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1kits (10Vials) .
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▎ SS-31 ƒe Dɔwɔɖoɖo
Dzɔtsoƒe: PubChem |
Nusiwo kplɔ wo nɔewo ɖo: RXKF Molekyulãwo ƒe Mɔfiame: C 32H 49N 9O5 Molekyulã ƒe Kpekpeme: 639.8g/mol CAS ƒe xexlẽdzesi: 736992-21-5 PubChem ƒe CID: 11764719 Nya siwo sɔ kple wo nɔewo: Elamipretide |
▎ SS-31 Numekuku
Nukae nye numekuku si wowɔ le SS-31 ŋu?
SS-31 nye tsi me ʋeʋẽ, ʋeʋẽ lilili cationic, mitochondria-taɖodzinu tetrapeptide (Sabbah HN, 2022). Eƒe atikewo ƒe wɔwɔme tɔxɛ wɔnɛ be wòte ŋu gena ɖe mitochondrial membrane ememetɔ me bɔbɔe eye wònɔa teƒe ɖeka hena ɣeyiɣi kpui aɖe. Etɔxɛe la, ate ŋu abla ɖe cardiolipin, si nye mitochondrial membrane ememetɔ ƒe akpa vevi aɖe ŋu, si ana wòawɔ eƒe ŋusẽkpɔɖeamedzi si ana mitochondria ƒe dɔwɔwɔ nanyo ɖe edzi.
Atikewo ƒe wɔwɔme tɔxɛ sia nye gɔmeɖoanyi na eŋudɔwɔwɔ le dɔléle vovovowo dada me. Dɔléle geɖewo do ƒome kple mitochondria ƒe dɔmawɔmawɔ nyuie, abe Barth ƒe dɔléle, dzi ƒe dɔmawɔmawɔ nyuie, ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie, kple bubuawo Mitochondria wɔa akpa vevi aɖe le lãmenugbagbeviwo ƒe ŋusẽ wɔwɔ, oxidative stress ƒe ɖoɖowɔwɔ, kple akpa bubuwo me. Ne mitochondria ƒe dɔwɔwɔ gblẽ la, ate ŋu ahe kuxiwo abe lãmenugbagbeviwo ƒe ŋusẽ si mesɔ gbɔ o, oxidative stress ƒe dzidziɖedzi, kple ahɔhɔ̃mekawo ƒe dɔdzẽ vɛ, siwo hã hea dɔléle vovovowo vɛ.
SS-31 ƒe numekuku kple ewɔwɔ ƒe taɖodzinue nye be woaɖo taɖodzinu na dɔléle siawo siwo do ƒome kple mitochondria, aɖe dɔléle ƒe dzesiwo dzi akpɔtɔ to mitochondria ƒe dɔwɔwɔ nyuie wu kple dɔnɔwo ƒe agbenɔnɔ ƒe nyonyome kple agbetsitsi ƒe agbɔsɔsɔme dodo ɖe ŋgɔ me. Esi wole numekuku deto si yi edzi le mitochondria ƒe nugbagbeŋutinunya ŋu ta la, vivivi la, amewo va de dzesi mitochondria ƒe vevienyenye le dɔlélewo ƒe dzɔdzɔ kple woƒe dzɔdzɔ me.
Numekulawo kpɔe be mitochondria ƒe dɔmawɔmawɔ nyuie do ƒome kplikplikpli kple dɔléle vovovowo ƒe dɔlélenutsiŋutete ƒe dɔwɔwɔ. Le kpɔɖeŋu me, le ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie me la, nyawo abe ahɔhɔ̃mekawo ƒe mitochondria ƒe dɔmawɔmawɔ nyuie, ahɔhɔ̃mekawo ƒe dɔdzẽ si nɔa anyi didi, protein siwo me aɖi le ƒe ƒuƒoƒo, kple ahɔhɔ̃mekawo ƒe tsɔtsrɔ̃ [1] . Hafi SS-31 nage ɖe dɔdamɔnu ŋuti numekuku me la, wowɔ numekuku geɖe do ŋgɔ na dɔdamɔnu. Numekuku siawo dometɔ aɖewoe nye dodokpɔ siwo wowɔ le lãmenugbagbeviwo ƒe kpɔɖeŋuwo kple lãwo ƒe kpɔɖeŋuwo ŋu be woatsɔ ada atike la ƒe dedienɔnɔ, eƒe dɔwɔwɔ, kple atike ƒe dɔwɔwɔ ƒe nɔnɔmewo kpɔ. Le kpɔɖeŋu me, le Barth ƒe dɔléle ŋuti numekuku me la, SS-31 ɖe ŋutete si le esi be wòana mitochondrial bioenergetics kple morphology nanyo ɖe edzi kabakaba le induced pluripotent stem cell models me fia [2]..
