Cocer Peptides ye ŋlɔe 
ŋkeke 25 enye sia
NYATAKAKAWO KPLE NUSIWO WOTSƆ ƑE NYATAKAKA SIWO KAtã WOÐO LE NYATAKAKADZRAÐOƑE SIA ME LA KPLE NYATAKAKAWO kaka KPLEE NUFIAFIA ƑE TAÐOÐOWO KO.
Wotrɔ asi le atike siwo wona le nyatakakadzraɖoƒe sia ŋu na numekuku le vitro ɖeɖeko. Wowɔa numekuku le vitro (Latingbe me: *le ahuhɔ̃e me*, si gɔmee nye le ahuhɔ̃e me) le amegbetɔ ƒe ŋutilã godo. Atike siawo menye atikewo o, United States ƒe Nuɖuɖu Kple Atike Ŋuti Dɔwɔƒe (FDA) meda asi ɖe wo dzi o, eye mele be woazã wo atsɔ axe mɔ ɖe atikewɔwɔ, dɔléle, alo dɔléle aɖeke nu, adae, alo adae o. Se de se vevie be woatsɔ atike siawo ade amegbetɔ alo lãwo ƒe ŋutilã me le mɔ ɖesiaɖe nu.
Lolo akpa kple lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe kuxi siwo do ƒome kplii va zu xexeame katã ƒe dukɔa ƒe lãmesẽnya, si wɔe be nudede dɔa me siwo le dedie eye wowɔa dɔ nyuie didi le vevie ŋutɔ. Togbɔ be amegbetɔ ƒe tsitsi ƒe lãmetsi (hGH) ɖee fia be ŋutete le eŋu be wòada lolo akpa hã la, dedienɔnɔ ŋuti dzitsitsiwo xea mɔ na eŋudɔwɔwɔ ɣeyiɣi didi. Wokpɔe be AOD9604, si nye peptide kakɛ aɖe si tso hGH ƒe C-nuwuƒe nuto (Tyr-hGH177-191) me la, hGH ƒe ami dzi ɖeɖe kpɔtɔ ƒe dɔwɔwɔ le esi eƒe ŋusẽkpɔɖeamedzi gbegblẽ aɖeke manɔmee. Numekuku siwo wowɔ nyitsɔ laa keke eƒe dɔwɔwɔ ɖe enu, eye antioxidant kple metabolic support effects do abe numekuku veviwo ene.
Nɔnɔmetata 1 Lolo akpa ƒe bɔbɔ le United States ƒe ame tsitsiwo (ƒe 20–74).
1. AOD9604 ƒe antioxidant ŋusẽkpɔɖeamedziwo
Kadodo si le oxidative stress kple dɔléle dome
Oxidative stress fia nɔnɔme si me, le nu vovovo siwo gblẽa nu le ame ŋu me la, ŋutilãa wɔa oxygen ƒomevi siwo wɔa dɔ (ROS) kple nitrogen ƒomevi siwo wɔa dɔ (RNS) ƒe agbɔsɔsɔ si gbɔ eme, si wɔnɛ be oxidative gblẽna si wu ŋutete si le ŋutilãa si be wòakɔ lã ƒomevi siawo ŋu. Dadasɔ sia si mele oxidative kple antioxidant systems dome o la hea lãmenugbagbeviwo ƒe gbegblẽ vɛ. Dɔléle gbogbo aɖewo, siwo dometɔ aɖewoe nye dzitodzito me dɔléle, suklidɔ, ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie, kple aklãdɔ si me ami mele o (NAFLD) do ƒome kplikplikpli kple oxidative stress. Le dɔléle ƒe nɔnɔme siawo me la, ROS ƒe agbɔsɔsɔ si dzi ɖe edzi le lãmenugbagbeviwo me dzea biomolecules abe lipids, proteins, kple DNA ene dzi, si wɔnɛ be lãmenugbagbeviwo megawɔa dɔ nyuie o eye wokuna.
