|
1kits (10Vials) .
| Agbɔsɔsɔ: | |
|---|---|
▎ Ipa ƒe Dɔwɔɖoɖo
Dzɔtsoƒe: PubChem |
Nusiwo kplɔ wo nɔewo ɖo: XHXFK Molekyulãwo ƒe Mɔfiame: C 38H 49N 9O5 Molekyulãwo ƒe Kpekpeme: 711.9 g/mol CAS ƒe xexlẽdzesi: 170851-70-4 PubChem ƒe CID: 9831659 Nya siwo sɔ kple wo nɔewo: NNC-26-0161;UNII-Y9M3S784Z6;Ipa ACETATE |
▎ Ipa Numekuku
Nukae nye Ipa ƒe numekuku?
Dɔgbo me tsi ƒuƒlu si tsi megbe nye nɔnɔme si bɔ, eye fifia la, atikewɔmɔnu nyui ʋɛ aɖewo koe li. Numekukuwo ɖee fia be Ipa, abe peptidomimetic si wowɔ ene, wɔa dɔ ɖe ghrelin xɔla dzi eye ate ŋu akpɔ ŋusẽ ɖe dɔgboa ƒe tsi ƒuƒlu si tsi megbe dzi le atikewɔwɔ me. Le numekuku aɖe si wowɔ le dɔgbo ƒe ʋuʋu ƒe kpɔɖeŋu si nye lãklewo ŋu me la, ƒodo ƒe dɔwɔwɔ kple dɔgbo ƒe asitɔtrɔ le dɔgboa ŋue na dɔgbo ƒe ʋuʋu, eye wokpɔe be Ipa ate ŋu ana dɔgboa ƒe tsi ƒuƒlu kabakaba [1] ..
Dɔwɔwɔ vɔ megbe ileus nye kuxi vevi aɖe le atikewɔnyawo me, eye atikewɔwɔmɔnu nyui aɖeke mele eme o. Ghrelin ƒe xɔla ƒe ʋuʋu kpɔa ŋusẽ ɖe dɔgboa ƒe akpa si le etame kple esi le ete siaa dzi si doa ʋuʋu ɖe ŋgɔ. Abe ghrelin receptor agonist ene la, asixɔxɔ si woate ŋu azã le Ipa ŋu le dɔwɔwɔ vɔ megbe ileus dada me. Le kpɔɖeŋu me, le numekuku aɖe me la, wowɔ numekuku aɖe si wowɔ le mɔkpɔkpɔ me, si wowɔ le vome, si me wokpɔ kpeɖodzi le, si dzi wokpɔ ŋusẽ ɖo le dɔnɔ siwo woɖe dɔgboa le le ƒodo ƒe dɔwɔwɔ vɔ megbe ŋu be woatsɔ ada Ipa ƒe dedienɔnɔ kple eƒe dɔwɔwɔ kpɔ [2]..
Ipa nye peptide siwo ɖea tsitsi ƒe lãmetsiwo (GHRPs) me tɔ, si nye pentapeptide si wowɔ si te ŋu doa ŋusẽ tsitsi ƒe lãmetsi si dona tso hypothalamus kple pituitary gland me. Tsitsi ƒe lãmetsi wɔa akpa vevi aɖe le ŋutilã ƒe tsitsi, edzadzraɖo, kple eƒe lãmenugbagbeviwo ƒe dɔwɔwɔ me, eyata akpa si Ipa wɔna le tsitsi ƒe lãmetsi ƒe ɖoɖowɔwɔ me hã he ame geɖe ƒe susu [3]..
Le asixɔxɔ si ate ŋu anɔ Ipa ŋu le dɔgboa ƒe ƒuƒlu si tsi megbe, dɔwɔwɔ vɔ megbe ƒe ƒunukpeƒetetedɔ, kple akpa si wòwɔna abe peptide si ɖea tsitsi ƒe lãmetsiwo ɖa ene dada me ta la, Ipa he numekuku geɖe ƒe susu.
Nukae nye Ipa ƒe dɔwɔwɔ ƒe mɔnu?
