Cocer Peptides ye 
ŋlɔe ɣleti 1 enye sia
NYATAKAKAWO KPLE NUSIWO WOTSƆ ƑE NYATAKAKA SIWO KAtã WOÐO LE NYATAKAKADZRAÐOƑE SIA ME LA KPLE NYATAKAKAWO kaka KPLEE NUFIAFIA ƑE TAÐOÐOWO KO.
Wotrɔ asi le atike siwo wona le nyatakakadzraɖoƒe sia ŋu na numekuku le vitro ɖeɖeko. Wowɔa numekuku le vitro (Latingbe me: *le ahuhɔ̃e me*, si gɔmee nye le ahuhɔ̃e me) le amegbetɔ ƒe ŋutilã godo. Atike siawo menye atikewo o, United States ƒe Nuɖuɖu Kple Atike Ŋuti Dɔwɔƒe (FDA) meda asi ɖe wo dzi o, eye mele be woazã wo atsɔ axe mɔ ɖe atikewɔwɔ, dɔléle, alo dɔléle aɖeke nu, adae, alo adae o. Se de se vevie be woatsɔ atike siawo ade amegbetɔ alo lãwo ƒe ŋutilã me le mɔ ɖesiaɖe nu.
1.Kpɔɖeŋu bliboa
Le agbeŋutinunya gome la, tsitsi kple ame ŋutɔ ƒe nuɖuɖu nye numekuku vevi siwo he amewo ƒe susu ŋutɔ. Telomeres, abe domenyiŋusẽfianu tɔxɛ siwo le domenyiŋusẽfianu ƒe nuwuwu ene, wɔa akpa vevi aɖe le nuwɔna eveawo siaa me. Esi numekukuwo le edzi yim la, ƒomedodo sesẽ si le telomeres, tsitsi, kple autophagy dome la va le dzedzem nyuie wu.
Nɔnɔmetata 1 Telomere ƒe ʋuʋu, telomere ƒe didime, kple telomerase.
2.Telomere ƒe Dɔwɔɖoɖo Kple Dɔwɔwɔ Ŋuti Nyatakaka Kpuie
2.1 Telomere ƒe Dɔwɔɖoɖo
Telomeres nye nucleotide siwo gbugbɔna kplɔ wo nɔewo ɖo siwo wodzra ɖo ŋutɔ siwo le domenyiŋusẽfianu siwo le fli me ƒe nuwuwu le eukaryotic nugbagbewo me. Wonyea nusiwo gbugbɔna bɔbɔe siwo me guanine (G) sɔ gbɔ ɖo, eye amegbetɔ ƒe telomere gbugbɔgagblɔ ƒe ɖoɖo si nye TTAGGG. Dɔwɔnu sia kpɔa domenyiŋusẽfianu ƒe nugbɔwo ta tso nucleases ƒe gbegblẽ me, xea mɔ na domenyiŋusẽfianu ƒe ƒoƒo ɖekae, eye wònana domenyiŋusẽfianu ƒe liƒo nɔa anyi. Telomeric DNA kple protein siwo blana ɖe eŋu koŋue nye telomere ƒe wɔwɔme. Protein siawo wɔa dɔ kple telomeric DNA tsɔ wɔa xɔtunu tɔxɛ siwo le ɖoɖo nu wu, si wɔnɛ be telomere ƒe liƒo ganyo ɖe edzi.