Le numekuku si wowɔ tso ahɔhɔ̃mekawo ƒe dɔlélewo ŋu me la, SS-31 ɖe ahɔhɔ̃mekawo takpɔkpɔ ƒe ŋusẽkpɔɖeamedzi fia le lã geɖe ƒe kpɔɖeŋuwo me, siwo dometɔ aɖewoe nye mitochondrial gbɔgbɔ ƒe ŋusẽdodo, ahɔhɔ̃mekawo ƒe dɔdzẽ ƒe mɔxexe, kple mɔxexe ɖe protein siwo me aɖi le ƒe ƒoƒo ƒu nu [1] . SS-31 kpɔ gome le dɔdamɔnu ŋuti numekuku geɖe siwo ku ɖe dɔléle vovovowo ŋu me xoxo.
Le dzidɔ dada me la, dodokpɔ aɖe si wowɔ le vome, si me wozã atike si me womezãa atike o le ɖee fia be SS-31 dodo zi ɖeka le dedie eye woate ŋu alɔ̃ ɖe edzi nyuie, eye SS-31 ƒe agbɔsɔsɔ gã ate ŋu ana miameʋuka ƒe lolome nanyo ɖe edzi, si ɖo kpe akpa si wòate ŋu awɔ le dzidɔ dada me dzi [3]..
Nukawoe nye SS-31 ƒe dɔwɔwɔ ƒe mɔnu tɔxɛwo le dɔléle ƒe kpɔɖeŋu vovovowo me?
1. Mɔnu si wɔa dɔ le ʋu ƒe sisi ƒe ʋuʋu kple aortic balloon ƒe ʋuʋu ƒe kpɔɖeŋu me
Le ischemia-reperfusion injury (IRI) si ʋu ƒe sisi kple aortic balloon occlusion (REBOA) hena vɛ ƒe kpɔɖeŋu me la, mitochondria ƒe gbegblẽ wɔa akpa vevi aɖe. SS-31 ate ŋu aɖe kristalo-tsi didi dzi akpɔtɔ eye wòakpɔ ayiku kple dzi ta. Etɔxɛe la, ate ŋu aɖe creatinine, troponin, kple interleukin-6 ƒe agbɔsɔsɔ si le ʋumenu me dzi akpɔtɔ, gake mekpɔa ŋusẽ aɖeke ɖe plasma lactate ƒe agbɔsɔsɔ mamlɛtɔ dzi o. SS-31 ate ŋu aɖe IRI dzi akpɔtɔ to mitochondria takpɔkpɔ me, si aʋu atikewɔwɔmɔnu yeyewo na dɔnɔ siwo ŋu IRI le le ʋu dodo vɔ megbe [4]..
2. Mɔnu si wɔa dɔ le Barth ƒe dɔlélea me
Barth ƒe dɔlélea nye dɔléle si mebɔ o si do ƒome kple X si ƒe dzesi enye dzitodzito me dɔléle, ƒumeŋuɖui ƒe lãmekawo ƒe gbɔdzɔgbɔdzɔ, tsitsi ƒe megbetsitsi, kple ʋumenugbagbeviɣidɔ si nɔa tsatsam. SS-31 nye tetrapeptide si me tsi le, si ʋẽna lilili, si nye cationic, si woɖo taɖodzinu na mitochondria, si ate ŋu age ɖe mitochondria ƒe gotagome lãkusi me eye wòabla ɖe cardiolipin ŋu. Edoa lãmenugbagbeviwo ƒe lãmesẽ ɖe ŋgɔ to ŋusẽ wɔwɔ nyuie wu kple mɔxexe ɖe oxygen ƒomevi siwo wɔa dɔ ƒe wɔwɔme fũ akpa nu, si wɔnɛ be oxidative stress dzi ɖena kpɔtɔna. Le Barth ƒe dɔlélea ƒe lãmenugbagbevi siwo ŋu ŋusẽ geɖe le siwo wodo ɖa kple dɔléle bubu siwo do ƒome kple domenyiŋusẽfianu siwo ƒe dzesi enye ɖeviwo ƒe dzitodzito me dɔléle me la, SS-31 ate ŋu ana mitochondrial bioenergetics kple morphology nanyo ɖe edzi kabakaba. Numekuku geɖe me tsonu ɖo kpe SS-31 zazã abe atike si woate ŋu azã na dɔnɔ siwo ŋu Barth ƒe dɔlélea le ene dzi, vevietɔ le nɔnɔme siwo me wokpɔ dzitodzito me dɔléle le [2] ..