1. Tsitsi ƒe lãmetsiŋusẽ ƒe dodo:
Ipa nye peptide siwo ɖea tsitsi ƒe lãmetsiwo (GHRPs) me, siwo ate ŋu ana tsitsi ƒe lãmetsi nado tso hypothalamus kple pituitary gland me. Dodokpɔ siwo wowɔ le vitro kple le vivo me la, Ipa ɖe ŋusẽ gã aɖe fia eye wòwɔa dɔ nyuie le tsitsime lãmetsiŋusẽ ƒe dodo me. Le kpɔɖeŋu me, le numekuku aɖe me la, ŋusẽ kple dɔwɔwɔ si le Ipa ŋu le tsitsi ƒe lãmetsi si dona tso lãmenugbagbevi gbãtɔ siwo nye sisiblisi me la sɔ kple GHRP-6 tɔ [3] . Eƒe dɔwɔwɔ ƒe mɔnu enye be wòaʋã tsitsiŋusẽ ƒe dodo to GHRP-like receptors dɔwɔwɔ me. To atikeŋutinunya me numekuku me la, woɖo kpe edzi be abe GHRP-6 ene la, Ipa doa ŋusẽ tsitsiŋusẽ ƒe dodo to GHRP-like receptors dzi.
2. Ŋusẽkpɔɖeamedzi ɖe dɔgbo ƒe dɔwɔwɔ dzi
Dɔgbo me tsi ƒuƒlu kabakaba:
Le lãkle ƒe kpɔɖeŋuwo me la, Ipa ate ŋu ana dɔgboa ƒe tsi ƒuƒlu kabakaba. Dɔgbo ƒe dɔwɔwɔ nana be dɔgboa me tsi ƒua tsi megbe, gake ne wodo Ipa (0.014 μmol/kg to ʋuka me) vɔ la, dɔgboa me tsi ƒuƒlu kabakaba ŋutɔ. Ipa doa ŋusẽ dɔgbo ƒe ʋuʋu eye wònaa dɔgbo ƒe ƒuƒlu kabakaba to mɔnu si domenɔlae nye ghrelin xɔla ƒe dɔwɔwɔ, si lɔ cholinergic excitatory neurons ɖe eme (Greenwood-Van Meerveld B, 2012).
Dɔwɔwɔ vɔ megbe ileus ƒe dzesiwo ƒe nyonyo:
Le dɔdzẽ ƒe kpɔɖeŋu siwo wowɔ le dɔwɔwɔ vɔ megbe ƒe ileus me la, Ipa ate ŋu ana dzesiawo nanyo ɖe edzi. Le Ipa dodo vɔ megbe la, Ipa (1mg/kg) alo GHRP-6 (20μg/kg) ƒe agbɔsɔsɔ ɖeka ate ŋu aɖe ɣeyiɣi si woatsɔ aɖu aɖuɖɔ zi gbãtɔ dzi akpɔtɔ. Ipa (0.1 alo 1mg/kg) dodo enuenu ate ŋu ana aɖuɖɔ si dona le lãme na ame, nuɖuɖu si woɖuna, kple lolo nadzi ɖe edzi ŋutɔ [4]..
3. Ŋusẽ si wòkpɔna ɖe insulin ƒe dodo dzi
Ipa ate ŋu ana insulin nado le sisiblisi siwo sɔ kple esiwo ŋu suklidɔ le ƒe dɔgbo ƒe lãkusi kakɛwo me. Woate ŋu axe mɔ ɖe insulin ƒe dodo si Ipa hena vɛ ƒe dzidziɖedzi nu vevie to diltiazem, yohimbine, propranolol, alo atropine, propranolol, kple yohimbine ƒe ƒuƒoƒo zazã me. Le sisiblisi siwo ŋu suklidɔ le gome la, atropine ate ŋu aɖe insulin ƒe dodo si Ipa hena vɛ dzi akpɔtɔ ŋutɔ, gake womekpɔa ŋusẽ sia le sisiblisi siwo sɔ me o. Esia ɖee fia be Ipa doa ŋusẽ insulin ƒe dodo to calcium mɔnu kple adrenergic receptor mɔwo dzi [5]..
