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1kits （10Ibikoresho）
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Imiterere ya Ipa
Inkomoko: PubChem |
Urukurikirane: XHXFK Inzira ya molekulari: C 38H 49N 9O.5 Uburemere bwa molekuline: 711.9 g / mol Numero ya CAS: 170851-70-4 PubChem CID: 9831659 Synonyme: NNC-26-0161 ； UNII-Y9M3S784Z6 ； Ipa ACETATE |
Research Ipa Ubushakashatsi
Ni ubuhe bushakashatsi bwakozwe na Ipa?
Gutinda gukuramo gastrici ni ibintu bisanzwe, kandi kuri ubu, hari uburyo bwiza bwo kuvura. Ubushakashatsi bwerekanye ko Ipa, nka peptidomimetike ikora, ikora kuri reseptor ya ghrelin kandi ishobora kugira ingaruka zo kuvura gutinda gusohora gastric. Mu bushakashatsi bwakozwe ku cyitegererezo cy’imbeba ya gastroparesis, gastroparesis yatewe no kubaga inda no gukoresha amara, kandi byagaragaye ko Ipa ishobora kwihutisha gusiba gastric [1].
Ileus nyuma yibikorwa ni ikibazo gikomeye mubikorwa byubuvuzi, bidafite ingamba zifatika zo kuyobora. Ghrelin reseptor stimulation igira ingaruka-itera imbaraga kubice byo hejuru no hepfo byinzira ya gastrointestinal. Nka ghrelin reseptor agonist, Ipa ifite agaciro gashobora gukoreshwa mukuvura ileus nyuma yibikorwa. Kurugero, mubushakashatsi bwakozwe, ubushakashatsi buteganijwe, buteganijwe, bugenzurwa nubushakashatsi bwakozwe ku barwayi batewe amara nyuma yo kubagwa mu nda kugirango basuzume umutekano n’akamaro ka Ipa [2].
Ipa ni iy'imisemburo ikura irekura peptide (GHRPs), ikaba ari pentapeptide ya syntetique ishobora gutera imbaraga zo gusohora imisemburo ikura ikomoka kuri hypothalamus na glande ya pitoito. Imisemburo ikura igira uruhare runini mu mikurire y’umubiri, gusana, no guhindagurika, bityo uruhare rwa Ipa mu kugenga imisemburo ikura na rwo rwashimishije abantu benshi [3].
Bitewe n'akamaro kayo mu kuvura gutinda kwa gastrici gutinda, ileus nyuma yo kubagwa, n'uruhare rwayo nka hormone yo gukura irekura peptide, Ipa yakunze ubushakashatsi cyane.
Ni ubuhe buryo bwo gukora bwa Ipa?
1. Gukangurira gusohora imisemburo ikura:
Ipa ni iy'imisemburo ikura irekura peptide (GHRPs), ishobora gutera imbaraga zo gusohora imisemburo ikura muri hypothalamus na glande ya pitoito. Muri vitro no mubushakashatsi bwa vivo, Ipa yerekanye imbaraga ningirakamaro mukurekura imisemburo ikura. Kurugero, mubushakashatsi, imbaraga nimbaraga za Ipa mukurekura imisemburo ikura mungirangingo yibanze ya pituito yari imeze nka GHRP-6 [3] . Uburyo bwibikorwa ni ugukangurira gusohora imisemburo ikura mugukoresha reseptor zimeze nka GHRP. Binyuze mu isesengura rya farumasi, hemejwe ko nka GHRP-6, Ipa itera kurekura imisemburo ikura binyuze muri reseptor zimeze nka GHRP.
2. Ingaruka ku nzira ya gastrointestinal
Kwihutisha ubusa gastric:
Muburyo bwimbeba, Ipa irashobora kwihuta gusiba gastric. Kubaga inda biganisha ku gutinda kwa gastrica, ariko nyuma yo gutanga Ipa (0.014 µmol / kg imitsi), gusiba gastric byihuta cyane. Ipa itera ubwonko bwa gastrica kandi yihutisha gusohora gastrici binyuze muburyo bwahujwe no gukora reseptor ya ghrelin, irimo neuron ya cholinergic ishimishije (Greenwood-Van Meerveld B, 2012).
