Los ntawm Cocer Peptides 
25 hnub dhau los
Tag nrho cov kab lus thiab cov ntaub ntawv ntawm cov khoom lag luam muab rau ntawm lub vev xaib no tsuas yog rau cov ntaub ntawv tshaj tawm kev tshaj tawm thiab cov hom phiaj kev kawm.
Cov khoom muab rau hauv lub vev xaib no yog npaj tshwj xeeb rau kev tshawb fawb hauv vitro. Kev tshawb fawb hauv vitro (Latin: * hauv iav *, lub ntsiab lus hauv iav) yog ua los ntawm tib neeg lub cev. Cov khoom no tsis yog tshuaj, tsis tau txais kev pom zoo los ntawm US Food and Drug Administration (FDA), thiab yuav tsum tsis txhob siv los tiv thaiv, kho, lossis kho txhua yam mob, kab mob, lossis mob. Nws raug txwv nruj raws li txoj cai los qhia cov khoom no rau hauv tib neeg lossis tsiaj lub cev hauv txhua daim ntawv.
Kev rog rog thiab nws cov kab mob metabolic cuam tshuam tau dhau los ua teeb meem kev noj qab haus huv thoob ntiaj teb, ua rau kev tshawb nrhiav kev nyab xeeb thiab muaj txiaj ntsig tseem ceeb. Thaum tib neeg txoj kev loj hlob hormone (hGH) qhia tau tias muaj peev xwm kho tau kev rog, kev txhawj xeeb txog kev nyab xeeb txwv nws txoj kev siv mus ntev. AOD9604, peptide fragment los ntawm C-terminal cheeb tsam ntawm hGH (Tyr-hGH177-191), tau pom tias muaj hGH cov kev ua kom txo cov rog yam tsis muaj kev phiv. Cov kev tshawb fawb tsis ntev los no tau nthuav dav ntawm nws cov haujlwm, nrog rau cov tshuaj tua kab mob antioxidant thiab metabolic txhawb kev tshwm sim los ua cov kev tshawb fawb tseem ceeb.
Daim duab 1 Obesity prevalence hauv Asmeskas cov neeg laus (20-74 xyoo).
1. Cov teebmeem antioxidant ntawm AOD9604
Kev sib raug zoo ntawm oxidative kev nyuaj siab thiab kab mob
Oxidative stress yog hais txog qhov xwm txheej uas, nyob rau hauv ntau yam teeb meem stimuli, lub cev tsim ntau ntau ntawm cov pa reactive oxygen hom (ROS) thiab reactive nitrogen hom (RNS), ua rau oxidative puas ntau tshaj lub cev lub peev xwm los tshem tawm cov hom no. Qhov kev tsis sib haum no ntawm oxidative thiab antioxidant systems ua rau cov ntaub so ntswg puas. Ntau yam kab mob, suav nrog kab mob plawv, ntshav qab zib, kab mob neurodegenerative, thiab kab mob uas tsis yog-alcoholic fatty siab (NAFLD), muaj feem cuam tshuam nrog oxidative stress. Hauv cov kab mob no, cov qib ROS nce siab hauv cov hlwb tawm tsam biomolecules xws li lipids, proteins, thiab DNA, ua rau lub cev tsis ua haujlwm thiab tuag.
AOD9604 Antioxidant Mechanism of Action
AOD9604 exerts nws cov teebmeem los ntawm kev tswj lub intracellular antioxidant enzyme system. Superoxide dismutase (SOD), glutathione peroxidase (GPx), thiab catalase (CAT) yog ib qho tseem ceeb hauv cov cellular antioxidant enzymes uas tuaj yeem tshem tawm ROS thiab tswj kev sib npaug ntawm cov cellular redox. AOD9604 tuaj yeem txhim kho kev qhia lossis kev ua haujlwm ntawm cov enzymes antioxidant, yog li txhim kho cellular antioxidant tiv thaiv muaj peev xwm. Ntawm qhov tod tes, AOD9604 tuaj yeem koom ncaj qha rau hauv kev tshem tawm cov dawb radicals. Qee pawg hauv nws cov qauv molecular yuav muaj peev xwm ntes ROS thiab RNS, yog li txo lawv cov kev puas tsuaj rau cov hlwb.
Hauv kev tshawb fawb siv tus qauv nas ntawm cov kab mob tsis muaj dej cawv fatty siab, kev kho mob nrog AOD9604 ua rau muaj kev txo qis hauv malondialdehyde (MDA) qib hauv daim siab. MDA yog cov khoom lag luam ntawm lipid peroxidation, thiab nws cov qib txo qis qhia tias txo qis hauv oxidative kev nyuaj siab. Kev ua haujlwm ntawm SOD thiab GPx hauv daim siab tau nce ntxiv, qhia tias AOD9604 tuaj yeem txo oxidative kev nyuaj siab los ntawm kev txhim kho cov haujlwm ntawm cov enzymes antioxidant. Qhov no qhia tau hais tias AOD9604 muaj txiaj ntsig zoo rau kev txhim kho oxidative kev ntxhov siab ntawm lub siab, muab cov pov thawj kev sim rau nws daim ntawv thov hauv kev kho mob ntsig txog.