4. Vevesese dzi ɖeɖe kpɔtɔ
Le dodokpɔ ƒe kpɔɖeŋuwo me le non-inflammatory visceral hypersensitivity kple somatic mechanical allodynia me la, Ipa, abe ghrelin receptor agonist si ŋu seɖoƒe le le gota gome ene, ate ŋu aɖe dɔgbo ƒe seselelãme si gbɔ eme kple somatic allodynia dzi akpɔtɔ ŋutɔ. Eƒe dɔwɔwɔ ƒe mɔnu nye domenɔla to ghrelin xɔla gbɔ, eye dɔlékuiwutike sia ate ŋu axe mɔ na ghrelin xɔla ƒe mɔxenu H0900 [6] ..
Ekpɔ ŋusẽ si Ipa kpɔna ɖe insulin ƒe dodo tso dɔgbo ƒe lãkusi kakɛ siwo le sisiblisi siwo sɔ kple suklidɔlélawo me dzi.
Dzɔtsoƒe:PubMed [5] .
Nukae nye Ipa ƒe dɔwɔwɔwo?
1. Tsitsi ƒe lãmetsi ƒe dodo ɖe ŋgɔ
Ipa ate ŋu ana tsitsi ƒe lãmetsiŋusẽ nado le hypothalamus kple pituitary gland me. Tsitsi ƒe lãmetsi wɔa akpa vevi aɖe le amegbetɔ ƒe ŋutilã me, eye wòdoa protein ƒe wɔwɔme, lãmenugbagbeviwo ƒe dzidziɖedzi, kple lãmenugbagbeviwo ɖɔɖɔɖo ɖe ŋgɔ. Eyata woateŋu azã Ipa atsɔ ada tsitsi ƒe lãmetsi ƒe anyimanɔmanɔ alo dɔléle bubu siwo do ƒome kple tsitsi ƒe lãmetsi ƒe dɔmawɔmawɔ nyuie [7]..
2. Dɔgbo ƒe dɔwɔwɔ nyuie wu
Dɔgbo me tsi ƒuƒlu kabakaba:
Le lãkle ƒe kpɔɖeŋuwo me la, Ipa naa ƒodo ƒe ƒuƒlu kabakaba le dɔwɔwɔ vɔ megbe ileus ƒe kpɔɖeŋuwo me to mɔnu si domenɔlae nye tsitsi ƒe lãmetsi si ɖea peptide xɔla ƒe dɔwɔwɔ, si lɔ cholinergic excitatory neurons ɖe eme [1] . Dɔgbo ƒe dɔwɔwɔ nana be dɔgboa ƒe ʋuʋu tsi megbe, eye Ipa dodo ate ŋu aɖe nuɖuɖu susɔe siwo le dɔgboa me ƒe agbɔsɔsɔ dzi akpɔtɔ ŋutɔ, si ana dɔgboa ƒe ʋuʋu nanyo ɖe edzi.
Dɔgbo ƒe peristalsis dodo ɖe ŋgɔ:
Le ʋetsuviwo ƒe dɔwɔwɔ vɔ megbe ileus ƒe kpɔɖeŋuwo me la, Ipa ate ŋu ana dɔnɔwo ƒe dzesiwo nanyo ɖe edzi. Le kpɔɖeŋu me, le sisiblisi ƒe kpɔɖeŋu me la, Ipa ate ŋu aɖe ɣeyiɣi si wotsɔ ɖea aɖuɖɔ zi gbãtɔ le amekoko megbe dzi akpɔtɔ, ana aɖuɖɔ si dona, nuɖuɖu, kple lolo nadzi ɖe edzi [4] . Ipa dodo enuenu ate ŋu ana aɖuɖɔ si woƒo ƒu, nuɖuɖu si woɖuna, kple lolo nadzi ɖe edzi ŋutɔ, si fia be ekpɔa ŋusẽ nyui ɖe dɔgboa ƒe dɔwɔwɔ dzi le ɖoɖowɔwɔ me.
