|
1 kits (10 Vials)
| Yawan: | |
|---|---|
▎ Tsarin Ipa
Source: PubChem |
Jerin: XHXFK Tsarin kwayoyin halitta: C 38H 49N 9O5 Nauyin Kwayoyin Halitta: 711.9 g/mol Lambar CAS: 170851-70-4 Saukewa: 9831659 Synonyms: NNC-26-0161;UNII-Y9M3S784Z6;Ipa ACETATE |
▎ Ipa Bincike
Menene asalin binciken Ipa?
Jinkirin zubar da ciki wani yanayi ne na kowa, kuma a halin yanzu, akwai ƴan zaɓuɓɓukan magani masu inganci. Bincike ya gano cewa Ipa, a matsayin peptidomimetic na roba, yana aiki akan mai karɓa na ghrelin kuma yana iya samun sakamako na warkewa akan jinkirta zubar da ciki. A cikin binciken da aka yi akan samfurin gastroparesis na rodent, gastroparesis ya haifar da tiyata ta ciki da magudin hanji, kuma an gano cewa Ipa na iya hanzarta zubar da ciki [1]..
Bayan aikin gida babban ƙalubale ne a cikin aikin asibiti, rashin ingantaccen dabarun gudanarwa. Ƙwararrun mai karɓa na Ghrelin yana da tasiri mai haɓaka motsi a kan duka babba da ƙananan sassa na gastrointestinal tract. A matsayin agonist mai karɓar mai karɓa na ghrelin, Ipa yana da yuwuwar ƙimar aikace-aikacen a cikin jiyya na bayan tiyata. Alal misali, a cikin binciken, an gudanar da bincike mai yiwuwa, bazuwar, sarrafawa ta hanyar tabbatar da ra'ayi akan marasa lafiya da ke fama da ciwon hanji bayan tiyata na ciki don kimanta aminci da tasiri na Ipa [2].
Ipa yana cikin peptides na haɓakar haɓakar hormone mai sakin peptides (GHRPs), wanda shine pentapeptide na roba wanda ke iya haɓaka sakin hormone girma daga hypothalamus da glandan pituitary. Hormone mai girma yana taka muhimmiyar rawa wajen haɓakar jiki, gyarawa, da haɓakar haɓakar jiki, don haka rawar Ipa wajen daidaita yanayin girma ya jawo hankalin jama'a sosai [3]..
Saboda yuwuwar darajarsa wajen magance jinkirin zubar da ciki, bayan tiyata, da kuma matsayinsa na hormone girma mai sakin peptide, Ipa ya jawo hankalin bincike mai yawa.
Menene tsarin aikin Ipa?
1. Ƙarfafa sakin hormone girma:
Ipa yana cikin hormone girma peptides (GHRPs), wanda zai iya haifar da sakin hormone girma daga hypothalamus da pituitary gland shine yake. In vitro da in vivo gwaje-gwaje, Ipa ya nuna babban ƙarfi da inganci wajen sakin hormone girma. Alal misali, a cikin binciken, ƙarfin da tasiri na Ipa a cikin sakin hormone girma daga ƙananan ƙwayoyin pituitary na farko sun kasance daidai da na GHRP-6 [3] . Hanyar aikinta shine don tada sakin hormone girma ta hanyar kunna masu karɓa kamar GHRP. Ta hanyar nazarin magunguna, an tabbatar da cewa kamar GHRP-6, Ipa yana ƙarfafa sakin hormone girma ta hanyar GHRP-kamar masu karɓa.
2. Tasiri akan gastrointestinal tract
Hanzarta zubar ciki:
A cikin ƙirar rodent, Ipa na iya hanzarta zubar da ciki. Yin tiyatar cikin ciki yana haifar da jinkirin zubar da ciki, amma bayan gudanar da Ipa (0.014 μmol/kg cikin jini), zubar da ciki yana ƙaruwa sosai. Ipa yana ƙarfafa ƙanƙarar ciki kuma yana haɓaka ɓarna na ciki ta hanyar hanyar daidaitawa ta hanyar kunna mai karɓar ghrelin, wanda ya haɗa da ƙwayoyin cuta na cholinergic (Greenwood-Van Meerveld B, 2012).
Ingantattun alamomin ciwon bayan tiyata:
A cikin nau'ikan rodent na gidan bayan tiyata, Ipa na iya inganta alamun. Bayan gudanar da aikin Ipapa, kashi ɗaya na Ipa (1mg/kg) ko GHRP-6 (20μg/kg) na iya rage lokacin da za a yi bayan gida na farko. Maimaita sarrafa Ipa (0.1 ko 1mg/kg) na iya haɓaka yawan fitowar fecal, cin abinci, da riba mai nauyi [4].
3. Tasiri kan fitowar insulin
Ipa na iya tayar da fitowar insulin a cikin gutsuttsuran nama na al'ada da berayen masu ciwon sukari. Ƙarfafawar ƙwayar insulin ta hanyar Ipa za a iya hana shi sosai ta hanyar diltiazem, yohimbine, propranolol, ko haɗuwa da atropine, propranolol, da yohimbine. A cikin berayen masu ciwon sukari, atropine na iya rage haɓakar insulin ta hanyar Ipa, amma ba a lura da wannan tasirin a cikin berayen na yau da kullun. Wannan yana nuna cewa Ipa yana ƙarfafa sakin insulin ta hanyar tashar calcium da hanyoyin masu karɓa na adrenergic [5].