3. Mɔnu si wɔa dɔ le ayikudɔ si nye autosomal dominant polycystic kidney disease (ADPKD) me .
Wobu fufɔfɔ be enaa ƒunukpeƒetetedɔ ƒe ŋgɔyiyi gasẽna ɖe edzi le autosomal dominant polycystic kidney disease (ADPKD) me. Gake womekafu tolvaptan, si nye atike ɖeka kolia si dzi FDA da asi ɖo na ame tsitsiwo ƒe ADPKD, na ADPKD dɔnɔ siwo fɔ fu o le esi wòate ŋu agblẽ nu le fugboea ŋu ta. SS-31 nye tetrapeptide si kpɔa mitochondria ta si wokpɔ be enaa ayikudɔ ƒe ŋgɔyiyi nyona ɖe edzi le Pkd1RC/RC mice siwo fɔ fu me, esime wòɖea ERK1/2 ƒe phosphorylation dzi kpɔtɔna eye wònaa mitochondria supercomplexes ƒe wɔwɔme nyona ɖe edzi. Tsɔ kpe ɖe eŋu la, SS-31 ate ŋu atso vidzidɔa kple no me notsi me, si ana vidzĩwo ƒe ayikudɔ sesẽ si me ʋumenugbagbeviɣidɔ le nanyo ɖe edzi evɔ womekpɔ ŋusẽ aɖeke ɖe vidzidɔ alo nuveviwɔame dzi o. Numekuku siawo siwo wowɔ do ŋgɔ na dɔdamɔnu la ɖo kpe SS-31 ƒe dɔdamɔnu dodokpɔ siwo woate ŋu awɔ dzi [5]..
4. Mɔnu si dzi wòtona wɔa dɔ le dzidɔ me
Le dzidɔ (HF) me la, wonya be tɔtrɔ gbegblẽwo vaa mitochondria me. SS-31 kpɔa ŋusẽ nyui ɖe amegbetɔ ƒe dzi ƒe dɔmawɔmawɔ nyuie ƒe mitochondrial kple supercomplex dɔwɔwɔwo dzi. Ate ŋu adzi oxygen ƒe sisi ɖe edzi ŋutɔ, complex I kple complex IV ƒe dɔwɔnawo, kple complex IV ƒe dɔwɔwɔ si do ƒome kple supercomplexes le amegbetɔ ƒe dzi ƒe mitochondria siwo gbɔdzɔ me, si ana amegbetɔ ƒe mitochondria ƒe dɔwɔwɔ ƒe kpododonu nanyo ɖe edzi ŋutɔ [6]..
Le ɖevi siwo ŋu dzidɔ si wodzina le ventricle ɖeka me (SV CHD) gome la, dɔdamɔnu siwo fia be woado dzitodzito na ame ɖee fia be mitochondria ƒe dɔmawɔmawɔ nyuie le wo ŋu. SS-31 nye pentapeptide si tɔa ŋku cardiolipin si ate ŋu ana mitochondrial supercomplexes (complex I, III, IV) ƒe kadodo nanyo ɖe edzi. Le ɖevi siwo ŋu SV CHD le ƒe dzi me la, SS-31 ate ŋu ana complex I ƒe dɔwɔwɔ kple gbɔgbɔtsixe si sɔ gbɔ wu (MR) nanyo ɖe edzi, si fia be ewɔa eƒe ŋusẽkpɔɖeamedzi koŋ to mitochondrial supercomplexes ƒe nyonyo me [7]..
