Ipa miligaramu 10

▎ Ipa ka sigicogo

Sɔrɔyɔrɔ: PubChem

A kɛcogo: XHXFK Formula molekilɛri: C 38H 49N 9O5 Molecules girinya: 711,9 g/mol CAS nimɔrɔ: 170851-70-4 PubChem ka CID: 9831659. Bamako, Mali Kɔrɔɲɔgɔnmaw: NNC-26-0161;UNII-Y9M3S784Z6;Ipa ACETATE

▎ Ipa Sɛgɛsɛgɛli

Ipa ka ɲininiw kɛcogo ye mun ye?

Kɔnɔbara basigilen kɔfɛ, o ye bana ye min ka teli ka kɛ, wa sisan, furakɛli suguya caman tɛ yen minnu bɛ se ka kɛ. Sɛgɛsɛgɛliw y’a jira ko Ipa, i n’a fɔ pepitidomimɛtiki sintetiki, a bɛ baara kɛ grelin minɛbaga kan, wa a bɛ se ka furakɛli nɔ bila kɔnɔbara lankolonya kɔtigɛlen na. Sɛgɛsɛgɛli dɔ la min sosow ka kɔnɔbara basigilen modɛli kan, kɔnɔboli sababu bɔra kɔnɔbara opereli ni banakɔtaa sɛgɛsɛgɛli fɛ, wa a jirala ko Ipa bɛ se ka kɔnɔbara lankolonya teliya^kɛra .

Opereli kɔfɛ ileus ye gɛlɛyaba ye kɛnɛyaso baarakɛcogo la, a furakɛcogo ɲumanw tɛ a la. Ghrelin minɛbagaw lawulili bɛ nɔ bila kɔnɔbara basigilen sanfɛla ni duguma yɔrɔ fila bɛɛ la. I n’a fɔ grelin minɛbaga agoniste, Ipa nafa bɛ se ka kɛ opereli kɔfɛ ileus furakɛli la. Misali la, sɛgɛsɛgɛli dɔ la, sɛgɛsɛgɛli dɔ kɛra banabagatɔw kan minnu bɛ banakɔtaa tigɛ kɔnɔbara opereli kɔfɛ walasa ka Ipa lakanani n’a nafa ^jateminɛ.

Ipa ye bonya hormone releasing peptides (GHRPs) ye, o ye pentapeptide sintetiki ye min bɛ se ka bonya hormone bɔli lawuli ka bɔ hypothalamus ni pituitary gland la. Bonya hormone jɔyɔrɔ ka bon farikolo ka bonya, a dilancogo ani a ka farikoloɲɛnajɛ la, o la Ipa jɔyɔrɔ min bɛ bonya hormone labɛnni na, o fana ye mɔgɔw hakili ^sama.

K’a sababu kɛ a nafa bɛ se ka kɛ kɔnɔbara lankolonya mɛnni furakɛli la, opereli kɔfɛ, ani a jɔyɔrɔ i n’a fɔ pepitiri min bɛ bonya hormone bɔ, Ipa ye ɲininikɛlaw ka ɲɛmajɔba sama.

Ipa ka baarakɛcogo ye mun ye?

1. Ka bonya hormone bɔli lawuli: 

Ipa bɛ bonya hormone releasing peptides (GHRPs) dɔ ye, o bɛ se ka bonya hormone bɔli lawuli ka bɔ hypothalamus ni pituitary gland la. In vitro ani in vivo kɔlɔsiliw, Ipa ye fanga ni nafa caman jira ka ɲɛsin bonya hormone bɔli ma. Misali la, sɛgɛsɛgɛli dɔ la, Ipa fanga ni a nafa ka bon ka bonya hormone bɔ sosow ka pituitary cellules fɔlɔw la, o ni GHRP-6 ta bɔlen don ^[3] . A kɛcogo ye ka bonya hormone bɔli lawuli ni GHRP ɲɔgɔnna fɛnw tali ye. Furakɛcogo sɛgɛsɛgɛli fɛ, a jirala ko i n’a fɔ GHRP-6, Ipa bɛ bonya hormone bɔli lawuli GHRP ɲɔgɔnna fɛnw fɛ.