3. Vevesese dzi ɖeɖe kpɔtɔ
Vevesese si le lãkusi kple ŋutilã me dzi ɖeɖe kpɔtɔ:
Numekukuwo ɖee fia be Ipa, abe tsitsime lãmetsi si ɖea peptide receptor agonist ene la, ƒe dɔlékuiwutikewo le esi. Le dodokpɔ ƒe kpɔɖeŋu siwo me dɔgbo ƒe lãkusi me dɔdzẽ mele o me la, Ipa ate ŋu aɖe lãkusi ƒe dɔléle si menye dɔdzẽ o kple somatic mechanical allodynia dzi akpɔtɔ ŋutɔ [6]..
Eƒe dɔwɔwɔ ƒe mɔnu ate ŋu anye domenɔla na tsitsi ƒe lãmetsi si ɖea asi le peptide xɔla ŋu, si kpɔa gome le lãkusi kple ŋutilã ƒe seselelãme si gbɔ eme ƒe ɖoɖowɔwɔ me, si ana mɔnu yeye si ate ŋu anɔ lãmekawo kple ŋutilã me vevesese sesẽwo dada.
Nukae nye numekuku ƒe ŋgɔyiyi si Ipa wɔ le tsitsime lãmetsiŋusẽ ƒe anyimanɔmanɔ dada me?
Tsitsi ƒe lãmetsi ƒe anyimanɔmanɔ nye dɔléle si tsoa tsitsi ƒe lãmetsi si mesɔ gbɔ o tso ŋgɔgbe lãkusi me, si ate ŋu akpɔ ŋusẽ ɖe ɖeviwo ƒe tsitsi kple tsitsi kpakple ame tsitsiwo ƒe ŋutilã ƒe asitɔtrɔ dzi. Le ƒe ʋɛ siwo va yi me la, Ipa, abe tsitsime lãmetsiŋusẽ ƒe ʋuʋudedi ene, he amewo ƒe susu le tsitsime lãmetsiŋusẽ ƒe anyimanɔmanɔ dada me. Nusiwo gbɔna nye numekuku ƒe ŋgɔyiyi si sɔ le Ipa ŋu le tsitsi ƒe lãmetsiŋusẽ ƒe anyimanɔmanɔ dada me.
1. Ŋusẽ si Ipa kpɔna ɖe tsitsi ƒe lãmetsiŋusẽ ƒe dodo dzi si doa ŋusẽ ame
Ipa ate ŋu aʋã tsitsi ƒe lãmetsi si dona le lãme na ame. Numekukuwo ɖee fia be Ipa ateŋu awɔ dɔ aduadu kple tsitsi ƒe lãmetsi si ɖea lãmetsiŋusẽ (GHRH) be wòana tsitsi ƒe lãmetsi ƒe dodo nadzi ɖe edzi [8] . Le lãwo dodokpɔwo me la, le Ipa zazã atraɖii ŋkeke 21 megbe le sisiblisi nyɔnuvi suewo me, ne wotsɔe sɔ kple ƒuƒoƒo si me wokpɔa wo gbɔ le la, basal growth hormone ƒe dodo le pituitary cells ƒe monolayer culture me dzi ɖe edzi. Le ɣeyiɣi ma ke me la, Ipa kple GHRH ate ŋu aʋã tsitsiŋusẽ ƒe dodo tso lãkusi me lãmenugbagbevi siwo wode agble me le vitro. Gake le GHRH ƒe ƒuƒoƒo si wowɔ do ŋgɔ na atikewɔwɔ me la, tsitsi ƒe lãmetsiŋusẽ ƒe ŋuɖoɖo si kplɔe ɖo ɖe dzideƒoname ŋu medzi ɖe edzi o, gake le Ipa ƒe ƒuƒoƒo si wowɔ do ŋgɔ na atikewɔwɔ me la, nudzɔdzɔ aɖeke menɔ anyi si me woɖea seselelãme ɖa le o, si ɖee fia be Ipa mehea tsitsi ƒe lãmetsiŋusẽ ƒe ŋuɖoɖo ƒe seselelãme dzi ɖeɖe kpɔtɔ vɛ le sisiblisi nyɔnuvi suewo me o [8]..