5. Mɔnu si wɔa dɔ le suklidɔ ƒe ayikudɔ me
Le suklidɔ ƒomevi 2 ƒe db/db mouse model me la, suklidɔ ƒe ayikudɔ (DKD) do ƒome kple ayiku kple dzitodzito me superoxide ƒe agbɔsɔsɔ dzi ɖeɖe kpɔtɔ. Mitochondria-takpɔnu si nye SS-31 (si woyɔna hã be MTP-131, SS-31, alo Bendavia) ate ŋu axe mɔ ɖe proteinuria, aɖuɖɔtoe me H2O2, kple glomerular mesangial matrix ƒe dzidziɖedzi nu vevie le db/db mice me, eye wòakpɔ ayiku me superoxide wɔwɔ ƒe agbɔsɔsɔ ta keŋkeŋ le mice siawo me. SS-31 ate ŋu aɖe ayiku me lysocardiolipin bliboa kple lysocardiolipin ƒe hatsotso sue vevitɔwo hã dzi akpɔtɔ le db/db mice me, eye wòakpɔ lysocardiolipin acyltransferase 1 ƒe ɖeɖefia ta ŋutilã me superoxide ƒe agbɔsɔsɔ to cardiolipin ƒe tɔtrɔ yeye dzi kpɔkpɔ me [8] ..
Nɔnɔmetata si wosusu be elamipretide kpɔa ŋusẽ ɖe ahɔhɔ̃mekawo takpɔkpɔ dzi ɖe ahɔhɔ̃mekawo ƒe mitochondria ƒe nyonyome dzi kpɔkpɔ dzi kpuie.
Dzɔtsoƒe:PubMed [1] .
Nukae nye SS-31 ƒe dɔwɔwɔ siwo do ƒome kplii?
Dzitodzito me dɔléle le Barth ƒe dɔlélea me: Barth ƒe dɔléle nye dɔléle si mebɔ o eye ate ŋu ade ame ƒe agbe afɔku me si do ƒome kple X si ƒe dzesiwoe nye dzitodzito me dɔléle, ƒumeŋuɖui ƒe gbɔdzɔgbɔdzɔ, tsitsi ƒe megbetsitsi, kple cyclic neutropenia. Dɔnɔwo ate ŋu aku le woƒe vidzĩme eye woate ŋu axɔ dzitodzito me dɔléle si kpe ɖe dɔlélenutsiŋutete ƒe gbɔdzɔgbɔdzɔ vevie ŋu. SS-31 hea kuxiwo kple mɔnukpɔkpɔwo siaa vɛ na dzitodzito me dɔléle dada le dɔnɔ siwo ŋu Barth ƒe dɔlélea le ŋu. Numekuku geɖe me tsonu ɖo kpe edzi be wozãnɛ abe atike si woate ŋu azã na dɔnɔ siwo ŋu Barth ƒe dɔlélea le ene, vevietɔ ne wokpɔ dzitodzito me dɔléle. Ate ŋu akpɔ ŋusẽ ɖe dzitodzito me dɔléle ƒe ŋgɔyiyi dzi tegbee eye wòatrɔ miameʋuka si do kpo nu ƒe tɔtrɔ vivivi kple eƒe wɔwɔme le xexeame katã, lãmenugbagbeviwo, kple molecule ƒe ɖoɖo nu [2]..
Dzidɔ si wodzina le ventricle ɖeka me:
Dzidɔ si wodzinae nye dzidɔ si bɔ wu le vidzidzi, eye dzidɔ sesẽ si wodzina le dzitodzito ɖeka me ye nye nu vevitɔ si fia be woado vidzĩwo ƒe dzitodzito, eye atikewɔwɔmɔnu ʋɛ aɖewo koe li fifia. Wokpɔe be mitochondria ƒe dɔmawɔmawɔ nyuie le ɖevi siwo ŋu dzitodzito ɖeka ƒe dzidɔ le ƒe dzi me, eye peptide SS-31 si woɖo taɖodzinu na mitochondria ate ŋu ana dzia ƒe mitochondria ƒe dɔwɔwɔ nanyo ɖe edzi. Ehiã be woagawɔ numekuku bubuwo tso ŋutete si le atike sia ŋu be wòana dzitodzito ƒe dɔwɔwɔ nanyo ɖe edzi eye wòahe ʋudodo ƒe ŋgɔyiyi ɖe megbe ŋu [7] ..
