By Cocer Peptides 
kwanaki 25 da suka gabata
DUKKANIN LABARI DA BAYANIN KYAUTATAWA DA AKE BAYAR A WANNAN SHAFIN KAWAI DOMIN WATSA BAYANI NE DA MANUFOFIN ILIMI.
Kayayyakin da aka bayar akan wannan gidan yanar gizon an yi niyya ne kawai don binciken in vitro. Binciken in vitro (Latin: *a cikin gilashi*, ma'ana a cikin gilashin gilashi) ana gudanar da shi a wajen jikin mutum. Waɗannan samfuran ba magunguna ba ne, Hukumar Abinci da Magunguna ta Amurka (FDA) ba ta amince da su ba, kuma dole ne a yi amfani da su don hanawa, magani, ko warkar da duk wani yanayi na likita, cuta, ko cuta. Doka ta haramta shigar da waɗannan samfuran cikin jikin mutum ko dabba ta kowace hanya.
Kiba da rikice-rikicen da ke tattare da ita sun zama batun lafiyar jama'a a duniya, yana mai da bincike don amintaccen aiki mai inganci. Yayin da hormone girma na ɗan adam (hGH) yana nuna yuwuwar magance kiba, matsalolin aminci suna iyakance amfani da shi na dogon lokaci. AOD9604, guntun peptide daga yankin C-terminal na hGH (Tyr-hGH177-191), an gano ya mallaki aikin rage kitse na hGH ba tare da illarsa ba. Binciken da aka yi kwanan nan ya fadada akan ayyukansa, tare da maganin antioxidant da tasirin tasirin rayuwa wanda ke fitowa a matsayin mahimman wuraren bincike.
Hoto 1 Yawan kiba a cikin manya na Amurka (shekaru 20-74).
1. Sakamakon antioxidant na AOD9604
Haɗin kai tsakanin damuwa na oxidative da cuta
Damuwa na Oxidative yana nufin yanayin da, a ƙarƙashin nau'ikan motsa jiki daban-daban, jiki yana samar da nau'in oxygen mai aiki da yawa (ROS) da nau'in nitrogen mai amsawa (RNS), wanda ke haifar da lalacewar oxidative wanda ya wuce ikon jiki na share waɗannan nau'in. Wannan rashin daidaituwa tsakanin tsarin oxidative da antioxidant yana haifar da lalacewar nama. Cututtuka da yawa, ciki har da cututtukan zuciya da jijiyoyin jini, ciwon sukari, cututtukan neurodegenerative, da cututtukan hanta marasa-giya (NAFLD), suna da alaƙa da alaƙa da damuwa na oxidative. A cikin waɗannan jihohin cututtukan, haɓaka matakan ROS na ciki na ciki suna kai hari ga kwayoyin halitta kamar lipids, sunadarai, da DNA, wanda ke haifar da tabarbarewar salula da mutuwa.
AOD9604 Kayan aikin Antioxidant na Aiki
AOD9604 yana aiwatar da tasirin sa ta hanyar daidaita tsarin enzyme antioxidant intracellular. Superoxide dismutase (SOD), glutathione peroxidase (GPx), da catalase (CAT) suna da mahimmancin enzymes antioxidant na ciki wanda zai iya lalata ROS kuma ya kula da ma'auni na redox na ciki. AOD9604 na iya daidaita magana ko aiki na waɗannan enzymes na antioxidant, don haka haɓaka ƙarfin kariya na antioxidant na salula. A gefe guda, AOD9604 na iya shiga kai tsaye a cikin ɓarna na radicals kyauta. Wasu ƙungiyoyi a cikin tsarin kwayoyin halitta na iya samun ikon kama ROS da RNS, don haka rage lalacewarsu ga sel.
A cikin binciken da aka yi amfani da samfurin linzamin kwamfuta na cututtukan hanta maras barasa, jiyya tare da AOD9604 ya haifar da raguwa mai yawa a cikin matakan malondialdehyde (MDA) a cikin hanta. MDA samfur ne na peroxidation na lipid, kuma raguwar matakansa yana nuna raguwa a cikin damuwa na iskar oxygen. Ayyukan SOD da GPx a cikin hanta ya karu, yana nuna cewa AOD9604 na iya rage lalacewar danniya ta hanyar haɓaka aikin enzymes antioxidant. Wannan yana nuna cewa AOD9604 yana da tasiri mai kyau akan inganta yanayin danniya na hanta, yana ba da shaidar gwaji don aikace-aikacensa a cikin maganin cututtuka masu dangantaka.
2. Taimakon Taimakon Metabolic na AOD9604
Tasiri kan Metabolism na Lipid
AOD9604 yana nuna tasiri mai mahimmanci akan metabolism na lipid. A cikin ƙirar linzamin kwamfuta mai kiba, allurar intraperitoneal na dogon lokaci na AOD9604 ya haifar da rage nauyin jiki da kitsen jiki. Wannan sakamako na iya haɗawa da hanyar β-adrenergic, musamman ma β (3) -adrenergic receptor (β (3) -AR), mai karɓa na farko na lipolytic a cikin adipocytes. Bayan kwanaki 14 na gudanarwar AOD9604 a cikin mice masu kiba, matakin magana na β (3) -AR RNA ya karu, yana maido da matakan β (3) -AR RNA da aka rage a cikin berayen masu kiba zuwa matakan kwatankwacin waɗanda ke cikin berayen da ba su da ƙarfi, don haka haɓaka lipolysis da haɓaka haɓakar hankali. A cikin β (3) - AR knockout mice, amfani da dogon lokaci na AOD9604 ya kasa samar da canje-canje masu nauyi iri ɗaya da tasirin haɓakawa na lipolysis kamar yadda a cikin nau'in nau'in sarrafa nau'in daji, yana nuna cewa β (3) -AR yana taka muhimmiyar rawa a cikin tsarin AOD9604 na tsarin metabolism. A cikin m gwaje-gwaje, AOD9604 har yanzu ya karu makamashi kashe kudi da kuma hadawan abu da iskar shaka a cikin β (3) -AR gene knockout mice, bayar da shawarar cewa AOD9604 na iya rinjayar lipid metabolism ta wasu hanyoyi.
Hoto 2 Sakamakon guda ɗaya na intraperitoneal na yau da kullum (ip) na saline, AOD9604, ko hormone girma na mutum (hGH) akan canje-canjen nauyin jiki a cikin namiji C57BL / 6J (A) ko kiba (ob / ob) mice (B) fiye da kwanaki 14.
Tasiri kan carbohydrate metabolism
Dangane da metabolism na carbohydrate, AOD9604 ya bambanta sosai da hGH. Gwaje-gwaje na asibiti sun nuna cewa AOD9604 ba shi da tasiri a kan matakan IGF-1 na jini, yana tabbatar da tunanin cewa ba ya aiki ta hanyar IGF-1. Sakamako daga gwajin haƙuri na glucose na baka ya nuna cewa, ba kamar hGH ba, AOD9604 ba ya yin mummunan tasiri akan metabolism na carbohydrate. Wannan yana nufin cewa AOD9604 na iya daidaita metabolism na lipid ba tare da tsoma baki tare da metabolism na carbohydrate na yau da kullun ba, yana ba da fa'ida ta musamman don haɓaka matsayin rayuwa.