2. Metabolic Support Effects ntawm AOD9604
Cov txiaj ntsig ntawm Lipid Metabolism
AOD9604 nthuav tawm cov kev cai tseem ceeb ntawm lipid metabolism. Hauv cov qauv nas rog rog, kev txhaj tshuaj ntev ntev ntawm AOD9604 ua rau txo lub cev hnyav thiab lub cev rog. Cov nyhuv no yuav cuam tshuam nrog β-adrenergic txoj hauv kev, tshwj xeeb tshaj yog β(3)-adrenergic receptor (β(3)-AR), thawj lipolytic receptor hauv adipocytes. Tom qab 14 hnub ntawm AOD9604 kev tswj hwm hauv cov nas rog rog, cov lus qhia theem ntawm β(3)-AR RNA nce, rov ua kom cov qib β(3)-AR RNA hauv cov nas rog rog mus rau qib piv rau cov nas ntshiv, yog li txhawb lipolysis thiab txhim kho lipolytic rhiab heev. Hauv β(3)-AR knockout nas, kev siv ntev ntev ntawm AOD9604 ua tsis tiav los tsim cov kev hloov pauv hnyav thiab lipolysis-txhim kho cov teebmeem xws li hauv cov nas tswj tsiaj qus, qhia tias β(3)-AR plays lub luag haujlwm tseem ceeb hauv AOD9604 txoj cai ntawm lipid metabolism. Hauv kev sim mob hnyav, AOD9604 tseem nce kev siv hluav taws xob thiab roj oxidation hauv β(3)-AR gene knockout nas, qhia tias AOD9604 tseem tuaj yeem cuam tshuam lipid metabolism los ntawm lwm txoj hauv kev.
Daim duab 2 Cov nyhuv ntawm ib zaug ib hnub intraperitoneal (ip) koob tshuaj saline, AOD9604, lossis tib neeg kev loj hlob hormone (hGH) ntawm lub cev hnyav hloov pauv hauv txiv neej lean C57BL / 6J (A) lossis rog (ob / ob) nas (B) dhau 14 hnub.
Kev cuam tshuam rau cov metabolism hauv carbohydrate
Nyob rau hauv cov nqe lus ntawm carbohydrate metabolism, AOD9604 txawv heev ntawm hGH. Kev sim tshuaj ntsuam xyuas qhia tias AOD9604 tsis muaj kev cuam tshuam rau qib ntshav IGF-1, lees paub qhov kev xav tias nws tsis ua los ntawm IGF-1. Cov txiaj ntsig los ntawm kev ntsuas qhov ncauj qhov ncauj pom tau tias, tsis zoo li hGH, AOD9604 tsis cuam tshuam rau cov metabolism hauv carbohydrate. Qhov no txhais tau hais tias AOD9604 tuaj yeem tswj hwm lipid metabolism yam tsis cuam tshuam nrog cov carbohydrate metabolism hauv ib txwm, muab qhov tshwj xeeb zoo hauv kev txhim kho cov txheej txheem metabolic.
Kev cuam tshuam rau daim siab metabolism
Hauv kev tshawb fawb ntawm cov nas uas tsis muaj dej cawv fatty siab kab mob, AOD9604 tsis tsuas yog cuam tshuam rau lipid metabolism, tab sis kuj tswj tag nrho cov metabolic xeev ntawm daim siab. Ntxiv nrog rau kev txo qis oxidative kev nyuaj siab, AOD9604 tuaj yeem txhim kho hepatic steatosis los ntawm kev tswj cov kev qhia ntawm cov noob ntsig txog lipid synthesis, thauj, thiab cov metabolism hauv lub siab. Nws tuaj yeem cuam tshuam qhov kev qhia ntawm cov enzymes tseem ceeb xws li fatty acid synthase (FAS) thiab acetyl-CoA carboxylase (ACC), txo fatty acid synthesis nyob rau hauv daim siab, txhawb fatty acid β-oxidation, thiab li no alleviating hepatic rog tsub zuj zuj.
3. Muaj peev xwm siv tau ntawm AOD9604's Dual Action
Daim ntawv thov nyob rau hauv Obesity thiab Lwm Cov Kab Mob Metabolic
Muab AOD9604's antioxidant thiab metabolic txhawb cov teebmeem, nws tuav cov txiaj ntsig ntawm daim ntawv thov hauv kev kho mob rog rog thiab lwm yam kab mob metabolic xws li hom 2 mob ntshav qab zib thiab kab mob tsis muaj dej cawv fatty siab. Rau cov neeg mob rog rog, AOD9604 tuaj yeem txhawb lipid metabolism, txo cov rog hauv lub cev, thiab txhim kho cov tshuaj insulin, yog li pab tswj ntshav qabzib. Rau cov neeg mob uas tsis yog-alcoholic fatty siab kab mob, nws muaj peev xwm ob leeg alleviate daim siab oxidative kev nyuaj siab puas thiab tswj daim siab lipid metabolism, muaj peev xwm ua raws li ib tug tshiab lub tswv yim los txhim kho daim siab ua hauj lwm thiab qeeb cov kab mob.