Kunoza ibimenyetso bya ileus nyuma yo kubagwa:
Muburyo bwimbeba ya ileus nyuma yo kubagwa, Ipa irashobora kunoza ibimenyetso. Nyuma yubuyobozi bwa Ipa nyuma yubuvuzi, ikinini kimwe cya Ipa (1mg / kg) cyangwa GHRP-6 (20μg / kg) gishobora kugabanya igihe cyo kwiyuhagira bwa mbere. Gusubiramo inshuro nyinshi Ipa (0.1 cyangwa 1mg / kg) birashobora kongera cyane umusaruro mwinshi wa fecal, gufata ibiryo, no kongera ibiro [4].
3. Ingaruka ku gusohora kwa insuline
Ipa irashobora gutuma insuline isohoka mubice bya pancreatic tissue ibice byimbeba zisanzwe na diyabete. Ubwiyongere bw'isohoka rya insuline buterwa na Ipa burashobora guhagarikwa cyane na diltiazem, yohimbine, propranolol, cyangwa guhuza atropine, propranolol, na yohimbine. Imbeba za diyabete, atropine irashobora kugabanya cyane imisemburo ya insuline iterwa na Ipa, ariko iyi ngaruka ntabwo igaragara mu mbeba zisanzwe. Ibi byerekana ko Ipa itera gusohora insuline ikoresheje umuyoboro wa calcium n'inzira ya reseptor ya adrenergic [5].
4. Kugabanya ububabare
Muburyo bwubushakashatsi bwa hypersensitivite ya visceral na inflammatory allodynia, Ipa, nka ghrelin reseptor agonist yagabanijwe, irashobora kugabanya cyane hyperensitivite ya colonike na allodynia. Uburyo bwibikorwa byabwo bwahujwe na reseptor ya ghrelin, kandi izo ngaruka zirwanya anticociceptive zirashobora guhagarikwa na ghrelin reseptor antagonist H0900 [6].
S uburyo ingaruka za Ipa ku gusohora kwa insuline ziva mubice bya pancreatic tissue ibice byimbeba zisanzwe na diyabete.
Inkomoko: PubMed [5]
Ni ubuhe buryo bukoreshwa na Ipa?
1. Guteza imbere kurekura imisemburo ikura
Ipa irashobora gutuma habaho gusohora imisemburo ikura muri hypothalamus na glande ya pitoito. Imisemburo ikura igira uruhare runini mu mubiri w'umuntu, harimo guteza imbere intungamubiri za poroteyine, ikwirakwizwa ry'uturemangingo, no gusana ingirangingo. Kubwibyo, Ipa irashobora gukoreshwa mukuvura kubura imisemburo ikura cyangwa izindi ndwara zijyanye no kubura imisemburo ikura [7].
2. Kunoza imikorere ya gastrointestinal
Kwihutisha ubusa gastric:
Muri moderi yimbeba, Ipa yihutisha gusohora gastrica muburyo bwa ileus nyuma yo kubagwa hakoreshejwe uburyo bwahujwe no gukora imisemburo ikura irekura peptide reseptor, irimo neuron ya cholinergique itera imbaraga [1] . Kubaga mu nda biganisha ku gutinda kwa gastrica, kandi imiyoborere ya Ipa irashobora kugabanya cyane igipimo cyibiribwa bisigaye mu gifu, bityo bikagenda neza.
Gutezimbere gastrointestinal peristalsis:
Muburyo bwimbeba ya ileus nyuma yo kubagwa, Ipa irashobora kunoza ibimenyetso byabarwayi. Kurugero, muburyo bwimbeba, Ipa irashobora kugabanya igihe cyo kwandura bwa mbere nyuma yo kubagwa, kongera umusaruro wa fecal, gufata ibiryo, no kongera ibiro [4] . Gusubiramo inshuro nyinshi Ipa birashobora kongera cyane umusaruro mwinshi wa fecal, gufata ibiryo, no kongera ibiro, byerekana ingaruka nziza zogukora kumikorere ya gastrointestinal.