2.2 Telomeres ƒe Dɔwɔwɔwo
Dɔ vevi siwo telomerewo wɔna dometɔ ɖekae nye be woakpɔ 'nuwuwu ƒe dzidziɖedzi ƒe kuxia gbɔ.' Le DNA ƒe dzidziɖedzi ƒe nɔnɔmewo ta la, DNA polymerases dzɔdzɔewo mate ŋu agbugbɔ domenyiŋusẽfianu siwo le fli me ƒe nuwuƒewo awɔ bliboe o, si wɔnɛ be telomerewo nɔa kpuie vivivi le lãmenugbagbeviwo ƒe mama ɖesiaɖe me. Telomeres ƒe anyinɔnɔ xea mɔ na nuwuwu sia ƒe kpuiƒe, si wɔnɛ be domenyiŋusẽfianuwo ƒe blibonyenye kple woƒe liƒo nɔa te. Telomeres hã wɔa akpa vevi aɖe le lãmenugbagbeviwo ƒe tsatsam ƒe ɖoɖowɔwɔ me. Ne telomerewo le kpuie va ɖo afi aɖe la, woʋãa lãmenugbagbeviwo ƒe tsatsam ƒe teƒewo, si wɔnɛ be lãmenugbagbeviwo gena ɖe tsitsi alo apoptosis me, si wɔnɛ be woƒe ŋutete be woadzi ɖe edzi seɖoƒemanɔmee la dzi ɖena kpɔtɔna. Mɔnu sia ɖe dzesi le mɔxexe ɖe dɔdzẽ ƒe dzɔdzɔ nu me eye wòdo ƒome kplikplikpli kple nugbagbeviwo ƒe tsitsi.
3. Ƒomedodo Si Le Telomeres Kple Tsitsi Dome
3.1 Telomere ƒe Kpuienyenye abe Tsitsi ƒe Dzesi ene
Ne ƒexɔxɔ le dzidzim ɖe edzi la, telomere siwo le lãmenugbagbevi siwo sɔ ƒe akpa gãtɔ me ƒe didime nɔa kpuie vivivi, si nye nudzɔdzɔ si wokpɔna le lãkusi kple ŋutinu vovovowo me. Le amegbetɔ ƒe ʋumenugbagbevi dzĩ siwo le gota gome la, telomere ƒe didime dzi ɖena kpɔtɔna ŋutɔ ne ame tsi. Numekukuwo ɖee fia be telomere ƒe kpuiƒe do ƒome kplikplikpli kple ŋutilã me tɔtrɔ vovovo siwo do ƒome kple tsitsi, abe lãmenugbagbeviwo ƒe dzidziɖedzi ƒe ŋutete dzi ɖeɖe kpɔtɔ, lãmenugbagbeviwo ƒe gbugbɔgadzɔ ƒe ŋutete si gbɔdzɔ, kple dɔléle vovovo siwo nɔa anyi didi ƒe afɔku si dzi ɖe edzi ene. Le lãmenugbagbeviwo ƒe ɖoɖo nu la, ne telomerewo le kpuie va ɖo didime vevi aɖe la, lãmenugbagbeviwo bu woƒe dzidziɖedzi ƒe ŋutete eye wogena ɖe tsitsi ƒe nɔnɔme me, si ƒe dzesi enye lãmenugbagbeviwo ƒe nɔnɔme ƒe tɔtrɔ, lãmenugbagbeviwo ƒe dɔwɔwɔ dzi ɖeɖe kpɔtɔ, kple β-galactosidase (SA-β-Gal) si do ƒome kple tsitsi ƒe ɖeɖefia ƒe dzidziɖedzi.
3.2 Mɔnu siwo dzi telomere ƒe kpuiƒe tona hea tsitsi vɛ
Mɔ siwo dzi telomere ƒe kpuiƒe tona hea tsitsi vɛ koŋ lɔ DNA ƒe gbegblẽ ƒe ŋuɖoɖo ƒe mɔnuwo ɖe eme. Ne telomerewo le kpuie va ɖo afi aɖe la, woƒe wɔwɔme meganɔa te o, eye ametakpɔdɔ si le telomere ƒe nuwuƒewo meganɔa anyi o, si wɔnɛ be lãmenugbagbeviwo dea dzesi domenyiŋusẽfianu ƒe nuwuƒewo be wonye teƒe siwo DNA gblẽa nu le. Esia naa DNA ƒe nugbegblẽ ƒe ŋuɖoɖo ƒe dzesimɔ vovovowo, abe ATM/ATR-p53-p21 mɔ ene, wɔa dɔ. Ne wowɔ dɔ la, protein siwo nye ATM (ataxia-telangiectasia mutated) alo ATR (ataxia-telangiectasia kple Rad3-related) proteinwo wɔa phosphorylate na p53 protein siwo le anyime, si wɔnɛ be woƒe liƒo dzina ɖe edzi eye wòdoa woƒe gege ɖe lãmenugbagbeviwo ƒe nucleus me ɖe ŋgɔ. Abe nuŋɔŋlɔ ƒe akpa vevi aɖe ene la, ekpɔa domenyiŋusẽfianu siwo kplɔ wo nɔewo ɖo siwo do ƒome kple lãmenugbagbeviwo ƒe tsatsam ƒe nuléle kple tsitsi, siwo dome p21 hã le, ƒe ɖeɖefia dzi. p21 xea mɔ na cyclin-dependent kinases (CDKs) ƒe dɔwɔwɔ, si wɔnɛ be lãmenugbagbeviwo megayia ŋgɔ tso G1 ƒe akpaa yia S ƒe akpaa me o, si wɔnɛ be lãmenugbagbeviwo ƒe tsatsam ƒe nutsitsi eye mlɔeba wòhea lãmenugbagbeviwo ƒe tsitsi vɛ. Telomere ƒe kpuiƒe ate ŋu ado tsitsi hã ɖe ŋgɔ to ŋusẽkpɔkpɔ ɖe mitochondria ƒe dɔwɔwɔ dzi. Telomere ƒe gbegblẽ hea mitochondrial oxidative stress dzina ɖe edzi eye mitochondrial membrane ƒe ŋutete dzi ɖena kpɔtɔna, si wɔnɛ be ekpɔa ŋusẽ ɖe mitochondrial ŋusẽ ƒe asitɔtrɔ kple lãmenugbagbeviwo me redox ƒe dadasɔ dzi, si wɔnɛ be tsitsi ƒe ɖoɖoa dzina ɖe edzi.
3.3 Telomeres kple Dɔléle siwo do ƒome kple ƒexɔxɔ
Dɔléle geɖe siwo do ƒome kple tsitsi, abe dzitodzito me dɔlélewo, ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie, kple kansa ene, do ƒome kplikplikpli kple telomere ƒe kpuiƒe. Le dzitodzito me dɔlélewo me la, telomere ƒe kpuiƒe do ƒome kplikplikpli kple lãmenugbagbeviwo ƒe dɔmawɔmawɔ nyuie kple ʋukawo ƒe ʋuʋu. Ʋumenugbagbevi dzĩwo ƒe telomere siwo le gota ƒe didime le dzitodzito me dɔléle dɔnɔwo me le kpuie ŋutɔ wu esiwo le lãmesẽ me, eye telomere ƒe didime do ƒome gbegblẽ kple dɔlélea ƒe sesẽ. Le ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie abe Alzheimer ƒe dɔléle kple Parkinson ƒe dɔléle ene me la, telomere ƒe didime le ahɔhɔ̃meka siwo le ahɔhɔ̃a me hã dzi ɖena kpɔtɔna ŋutɔ. Telomere ƒe kpuiƒe ate ŋu ana DNA ƒe gbegblẽ naƒo ƒu eye apoptosis nadzi ɖe edzi le ahɔhɔ̃mekawo me, si ana ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie nayi edzi kabakaba. Le kansa me la, togbɔ be zi geɖe la, mɔnu siwo dzi woato alé telomere ƒe didime ɖe te (abe telomerase ƒe dɔwɔwɔ ene) le kansa lãmenugbagbeviwo si hã la, telomere ƒe kpuiƒe le tumorigenesis ƒe gɔmedzedze ate ŋu ahe domenyiŋusẽfianu ƒe malikenyenye vɛ, si ana domenyiŋusẽfianu ƒe tɔtrɔ ƒe mɔnukpɔkpɔ nadzi ɖe edzi eye wòanye gɔmeɖoanyi na dɔdzẽ ƒe tsitsi.