Daim ntawv thov hauv Kev Noj Qab Haus Huv Kev Noj Qab Haus Huv
Hauv kev ua kis las khoom noj khoom haus, AOD9604's antioxidant thiab metabolic txhawb zog kuj tseem zoo nkauj. Thaum lub sij hawm kev cob qhia siab, cov neeg ncaws pob tsim ntau ntau ntawm ROS, ua rau oxidative kev nyuaj siab puas tsuaj, thaum lub zog metabolism xav tau nce. AOD9604 tuaj yeem pab tshem tawm ROS, txo cov leeg nqaij thiab kev puas tsuaj, thaum txhawb nqa cov roj oxidation rau lub zog, yog li txhim kho kev ua kom muaj zog thiab muaj peev xwm rov qab los. Txawm hais tias AOD9604 qhia tau zoo heev antioxidant thiab metabolic txhawb cov teebmeem, nws txoj kev nyab xeeb yog qhov tseem ceeb tshaj plaws. Ntau qhov kev tshawb fawb tau soj ntsuam kev nyab xeeb ntawm AOD9604. Hauv rau randomized, ob-dig muag, kev sim tshuaj placebo, AOD9604 tsis muaj kev cuam tshuam rau qib ntshav IGF-1, tsis muaj kev cuam tshuam tsis zoo rau cov metabolism hauv carbohydrate, thiab tsis muaj tshuaj tiv thaiv AOD9604. Tsis muaj cov tsos mob tshem tawm lossis cov xwm txheej tsis zoo uas cuam tshuam nrog AOD9604 tau txais. Hauv kev tshawb fawb toxicology ntev hauv cov nas thiab cynomolgus liab, kev tswj hwm qhov ncauj ntev ntawm AOD9604 kuj tau qhia nws txoj kev nyab xeeb dav dav, tsis muaj cov cim qhia ntawm genotoxicity.
Daim duab 3 Hauv vitro degradation ntawm AOD9604 hauv nas ntshav ntawm chav sov. Tom qab 56 feeb, peptide raug tshem tawm tag nrho. Lub neej ib nrab yog kwv yees li 4 feeb. Cov tsos ntawm AOD9604 amino-terminal truncated fragments (-xaa) yog pom.
4. Cov lus xaus
AOD9604, raws li ib qho peptide fragment nrog cov cim dual kev ua, pab hauv antioxidant thiab metabolic txhawb. Nws cov tshuaj tiv thaiv antioxidant pab txo cov ntaub so ntswg puas cuam tshuam nrog oxidative kev nyuaj siab, thaum nws cov metabolic txhawb kev ua tau zoo tswj cov lipid, carbohydrate, thiab daim siab metabolism. Qhov no ua rau nws tseem ceeb hauv kev kho cov rog rog thiab cov kab mob metabolic, nrog rau kev noj zaub mov zoo.
Qhov chaw
[1] Dehbashi M, Fathi M, Hosseini SRA, et al. اثر هشت هفته تمرین استقامتی و تزریق قطعه لیپولیتیک هورمون رشد (AOD9604) بر آنزیمهای کبد و CK18 ی و شهالدای کبد و CK18 ی و شهالدای کبد و CK18 ی و شهالدهای کبد و CK18 به کبد چرب غیرالکلی ناشی از رژیم غذایی پر چرب, 2021 [C]. https://api.semanticscholar.org/CorpusID: 236556287
[2] EMIM, Kenley D. L. Kev Nyab Xeeb thiab Metabolism ntawm AOD9604, Cov Khoom Noj Ntshiab Nutraceutical rau Txhim Kho Metabolic Health[J]. Phau ntawv Journal of Endocrinology thiab Metabolism, 2014, 4: 64-77. https://api.semanticscholar.org/CorpusID: 67761634
[3] Stier H, Vos E, Kenley D. Phau ntawv Journal of Endocrinology thiab Metabolism, 2013, 3:7-15. https://api.semanticscholar.org/CorpusID:56559133
[4] Melnikova I, Wages D. Anti-obesity therapies[J]. Nature Reviews Drug Discovery, 2006,5(5):369-370.DOI:10.1038/nrd2037.
[5] Heffernan M, Summers RJ, Thorburn A, et al. Cov teebmeem ntawm tib neeg GH thiab nws cov lipolytic fragment (AOD9604) ntawm lipid metabolism tom qab kev kho mob ntev hauv cov nas rog rog thiab beta(3)-AR khob tawm nas[J]. Endocrinology, 2001,142(12):5182-5189.DOI:10.1210/endo.142.12.8522.
Cov khoom muaj rau kev tshawb fawb siv nkaus xwb:
