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1 ngwa (10 Vials)
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▎ Thymulin Ọdịdị
Isi mmalite: PubChem |
Usoro: XAKSQGGSN Ụdị mkpụrụ ndụ: C 33H 54N 12O15 Ibu ibu: 858.9 g/mol Nọmba CAS: 63958-90-7 PubChem CID: 3085284 Ihe atụ: Nonathymulin |
▎ Thymulin Nnyocha
Gịnị bụ ndabere nyocha nke Thymulin?
Nnyocha na Thymulin malitere site na nyocha nke ndị ọkà mmụta sayensị mere ihe ndị na-adịghị ahụkebe na-adịghị ahụkebe n'ime ihe ndị thymic. N'afọ ndị 1970, obere polypeptide a nke mejupụtara amino acid 43 dịpụrụ adịpụ site na bovine thymus, a chọpụtakwara na ọ na-arụ ọrụ dị mkpa na ọdịiche dị na cell cell, karịsịa n'ịhazi mmepe nke cell T, si otú a na-amalite nyocha miri emi na Thymulin.
Site na nyocha na-aga n'ihu, ọrụ Thymulin ejirila nke nta nke nta gbasaa. Ọ bụghị naanị na ọ na-egosiputa ama ama na nhazi nke usoro ahụ ji alụso ọrịa ọgụ ma na-egosipụtakwa ikike dị ukwuu na nrụzi anụ ahụ, mgbochi mbufụt, na mgbochi fibrosis. Nchọpụta ndị a emeela ka nyocha Thymulin gbasaa ọtụtụ ọzụzụ, ebe ndị ọkà mmụta sayensị na-enyocha ọrụ ọgwụgwọ ya na ọrịa mkpali dị ka ụkwara ume ọkụ na otutu sclerosis, yana ọnọdụ dị ka mmerụ ahụ myocardial na nsogbu COVID-19, na-atọ ntọala ntọala maka ngwa ụlọ ọgwụ ya.
Kedu ihe bụ usoro ọrụ nke Thymulin?
Usoro mgbochi mkpali
Mgbochi nke Mgbasa Ozi Mgbasa Ozi: Thymulin nwere ike belata ntọhapụ nke ndị mgbasa ozi mkpali dị ka cytokines na chemokines. N'oge nzaghachi mkpali, a na-ahapụ ndị ogbugbo ndị a nke ukwuu, na-ebute mgbaàmà mkpali. Dịka ọmụmaatụ, na ụdị oke nke mbufụt nke Freund's adjuvant (CFA) zuru ezu kpatara, ọgwụgwọ Thymulin belatara mmepụta nke cytokines pro-inflammatory spinal dị ka tumor necrosis factor-α (TNF-α) na interleukin-6 (IL-6), si otú ahụ na-ebelata nzaghachi mkpali [1]..
Nkwalite nke Ihe Na-egbochi Mgbochi: Ọ nwekwara ike ịkwalite ihe mgbochi mkpali dị ka interleukin-10 (IL-10). IL-10 bụ cytokine na-egbochi mkpali dị egwu nke na-egbochi ọrụ nke mkpụrụ ndụ mkpali ma na-ebelata mbufụt. Site n'ịkwalite IL-10, Thymulin na-enyere aka ịnọgide na-enwe nguzozi mkpali nke ahụ ma na-egbochi mmebi anụ ahụ site na oke mbufụt [2]..
Iwu nke ihe odide ederede na ndị ogbugbo: Thymulin na-enweta njikwa molikula nke mbufụt site na ịhazi ihe ederede na ndị ogbugbo. Ihe odide ederede na-achịkwa okwu nke mkpụrụ ndụ ihe nketa metụtara mbufụt, na Thymulin nwere ike imetụta ọrụ nke ihe ndị a, si otú ahụ belata njikọ nke protein ndị metụtara mbufụt na ịnweta mmetụta mgbochi mkpali [2]..
Mechanism antihyperalgesic
Mmetụta na Spinal Microglia: N'ụdị mgbu na-egbuke egbuke, Thymulin na-egbochi ịmalite microglia spinal. Microglia na-arụ ọrụ site na mkpali mkpali, na-ahapụ ọtụtụ ndị mgbasa ozi mkpali nke na-eme ka nghọta mgbu dịkwuo njọ. Thymulin na-ebelata ntọhapụ nke ndị ogbugbo ndị a site na ibelata ọrụ microglial, si otú a na-ebelata hyperalgesia. N'ụdị oke mkpali nke CFA kpatara, ọgwụgwọ Thymulin belatara nke ukwuu hyperalgesia thermal na paw edema ka ọ na-ebelata ọrụ microglial na-ebute CFA [1] .