4. Ƒomedodo Si Le Telomeres Kple Autophagy Dome
4.1 Autophagy ƒe ɖoɖowɔwɔ to Telomeres dzi
Autophagy nye lãmenugbagbeviwo me ƒe wo ɖokui gblẽna kple wo gbugbɔgazã ƒe mɔnu vevi aɖe si ɖea ŋutinu siwo gblẽ, protein siwo womebla nyuie o, kple dɔlékuiwo ɖa le lãmenugbagbevi la me, si wɔnɛ be lãmenugbagbeviwo me ƒe nɔnɔme nɔa te. Numekuku siwo wowɔ nyitsɔ laa ɖee fia be ɖoɖowɔwɔ ƒe ƒomedodo sesẽ aɖe le telomeres kple autophagy dome. Telomere ƒe kpuiƒe ate ŋu ana autophagy. Ne telomerewo le kpuie va ɖo afi aɖe le lãmenugbagbeviwo ƒe mama alo nu bubuwo ta la, wowɔa dɔ le lãmenugbagbeviwo me nuteɖeamedzi ƒe dzesimɔwo ŋu, si wɔnɛ be woʋãa wo ɖokui ɖuɖu. Le lãmenugbagbevi siwo me telomerase mele o ƒe kpɔɖeŋu aɖewo me la, ne telomerewo le kpuie vivivi la, protein siwo do ƒome kple autophagy ƒe ɖeɖefia dzina ɖe edzi ŋutɔ, eye autophagosomes ƒe xexlẽme hã dzina ɖe edzi ŋutɔ. Autophagy ate ŋu akpɔ ŋusẽ ɖe telomere ƒe liƒo hã dzi le wo nɔewo yome. To nusiwo gblẽa nu le DNA ŋu ɖeɖeɖa kple lãmenugbagbeviwo ƒe nutome ƒe liƒo me léle ɖe asi me la, autophagy kpɔa telomere ta tso nusiwo gblẽ me le mɔ si mele tẽ o nu eye wònaa telomere ƒe kpuiƒe ƒe ɖoɖoa dzi ɖena kpɔtɔna.
Nutata 2 Telomeric structures siwo mesɔ o ƒe agbɔsɔsɔ le PBMCwo me dzina ɖe edzi ne nunala ƒe ƒexɔxɔ.
4.2 Molekyulã ƒe mɔnuwo na telomere ƒe ɖoɖowɔwɔ ɖe autophagy ŋu
Molekyulã ƒe mɔnu siwo dzi telomerewo tona ɖɔa autophagy ɖo la lɔ dzesimɔ vovovowo ɖe eme. Le esiawo dome la, mTOR (mechanistic target of rapamycin) ƒe dzesimɔ nye tɔdzisasrã vevi aɖe si doa ka kple telomeres kple autophagy. mTOR nye serine/threonine protein kinase si dea dzesi lãmenugbagbeviwo me nunyiame ƒe nɔnɔme, ŋusẽ ƒe agbɔsɔsɔ, kple tsitsi ƒe dzesiwo, si wɔnɛ be wòɖɔa lãmenugbagbeviwo ƒe dɔwɔwɔwo abe tsitsi, dzidziɖedzi, kple autophagy ene ɖo. Numekukuwo ɖee fia be telomerase ƒe akpa sue si naa nu ʋãna, si nye TERT (telomerase reverse transcriptase), ate ŋu awɔ nu kple mTOR eye wòaxe mɔ ɖe mTOR complex 1 (mTORC1) ƒe kinase ƒe dɔwɔwɔ nu. Le nɔnɔme siwo sɔ me la, mTORC1 le nɔnɔme si me wowɔa dɔ le me, si xea mɔ na autophagy ƒe dzɔdzɔ. Gake ne telomerewo le kpuie alo TERT ƒe ɖeɖefia mesɔ o la, TERT ƒe mɔxexeɖedɔléle nu ƒe ŋusẽkpɔɖeamedzi ɖe mTORC1 dzi dzina ɖe edzi, si wɔnɛ be mTORC1 ƒe dɔwɔwɔ dzi ɖena kpɔtɔna, si wɔnɛ be mɔxexe ɖe autophagy nu dzina ɖe edzi eye wòdoa eƒe gɔmedzedze ɖe ŋgɔ.
