Thymulin 10mg

Imiterere ya Thymulin Structure

Research bwa Thymulin Ubushakashatsi

Ni ubuhe bushakashatsi bwakozwe na Thymulin?  

Ubushakashatsi kuri Thymulin bwatangiranye nubushakashatsi bwakozwe mubushakashatsi bwibigize ubudahangarwa bw'umubiri wa thymic. Mu myaka ya za 70, iyi polypeptide ntoya igizwe na aside amine 43 yatandukanijwe na bovine thymus, kandi byavumbuwe kugira uruhare runini mu gutandukanya ingirabuzimafatizo, cyane cyane mu kugenzura iterambere ry’uturemangingo T, bityo itangiza ubushakashatsi bwimbitse kuri Thymulin.  

Hamwe niterambere ryubushakashatsi, imikorere ya Thymulin yaguwe buhoro buhoro. Ntabwo yerekana gusa umwanya munini mu kugenzura ubudahangarwa bw'umubiri ahubwo inagaragaza imbaraga zikomeye mu gusana ingirabuzimafatizo, kurwanya indwara, no kurwanya fibrosis. Ibyavuye mu bushakashatsi byatumye ubushakashatsi bwa Thymulin bugera ku bumenyi butandukanye, abahanga mu bya siyansi bashakisha uruhare rwayo mu kuvura indwara zanduza nka asima na sclerose nyinshi, ndetse n’imiterere nko gukomeretsa myocardial hamwe n’ibibazo bya COVID-19, bishyiraho urufatiro rw’ibikorwa byo kuvura.  

Ni ubuhe buryo bwo gukora bwa Thymuline?  

Uburyo bwo kurwanya ibicanwa  

Kubuza abunzi ba Inflammatory kurekura: Thymuline irashobora kugabanya irekurwa ryabunzi batera nka cytokine na chemokine. Mugihe cyo gusubiza umuriro, aba bahuza bararekuwe cyane, bikurura ibimenyetso byumuriro. Kurugero, muburyo bwimbeba yubushuhe buterwa no kwuzuza kwa Freund (CFA), kuvura Thymuline byagabanije umusaruro wa cytokine yumugongo nka fonctionnement yibibyimba-α (TNF-α) na interleukin-6 (IL-6), bityo bigabanya igisubizo cyo gutwika ^[1].  

Kugenzura ibintu birwanya indwara: Irashobora kandi kugenzura ibintu birwanya inflammatory nka interleukin-10 (IL-10). IL-10 ni cytokine ikomeye yo kurwanya inflammatory ibuza ibikorwa bya selile inflammatory kandi igabanya gucana. Mugukurikiza IL-10, Thymuline ifasha kugumana uburibwe bwumubiri kandi ikarinda kwangirika kwingirangingo ^..  

Kugena ibintu byandikirwa hamwe nabunzi: Thymuline igera kuri molekuline yo kugenzura ibicanwa binyuze muguhuza ibintu byandikirwa hamwe nabunzi. Impapuro zanduza zigenga imiterere ya genes zijyanye no gutwika, kandi Thymuline irashobora guhindura imikorere yibi bintu, bityo bikagabanya synthesis ya proteine ​​ziterwa no gutwika no kugera ku ngaruka zo kurwanya inflammatory ^[2].  

Uburyo bwa Antihyperalgesic  

Ingaruka kuri Microglia yumugongo: Muburyo bwububabare bukabije, Thymuline ibuza gukora microglia yumugongo. Microglia itangira gukangurwa no gukongeza umuriro, ikarekura abunzi benshi batera ububabare bwongera ububabare. Thymuline igabanya irekurwa ryaba bunzi mugabanya mikorobe, bityo bikagabanya hyperalgesia. Mu buryo bwa CFA buterwa no kwerekana imbeba, kuvura Thymuline byagabanije cyane hyperalgesia yumuriro hamwe nindwara ya paw mugihe bigabanya mikorobe iterwa na CFA ^. .