3. Kugabanya ububabare
Kugabanya ububabare bwa visceral na somatike:
Ubushakashatsi bwerekana ko Ipa, nka hormone yo gukura irekura peptide reseptor agonist, ifite imiti igabanya ubukana. Muburyo bwubushakashatsi butagira epithelial colonique, Ipa irashobora kugabanya cyane hyperensitivite ya visceral visceral hypertensitivite na allodynia ya somatike [6].
Uburyo bwibikorwa byabwo bushobora guhuzwa na hormone yo gukura irekura peptide reseptor, ikagira uruhare mukugenzura hyperensitivite ya visceral na somatike, itanga uburyo bushya bwo kuvura ububabare bukabije bwimyanya ndangagitsina na somatike.
Ni ubuhe bushakashatsi bwakozwe na Ipa mu kuvura kubura imisemburo ikura?
Gukura imisemburo ya hormone ni indwara iterwa no gusohora kudahagije imisemburo ikura iva mu mitsi ya pitoito y'imbere, ishobora kugira ingaruka ku mikurire no gukura kw'abana ndetse no guhindagurika k'umubiri w'abantu bakuru. Mu myaka yashize, Ipa, nk'imisemburo ikura ya secretagogue, yakunze kwitabwaho cyane mu kuvura ibura ry'imisemburo ikura. Ibikurikira niterambere ryubushakashatsi bwa Ipa mukuvura kubura imisemburo ikura.
1. Ingaruka zikangura Ipa kumisemburo ikura
Ipa irashobora gutuma imisemburo ikura. Ubushakashatsi bwerekana ko Ipa ishobora gukorana hamwe na hormone yo gukura irekura imisemburo (GHRH) kugirango yongere imisemburo ikura [8] . Mu bushakashatsi bw’inyamaswa, nyuma yiminsi 21 yo kuvura karande hamwe na Ipa mu mbeba z’abakobwa bakiri bato, ugereranije nitsinda rishinzwe kugenzura, imisemburo yo gukura yibanze mu muco wa monolayeri y’ingirabuzimafatizo ya pitoito yariyongereye. Muri icyo gihe, Ipa na GHRH birashobora gutuma imisemburo ikura iva mu ngirabuzimafatizo zifite imiterere ya vitro. Nyamara, mu itsinda ryitegura rya GHRH, imisemburo ikura nyuma yo gukura kwatewe no gukanguka ntabwo yongerewe imbaraga, mu gihe mu itsinda ryitiriwe Ipa, nta kintu na kimwe cyigeze kibaho, byerekana ko Ipa itatuma umuntu yanga imisemburo ikura y’imbeba z’abakobwa [8].
2. Ingaruka za Ipa kubyongera ibiro
Imiyoborere idakira ya Ipa irashobora kongera neza uburemere bwimbeba zabakobwa. Igenzura rya buri munsi ryerekana ko ijanisha ryiyongera ryibiro mumatsinda yo kwitegura Ipa hamwe nitsinda rya GHRH risumba ayandi murwego rwo kugenzura [8] . Ibi bifitanye isano nuko Ipa itera ururenda rwa hormone yo gukura, ari nako itera intungamubiri za poroteyine no gukura kwa selile.
3. Ingaruka ya Ipa kumiterere yamagufwa
Muburyo bwimbeba yimbeba ikuze, byagaragaye ko imisemburo ikura ya secretagogue Ipa ishobora kurwanya ingaruka za catabolike ya glucocorticoide (GC) kumitsi ya skelete. Ugereranije n'itsinda ryatewe na GC ryonyine, mu nyamaswa zatewe na GC na Ipa, impagarara nyinshi za tetanike z'imitsi y'inyana ziyongereye ku buryo bugaragara, kandi igipimo cy'amagufwa ya periosteal cyiyongereyeho kane [8, 9] . Ibi byerekana ko Ipa igira ingaruka nziza mukubungabunga imbaraga zimitsi no guteza imbere amagufwa, kandi irashobora gufasha kwirinda ingorane nka osteoporose kubarwayi bafite imisemburo ikura.
