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▎ Ipa Structure
Isi mmalite: PubChem |
Usoro: XHXFK Ụdị mkpụrụ ndụ: C 38H 49N 9O5 Ibu ibu: 711.9 g/mol Nọmba CAS: 170851-70-4 PubChem CID: 9831659 Okwu ndị yiri: NNC-26-0161；UNII-Y9M3S784Z6；Ipa ACETATE |
▎ Ipa Research
Kedu ihe ndabere nyocha nke Ipa?
Ịkwụsị afọ ojuju bụ ọnọdụ a na-ahụkarị, ma ugbu a, enwere nhọrọ ọgwụgwọ ole na ole dị irè. Nnyocha achọpụtala na Ipa, dị ka peptidomimetic synthetic, na-eme ihe na-anabata ghrelin ma nwee ike inwe mmetụta ọgwụgwọ na igbu oge na-egbu oge. N'ime ọmụmụ banyere ụdị gastroparesis òké, gastroparesis kpatara ya site n'ịwa ahụ afọ na nhịahụ eriri afọ, a chọpụtakwara na Ipa nwere ike ime ngwa ngwa nsị gastric [1]..
Ileus ịwachara ahụ bụ nnukwu ihe ịma aka na omume ụlọ ọgwụ, enweghị usoro njikwa dị irè. Ihe mkpali nnabata nke Ghrelin nwere mmetụta na-akwalite motility na akụkụ elu na akụkụ ala nke eriri afọ. Dị ka agonist receptor ghrelin, Ipa nwere uru ngwa ngwa na ọgwụgwọ nke ileus na-esote. Dịka ọmụmaatụ, n'ime ọmụmụ ihe, a na-eduzi ọmụmụ ihe na-atụ anya, nke a na-achịkwaghị achịkwa, nke a na-achịkwa na ndị ọrịa na-enweta nrịanrịa nke eriri afọ mgbe ịwa ahụ abdominal iji nyochaa nchekwa na ịdị irè nke Ipa [2]..
Ipa bụ nke homonụ na-eto eto na-ewepụta peptides (GHRPs), nke bụ pentapeptide sịntetik nke nwere ike ịkpali ntọhapụ nke hormone uto sitere na hypothalamus na gland pituitary. Hormonụ na-eto eto na-ekere òkè dị mkpa n'ịkwalite ahụ, nrụzi, na metabolism, ya mere ọrụ Ipa na ịchịkwa hormone uto adọtawokwa nlebara anya zuru ebe niile [3].
N'ihi uru ọ bara n'ịgwọ mkpofu gastric na-egbu oge, ileus na-arụ ọrụ nke ọma, na ọrụ ya dị ka hormone na-eto eto na-ewepụta peptide, Ipa adọtala nleba anya nyocha.
Kedu ihe bụ usoro nke Ipa?
1. Na-akpali ntọhapụ nke hormone ibu:
Ipa bụ nke homonụ na-eto eto na-ahapụ peptides (GHRPs), nke nwere ike ịkpalite ntọhapụ nke hormone ibu site na hypothalamus na pituitary gland. Nnwale in vitro na in vivo, Ipa egosila ike dị elu na ịdị irè n'ịtọhapụ hormone na-eto eto. Dịka ọmụmaatụ, n'ime ọmụmụ ihe, ike na ịdị irè nke Ipa na-ahapụ hormone na-eto eto site na sel pituitary bụ isi dị ka nke GHRP-6 [3] . Usoro ya na-eme bụ ịkwalite ntọhapụ nke hormone na-eto eto site na ịgbalite ndị na-anabata GHRP. Site na nyocha nke ọgwụ, ekwenyela na dị ka GHRP-6, Ipa na-akpali ntọhapụ nke hormone na-eto eto site na ndị na-anabata GHRP.
2. Mmetụta na eriri afọ tract
Na-eme ka mkpofu afọ dị ngwa ngwa:
N'ụdị òké, Ipa nwere ike mee ka mkpofu afọ dị ngwa ngwa. Ịwa ahụ afọ na-eduga n'ịkwụsị ịpụsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịrịa, ma mgbe nchịkwa nke Ipa (0.014 µmol/kg n'ime intravenous), na-ebuwanye ibu nke ukwuu. Ipa na-akpali nkwekọ eriri afọ ma na-eme ka mkpofu afọ dị ngwa ngwa site na usoro agbadoro site na ntinye nke nnabata ghrelin, gụnyere cholinergic excitatory neurons (Greenwood-Van Meerveld B, 2012).