Uruhare muri p38 MAPK Yerekana Inzira: Thymuline igabanya fosifora ya p38 mitogen-ikora protein kinase (p38 MAPK). Inzira ya p38 MAPK yerekana inzira ningirakamaro mukumenyesha ububabare no kubabara; fosifora yayo ikora urukurikirane rw'ibimenyetso byerekana molekile, biganisha ku musaruro w'abunzi batera umuriro na hyperalgesia. Thymuline igabanya ububabare butwika muguhagarika p38 MAPK fosifora no guhagarika iyi nzira yerekana ^[1].  

Uburyo bwo gukingira indwara  

T Lymphocyte Itandukaniro: Thymuline ni imisemburo ikenewe mugutandukanya T lymphocyte, ingenzi kumikurire isanzwe no kubungabunga imikorere ya lymphocytes T. Ifite uruhare mukugereranya igipimo cyutugingo ngengabuzima twa T na selile suppressor selile, bigira uruhare mukuringaniza no gutuza kwimikorere yumubiri. Urwego rwa Thymuline rudasanzwe rushobora gutuma T lymphocyte idakora neza n'indwara ziterwa n'ubudahangarwa.  

Amabwiriza yimikorere ya selile Immune: Muri moderi ya granuloma yimbeba yatewe na bacille Calmette-Guérin (BCG), 5CH ya Thymuline yagengaga itandukanyirizo rya fagocytes yaho na sisitemu, iteza imbere itandukanyirizo rya B1 peritoneal stem phagocytes, kandi byongera umubare wa CD4⁺ na CD8⁺ T lymphomatite. Ibi byerekana ko Thymuline igenga imikorere yingirabuzimafatizo ^[2] .  

Uburyo bwibikorwa kuri sisitemu ya Neuroendocrine  

Amabwiriza agenga ibice bibiri: Umusaruro no gusohora kwa Thymuline bigira ingaruka zikomeye kuri sisitemu ya neuroendocrine, kandi irashobora no gukora nka peptide ya hypophysiotropique kuri sisitemu ya neuroendocrine. Iyi mibanire y’ibice byombi yerekana ko Thymuline igira uruhare runini mu mikoranire hagati ya neuroendocrine na sisitemu y’umubiri, ifasha kugumana uburinganire bw’umubiri muri rusange ^[3].  

Ni ubuhe buryo bukoreshwa na Thymulin?  

Ingaruka zo Kurwanya  

Kugabanya ububabare butwika: Muburyo bwo gutwika imbeba (nka moderi ya CFA iterwa no gutwika), gutera intraperitoneal ya Thymuline byagabanije cyane CFA iterwa na hyperalgesia yumuriro na edema. Ubushakashatsi bwakozwe na molekuline bwerekanye ko Thymulin yagabanije gukora mikorobe iterwa na CFA, p38 ya fosifori ya MAPK, hamwe na cytokine yumugongo (urugero, TNF-α, IL-6), bityo bikagabanya uburibwe no kugabanya ibimenyetso byububabare ^[1].  

Gutezimbere kwa Airway Inflammation: Muburyo bwimbeba yimbeba ya asima ya allergique, imiti ya Thymulin ivura yunganirwa na ADN nanoparticles yarinze ibihaha. Igipimo kimwe cya ADN nanoparticles itwara plasidike ya Thymuline yahagaritse ibisubizo by’ibihaha mu bihaha by’imbeba ya asima ya allergique yatewe na ovalbumin, harimo no kugabanya kwinjira mu ngirabuzimafatizo no kunoza ubukanishi bw’ibihaha ^[4] (Da SA, 2014). Byongeye kandi, kuvura indwara ya asima yuzuye hamwe na plasidike yerekana Thymuline itangwa binyuze muri nanoparticles yamenyesheje ibintu byingenzi by’indwara ziterwa n’umuriro udakira mu bihaha bya asima nyuma yiminsi 20, byahujwe n’ubuvuzi hamwe no kurwanya indwara ya anti-inflammatory na anti-fibrotic ^[4].  

Igishushanyo 1 Umubare wabunzi ba asima muri BALF. Urwego rwa porotokore ya TH2 cytokine, harimo (A) IL-4 na (B) IL-13, (C) cytokine irwanya inflammatory, IL-10, na cytokine ya profibrotic, harimo (D) VEGF na (E) TGF-β, byagereranijwe na ELISA (imbeba n = 6 kuri buri tsinda).  