2. A bɛ nɔ bila kɔnɔbara la

Kɔnɔbara lankolonya teliya: 

Sogow ka misaliw la, Ipa bɛ se ka kɔnɔbara lankolonya teliya. Kɔnɔbara opereli bɛ kɛ sababu ye ka kɔnɔbara lankolonya bila kɔfɛ, nka Ipa tali kɔfɛ (0,014 μmol/kg jolisira fɛ), kɔnɔbara lankolonya bɛ teliya kosɛbɛ. Ipa bɛ kɔnɔbara sɔgɔsɔgɔli lawuli ani ka kɔnɔbara lankolonya teliya fɛɛrɛ dɔ fɛ min bɛ kɛ sababu ye ka grelin minɛbaga ka baara kɛ, o min bɛ kɛ ni kolinɛriji wulicogo sɔgɔsɔgɔninjɛw ye (Greenwood-Van Meerveld B, 2012).

Opereli kɔfɛ ileus taamasiɲɛw ɲɛnabɔli: 

Opereli kɔfɛ ileus (ileus) sogow ka misaliw la, Ipa bɛ se ka bana taamasiɲɛw ɲɛ. Ipa tali kɔfɛ opereli kɔfɛ, Ipa tata hakɛ kelen (1mg/kg) walima GHRP-6 (20μg/kg) bɛ se ka dɔ bɔ waati la ka se nɔgɔ fɔlɔ ma. Ipa tali siɲɛ caman (miligaramu 0,1 walima miligaramu 1/kg) bɛ se ka dɔ fara kosɛbɛ nɔgɔ bɔli kan, dumuni dunta, ani farikolo girinya caya ^{[4] .}.

3. A bɛ nɔ bila inisɔndiya bɔli la

Ipa bɛ se ka inisɔndiya bɔli lawuli sosow la minnu ka kɛnɛ ani minnu bɛ sukarodunbana na. Inisɔn bɔli caya min bɛ sɔrɔ Ipa fɛ, o bɛ se ka bali kosɛbɛ dilitiyazem, yohimbine, propranolol walima atropine, propranolol ani yohimbine faralen ɲɔgɔn kan. Jabɛtibanabagatɔw la, atropini bɛ se ka dɔ bɔ kosɛbɛ inisɔndiya la min bɛ sɔrɔ Ipa fɛ, nka o nɔ tɛ ye sosow la minnu ka kɛnɛ. O b’a jira ko Ipa bɛ inisɔndiya bɔli lawuli ka tɛmɛn kalisiyɔmu sira fɛ ani adɛrɛnerji sɔrɔyɔrɔw fɛ ^{[5] .}.

4. Dimi nɔgɔyali

Kɔrɔbɔli misaliw la, minnu bɛ kɛ ni kɔnɔnatumuw ka fɛnɲɛnamafagalanw ye minnu tɛ funu ye ani farikolojidɛsɛ masinko alodini, Ipa, i n’a fɔ ghrelin minɛbaga agoniste min dantigɛlen don a lamini na, o bɛ se ka kolotuguda sɔgɔsɔgɔninjɛ ni somatiki allodini dɔgɔya kosɛbɛ. A kɛcogo bɛ kɛ sababu ye ka grelin minɛbaga fɛ, wa o banakisɛfagalan in bɛ se ka bali grelin minɛbaga kɛlɛbaga H0900 fɛ ^{[6] .}.

A bɛ Ipa nɔ jira inisɔndiya bɔli la ka bɔ sosow la minnu ka kɛnɛ ani minnu ka sukarodunbana bɛ u la.

Soso:PubMed ^{[5] Ɲɛjirali dɔw.}

Ipa ka baarakɛcogo ye mun ye?

1. Ka bonya hormone bɔli sabati

Ipa bɛ se ka bonya hormone bɔli lawuli ka bɔ hypothalamus ni pituitaire gland la. Bonya hormone jɔyɔrɔ ka bon hadamaden farikolo la, i n’a fɔ farikolojɔli dumuniw sɔrɔli, farikolokisɛw caya ani farikolo yɔrɔw dilancogo. O la, Ipa bɛ se ka kɛ ka bonya hormone dɛsɛ furakɛ walima bana wɛrɛw minnu bɛ tali kɛ bonya hormone dɛsɛ la ^{[7] .}.

2. Ka kɔnɔbara basigilen baara ɲɛ

Kɔnɔbara lankolonya teliya: 

Sogow ka misaliw la, Ipa bɛ kɔnɔbara lankolonya teliya opereli kɔfɛ ileus misaliw la, fɛɛrɛ dɔ fɛ min bɛ kɛ sababu ye ka bonya hormone bɔ pepitiri minɛbaga baarakɛli fɛ, o min bɛ kɛ ni wulilanw ^kolinɛriji ye Kɔnɔbara opereli bɛ kɛ sababu ye ka kɔnɔbara lankolonya bila kɔfɛ, wa Ipa tali bɛ se ka dumuni tolenw hakɛ dɔgɔya kosɛbɛ kɔnɔbara la, o bɛ kɔnɔbara lamagacogo ɲɛ.

 Kɔnɔbara basigilen (peristalsis) sabatili: 

Opereli kɔfɛ ileus (ileus) sogow ka misaliw la, Ipa bɛ se ka banabagatɔw ka bana taamasiɲɛw ɲɛ. Misali la, sosow ka misali la, Ipa bɛ se ka dɔ bɔ waati la ka se nɔgɔ bɔli fɔlɔ ma opereli kɔfɛ, ka dɔ fara nɔgɔ bɔli kan, ka dumuni dunta caya, ani ka dɔ fara a girinya kan ^[4] . Ipa tali segin-segin bɛ se ka dɔ fara kosɛbɛ nɔgɔ bɔli kan, dumuni dunta, ani farikolo girinya, o b’a jira ko a bɛ nɔ ɲuman bila kɔnɔbara baara la.

3. Dimi lajɔli

Dimi min bɛ kɛ kɔnɔbara ni farikolo yɔrɔw la, o lajɔ: 

Sɛgɛsɛgɛliw y’a jira ko Ipa, i n’a fɔ bonya hormone min bɛ pepitiri minɛbaga bɔ, o bɛ ni banakisɛfagalanw ye. Kɔrɔbɔli misaliw la, ni kolotuguda ɲɛgɛnɛsira funu tɛ, Ipa bɛ se ka dɔ bɔ kosɛbɛ kɔnɔbara basigilen na min tɛ funu ye ani somatiki mekaniki alodini ^{[6] .}.

A kɛcogo bɛ se ka kɛ sababu ye ka bonya hormone bɔ pepitiri minɛbaga fɛ, ka a sen don kɔnɔnatumuw ni farikolo yɔrɔw ka fɛnɲɛnamafagalanw tali la, o bɛ se ka kɛ fɛɛrɛ kura ye min bɛ se ka kɛ dimi jugumanba ni farikolo dimi furakɛli la.

Ipa ka ɲininiw ɲɛtaa ye mun ye bonya furakɛli la?

Bonya hormone dɛsɛ ye bana ye min bɛ sɔrɔ bonya hormone bɔli fɛ ka ɲɛ ka bɔ ɲɛgɛnɛsira ɲɛfɛla la, o bɛ se ka nɔ bila denmisɛnw ka bonya ni u ka yiriwali la ani balikuw farikolo la. San laban ninnu na, Ipa, n’o ye bonya hormone secretagogue ye, o ye mɔgɔw ɲɛnajɛ kosɛbɛ bonya hormone dɛsɛ furakɛli la. Ninnu ye Ipa ka ɲinini ɲɛtaa ye min bɛ tali kɛ o la, bonya furakɛli la.

1. Ipa ka nɔ min bɛ mɔgɔ bila ka wuli, o bɛ bonya hormone bɔli la

Ipa bɛ se ka bonya hormone bɔli lawuli. Sɛgɛsɛgɛliw y’a jira ko Ipa bɛ se ka baara kɛ ɲɔgɔn fɛ ni bonya hormone releasing hormone (GHRH) ye walasa ka bonya hormone bɔli caya ^[8] . Baganw ka kɛlɛli la, tile 21 furakɛli kuntaalajan kɔfɛ ni Ipa ye soso musomanninw na, ni i ye a suma ni kɔrɔsili kulu ye, basigi bonya hormone bɔli cayara pituitaire selilɛriw ka sɛnɛcogo kelen na. O waati kelen na, Ipa ni GHRH bɛ se ka bonya hormone bɔli lawuli ka bɔ pituitaire cellules cultures la in vitro. Nka, GHRH furakɛli ɲɛfɛ kulu la, o kɔfɛ, bonya hormone jaabi min bɛ sɔrɔ lawulili la, o ma bonya, k’a sɔrɔ Ipa furakɛli ɲɛfɛ kulu la, o ɲɔgɔnna desensitization ko si ma sɔrɔ, o b’a jira ko Ipa tɛ na ni desensitization ye bonya hormone jaabi la soso musoman fitininw ^na.

2. Ipa nɔ min bɛ mɔgɔ farikolo girinya la

Ipa tali kuntaalajan bɛ se ka dɔ fara wulu musomanninw girinya kan kosɛbɛ. Don o don kɔlɔsili b’a jira ko Ipa furakɛli ɲɛfɛ kulu ni GHRH furakɛli ɲɛfɛ kulu girinya kɛmɛsarada la, o ka ca ni kɔrɔsili kulu ta ye ^[8] . O bɛ tali kɛ a la ko Ipa bɛ bonya hormone bɔli lawuli, o min bɛ kɛ sababu ye ka farikolojɔli dumuniw dilanni ni selilɛriw falen.

3. Ipa nɔ min bɛ kolo dilancogo la

Sogo balikuw ka misali la, a jirala ko bonya hormone secretagogue Ipa bɛ se ka glucocorticoïdes (GC) ka catabolic nɔw kɛlɛ kolotugudaw ni kolo la. Ni an ye a suma ni kulu ye min pikirila ni GC dɔrɔn ye, bagan minnu pikirila ni GC ni Ipa fila bɛɛ ye, misiden farikolo tetaniki tansiyɔn hakɛ cayalenba cayara kosɛbɛ, ani kolotugudaw kolo bɔli hakɛ cayara siɲɛ naani ^[8 , O b’a jira ko Ipa bɛ nɔ ɲuman bila farikolo fanga sabatili la ani ka koloci sabati, wa a bɛ se ka dɛmɛ don ka gɛlɛyaw bali i n’a fɔ koloci banabagatɔw la minnu ka bonya hormone dɛsɛ bɛ u la.

4. Ipa nɔ min bɛ kɔnɔbara baara la

I n’a fɔ bonya ɔrimɔni bɔli ɔrimɔni agoniste sugandilen ani bonya hormone bɔli pepitiri minɛbaga agoniste, Ipa ye furakɛli nafa jira sosow ka misali la opereli kɔfɛ banakɔtaa paralizi. Ipa walima pepitiri min bɛ bonya hormone (GHRP)-6 tali siɲɛ kelen, o ye waati surunya opereli kɔfɛ banakɔtaa fɔlɔ la, nka a ma nɔ bila nɔgɔ bɔli la, dumuni dunta la, walima a girinya la. Ipa bɛ dɔ fara nɔgɔ bɔli kan, dumuni dunta, ani farikolo girinya. O b’a jira ko Ipa jɔyɔrɔ bɛ se ka kɛ kɔnɔbara baara ɲɛnabɔli la, wa a bɛ se ka dɛmɛ don ka dumunikɛcogo ni dumunifɛnw minɛcogo ɲɛ banabagatɔw la minnu ka bonya hormone dɛsɛ bɛ u la. ^{[4] .}.

Kuma surun na, i n’a fɔ bonya hormone bɔli ɲɛnama sugandilen, Ipa bɛ bonya hormone bɔli lawuli ka ɲɛ ni a bɛ bonya hormone-releasing peptide receptor (GHS receptor) baara, k’a sɔrɔ a ma nɔba bila adrénocorticotropic hormone (ACTH) ni cortisol hakɛ la. A ka baara dɔw ye ka bonya hormones bɔli sabati, ka kɔnɔbara lamagacogo ɲɛnabɔ, ani ka dimi nɔgɔya. A ka sugandili ka bon ani a ka laɲini caman kɛcogo bɛ se ka kɛ kɛnɛyaso la, o b’a to a bɛnnen don ka kɛ cogoyaw la i n’a fɔ bonya hormone dɛsɛ, banakɔtaa balili opereli kɔfɛ, ani dimi madali.

A sɛbɛnbaga ko la

Fɛn minnu kofɔlen dòn san fɛ, olu bɛɛ ɲinini Kɛra, k’u Labɛn ani k’u Lajɛ Cocer Peptides fɛ.

Dɔnniya gafe sɛbɛnbaga

Raun K ye ɲininikɛla ye min ni Danmakɛ Tekniki Iniwɛrisite (DTU) ani Novo Nordisk Foundation cɛsirilen don. A ka ɲininiw ɲɛsinnen bɛ baara caman ma, i n’a fɔ Endocrinology & Metabolism, Orthopaedics, Nutrition & Dietetics, Veterinary Sciences, aniEngineering. A ka baara ka teli ka sinsin fura sabatilenw ni kokuradonniw yiriwali kan, kɛrɛnkɛrɛnnenya la, biyoteknoloji ni biyo-sɔrɔko siratigɛ la.

Raun K ye dɛmɛ don porozɛw la minnu ɲɛsinnen bɛ Novo Nordisk Foundation Center for Biosustainability ma DTU la, o min ɲɛsinnen bɛ selilu izini dilanni ɲɛtaa ma, farikoloɲɛnajɛ injiniyɛri, ani biologi sintetiki walasa ka ɲɛnamaya sabatili sabati. Ka fara o kan, a sen bɛ ɲininiw daminɛ na, minnu kun ye ka dɔ bɔ jigi da fɛnw kan minnu sinsinnen bɛ fɛnɲɛnamafagalanw kan, ani ka jiginniw yiriwa jirisunw na, biyoproduction solutions fɛ.

A ka baara bɛ tali kɛ fana ɛntɛrinɛti baarakɛcogo la, i n’a fɔ katalisita ni biyoporozɛw yiriwali walasa ka izini ni sigida sabatili kɛ. Raun K ka dɔnniyaw ni ɲɔgɔn cɛ fɛɛrɛ bɛ dɔnniya ɲininiw ni waleyali waleyaliw cɛ, ka dɛmɛba don kalanko ni izini siratigɛ la. Raun K tɔgɔ sɛbɛnnen bɛ citation (citation) ɲɛfɔli sɛbɛn kɔnɔ [3].

▎ Sɛbɛn minnu bɛ tali kɛ o la

[1] Greenwood-Van Meerveld B, Tyler K, Mohammadi E, Pietra C. Ipa, n’o ye ghrelin mimɛtiki ye, o nafa ka bon kɔnɔbara basigilen na, opereli kɔfɛ ileus (ileus) sosow ka misali la. Journal de pharmacologie expérimentale 2012; 4: 149-55.DOI:10.2147/JEP.S35396. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew.

[2] Beck D. E., Sweeney W. B., McCarter M. D., ani mɔgɔw ye baara kɛ ni u ye. Ghrelin mimetic Ipa ka sɛgɛsɛgɛli nata, min kɛra k’a sɔrɔ a ma kɛ cogo si la, min kɛra ni hakili ye, min bɛ kɛ ni hakilina dalilu ye, opereli kɔfɛ ileus furakɛli kama banakɔtaa tigɛbaga banabagatɔw la. INT J KOLORƐKƐTI DIS 2014; 29(12): 1527-34.DOI:10.1007/s00384-014-2030-8.. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew.

[3] Raun K, Hansen B. S., Johansen N. L., ani mɔgɔ wɛrɛw. Ipa, o ye bonya hormone secretagogue sugandilen fɔlɔ ye. EUR J ENDOCRINOL 1998 sàn; 139(5): 552-61.DOI:10.1530/eje.0.1390552. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew.

[4] Venkova K, Mann W, Nelson R, Greenwood-Van Meerveld B. Ipa, min ye Ghrelin mimetic kura ye, ka se ka kɛ sogow ka misali la opereli kɔfɛ Ileus la. J PHARMACOL EXP SAN 2009 ƝƐNABƆLI; 329(3): 1110-6.DOI:10.1124/jpet.108.149211. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew.

[5] Adeghate E. A., Ponery A. S., ani a ɲɔgɔnnaw. Inisɔn bɔli fɛɛrɛ min bɛ sɔrɔ Ipa fɛ ka bɔ sosow la minnu ka kɛnɛ ani minnu bɛ sukarodunbanabagatɔw ka kɔnɔbara la. Neuro endocrinologie sɛbɛnw san 2004; 25 6: Ɲɛjirali 403-6.

[6] N Mohammadi E, Louwies T, Pietra C, Northrup SR, Greenwood-Van Meerveld B. Ɲɛgɛnɛsiraw ni farikolo yɔrɔw dɔgɔyali Ghrelin Mimetics fɛ. J Exp Farmasi 2020; 12: 267-74.DOI:10.2147/JEP.S249747. Bamako : DNAFLA, 2006.

[7] Papak M. Ipa - bεnkansεbεn i funkcija.; 2016 sàn.

Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew

[8] Jiménez-Reina L, Cañete R, de la Torre MJ, Bernal G. Furakɛli kuntaalajan nɔ min bɛ sɔrɔ ni bonya hormone secretagogue Ipa ye, soso musoman fitininw na:: somatotroph response in vitro. HISTOL HISTOPATHOL 2002 sàn; 17(3): 707-14. Ɲɛjirali dɔw. DOI: 10,14670/HH-17,707. Ɲɛjirali dɔw bɛ kɛ

[9] Andersen NB, F KMO, Johansen PB, Andreassen TT, Rtoft GO, Oxlund H. Bonya-hormone secretagogue Ipa bɛ glucocorticoïde (glucocorticoïdes) dɔgɔyali kɛlɛ balikuw kolo jɔli la. Bonya hormone & IGF ɲinini : bonya hormone ɲinini jɛkulu ni diɲɛ IGF ɲinini jɛkulu ka gafe ofisiyali san 2001; 11 5: 266-72.DOI:10.1054/GHIR.2001.0239. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew.

BƐƐRƐ KUNNAFONIW NI FƐRƐW KUNNAFONIW BƐƐ MIN BƐ NI WEBSITE KAN NA, olu BƐ KUNNAFONIW FƆLƆ DƆRƆN NI KALANSENW YE.  

Fɛn minnu bɛ di nin siti in kan, olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *in glass*, o kɔrɔ ye gilasi minɛnw na) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.