Mmalite mgbaàmà nke postoperative ileus:
N'ụdị òké nke ileus arụchara arụ ọrụ, Ipa nwere ike imeziwanye mgbaàmà. Mgbe nchịkwa nke Ipa gasịrị, otu dose nke Ipa (1mg/kg) ma ọ bụ GHRP-6 (20μg / kg) nwere ike ibelata oge na-ekpochapụ mbụ. Nlekọta Ipa ugboro ugboro (0.1 ma ọ bụ 1mg/kg) nwere ike ịbawanye mmepụta fecal , oriri, na uru ibu [4].
3. Mmetụta na insulin secretion
Ipa nwere ike kpalite mpụta insulin n'ime iberibe anụ ahụ nke oke nkịtị na ọrịa shuga. Mmụba nke insulin nzuzo nke Ipa na-ebute nwere ike igbochi nke ukwuu site na diltiazem, yohimbine, propranolol, ma ọ bụ ngwakọta nke atropine, propranolol, na yohimbine. N'ime oke ndị ọrịa mamịrị, atropine nwere ike ibelata insulin nzuzo nke Ipa na-ebute, mana anaghị ahụ mmetụta a na oke nkịtị. Nke a na-egosi na Ipa na-akpali ntọhapụ insulin site na ọwa calcium na adrenergic ụzọ nnabata [5]..
4. Na-ebelata ihe mgbu
N'ụdị nnwale nke hypersensitivity visceral na-enweghị mkpali na somatic mechanical allodynia, Ipa, dị ka ihe mgbochi ghrelin receptor agonist, nwere ike belata hypersensitivity colonic na somatic allodynia. Usoro ihe omume ya bụ onye na-anabata ghrelin, yana mmetụta antinociceptive a nwere ike igbochi ya site na ghrelin antagonist H0900 [6]..
Kedu ka mmetụta Ipa si dị na mpụta insulin site na mpekere anụ ahụ pancreatic nke oke nkịtị na ọrịa shuga.
Isi mmalite: PubMed [5]
Kedu ihe bụ ngwa nke Ipa?
1. Na-akwalite ntọhapụ nke hormone na-eto eto
Ipa nwere ike kpalite ntọhapụ nke hormone na-eto eto site na hypothalamus na pituitary gland. Hormone uto na-arụ ọrụ dị mkpa n'ime ahụ mmadụ, gụnyere ịkwalite njikọ protein, mmụba cell, na nrụzi anụ ahụ. Ya mere, enwere ike iji Ipa na-agwọ ụkọ hormone na-eto eto ma ọ bụ ọrịa ndị ọzọ metụtara ụkọ hormone uto [7].
2. Ịkwalite ọrụ eriri afọ
Na-eme ka mkpofu afọ dị ngwa ngwa:
N'ụdị òké, Ipa na-eme ka mkpofu gastric dị n'ụdị nke postoperative ileus site na usoro agbaziri site na ntinye nke hormone uto na-ahapụ peptide receptor, gụnyere cholinergic excitatory neurons [1] . Ịwa ahụ nke afọ na-eduga n'ịkwụsị nsị nke afọ, na nchịkwa nke Ipa nwere ike ibelata oke nri fọdụrụnụ n'ime afọ, si otú ahụ na-eme ka motility gastric dịkwuo mma.
Na-akwalite peristalsis nke eriri afọ:
N'ụdị òké nke ileus na-arụ ọrụ, Ipa nwere ike imeziwanye mgbaàmà nke ndị ọrịa. Dịka ọmụmaatụ, n'ụdị oke oke, Ipa nwere ike ibelata oge mbụ ịsa ahụ mgbe a wachara ya ahụ, mụbaa mmepụta fecal, oriri nri, na ibu ibu [4] . Nlekọta nke Ipa ugboro ugboro nwere ike ime ka mmepụta fecal na-agbakọta nke ọma, iri nri, na uru dị arọ, na-egosi mmetụta nchịkwa ya dị mma na ọrụ eriri afọ.