2. Ŋusẽ si Ipa kpɔna ɖe lolo dzi
Ipa dodo atraɖii ate ŋu ana sisiblisi nyɔnuviwo ƒe kpekpeme nadzi ɖe edzi nyuie. Gbesiagbe ŋkuléle ɖe eŋu ɖee fia be kpekpeme ƒe dzidziɖedzi ƒe alafa memamã le Ipa ƒe ƒuƒoƒo si do ŋgɔ na atikewɔwɔ kple GHRH ƒe ƒuƒoƒo si do ŋgɔ na atikewɔwɔ me sɔ gbɔ wu esi le ƒuƒoƒo si me wokpɔa wo gbɔ le me [8] . Esia do ƒome kple nyateƒe si wònye be Ipa doa ŋusẽ tsitsi ƒe lãmetsi si dona, si hã doa protein ƒe wɔwɔme kple lãmenugbagbeviwo ƒe tsitsi ɖe ŋgɔ.
3. Ŋusẽ si Ipa kpɔna ɖe ƒu ƒe wɔwɔme dzi
Le sisiblisi tsitsi ƒe kpɔɖeŋu aɖe me la, wokpɔe be tsitsiŋusẽ ƒe lãmetsi si woɖena tsoa lãme na ame si nye Ipa ate ŋu atsi glucocorticoids (GC) ƒe catabolic ŋusẽkpɔɖeamedzi ɖe ƒunukpeƒeŋusẽ kple ƒu dzi nu. Ne wotsɔe sɔ kple ƒuƒoƒo si wodo GC ɖeɖeko la, le lã siwo wodo GC kple Ipa siaa me la, tetanic tension si sɔ gbɔ wu le nyitsu ƒe lãmeka me dzi ɖe edzi ŋutɔ, eye ƒu ƒe wɔwɔme le ƒunukpeƒewo dzi ɖe edzi zi gbɔ zi ene [8, 9] . Esia ɖee fia be Ipa kpɔa ŋusẽ nyui ɖe lãmekawo ƒe ŋusẽ me léle ɖe asi kple ƒu ƒe wɔwɔme dodo ɖe ŋgɔ dzi, eye ate ŋu akpe ɖe ame ŋu be woaxe mɔ ɖe kuxiwo abe ƒumeŋuɖui ene nu le dɔnɔ siwo ƒe tsitsime lãmetsiŋusẽ mele o ŋu.
4. Ŋusẽ si Ipa kpɔna ɖe dɔgboa ƒe dɔwɔwɔ dzi
Abe tsitsime lãmetsiŋusẽtike si ɖea lãmetsiŋusẽtike tiatia kple tsitsimeŋusẽ si ɖea peptide xɔla agonist ene la, Ipa ɖe atikewɔwɔ ƒe ŋutete fia le sisiblisi ƒe kpɔɖeŋu si wowɔ le dɔwɔwɔ vɔ megbe dɔgbo ƒe lãmetutudɔ ŋu me. Ipa alo peptide si ɖea tsitsimeŋusẽ (GHRP)-6 zazã zi ɖeka na ɣeyiɣi si wotsɔ ʋua dɔgbo zi gbãtɔ le dɔwɔwɔ vɔ megbe la dzi ɖe kpɔtɔ, gake mekpɔ ŋusẽ aɖeke ɖe aɖuɖɔ si dona le lãme na ame ƒe ƒuƒoƒo, nuɖuɖu si woɖuna, alo lolo dzi o. Ipa dzia aɖuɖɔ si dona le lãme na ame, nuɖuɖu si woɖuna, kple lolo ɖe edzi. Esia fia be Ipa ate ŋu awɔ akpa aɖe le dɔgboa ƒe dɔwɔwɔ nyuie wu me eye ate ŋu akpe ɖe nuɖuɖumeŋusẽ kple nuléle ƒe dɔwɔwɔ ŋu wòanyo ɖe edzi le dɔnɔ siwo ƒe tsitsime lãmetsiŋusẽ mele o me. [4] ..