AOD9604 Antioxidant ƒe Dɔwɔwɔ ƒe Mɔnu
AOD9604 wɔa eƒe ŋusẽkpɔɖeamedziwo to lãmenugbagbeviwo me antioxidant enzyme system ƒe ɖoɖowɔwɔ me. Superoxide dismutase (SOD), glutathione peroxidase (GPx), kple catalase (CAT) nye lãmenugbagbeviwo me antioxidant enzyme vevi siwo ate ŋu axɔ ROS eye woalé lãmenugbagbeviwo me redox ƒe dadasɔ me ɖe asi. AOD9604 ate ŋu adzi antioxidant enzyme siawo ƒe ɖeɖefia alo dɔwɔwɔ ɖe edzi, si ana lãmenugbagbeviwo ƒe antioxidant takpɔkpɔ ŋutetewo nadzi ɖe edzi. Le go bubu me la, AOD9604 ate ŋu akpɔ gome le free radicals ɖeɖeɖa me tẽ. Ŋutete ate ŋu anɔ ƒuƒoƒo aɖewo si le eƒe molecule ƒe wɔwɔme me be woalé ROS kple RNS, si ana woƒe nugbegblẽ le lãmenugbagbeviwo ŋu dzi naɖe akpɔtɔ.
Le numekuku aɖe si wowɔ tsɔ zã aklãdɔ si me ami mele o ƒe kpɔɖeŋu si wowɔ le sisiblisi me la, atikewɔwɔ kple AOD9604 na malondialdehyde (MDA) ƒe agbɔsɔsɔ dzi ɖe kpɔtɔ ŋutɔ le aklã ƒe lãmenugbagbeviwo me. MDA nye lipid peroxidation ƒe nuwɔna, eye eƒe agbɔsɔsɔ si dzi ɖe kpɔtɔ ɖee fia be oxidative stress dzi ɖe kpɔtɔ. SOD kple GPx ƒe dɔwɔwɔ le aklã me dzi ɖe edzi, si fia be AOD9604 ate ŋu aɖe oxidative stress ƒe nugbegblẽ dzi akpɔtɔ to antioxidant enzymes ƒe dɔwɔwɔ dzi ɖeɖe kpɔtɔ me. Esia ɖee fia be AOD9604 kpɔa ŋusẽ nyui ɖe aklã ƒe oxidative stress nɔnɔme ƒe nyonyo dzi, si na dodokpɔ me kpeɖodzi le eŋudɔwɔwɔ le dɔléle siwo do ƒome kplii dada me.
2. AOD9604 ƒe Lãmetsiŋusẽ ƒe Kpekpeɖeŋu ƒe Ŋusẽkpɔɖeamedzi
Ŋusẽkpɔɖeamedzi ɖe Lipid Metabolism Dzi
AOD9604 ɖea ɖoɖowɔwɔ ƒe ŋusẽkpɔɖeamedzi vevi aɖe fiana ɖe ami ƒe asitɔtrɔ le lãme na ame ŋu. Le sisiblisi lolo akpa ƒe kpɔɖeŋu me la, AOD9604 dodo ɖe dɔgboa me ɣeyiɣi didi na be eƒe kpekpeme kple ami dzi ɖe kpɔtɔ. Dɔwɔwɔ sia ate ŋu ado ƒome kple β-adrenergic mɔ, vevietɔ β(3)-adrenergic receptor (β(3)-AR), si nye lipolytic receptor vevitɔ le adipocytes me. Le ŋkeke 14 ƒe AOD9604 dodo na mi siwo lolo akpa megbe la, β(3)-AR RNA ƒe ɖeɖefia ƒe agbɔsɔsɔ dzi ɖe edzi, si na β(3)-AR RNA ƒe agbɔsɔsɔ si woxe mɔ na le mi siwo lolo akpa me la gaɖo agbɔsɔsɔ si sɔ kple esi le mice siwo me ami mele o me, si wɔe be ami ƒe ʋuʋu ɖe ŋgɔ eye wòdo ami ƒe ʋuʋu ƒe seselelãme ɖe ŋgɔ. Le β(3)-AR knockout mice me la, AOD9604 zazã ɣeyiɣi didi mete ŋu na kpekpeme ƒe tɔtrɔ kple lipolysis-dodzidzɔname ƒe ŋusẽkpɔɖeamedzi siwo le gbemelã ƒomevi siwo dzi wokpɔna me o, si ɖee fia be β(3)-AR wɔa akpa vevi aɖe le AOD9604 ƒe lipid metabolism dzi kpɔkpɔ me. Le dodokpɔ sesẽwo me la, AOD9604 gadzi ŋusẽzazã kple ami ƒe oxidation ɖe edzi le β(3)-AR domenyiŋusẽfianu knockout mice me, si fia be AOD9604 ate ŋu akpɔ ŋusẽ ɖe lipid ƒe asitɔtrɔ hã dzi to mɔ bubuwo dzi.
