinunya, nugbagbevi suesuewo ŋuti nunya (si srɔ̃a nu tso ŋusẽ si ŋutigbalẽ me nugbagbevi suesuesuewo kpɔna ɖe nusiwo ŋu ŋutilã melɔ̃a nu le o dzi), kple susuŋutinunya gɔ̃ hã (si dzroa ŋusẽ si ŋutigbalẽ ƒe nulɔdɔ siwo nɔa anyi didi kpɔna ɖe susu dzi me kpɔna), si ana woase ŋutigbalẽ ƒe nulɔdɔwo gɔme nyuie ahakpɔ wo dzi. Cousen, P ye woŋlɔ ɖe nyayɔyɔ ƒe numekugbalẽ me [4].