4. Rage ciwo
A cikin gwaje-gwajen gwaje-gwajen marasa kumburi visceral hypersensitivity da somatic inji allodynia, Ipa, a matsayin na gefe ƙuntatawa ghrelin receptor agonist, iya muhimmanci rage colonic hypersensitivity da somatic allodynia. Tsarin aikin sa yana yin sulhu ta hanyar mai karɓar ghrelin, kuma ana iya toshe wannan tasirin antinociceptive ta antagonist mai karɓar mai karɓar ghrelin H0900 [6].
S yaya tasirin Ipa akan fitowar insulin daga guntuwar nama na pancreatic na al'ada da berayen masu ciwon sukari.
Source:PubMed [5]
Menene aikace-aikacen Ipa?
1. Inganta sakin hormone girma
Ipa na iya haifar da sakin hormone girma daga hypothalamus da pituitary gland shine yake. Hormone na girma yana taka muhimmiyar rawa a cikin jikin mutum, ciki har da inganta haɓakar furotin, yaduwar kwayar halitta, da gyaran nama. Sabili da haka, ana iya amfani da Ipa don magance rashi na hormone girma ko wasu cututtuka da ke da alaka da rashin isasshen hormone girma [7].
2. Inganta aikin gastrointestinal
Hanzarta zubar ciki:
A cikin nau'ikan rodent, Ipa yana haɓaka zubar da ciki a cikin samfuran gidan bayan tiyata ta hanyar hanyar yin sulhu ta hanyar kunna hormone girma wanda ke sakin mai karɓar peptide, wanda ya haɗa da ƙananan ƙwayoyin cuta na cholinergic [1] . Yin tiyatar cikin ciki yana haifar da jinkirin zubar da ciki, kuma gudanarwar Ipa na iya rage yawan ragowar abinci a ciki, ta yadda zai inganta motsin ciki.
Inganta peristalsis gastrointestinal:
A cikin nau'ikan rodent na gidan bayan tiyata, Ipa na iya inganta alamun marasa lafiya. Alal misali, a cikin ƙirar bera, Ipa na iya rage lokacin da za a fara bayan gida bayan tiyata, ƙara yawan fitowar fecal, cin abinci, da nauyin nauyi [4] . Maimaita aikin Ipa na iya ƙara yawan fitowar fecal, cin abinci, da riba mai nauyi, yana nuna ingantaccen tasirin sa akan aikin gastrointestinal.
3. Rage ciwo
Rage ciwon visceral da ciwon somatic:
Bincike ya nuna cewa Ipa, a matsayin hormone girma mai sakin agonist peptide receptor agonist, yana da kaddarorin antinociceptive. A cikin samfura na gwaji ba tare da kumburin epithelial na colonic ba, Ipa na iya rage yawan rashin kumburin visceral hypersensitivity da somatic mechanical allodynia [6].
Hanyar aikinta na iya zama tsaka-tsaki ta hanyar hormone mai girma wanda ke sakin mai karɓar peptide, yana shiga cikin ka'idodin visceral da somatic hypersensitivity, yana ba da wata sabuwar hanyar da za ta iya magance ciwo mai tsanani na visceral da somatic.
Menene ci gaban bincike na Ipa a cikin maganin rashin lafiyar girma hormone?
Rashin girma na hormone cuta cuta ce da ke haifar da rashin isassun ƙwayar hormone girma daga glandar pituitary na baya, wanda zai iya rinjayar girma da ci gaban yara da kuma metabolism na jiki na manya. A cikin 'yan shekarun nan, Ipa, a matsayin sakatare na hormone girma, ya jawo hankalin tartsatsi a cikin maganin rashin lafiyar girma. Abin da ke biyo baya shine ci gaban bincike mai dacewa na Ipa a cikin maganin rashin lafiyar hormone girma.
1. The stimulating sakamako na Ipa a kan girma hormone mugunya
Ipa na iya tayar da ɓoyewar hormone girma. Bincike ya nuna cewa Ipa na iya yin aiki tare da haɓakar hormone mai sakin hormone (GHHRH) don haɓaka sakin hormone girma [8] . A cikin gwaje-gwajen dabba, bayan kwanaki 21 na jiyya na yau da kullun tare da Ipa a cikin ƙananan berayen mata, idan aka kwatanta da ƙungiyar kulawa, sakin basal girma na hormone a cikin al'adun monolayer na sel pituitary ya karu. A lokaci guda, Ipa da GHRH na iya haɓaka sakin hormone girma daga ƙwayoyin pituitary da aka haɓaka a cikin vitro. Duk da haka, a cikin GHRH pretreatment kungiyar, da m girma hormone amsa ga kara kuzari ba a inganta, yayin da a cikin Ipa pretreatment kungiyar, babu irin wannan desensitization sabon abu, yana nuna cewa Ipa ba ya haifar da desensitization na girma hormone amsa a cikin matasa mata berayen [8].