Inkomoko: PubMed ^[4]

Ingaruka zo gukingira indwara  

Kugena uburyo bwo gutwika Granulomatique: Muri moderi ya granuloma ya BCG iterwa na BCG, homeopathic 5CH-ivanze na Thymulin yagenzuye itandukaniro rya fagocytes yaho na sisitemu hamwe na T selile yimuka ya lymph node, bityo bigateza imbere uburyo bwo gutwika granulomatique. By'umwihariko, nyuma yiminsi 21 yanduye, imbeba zavuwe na Thymuline zagaragaje impinga ndende mu gutandukanya ingirabuzimafatizo za B1 peritoneal na phagocytes, kugabanya umubare wa fagocytes yanduye mu bisebe (byerekana kwandura indwara), no kongera umubare wa fagocytes B1 ukomoka kuri CD1, na CD8⁺ T lymphhocytes zaho ^..

Kugabanya ibimenyetso bya Autoimmune Encephalomyelitis Ibimenyetso: Muburyo bwimbeba yo gusubiramo-kohereza ubushakashatsi bwa autoimmune encephalomyelitis (rEAE), Thymuline ihambiriye polybutylcyanoacrylate (PBCA) nanoparticles yagabanije cyane ibimenyetso bya rEAE, kandi igabanya ibikorwa bya SAPK-J. Thymuline igenga ibikorwa byinzira ya NF-κB ikoresheje urubuga rwihariye rwa fosifora ya poroteyine ya RelA / p65 (ku mbuga za Ser276 na Ser536), kandi Thymuline ihujwe na nanoparticle yagize akamaro kuruta Thymuline yubusa, isezeranya ko ishobora kuvura iyi ndwara ^[5].  

Ingaruka zo kurwanya Fibrotic: Muri moderi ya asima ya allergique, Thymuline ntiyagabanije gucana gusa ahubwo yanabujije fibrosis yo mu bihaha. Kurugero, ADN nanoparticle-yunganirwa na Thymulin gene ivura yabujije koherezwa kwa kolagen hamwe na hypertrophy yimitsi yoroheje mu bihaha byimbeba, no kuvura asima yashizweho na plasidike yerekana Thymulin yatanzwe binyuze muri nanoparticles isanzwe fibrosis yimpyiko, byerekana ko Thymuline ibuza fiboside yumubiri kandi ikora neza ^{[4, 6]}.

Ibishobora gukoreshwa mu kuvura COVID-19: Mugihe c'icyorezo cya COVID-19, ubushakashatsi bwerekanye ko Thymulin ashobora kuba umuti w’indwara zikomeye za COVID-19. Indwara ya Cytokine iterwa no kutagira ubudahangarwa bw'umubiri ni bumwe mu buryo bukomeye buganisha ku rupfu rw'abarwayi ba COVID-19, kandi amabwiriza agenga umubiri ashobora kugabanya impfu. Nka peptide ya thimic, Thymulin yizeza kuvura indwara zikomeye za COVID-19 mu kugenzura umuyaga wa cytokine ^..  

Umwanzuro

Thymuline yerekana anti-inflammatory, immunomodulatory, na anti-fibrotic, ishobora kugabanya ububabare butwika, kunoza impemu zo mu kirere hamwe na fibrosis yo mu bihaha, kugabanya ibimenyetso bya rEAE, no kugabanya itandukaniro ry’umubiri muri granuloma. Ikoreshwa binyuze mu gutanga nanoparticle hamwe nubundi buryo, yerekanye imbaraga mu ndwara nka asima ya allergique kandi ifite ubushobozi bwo kuvura inkubi y'umuyaga ya COVID-19.

Ibyerekeye Umwanditsi

Ibikoresho byavuzwe haruguru byose byakorewe ubushakashatsi, byahinduwe kandi byakozwe na Cocer Peptides.