Leber ƒe domenyiŋusẽfianu ƒe ŋku ƒe ahɔhɔ̃mekawo ƒe dɔléle:
Numekuku aɖe da SS-31 zazã ɖe lãme na ame ƒe dedienɔnɔ, alesi woate ŋu alɔ̃ ɖe edzi, kple alesi wòate ŋu awɔ dɔ nyuie le dɔnɔ siwo ŋu Leber ƒe domenyiŋusẽfianu ƒe ŋkume ƒe dɔléle le dada me kpɔ. Nusiwo do tso eme ɖee fia be woɖe mɔ ɖe SS-31 ŋu nyuie, gake meɖo nukpɔkpɔ ƒe ŋutete ƒe nuwuƒe vevitɔ gbɔ o. Ke hã, nukpɔkpɔ ƒe dɔwɔwɔ ƒe dodokpɔ le open-label kekeɖenudɔa me kple post-hoc numekuku ɖe ŋgɔyiyi dedziƒonamewo fia le titina nukpɔkpɔ ƒe teƒe ƒe tete ɖa le mama dedie nu, si hiã be woagaku nu me yi ŋgɔe [9]..
Nukpɔkpɔ ƒe ahɔhɔ̃mekawo ƒe dɔléle si nu sẽ:
Wokpɔe be SS-31 (MTP-131), si nye tetrapeptide si nye molecule sue aɖe si wotu ɖe mitochondria dzi, ne wozãe kpe ɖe tumor necrosis factor inhibitor etanercept ŋu la, ate ŋu anye ahɔhɔ̃mekawo takpɔnu na ŋku ƒe lãkusi ƒe lãmenugbagbeviwo le ŋku ƒe lãmeka ƒe nuveviwɔame le sisiblisiwo me megbe. Etanercept alo MTP-131 si wozãna le ŋutigbalẽ te ɖeɖeko kple woƒe ƒoƒo ƒu katã ate ŋu ana ŋkume ƒe lãmenugbagbeviwo ƒe agbetsitsi nadzi ɖe edzi, gake womekpɔ ŋusẽ aɖeke si wɔa dɔ aduadu ne wozã wo ɖekae o [10]..
Nuveviwɔame le aklã me: SS-31 (SS-31) nye cationic peptide ʋeʋĩ yeye aɖe si ate ŋu atso ʋu kple ahɔhɔ̃ ƒe mɔxenu faa. Numekukuwo ɖee fia be SS-31 doa dɔwɔwɔ ƒe hayahaya ɖe ŋgɔ le aklã ƒe abixɔxɔ megbe to mɔxexe ɖe autophagic ƒe nugbegblẽ si cPLA2-tomemɔ dzi, mɔxexe ɖe lysosomal membrane permeability ƒe dzidziɖedzi nu, kple mɔxexe ɖe pyroptosis nu, eye asixɔxɔ si ate ŋu azãe le dɔdamɔnu me le eŋu [11]..
Ahɔhɔ̃mekawo ƒe dɔléle kple susu ƒe dɔmawɔmawɔ nyuie:
Le sisiblisi tsitsiwo gome la, lipopolysaccharide ate ŋu ana ŋutilã ƒe dɔdzẽ kple ahɔhɔ̃mekawo naxɔ dɔ, eye woate ŋu azã SS-31 atsɔ ada dɔe. Numekukuwo ɖee fia be menye ɖeko mɔxexe ɖe hippocampal neuroinflammation nu ate ŋu aɖe dɔdzẽ ƒe ŋuɖoɖo si le hippocampus me dzi akpɔtɔ ko o, ke ate ŋu ana ahɔhɔ̃a ƒe dɔwɔwɔ ƒe kadodo le nuto siwo do ƒome kple hippocampus hã nanyo ɖe edzi. Dɔdamɔnu si wozãna tsɔ tsia dɔdzẽ nu kaba kple SS-31 kpɔa ŋusẽ si nɔa anyi ɖaa ɖe ahɔhɔ̃mekawo ƒe dɔléle si lipopolysaccharide hena vɛ ƒe ŋusẽkpɔɖeamedzi dzi ɖeɖe kpɔtɔ dzi [12]..