Tasiri akan hanta metabolism
A cikin nazarin kan mice tare da cututtukan hanta maras-giya, AOD9604 ba wai kawai yana shafar metabolism na lipid ba amma kuma yana daidaita yanayin yanayin hanta gaba ɗaya. Bugu da ƙari, rage yawan damuwa na oxyidative, AOD9604 na iya inganta ciwon hanta ta hanyar daidaita maganganun kwayoyin halitta da ke da alaka da haɓakar lipid, sufuri, da metabolism a cikin hanta. Yana iya rinjayar maganganun maɓalli na enzymes irin su fatty acid synthase (FAS) da acetyl-CoA carboxylase (ACC), rage ƙwayar acid mai kitse a cikin hanta, inganta fatty acid β-oxidation, kuma ta haka yana rage yawan ƙwayar hanta.
3. Yiwuwar Aikace-aikace na AOD9604's Dual Action
Aikace-aikace a cikin Kiba da Cututtukan Metabolic masu alaƙa
Idan aka ba da tasirin antioxidant na AOD9604 da tasirin tasirin rayuwa, yana riƙe yuwuwar ƙimar aikace-aikacen a cikin kula da kiba da cututtukan da ke da alaƙa kamar su nau'in ciwon sukari na 2 da cututtukan hanta mara-giya. Ga marasa lafiya masu kiba, AOD9604 na iya haɓaka metabolism na lipid, rage kitsen jiki, da haɓaka haɓakar insulin, ta haka yana taimakawa sarrafa glucose na jini. Ga marasa lafiya da cututtukan hanta maras-giya, yana iya rage lalacewar hanta oxidative danniya da daidaita metabolism na lipid hanta, mai yuwuwar yin aiki a matsayin sabon dabarun inganta aikin hanta da jinkirin ci gaban cutar.
Aikace-aikace a cikin Abincin Wasanni
A fagen abinci mai gina jiki na wasanni, AOD9604's antioxidant da kayan tallafi na rayuwa suma suna da kyau. A lokacin horarwa mai tsanani, 'yan wasa suna samar da adadi mai yawa na ROS, wanda ke haifar da lalacewar danniya na oxidative, yayin da makamashin makamashi yana buƙatar karuwa. AOD9604 na iya taimakawa wajen share ROS, rage gajiyar tsoka da lalacewa, yayin da inganta haɓakar iskar shaka don makamashi, don haka haɓaka ƙarfin motsa jiki da ƙarfin dawowa. Kodayake AOD9604 yana nuna kyakkyawan maganin antioxidant da tasirin tallafi na rayuwa, amincin sa yana da matuƙar mahimmanci. Yawancin karatu sun kimanta amincin AOD9604. A cikin bazuwar shida, makafi biyu, gwaje-gwaje masu sarrafa wuribo, AOD9604 ba shi da tasiri a kan matakan IGF-1 na jini, babu wani mummunan tasiri akan metabolism na carbohydrate, kuma ba a gano magungunan anti-AOD9604 ba. Babu alamun janyewar ko munanan abubuwan da suka shafi shan AOD9604 da aka ruwaito. A cikin nazarin toxicology na yau da kullun a cikin berayen da birai na cynomolgus, gudanarwar baka na dogon lokaci na AOD9604 shima ya nuna amincin sa gabaɗaya, ba tare da alamun genotoxicity ba.
Hoto 3 In vitro lalatawar AOD9604 a cikin ƙwayar bera a zafin jiki. Bayan mintuna 56, an kawar da peptide gaba ɗaya. Rabin rayuwar kusan mintuna 4 ne. An nuna bayyanar AOD9604 amino-terminal truncated gutsutsu (-xaa).
4. Kammalawa
AOD9604, azaman guntun peptide tare da ayyuka biyu na musamman, yana taimakawa cikin maganin antioxidant da tallafin rayuwa. Ayyukansa na antioxidant yana taimakawa rage lalacewar nama da ke hade da danniya na oxyidative, yayin da aikin tallafi na rayuwa yana daidaita tsarin lipid, carbohydrate, da hanta metabolism. Wannan ya sa ya zama mahimmanci a cikin maganin kiba da cututtukan da ke da alaƙa, da kuma a cikin abinci mai gina jiki na wasanni.
Sources
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