Umwanditsi w'ikinyamakuru

Adriana Lopes da Silva nintiti ikomeye cyane mubuvuzi nubushakashatsi. Afatanije n’ibigo byinshi bizwi, birimo ibitaro Isiraheliita Albert Einstein, Universidade Estadual de Santa Cruz, Kaminuza ya Queensland, Kaminuza ya Toronto, na Universidade Federal do Rio de Janeiro. Ashigikiwe kandi na FAPERJ. Inyungu zubushakashatsi bwe zikoreshwa mubuvuzi rusange & Imbere, Sisitemu yubuhumekero, Pharmacology & Farumasi, na Physiology. Ibi bice byubushakashatsi nibyingenzi mugutezimbere ubuzima bwabantu nubumenyi bwubuvuzi.Adriana Lopes da Silva yanditse kurutonde rwavuzwe [6].

Imirongo ijyanye

[1] Nasseri B, Zaringhalam J, Daniali S, n'abandi. Ubuvuzi bwa Thymuline butera ububabare bukabije muguhindura inzira ya selile na selile yerekana inzira [J]. Immunopharmacology mpuzamahanga, 2019,70: 225-234.DOI: 10.1016 / j.intimp.2019.02.042.

[2] Haddad JJE, ENES, Garabedian B S. Thymulin: Molecule Irwanya Kurwanya Indwara [J]. Ubuvuzi bwa chimie yubu - Anti-Inflammatory & Anti-Allergie, 2005,4: 333-338. https://api.semanticscholar.org/CorpusID:55757311.

[3] Bonamin L, Sato C, Santana F, n'abandi. Gutandukanya no guhindura ibikorwa bya fagocyte muri murine granuloma nyuma yo kuvurwa na thymuline 5cH [J]. Ikinyamakuru mpuzamahanga cyubushakashatsi bukabije - ISSN 1982-6206, 2021,11: 148.DOI: 10.51910 / ijhdr.v11i40.580.

[4] Da SA, Martini SV, Abreu SC, n'abandi. ADN nanoparticle-yunganirwa na thymulin gene ivura irinda guhumeka umwuka muri asima ya allergique [J]. Ikinyamakuru cyo kugenzura gusohora, 2014,180: 125-133.DOI: 10.1016 / j.jconrel 2014.02.010.

[5] Lunin SM, Khrenov MO, Glushkova OV, n'abandi. Ingaruka zo Kurinda PBCA Nanoparticles Yapakishijwe Thymuline Kurwanya Gusubiramo-Gukuraho Uburyo bwa Autoimmune Encephalomyelitis mu mbeba [J]. Ikinyamakuru mpuzamahanga cyubumenyi bwa molecular, 2019,20 (21) .DOI: 10.3390 / ijms20215374.

[6] Da SA, de Oliveira GP, Kim N, n'abandi. Nanoparticle ishingiye kuri thymuline gene ivura ivura ihinduranya indwara nyamukuru ya asima ya allergique [J]. Iterambere ry'ubumenyi, 2020,6 (24): eaay7973.DOI: 10.1126 / sciadv.aay7973.

[7] Vishal C, Ajay K, Tech KR M. Thymulin - ibyiringiro bivuye mu gasanduku mu mpanuka ya COVID-19, 2020 [C]. https://api.semanticscholar.org/CorpusID:231646690

INGINGO ZOSE N'AMAKURU Y’IBICURUZWA BITANZWE KURI URU RUBUGA BISANZWE KUBONA AMAKURU N'INTEGO Z'UBUREZI.  

Ibicuruzwa byatanzwe kururu rubuga bigenewe gusa mubushakashatsi bwa vitro. Mu bushakashatsi bwa vitro (Ikilatini: * mu kirahure *, bisobanura mu bikoresho by'ibirahure) bikorwa hanze y'umubiri w'umuntu. Ibicuruzwa ntabwo ari imiti, ntabwo byemejwe n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA), kandi ntigomba gukoreshwa mu gukumira, kuvura, cyangwa gukiza indwara iyo ari yo yose y’ubuvuzi, indwara, cyangwa indwara. Birabujijwe rwose n'amategeko kwinjiza ibyo bicuruzwa mumubiri wabantu cyangwa inyamaswa muburyo ubwo aribwo bwose.