Tsɔ kpe ɖe eŋu la, p53 ƒe dzesimɔ hã wɔa akpa vevi aɖe le telomere ƒe autophagy ƒe ɖoɖowɔwɔ me. Telomere ƒe kpuiƒe nana p53 ƒe dzesimɔa wɔa dɔ, eye p53 ate ŋu aɖɔ autophagy ɖo to domenyiŋusẽfianu siwo do ƒome kple autophagy ƒe ɖeɖefia tɔtrɔ tẽ alo ŋusẽkpɔkpɔ ɖe mTOR ƒe dzesimɔ dzi le mɔ si mele tẽ o nu. Etɔxɛe la, p53 ate ŋu adzi domenyiŋusẽfianu siwo do ƒome kple autophagy abe LC3 kple Beclin1 ene ƒe ɖeɖefia ɖe dzi, si ado autophagosomes ƒe wɔwɔ ɖe ŋgɔ eye wòato esia me ahe autophagy vɛ.
4.3 Ŋusẽ si autophagy kpɔna ɖe telomere ƒe liƒo dzi
Wokpɔa ŋusẽ si autophagy kpɔna ɖe telomere ƒe liƒo dzi koŋ to homeostasis me léle ɖe asi le lãmenugbagbeviwo me nɔnɔme me. Autophagy ate ŋu akɔ oxygen ƒomevi siwo ƒo ƒu ɖe lãmenugbagbeviwo me (ROS) ŋu, si aɖe oxidative stress ƒe nugbegblẽ le telomere DNA ŋu dzi akpɔtɔ. ROS nye molecule siwo wɔa dɔ ŋutɔ le lãmenugbagbeviwo ƒe dɔwɔwɔ me, eye ROS si gbɔ eme ate ŋu agblẽ nu le DNA ŋu le oxidative me, si me telomere DNA hã le. Autophagy ate ŋu agblẽ nu le mitochondria siwo gblẽ le lãmenugbagbeviwo me hã ŋu, si axe mɔ ɖe ROS ƒe wɔwɔ fũ si mitochondria ƒe dɔmawɔmawɔ nyuie hena vɛ nu. Tsɔ kpe ɖe eŋu la, autophagy ate ŋu akɔ DNA ƒe nugbegblẽ ɖɔɖɔɖo proteinwo kple protein bubu siwo do ƒome kple telomere dzikpɔkpɔ ƒe ƒomevi siwo womebla nyuie o alo esiwo woƒo ƒu la ɖa, si ana woakpɔ egbɔ be wowɔa dɔ nyuie eye to esia me be telomere nali ke. Numekukuwo ɖee fia be lãmenugbagbevi siwo me autophagy ƒe gbɔdzɔgbɔdzɔ le la ɖea telomere DNA ƒe gbegblẽ si dzina ɖe edzi eye telomere ƒe kpuiƒe kabakaba fiana, evɔ autophagy hehe vɛ ate ŋu ana nudzɔdzɔ siawo nanyo ɖe edzi.
Telomere Nufiafia Zazã le Numekuku Siwo Tsi Tre Ðe Tsitsi Ŋu me
5.1 Telomerase ƒe Dɔwɔwɔ ƒe Mɔnuwo
Esi wònye be telomere ƒe kpuiƒe do ƒome kplikplikpli kple tsitsi ta la, telomere ƒe didime dzi kpɔkpɔ to telomerase ƒe dɔwɔwɔ me va zu mɔfiame vevi aɖe le numekuku siwo wowɔna tsɔ tsia tsitsi nu me. Telomerase nye ribonucleoprotein ƒe ƒuƒoƒo si me RNA kple proteinwo le si ate ŋu azã eya ŋutɔ ƒe RNA abe kpɔɖeŋu ene atsɔ awɔ telomere DNA eye wòatsɔe akpe ɖe domenyiŋusẽfianu ƒe nuwuwu ŋu, si ana telomere ƒe didime nakeke ɖe enu. Numekuku aɖewo zã atike siwo me molecule suewo le tsɔ na telomerase nawɔ dɔ. TA-65 nye atike sue aɖe si woɖe tso Astragalus me, eye woka nya ta be ewɔa dɔ ɖe telomerase dzi. Le dodokpɔ siwo wowɔ le lãwo ŋu me la, le TA-65 dodo vɔ megbe la, wokeke telomere ƒe didime ɖe enu na sisiblisiwo va ɖo afi aɖe, eye woƒe nɔnɔme aɖewo siwo do ƒome kple tsitsi abe ŋutigbalẽ ƒe ƒuƒu kple ɖa ƒe ƒuƒu ene hã nyo ɖe edzi.