2. Tasirin Ipa akan karuwar nauyi
Gudanar da lokaci na Ipa yana iya haɓaka nauyin ƙananan berayen mata yadda ya kamata. Kulawa na yau da kullun yana nuna cewa yawan karuwar nauyi a cikin ƙungiyar pretreatment Ipa da ƙungiyar pretreatment na GHRH ya fi girma fiye da wanda ke cikin ƙungiyar kulawa [8] . Wannan yana da alaƙa da gaskiyar cewa Ipa yana haɓaka haɓakar haɓakar hormone girma, wanda hakan ke haɓaka haɓakar furotin da haɓakar tantanin halitta.
3. Tasirin Ipa akan samuwar kashi
A cikin babban nau'in bera, an gano cewa secretagogue na hormone mai girma Ipa zai iya magance tasirin catabolic na glucocorticoids (GC) akan ƙwayar kwarangwal da kashi. Idan aka kwatanta da ƙungiyar da aka yi wa GC kadai, a cikin dabbobin da aka yi musu allura tare da GC da Ipa, matsakaicin tashin hankali na tetanic na tsokar maraƙi ya karu sosai, kuma haɓakar kashi na periosteal ya karu sau hudu [8, 9] . Wannan yana nuna cewa Ipa yana da tasiri mai kyau a kan kiyaye ƙarfin tsoka da inganta haɓakar kashi, kuma yana iya taimakawa wajen hana rikitarwa irin su osteoporosis a cikin marasa lafiya tare da ƙarancin hormone girma.
4. Sakamakon Ipa akan aikin gastrointestinal
A matsayin zaɓin haɓakar haɓakar haɓakar haɓakar agonist mai sakin hormone da haɓakar hormone mai sakin peptide agonist agonist, Ipa ya nuna tasirin warkewa a cikin ƙirar linzamin kwamfuta na intestinal intestinal postoperative. Gudanarwa guda ɗaya na Ipa ko peptide mai sakin hormone girma (GHRP) -6 ya rage lokacin zuwa motsin hanji na farko bayan aiki, amma ba shi da wani tasiri akan yawan fitowar fecal, cin abinci, ko riba mai nauyi. Ipa yana ƙara yawan fitowar fecal, cin abinci, da samun nauyi. Wannan yana nuna cewa Ipa na iya samun wata rawa wajen inganta aikin gastrointestinal kuma zai iya taimakawa wajen inganta aikin narkewa da sha a cikin marasa lafiya tare da raunin hormone girma. [4].
In summary, as a selective growth hormone secretion promoter, Ipa efficiently stimulates the release of growth hormone by activating the growth hormone-releasing peptide receptor (GHS receptor), without significantly affecting the levels of adrenocorticotropic hormone (ACTH) and cortisol. Ayyukanta sun haɗa da haɓaka haɓakar haɓakar haɓakar hormone girma, daidaita motsin ciki, da rage zafi. Babban zaɓinsa da halaye masu yawa na manufa suna ba da yuwuwar aikace-aikacen asibiti, yana sa ya dace don amfani da shi a cikin yanayi kamar ƙarancin haɓakar hormone, toshewar hanji bayan aiki, da kula da jin zafi.
Game da Marubuci
Abubuwan da aka ambata a sama duk bincike ne, gyara su kuma Cocer Peptides ne suka haɗa su.
Mawallafin Jaridar Kimiyya
Raun K mai bincike ne mai alaƙa da Jami'ar Fasaha ta Denmark (DTU) da Gidauniyar Novo Nordisk. Abubuwan bincikensa sun mamaye fannoni da yawa, gami da Endocrinology & Metabolism, Orthopedics, Nutrition & Dietetics, Kimiyyar dabbobi, da Injiniya. Ayyukansa sau da yawa suna mayar da hankali kan ci gaba da samar da mafita mai ɗorewa da sabbin abubuwa, musamman ma a fannin fasahar kere-kere da tattalin arziƙin halittu.
Raun K ya ba da gudummawa ga ayyukan da ke da alaƙa da Cibiyar Gidauniyar Novo Nordisk don Biosustainability a DTU, wacce aka sadaukar don haɓaka ƙirar masana'antar tantanin halitta, injiniyan rayuwa, da ilimin halitta na roba don ɗorewa bioproduction. Bugu da ƙari, ya shiga cikin shirye-shiryen bincike da nufin rage dogaro ga kayan tushen burbushin halittu da haɓaka canjin kore ta hanyar hanyoyin samar da halittu.
Har ila yau, aikinsa ya shafi aikace-aikacen injiniya, irin su ci gaba da haɓakawa da kuma bioprocesses don dorewar masana'antu da muhalli. Raun K's interdisciplinary approach gada binciken kimiyya da aikace-aikace masu amfani, yana ba da gudummawa mai mahimmanci ga bangarorin ilimi da masana'antu. An jera Raun K a cikin ambaton ambaton [3].