3. Iwepụ ihe mgbu
Na-ebelata ihe mgbu visceral na somatic:
Nnyocha na-egosi na Ipa, dị ka hormone na-eto eto na-ahapụ agonist peptide receptor agonist, nwere ihe ndị na-egbochi ihe. N'ụdị nnwale na-enweghị mbufụt epithelial colonic, Ipa nwere ike belata hypersensitivity visceral na-abụghị nke na-egbu egbu na somatic mechanical allodynia [6].
Usoro ọrụ ya nwere ike ịgbazite site na hormone nke na-eto eto na-ahapụ onye na-anabata peptide, na-ekere òkè na nhazi nke visceral na somatic hypersensitivity, na-enye usoro ọhụrụ nwere ike ịgwọ ọrịa nke nnukwu visceral na somatic mgbu.
Kedu ihe bụ ọganihu nyocha nke Ipa na ọgwụgwọ ụkọ hormone nke uto?
Mmụba nke homonụ na-eto eto bụ ọrịa na-akpata site na ụkọ homonụ nke na-eto eto site na gland pituitary anterior, nke nwere ike imetụta uto na mmepe nke ụmụaka na metabolism nke ndị okenye. N'ime afọ ndị na-adịbeghị anya, Ipa, dị ka ihe nzuzo nzuzo nke hormone na-eto eto, adọtala mmasị zuru oke na ọgwụgwọ nke ụkọ hormone na-eto eto. Ihe na-esonụ bụ ọganihu nyocha dị mkpa nke Ipa na ọgwụgwọ nke ụkọ hormone nke uto.
1. Mmetụta na-akpali akpali nke Ipa na mmepụta hormone nke uto
Ipa nwere ike kpalie nzuzo nke hormone nke uto. Nnyocha na-egosi na Ipa nwere ike ime synergistically na hormone na-ewepụta hormone na-eto eto (GHRH) iji mee ka ntọhapụ nke hormone na-eto eto [8] . Na anụmanụ nnwale, mgbe 21 ụbọchị nke na-adịghị ala ala ọgwụgwọ na Ipa na-eto eto ụmụ oke ụmụ oke, tụnyere ndị na-achịkwa otu, basal ibu hormone tọhapụ na monolayer omenala pituitary cell mụbara. N'otu oge ahụ, Ipa na GHRH nwere ike ịkpalite ntọhapụ nke hormone na-eto eto site na mkpụrụ ndụ pituitary omenala in vitro. Otú ọ dị, na GHRH pretreatment otu, ndị ọzọ na-eto eto na-eto eto nzaghachi mkpali na-adịghị emeziwanye, mgbe na Ipa pretreatment otu, ọ dịghị ihe dị otú ahụ desensitization phenomen, na-egosi na Ipa adịghị eduga desensitization nke uto hormone nzaghachi na-eto eto ụmụ oke ụmụ oke [8].
2. Mmetụta nke Ipa na ibu ibu
Ọchịchị na-adịghị ala ala nke Ipa nwere ike ịbawanye ibu nke oke ụmụ nwanyị na-eto eto. Nleba anya kwa ụbọchị na-egosi na pasent nke ibu ibu na ndị otu Ipa pretreatment na GHRH pretreatment otu dị elu karịa nke na-achịkwa [8] . Nke a metụtara eziokwu ahụ bụ na Ipa na-akpali mmepụta nke hormone nke na-eto eto, nke na-akwalite njikọ protein na uto cell.
3. Mmetụta nke Ipa na ọkpụkpụ ọkpụkpụ
N'ime ụdị oke oke okenye, a chọpụtala na secretagogue hormone nke na-eto eto Ipa nwere ike igbochi mmetụta catabolic nke glucocorticoids (GC) na anụ ahụ na ọkpụkpụ ọkpụkpụ. E jiri ya tụnyere otu a gbara naanị GC, n'ime anụmanụ ndị a na-agba ma GC na Ipa, oke tetanic nke akwara nwa ehi mụbara nke ukwuu, na nhazi ọkpụkpụ periosteal mụbara okpukpu anọ [8, 9] . Nke a na-egosi na Ipa nwere mmetụta dị mma n'ịkwado ike anụ ahụ na ịkwalite ọkpụkpụ ọkpụkpụ, ma nwee ike inye aka gbochie nsogbu ndị dị ka osteoporosis na ndị ọrịa nwere ụkọ hormone na-eto eto.