Autosomal dominant polycystic ayikudɔléle:
Wobu fufɔfɔ be enaa cysts ƒe ŋgɔyiyi gasẽna ɖe edzi le autosomal dominant polycystic kidney disease me. Wokpɔe be mitochondria-takpɔnu tetrapeptide SS-31 ate ŋu ana ayikudɔléle ƒe ŋgɔyiyi nanyo ɖe edzi le Pkd1^{RC/RC} mice siwo fɔ fu me, esime wòaɖe ERK1/2 ƒe phosphorylation dzi akpɔtɔ eye wòana mitochondria supercomplexes ƒe wɔwɔme nanyo ɖe edzi. SS-31 ate ŋu atso vidzidɔ kple no me notsi, si ana vidzĩwo ƒe ayikudɔ sesẽ si me ʋumenugbagbeviɣidɔ le nanyo ɖe edzi evɔ womede dzesi teratogenic alo nuveviwɔame aɖeke o [5]..
Dɔléle siwo gblẽa nu le ahɔhɔ̃mekawo ŋu:
SS-31 nye tetrapeptide sue aɖe si woɖo ɖe mitochondria ŋu si ɖe atikewɔwɔ ƒe ŋusẽkpɔɖeamedzi kple dedienɔnɔ fia le dɔléle vovovo siwo do ƒome kple mitochondria me. Le ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie me la, SS-31 ate ŋu ana mitochondrial gbɔgbɔ nanyo ɖe edzi, ana ahɔhɔ̃mekawo ƒe mitochondrial biogenesis nawɔ dɔ to mitochondrial biogenesis regulators kple translocator factors dzi, ana mitochondrial ƒe fusion nanyo ɖe edzi, axe mɔ na mitochondrial fission, ana mitophagy nadzi ɖe edzi, aɖe ahɔhɔ̃mekawo ƒe oxidative stress, ahɔhɔ̃mekawo ƒe dɔdzẽ, kple protein siwo me aɖi le ƒe ƒuƒoƒo dzi akpɔtɔ, axe mɔ na ahɔhɔ̃mekawo ƒe proteinwo ƒe ƒuƒoƒo apoptosis, eye wòdoa ahɔhɔ̃mekawo ƒe agbetsitsimɔwo ɖe ŋgɔ. Eyata SS-31 ate ŋu axe mɔ na ahɔhɔ̃mekawo ƒe dɔlélewo ƒe ŋgɔyiyi to mitochondria ƒe gbɔgbɔ, nugbagbewo ƒe dzɔdzɔ, fusion, kple ahɔhɔ̃mekawo ƒe agbetsitsi mɔwo dodo ɖe ŋgɔ me, eye wòaxe mɔ ɖe mitochondria ƒe mama, oxidative stress, ahɔhɔ̃mekawo ƒe dɔdzẽ, protein siwo me aɖi le ƒe ƒuƒoƒo, kple ahɔhɔ̃mekawo ƒe apoptosis nu [1] ..
Sarcopenia: Wokpɔe be kwasiɖa 8 ƒe atikewɔwɔ kple SS-31 ate ŋu atrɔ tɔtrɔ siwo do ƒome kple ƒexɔxɔ le protein phosphorylation me le ƒumelãwo ƒe lãmekawo me le nyɔnu tsitsiwo ƒe lãmekawo me ƒe akpa aɖe, si sɔ kple ƒunukpeƒeŋusẽ ƒe dɔwɔwɔ ƒe nyonyo kple tɔtrɔ siwo va protein S-glutathionylation me gbugbɔgaɖoanyi [13]..
Abe atike si woɖo ɖe mitochondria ŋu ene la, SS-31 naa mɔnu yeye aɖe si woatsɔ ada mitochondria dɔlélewo. To mitochondria ƒe wɔwɔme kple dɔwɔwɔ takpɔkpɔ me la, eɖe asixɔxɔ si le dɔdamɔnu ŋu fia le dɔlélewo abe LHON kple Barth ƒe dɔléle ene me, vevietɔ eɖe ŋusẽ gã aɖe fia le ŋku ƒe ahɔhɔ̃mekawo ƒe dɔléle sesẽ me. Ekpɔa ŋusẽ ɖe dɔléle vovovo siwo do ƒome kple mitochondria ƒe dɔmawɔmawɔ nyuie, abe dzidɔ kple ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie ene dzi, eye ate ŋu aɖe dzesiwo dzi akpɔtɔ eye wòahe dɔlélea ƒe ŋgɔyiyi ɖe megbe.