Ọrụ na p38 MAPK Signal Pathway: Thymulin na-ebelata phosphorylation nke p38 mitogen-activated protein kinase (p38 MAPK). Ụzọ nrịbama p38 MAPK dị oké mkpa na mkpali na ihe mgbu; phosphorylation ya na-eme ka usoro mkpụrụ ndụ ihe mgbaàmà dị n'okpuru, na-eduga n'ịmepụta ndị mgbasa ozi mkpali na hyperalgesia. Thymulin na-ebelata mgbu mgbu site na igbochi p38 MAPK phosphorylation na igbochi ụzọ mgbaàmà a [1].
Immunomodulatory Mechanism
T Ụdị Lymphocyte: Thymulin bụ hormone dị mkpa maka T lymphocyte dị iche iche, dị oke mkpa maka mmepe nkịtị na ịrụ ọrụ nke T lymphocytes. Ọ na-ekere òkè n'ịhazi nha nke mkpụrụ ndụ inyeaka T na-egbochi mkpụrụ ndụ, na-enye aka na nguzozi na nkwụsi ike nke usoro ahụ ji alụso ọrịa ọgụ. Ọkwa Thymulin na-adịghị mma nwere ike iduga arụ ọrụ T lymphocyte na ọrịa ndị metụtara mgbochi.
Usoro nke ọrụ mgbochi ọrịa: N'ime ụdị granuloma òké nke bacille Calmette-Guérin (BCG) kpatara, 5CH dilution nke Thymulin na-achịkwa ọdịiche nke phagocytes mpaghara na nke sistemu, kwalitere ọdịiche nke B1 peritoneal stem cell n'ime phagocytes, ma mụbaa ọnụ ọgụgụ CD8⁺ na lymphocytes na mpaghara. granulomatous mbufụt usoro. Nke a na-egosi na Thymulin na-ahazi ọrụ nke mkpụrụ ndụ na-alụso ọrịa ọgụ [2] .
Mechanism nke Action na Neuroendocrine System
Usoro iwu bidirectional: Mmepụta na nzuzo nke Thymulin na-enwe mmetụta dị ukwuu site na sistemụ neuroendocrine, ọ nwekwara ike rụọ ọrụ dị ka peptide hypophysiotropic na sistemụ neuroendocrine. Mmekọrịta usoro iwu bidirectional a na-egosi na Thymulin na-arụ ọrụ dị mkpa na mmekọrịta dị n'etiti neuroendocrine na sistemu ahụ ji alụso ọrịa ọgụ, na-enyere aka ịnọgide na-enwe nguzozi physiological n'ime ahụ [3]..
Kedu ihe bụ ngwa Thymulin?
Mmetụta mgbochi mkpali
Mwepụ nke Mgbu Mgbu: N'ụdị mbufụt oke (dị ka ụdị mbufụt nke CFA), injection intraperitoneal nke Thymulin na-ebelata nke ukwuu CFA-induced thermal hyperalgesia na paw edema. Ihe omumu ihe omumu nke ihe omumu gosiputara na Thymulin belatara CFA-induced microglial activation, p38 MAPK phosphorylation, na spinal pro-inflammatory cytokine (eg, TNF-a, IL-6), si otú a na-ebelata mbufụt na ibelata mgbaàmà mgbu [1].
Mmelite nke mbufụt nke ụgbọ elu: N'ụdị òké nnwale nke ụkwara ume ọkụ, usoro ọgwụgwọ Thymulin nke sitere na DNA nanoparticles na-egbochi mbufụt nke akpa ume. Otu mkpụrụ ọgwụ DNA nanoparticles na-ebu Thymulin plasmid gbochiri nzaghachi mkpali na ngụgụ nke ụmụ oke ụkwara ume ọkụ nke ovalbumin na-ama aka, gụnyere ibelata ntinye sel mkpali na imezi usoro ngụgụ [4] (Da SA, 2014). Na mgbakwunye, ọgwụgwọ intracheal nke ụkwara ume ọkụ zuru oke na Thymulin na-egosipụta plasmid ewepụtara site na nanoparticles na-ahazi njirimara isi pathological nke mbufụt na-adịghị ala ala na ngụgụ asthmatic ka ụbọchị 20 gasịrị, nke ọgwụgwọ jikọtara ọnụ na-egbochi mkpali na mgbochi fibrotic [4]..
Ọgụgụ 1 Ọnụ ọgụgụ ndị ogbugbo metụtara ụkwara ume ọkụ na BALF. Ọkwa nke cytokines pro-inflammatory TH2, gụnyere (A) IL-4 na (B) IL-13, (C) cytokine mgbochi mkpali, IL-10, na cytokines profibrotic, gụnyere (D) VEGF na (E) TGF-β, bụ ELISA (n = 6 mice kwa otu).