4. Mmetụta nke Ipa na ọrụ eriri afọ
Dị ka agonist nke hormone na-ewepụta hormone nke na-eto eto na hormone na-ewepụta agonist peptide receptor agonist, Ipa gosipụtara irè ọgwụgwọ na ụdị òké nke mkpọnwụ eriri afọ mgbe ọ gasịrị. Otu nchịkwa nke Ipa ma ọ bụ peptide na-ewepụta hormone na-eto eto (GHRP) -6 na-eme ka oge ahụ dị mkpụmkpụ na mgbatị afọ nke mbụ mgbe arụchara ọrụ, mana enweghị mmetụta na mmepụta fecal nke nchịkọta, oriri oriri, ma ọ bụ uru bara uru. Ipa na-abawanye mmepụta fecal, iri nri, na ibu ibu. Nke a na-egosi na Ipa nwere ike inwe ọrụ ụfọdụ n'ịkwalite ọrụ eriri afọ ma nwee ike inye aka melite ọrụ digestive na absorptive na ndị ọrịa nwere ụkọ hormone na-eto eto. [4].
Na nchịkọta, dị ka onye na-akwalite mmepụta nke hormone na-eto eto, Ipa na-arụ ọrụ nke ọma na-akpali ntọhapụ nke hormone na-eto eto site n'ime ka hormone na-ewepụta peptide receptor (GHS receptor), na-enweghị mmetụta dị ukwuu na ọkwa nke adrenocorticotropic hormone (ACTH) na cortisol. Ọrụ ya gụnyere ịkwalite mmepụta homonụ na-eto eto, na-achịkwa motility eriri afọ, na ibelata mgbu. Nhọrọ ya dị elu na njirimara ọtụtụ ebumnuche na-enye ikike ngwa ụlọ ọgwụ, na-eme ka ọ dị mma maka ojiji n'ọnọdụ ndị dị ka ụkọ hormone uto, mgbochi eriri afọ na-esote, na njikwa mgbu.
Banyere Onye dere ya
Ihe niile a kpọtụrụ aha n'elu bụ Cocer Peptides na-enyocha, dezie ma chịkọta ya.
Onye ode akwụkwọ akụkọ sayensị
Raun K bụ onye nyocha jikọtara ya na Technical University of Denmark (DTU) na Novo Nordisk Foundation. Ihe gbasara nyocha ya gbasara ọtụtụ ọzụzụ, gụnyere Endocrinology & Metabolism, Orthopedics, Nutrition & Dietetics, Sciences Veterinary, na Injinia. Ọrụ ya na-elekwasịkarị anya na mmepe nke ngwọta na-adịgide adịgide na nke ọhụrụ, karịsịa n'ihe gbasara nkà na ụzụ na akụ na ụba dabeere na bio.
Raun K enyela aka na oru metụtara Novo Nordisk Foundation Center for Biosustainability na DTU, bụ nke a raara nye ịkwalite mmepụta mmepụta cell, engineering metabolic, na sịntetik bayoloji maka bioproduction na-adịgide adịgide. Na mgbakwunye, o tinyela aka na atụmatụ nyocha nke ebumnuche ibelata ịdabere na ihe ndị sitere na fosil yana ịkwalite mgbanwe ndụ ndụ site na ngwọta bioproduction.
Ọrụ ya na-emetụkwa na ngwa injinia, dị ka mmepe nke ihe na-eme ka ihe na-emepụta ihe na bioprocesses maka ụlọ ọrụ mmepụta ihe na gburugburu ebe obibi. Raun K's interdisciplinary approach na-ejikọta nyocha sayensị na ngwa bara uru, na-enye aka dị ukwuu na ngalaba agụmakwụkwọ na ụlọ ọrụ mmepụta ihe. Edepụtara Raun K n'akwụkwọ ntụaka [3].