Nutata 2 Dɔ si saline, AOD9604, alo amegbetɔ ƒe tsitsi ƒe lãmetsi (hGH) ƒe agbɔsɔsɔme ɖeka si wodona ɖe dɔgboa me (ip) gbesiagbe kpɔna ɖe ŋutilã ƒe kpekpeme ƒe tɔtrɔ dzi le ŋutsu C57BL/6J (A) alo lolo akpa (ob/ob) mice (B) siwo me lãmesẽ mele o (B) me le ŋkeke 14 me.
Ŋusẽ si wòkpɔna ɖe carbohydrate ƒe asitɔtrɔ le lãmenugbagbeviwo ŋu dzi
Le carbohydrate ƒe asitɔtrɔ gome la, AOD9604 to vovo kura tso hGH gbɔ. Dɔdamɔnu dodokpɔwo ɖee fia be AOD9604 mekpɔa ŋusẽ aɖeke ɖe IGF-1 ƒe agbɔsɔsɔ si le ʋumenugbagbevi dzĩ me dzi o, si ɖo kpe nukpɔsusu si nye be mewɔa dɔ to IGF-1 dzi o dzi. Nusiwo do tso suklidɔ ƒe mɔɖeɖe ɖe nu me ƒe dodokpɔ me ɖee fia be, to vovo na hGH la, AOD9604 mekpɔa ŋusẽ gbegblẽ ɖe carbohydrate ƒe asitɔtrɔ dzi o. Esia fia be AOD9604 ate ŋu aɖɔ lipid ƒe asitɔtrɔ ɖo evɔ mado kplamatse carbohydrate ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ nyuie o, si ana viɖe tɔxɛ aɖe le lãmenugbagbeviwo ƒe dɔwɔwɔ nyuie wu me.
Ŋusẽ si wòkpɔna ɖe aklã ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ dzi
Le numekuku siwo wowɔ le sisiblisi siwo ŋu aklãdɔ si me ami mele o ŋu me la, menye ɖeko AOD9604 kpɔa ŋusẽ ɖe ami ƒe asitɔtrɔ dzi ko o, ke eɖɔa aklã ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe nɔnɔme bliboa hã ɖo. Tsɔ kpe ɖe oxidative stress dzi ɖeɖe kpɔtɔ ŋu la, AOD9604 ate ŋu ana aklã ƒe steatosis nanyo ɖe edzi to domenyiŋusẽfianu siwo do ƒome kple lipid ƒe wɔwɔme, ʋuɖoɖo, kple lãmenugbagbeviwo ƒe dɔwɔwɔ le aklã me ƒe ɖeɖefia dzi kpɔkpɔ me. Ate ŋu akpɔ ŋusẽ ɖe enzyme veviwo abe fatty acid synthase (FAS) kple acetyl-CoA carboxylase (ACC) ƒe ɖeɖefia dzi, aɖe ami ƒe wɔwɔme dzi akpɔtɔ le aklã me, ado ami ƒe β-oxidation ɖe ŋgɔ, eye wòato esia me aɖe aklã me ami ƒe ƒuƒoƒo dzi akpɔtɔ.
3. AOD9604 ƒe Dual Action ƒe Dɔwɔwɔ Siwo Woate Ŋu Azã
Dɔwɔwɔ le Lolo akpa Kple Lãmetsiŋusẽ ƒe Dɔléle Siwo Do Ƒome Kplii Me
Ne míebu AOD9604 ƒe antioxidant kple metabolic support effects ŋu la, eƒe dɔwɔwɔ ƒe asixɔxɔ le lolo akpa kple metabolic dɔléle siwo do ƒome kplii abe suklidɔ ƒomevi 2 kple aklãdɔ si me ami mele o dada me. Le dɔnɔ siwo lolo akpa gome la, AOD9604 ate ŋu ado ami ƒe dɔwɔwɔ ɖe ŋgɔ, aɖe ami si le ŋutilã me dzi akpɔtɔ, eye wòana insulin ƒe dɔwɔwɔ nanyo ɖe edzi, si ana wòakpe ɖe ʋumemi ƒe agbɔsɔsɔ dzi ɖuɖu ŋu. Le dɔnɔ siwo ŋu aklãdɔ si me ami mele o gome la, ate ŋu aɖe aklã ƒe nuteɖeamedzi ƒe nuteɖeamedzi ƒe gbegblẽ dzi akpɔtɔ eye wòana aklã me ʋumemi ƒe asitɔtrɔ, si ate ŋu anye mɔnu yeye si dzi woato ana aklã ƒe dɔwɔwɔ nanyo ɖe edzi eye dɔlélea nayi edzi blewu.
Dɔwɔwɔ le Kamedefefewo ƒe Nuɖuɖu Ŋuti Nunya me
Le kamedefefe me nunyiame gome la, AOD9604 ƒe antioxidant kple metabolic support ƒe ŋutetewo hã dzea ame ŋu. Le hehexɔxɔ si me ŋusẽ le ŋutɔ me la, kamedefefewɔlawo wɔa ROS gbogbo aɖe, si wɔnɛ be oxidative stress gblẽa nu le ame ŋu, evɔ ŋusẽ ƒe asitɔtrɔ le lãmenugbagbeviwo ŋu dzina ɖe edzi. AOD9604 ate ŋu akpe ɖe ame ŋu wòakɔ ROS ŋu, aɖe lãmekawo ƒe ɖeɖiteameŋu kple nugbegblẽ dzi akpɔtɔ, esime wòdoa ami ƒe oxidation ɖe ŋgɔ hena ŋusẽ, si ana kamedede ƒe dzidodo kple hayahaya ƒe ŋutete nadzi ɖe edzi. Togbɔ be AOD9604 ɖea antioxidant kple metabolic support ƒe ŋusẽkpɔɖeamedzi nyuiwo fiana hã la, eƒe dedienɔnɔ le vevie wu. Numekuku geɖe da AOD9604 ƒe dedienɔnɔ kpɔ. Le dodokpɔ ade siwo wowɔ le vome, siwo me wozã atike eve le, siwo me wozã atike si wotsɔ ɖɔa amee le me la, AOD9604 mekpɔ ŋusẽ aɖeke ɖe IGF-1 ƒe agbɔsɔsɔ si le ʋumenugbagbevi dzĩ me dzi o, womekpɔ ŋusẽ gbegblẽ aɖeke ɖe carbohydrate ƒe asitɔtrɔ le lãmenugbagbeviwo ŋu dzi o, eye womekpɔ dɔlékuiwutike aɖeke si tsi tre ɖe AOD9604 ŋu o. Womegblɔ asiɖeɖe le eŋu ƒe dzesi aɖeke alo nu gbegblẽ sesẽ aɖeke si do ƒome kple AOD9604 nono o. Le aɖiŋutinunya si nɔa anyi didi ŋuti numekuku siwo wowɔ le sisiblisiwo kple cynomolgus bosowo ŋu me la, AOD9604 nono ɣeyiɣi didi hã ɖe eƒe dedienɔnɔ bliboa fia, eye domenyiŋusẽfianu ƒe aɖi ƒe dzesi aɖeke menɔ eŋu o.