Le Agbalẽŋlɔla La Ŋu
Nusiwo míeyɔ ɖe etame la katã nye esiwo ŋu Cocer Peptides wɔ numekuku le, trɔ asi le wo ŋu eye woƒo wo nu ƒu.
Dzɔdzɔmeŋutinunya ƒe Agbalẽŋlɔla
Daneshgar N nye agbalẽnyala si kpɔ ŋusẽ ɖe agbalẽnyalawo dzi, eye eƒe sukudede do ƒome kplikplikpli kple Iowa Yunivɛsiti kple Oregon Dukɔa ƒe Yunivɛsiti. Eƒe numekuku ƒe akpawo keke ta eye wòde to, eye wòku ɖe nusɔsrɔ̃ vovovowo abe ame tsitsiwo kple ame tsitsiwo ƒe dɔlélewo ŋuti nunya, dzitodzito kple dzitodzitoŋutinunya, nugbagbeŋutinunya kple molecule biology, lãmenugbagbeviwo ŋuti nunya, kple kansa ŋuti nunya ŋu. Le ame tsitsiwo kple ame tsitsiwo ƒe dɔlélewo ŋuti nunya me la, Daneshgar N ɖoe kplikpaa be yeaku nu me le tsitsi ƒe nugbagbeŋutinunya ƒe mɔnuwo kple nudede dɔléle siwo do ƒome kple tsitsi me nyuie ŋu, kple mɔkpɔkpɔ be yeana ame tsitsiwo ƒe agbenɔnɔ kple lãmesẽ nanyo ɖe edzi to numekuku me.
Le dzitodzito kple dzidɔ ƒe akpa dzi la, ewɔa numekuku deto le dzitodzito me dɔlélewo ƒe dzɔdzɔ, dɔlélewo didi ƒe mɔnuwo, kple wo dada ƒe mɔnuwo ŋu, si kpena ɖe ame ŋu le mɔxexe ɖe dzitodzito me dɔlélewo nu kple wo dada me. Le nugbagbeŋutinunya kple molecule biology ƒe nyawo me la, etsɔa eƒe susu ɖoa biomolecules ƒe wɔwɔme, dɔwɔwɔ, kple woƒe kadodo ŋu, eye wòɖea agbe ƒe dɔwɔnawo ƒe nya ɣaɣlawo fiana le molecule ƒe ɖoɖo nu eye wònaa nukpɔsusu ƒe gɔmeɖoanyi na dɔlélewo gɔmesese kple wo dada. Le lãmenugbagbeviwo ŋuti nunya ƒe akpa dzi la, Daneshgar N léa fɔ ɖe lãmenugbagbeviwo ƒe wɔwɔme, dɔwɔwɔ, kple agbenɔnɔ ƒe sewo ŋu, eye wòsrɔ̃a nu tso dɔwɔwɔ veviwo abe lãmenugbagbeviwo ƒe dzesiwo ƒe tɔtrɔ kple lãmenugbagbeviwo ƒe tsatsam ƒe ɖoɖowɔwɔ ene ŋu, si naa kpeɖodzi veviwo hena lãmenugbagbeviwo ƒe dɔwɔwɔ le dɔlélewo ŋu sɔsrɔ̃. Le dɔdzẽŋutinunya me la, etsɔ eɖokui na be yeawɔ numekuku le dɔdzẽ ƒe dzɔdzɔ kple eƒe tsitsi ƒe mɔnuwo ŋu, kpakple dɔdzẽwo didi kple wo dada, adzro dzesi siwo woate ŋu ade dzesi dɔdzẽ kaba kple atikewɔwɔ ƒe taɖodzinu yeye siwo woatsɔ akpɔ dɔdzẽwo gbɔ, si ahe mɔkpɔkpɔ yeye vɛ na dɔdzẽ dɔnɔwo. Woŋlɔ Daneshgar N ŋkɔ ɖe nyayɔyɔ ƒe nyatakaka me [5].