Kpuie ko la, abe tsitsime lãmetsiŋusẽ ƒe ʋuʋu ƒe mɔ̃ tiatia ene la, Ipa doa ŋusẽ tsitsi ƒe lãmetsi ƒe dodo nyuie to tsitsi ƒe lãmetsi si ɖea peptide xɔla (GHS receptor) ƒe dɔwɔwɔ me, evɔ mekpɔa ŋusẽ boo aɖeke ɖe adrenocorticotropic hormone (ACTH) kple cortisol ƒe agbɔsɔsɔ dzi o. Eƒe dɔwɔwɔwo dometɔ aɖewoe nye tsitsime lãmetsiŋusẽ ƒe dodo ɖe ŋgɔ, dɔgbo ƒe dɔwɔwɔ nyuie, kple vevesese dzi ɖeɖe kpɔtɔ. Eƒe tiatiawɔwɔ gã kple taɖodzinu geɖe ƒe nɔnɔmewo naa ŋutete be woazãe le dɔdaƒewo, si wɔe be wòsɔ be woazãe le nɔnɔmewo abe tsitsime lãmetsiŋusẽ ƒe anyimanɔmanɔ, dɔgbo ƒe mɔxexe le dɔwɔwɔ vɔ megbe, kple vevesese dzi ɖuɖu me.
Le Agbalẽŋlɔla La Ŋu
Nusiwo míeyɔ ɖe etame la katã nye esiwo ŋu Cocer Peptides wɔ numekuku le, trɔ asi le wo ŋu eye woƒo wo nu ƒu.
Dzɔdzɔmeŋutinunya ƒe Agbalẽŋlɔla
Raun K nye numekula si do ƒome kple Denmark ƒe Mɔ̃ɖaŋu Yunivɛsiti (DTU) kple Novo Nordisk Foundation. Eƒe numekuku ƒe didiwo ƒo nu tso nu vovovowo ŋu, siwo dometɔ aɖewoe nye Endocrinology & Metabolism, Orthopedics, Nutrition & Dietetics, Veterinary Sciences, andEngineering. Zi geɖe la, eƒe dɔa ku ɖe egbɔkpɔnu siwo li tegbee kple esiwo me nu yeyewo le ƒe ŋgɔyiyi ŋu, vevietɔ le nugbagbeŋutinunya kple ganya siwo wotu ɖe nugbagbewo dzi ƒe nyawo me.
Raun K kpe asi ɖe dɔ siwo ku ɖe Novo Nordisk Foundation Center for Biosustainability ŋu le DTU, si tsɔ eɖokui na be yeado lãmenugbagbeviwo ƒe dɔwɔƒewo ƒe ɖoɖowɔwɔ ɖe ŋgɔ, lãmenugbagbeviwo ƒe dɔwɔwɔ, kple nugbagbeŋutinunya si wowɔ hena nugbagbewo wɔwɔ si li tegbee. Tsɔ kpe ɖe eŋu la, ekpɔ gome le numekuku ƒe ɖoɖo siwo ƒe taɖodzinue nye be woaɖe ŋuɖoɖo ɖe nusiwo wotu ɖe tomenukuku dzi dzi akpɔtɔ eye woado tɔtrɔ siwo me womezãa nu gbagbewo le o ɖe ŋgɔ to nugbagbewo wɔwɔ ƒe kuxiwo gbɔ kpɔnu dzi.
Eƒe dɔa ku ɖe mɔ̃ɖaŋununya ƒe dɔwɔwɔwo hã ŋu, abe nusiwo naa nu ʋãna kple nugbagbewo ƒe dɔwɔwɔ hena dɔwɔƒewo kple nutome ƒe nyonyome ene. Raun K ƒe mɔnu si wozãna le nusɔsrɔ̃ vovovowo me la ƒoa dzɔdzɔmeŋutinunya me numekuku kple wo zazã ŋutɔŋutɔ nu ƒu, eye wòwɔa akpa vevi aɖe le sukudede kple dɔwɔƒewo siaa me. Woŋlɔ Raun K ŋkɔ ɖe nyayɔyɔ ƒe numekugbalẽ me [3].