Nutata 3 AOD9604 ƒe gbegblẽ le vitro le sisiblisi ƒe ʋumenugbagbeviɣi me le xɔme ƒe dzoxɔxɔ nu. Le miniti 56 megbe la, woɖea peptide la ɖa keŋkeŋ. Afã ƒe agbenɔƒe anɔ abe miniti 4 ene. Woɖe AOD9604 amino-terminal truncated fragments (-xaa) ƒe dzedzeme fia.
4. Nyataƒoƒo
AOD9604, abe peptide kakɛ si si nuwɔna eve tɔxɛwo le ene, kpena ɖe antioxidant kple metabolic support ŋu. Eƒe antioxidant dɔwɔwɔ kpena ɖe ame ŋu wòɖea lãmenugbagbeviwo ƒe gbegblẽ si do ƒome kple oxidative stress dzi kpɔtɔna, evɔ eƒe metabolic support action ya kpɔa lipid, carbohydrate, kple aklã ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ dzi nyuie. Esia na wòɖe dzesi le lolo akpa kple lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe dɔléle siwo do ƒome kplii dada me, kpakple le kamedefefe me nunyiame me.
Dzɔtsoƒewo
[1] Dehbashi M, Fathie M, Hosseini SRA, kple ame bubuwo. اثر هشت هفته تمرین استقامتی و تزریق قطعه پولیتیک هورمون رشد (AOD9604) بر آنزیمهای کبد و CK18 موشهای سوری القاء شده به کبد چرب غیرالکلی ناشی از رژیم غذایی پر چرب، Ƒe 2021 [C] me. https://api.semanticscholar.org/CorpusID: 236556287. Ƒe 1999 ƒe ɣleti gbãtɔ me
[2] EMIM, Kenley D L. Dedienɔnɔ kple lãmenugbagbeviwo ƒe dɔwɔwɔ le AOD9604, si nye Nunyiame ƒe Nu yeye aɖe si naa lãmenugbagbeviwo ƒe lãmesẽ si nyo wu[J]. Journal of Endocrinology kple lãmenugbagbeviwo ƒe dɔwɔwɔ, 2014,4:64-77. https://api.semanticscholar.org/CorpusID: 67761634. Ƒe 1999 ƒe ɣleti gbãtɔ me
[3] Stier H, Vos E, Kenley D L. Dedienɔnɔ kple Mɔɖeɖe ɖe Hexadecapeptide AOD9604 ŋu le Amegbetɔwo me[J]. Journal of Endocrinology kple lãmenugbagbeviwo ƒe dɔwɔwɔ, 2013,3:7-15. https://api.semanticscholar.org/CorpusID: 56559133. Ƒe 1999 ƒe ɣleti gbãtɔ me
[4] Melnikova I, Fetu D. Atikewɔwɔ siwo tsia lolo akpa nu[J]. Dzɔdzɔme Totoɖeme Atikewo Ŋuti Kekeɖenuŋu, 2006,5 (5): 369-370.DOI: 10.1038 / nrd2037.
[5] Heffernan M, Dzomeŋɔli RJ, Thorburn A, kple ame bubuwo. Amegbetɔ ƒe GH kple eƒe lipolytic fragment (AOD9604) ƒe ŋusẽkpɔɖeamedzi ɖe lipid metabolism dzi le atikewɔwɔ atraɖii megbe le mice lolo akpa kple beta(3)-AR knock-out mice me[J]. Dɔlékuiŋutinunya, 2001, 142 (12): 5182-5189.DOI: 10.1210 / endo.142.12.8522.
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