Isi mmalite: PubMed [4]
Mmetụta Immunomodulatory
Usoro nke usoro mbufụt nke granulomatous: N'ime ụdị granuloma òké na-ebute BCG, homeopathic 5CH-diluted Thymulin na-achịkwa ọdịiche nke phagocytes mpaghara na sistemu na Mbugharị T cell na ọnụ ọgụgụ lymph mpaghara, si otú ahụ na-emeziwanye usoro mbufụt granulomatous. Kpọmkwem, mgbe ụbọchị 21 nke ọrịa gasịrị, ụmụ oke Thymulin na-emeso gosipụtara ọnụ ọgụgụ dị elu na ọdịiche nke B1 peritoneal stem cell n'ime phagocytes, belata ọnụ ọgụgụ nke phagocytes na-ebute ọrịa na ọnya (na-egosi ọrịa na-adịghị ala ala), na ụbara ọnụ ọgụgụ nke B1-enwetara phagocytes, CD4⁺, na CD4 na mpaghara lymphocytes ..
Enyemaka nke Experimental Autoimmune Encephalomyelitis Symptoms: N'ụdị òké nke nlọghachi azụ nnwale autoimmune encephalomyelitis (rEAE), Thymulin jikọtara ya na polybutylcyanoacrylate (PBCA) nanoparticles nanoparticles belatara akara ngosi rEAE nke ukwuu, belata ọkwa cytokine plasma cade na cytokine SAPκ, yana belata ọkwa cytokine plasma. ịgbalite. Thymulin na-ahazi ọrụ ụzọ NF-κB site na phosphorylation saịtị kpọmkwem nke protein RelA/p65 (na saịtị Ser276 na Ser536), na Thymulin na-ejikọta nanoparticle dị irè karịa Thymulin efu, na-ekwe nkwa dị ka ọgwụgwọ a na-atụ anya maka ọrịa a [5].
Mmetụta Anti-Fibrotic: N'ụdị ụkwara ume ọkụ na-egbu mgbu, Thymulin ọ bụghị nanị na-ebelata mbufụt kamakwa ọ na-egbochi fibrosis pulmonary. Ọmụmaatụ, DNA nanoparticle-mediated Thymulin genetherapy gbochiri ntinye collagen na hypertrophy muscle dị nro na ngụgụ òké, na ịgwọ ụkwara ume ọkụ na Thymulin na-egosipụta plasmid ewepụtara site na nanoparticles normalized pulmonary fibrosis, na-egosi na Thymulin na-egbochi fibrosis anụ ahụ ma na-enyere aka melite nhazi anụ ahụ na ọrụ [4]..
Ngwa nwere ike na ọgwụgwọ COVID-19: N'oge ọrịa COVID-19, ọmụmụ tụrụ aro na Thymulin nwere ike bụrụ ọgwụgwọ maka ikpe COVID-19 siri ike. Ọrịa ifufe nke Cytokine n'ihi nrụrụ mgbochi mgbochi bụ otu n'ime usoro kachasị egwu na-eduga ọnwụ na ndị ọrịa COVID-19 siri ike, na usoro sistemu ahụ ji alụso ọrịa ọgụ nwere ike ibelata ọnwụ. Dị ka peptide thymic, Thymulin na-ekwe nkwa maka ịgwọ ọrịa COVID-19 siri ike site na ịchịkwa oke ifufe cytokine [7].
Mmechi
Thymulin na-egosipụta mgbochi mkpali, immunomodulatory, na mgbochi fibrotic mmetụta, ike ibelata mkpali mgbu, na-eme ka airway mbufụt na pulmonary fibrosis, ibelata reEAE mgbaàmà, na-achịkwa dịghịzi cell iche iche na granulomas. Tinyere ya site na nnyefe nanoparticle na ụzọ ndị ọzọ, ọ egosipụtala ịdị irè n'ọrịa ndị dị ka ụkwara ume ọkụ ma nwee ike ịgwọ ajọ ifufe cytokine COVID-19.
Banyere Onye dere ya
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Onye ode akwụkwọ akụkọ sayensị
Adriana Lopes da Silva bụ ọkà mmụta nwere mmetụta dị ukwuu n'ihe gbasara ọgwụ na nyocha. Ọ jikọtara ya na ọtụtụ ụlọ ọrụ ama ama, gụnyere Hospitallọ Ọgwụ Israelta Albert Einstein, Universidade Estadual de Santa Cruz, Mahadum Queensland, Mahadum Toronto, na Universidade Federal do Rio de Janeiro. FAPERJ na-akwadokwa ya. Mmasị nyocha ya gbasara n'ofe General & Internal Medicine, Respiratory System, Pharmacology & Pharmacy, na Physiology. Ebe ọmụmụ ihe ndị a dị oke mkpa maka ịkwalite ahụike mmadụ na ahụike ahụike.Adriana Lopes da Silva ka edepụtara na ntinye aka [6].