4. Ingaruka ya Ipa kumikorere ya gastrointestinal
Nkumusemburo ukura wimisemburo irekura imisemburo agonist na hormone ikura ya peptide reseptor agonist, Ipa yerekanye uburyo bwiza bwo kuvura muburyo bwimbeba yimiterere yimitsi yo munda nyuma yo gutangira. Imiyoborere imwe ya Ipa cyangwa imisemburo ikura ya peptide (GHRP) -6 yagabanije igihe cyo gutangira amara ya mbere nyuma yo kubagwa, ariko ntibyagize ingaruka ku musemburo wa fecal, gufata ibiryo, cyangwa kongera ibiro. Ipa yongera umusaruro mwinshi wa fecal, gufata ibiryo, no kongera ibiro. Ibi byerekana ko Ipa ishobora kugira uruhare runini mugutezimbere imikorere ya gastrointestinal kandi ishobora gufasha kunoza imikorere yigifu no kwinjiza abarwayi bafite imisemburo ikura. [4].
Muri make, nka poroteyine yo gukura ikura itoranya, Ipa itera imbaraga cyane kurekura imisemburo ikura ikora imisemburo ikura peptide reseptor (GHS reseptor), itagize ingaruka zikomeye kurwego rwa hormone adrenocorticotropique (ACTH) na cortisol. Mubikorwa byayo harimo guteza imbere imisemburo ikura, kugabanya umuvuduko wa gastrointestinal, no kugabanya ububabare. Guhitamo kwinshi hamwe nibiranga intego nyinshi bitanga ubushobozi bwo kuvura, bigatuma bikoreshwa mugihe nko kubura imisemburo ikura, guhagarika amara nyuma yo kubagwa, no gucunga ububabare.
Ibyerekeye Umwanditsi
Ibikoresho byavuzwe haruguru byose byakorewe ubushakashatsi, byahinduwe kandi byakozwe na Cocer Peptides.
Umwanditsi w'ikinyamakuru
Raun K ni umushakashatsi ufatanije na kaminuza ya tekinike ya Danemarke (DTU) na Fondasiyo ya Novo Nordisk. Inyungu zubushakashatsi bwe zikubiyemo amasomo menshi, harimo Endocrinology & Metabolism, Orthopedics, Imirire & Dietetics, Science Veterinary Science, naEngineering. Ibikorwa bye bikunze kwibanda ku iterambere ryibisubizo birambye kandi bishya, cyane cyane mubijyanye nubumenyi bwibinyabuzima nubukungu bushingiye kuri bio.
Raun K yagize uruhare mu mishinga ijyanye n’ikigo cya Novo Nordisk Foundation gishinzwe kubungabunga urusobe rw’ibinyabuzima muri DTU, igamije guteza imbere igishushanyo mbonera cy’inganda, ubwubatsi bwa metabolojiya, hamwe n’ibinyabuzima byifashishwa mu binyabuzima birambye. Byongeye kandi, yagize uruhare mu bushakashatsi bugamije kugabanya gushingira ku bikoresho bishingiye ku myanda no guteza imbere inzibacyuho binyuze mu bisubizo by’ibinyabuzima.
Ibikorwa bye binareba no mubikorwa byubwubatsi, nko guteza imbere catalizator na bioprocesses kugirango inganda n’ibidukikije bibungabungwa. Uburyo butandukanye bwa Raun K buhuza ubushakashatsi bwa siyansi n’uburyo bukoreshwa, butanga umusanzu ukomeye haba mu masomo n’inganda. Raun K yanditse kurutonde rwerekana [3].