5.2 Autophagy ƒe ɖoɖowɔwɔ ƒe mɔnuwo
Esi wònye be akpa vevi si autophagy wɔna le lãmenugbagbeviwo ƒe homeostasis me léle ɖe asi kple telomeres takpɔkpɔ me ta la, autophagy dzi kpɔkpɔ hã va zu mɔnu si woate ŋu azã atsɔ atsi tsitsi nu. Le go ɖeka me la, woate ŋu awɔ autophagy to atike alo nunyiame ƒe nudede eme me. Rapamycin nye mTOR mɔxenu si wonya nyuie si naa autophagy to mɔxexe ɖe mTORC1 ƒe dɔwɔwɔ nu me. Le dodokpɔ siwo wowɔ le lãwo ŋu me la, rapamycin zazã na sisiblisi ƒe agbenɔƒe didi eye wòna ŋutilã ƒe dɔwɔwɔ si do ƒome kple tsitsi nyo ɖe edzi. Woka nya ta be dzɔdzɔmenu aɖewo abe resveratrol kple curcumin ene hã nana ame ŋutɔ ɖua nu. Dzɔdzɔmenu siawo ate ŋu aɖɔ autophagy ɖo to dzesimɔwo abe SIRT1 (silent information regulator 1) ƒe dɔwɔwɔ me. Le lãmenugbagbeviwo alo ame ɖekaɖeka siwo ƒe autophagy ƒe dɔwɔwɔ me gblẽ gome la, woate ŋu agbugbɔ autophagy ƒe dɔwɔwɔ aɖo anyi to domenyiŋusẽfianu ƒe atikewɔwɔ me. Woate ŋu atsɔ domenyiŋusẽfianu siwo do ƒome kple autophagy ade lãmenugbagbeviwo me to domenyiŋusẽfianu ƒe dɔlékuiwutikewo dzi be woatsɔ ado lãmenugbagbeviwo ƒe autophagy ŋutete ɖe ŋgɔ.
5.3 Nudede nyawo me ƒe mɔnu siwo wotsɔ ƒo ƒui
Ne míebu kadodo sesẽ si le telomeres, tsitsi, kple autophagy dome ŋu la, nudede nyawo me ƒokpli si woɖo taɖodzinu na telomeres kple autophagy siaa ate ŋu atsi tre ɖi na tsitsi ƒe mɔnu si wɔa dɔ wu. Woate ŋu azã telomerase activators kple autophagy inducers le ɣeyiɣi ɖeka me: telomerase activators kekea telomere ƒe didime ɖe enu, gake autophagy inducers ya kɔa lãmenugbagbeviwo ƒe akpa siwo gblẽ, si léa lãmenugbagbeviwo ƒe homeostasis me ɖe asi eye wowɔa dɔ aduadu tsɔ tsia tsitsi nu. Le lãwo ƒe dodokpɔwo me la, telomerase activators kple autophagy inducers zazã ƒo ƒu ɖe tsitsi ƒe ŋusẽkpɔɖeamedzi ɖedzesi aɖe fia wu atike eveawo dometɔ ɖesiaɖe ɖeɖeko, abe ŋutilã ƒe dɔwɔwɔ siwo do ƒome kple tsitsi ƒe nyonyo nyuie wu kple lãwo ƒe agbenɔƒe didi ene.
Nyanuwuwuw
Telomeres wɔa akpa vevi aɖe le tsitsi kple autophagy ƒe dɔwɔwɔwo me. Telomere ƒe kpuiƒe, abe tsitsi ƒe dzesi vevi aɖe ene, hea lãmenugbagbeviwo ƒe tsitsi kple dɔléle vovovo siwo do ƒome kple tsitsi to mɔnuwo abe DNA ƒe nugbegblẽ ƒe ŋuɖoɖomɔwo ƒe dɔwɔwɔ kple ŋusẽkpɔkpɔ ɖe mitochondria ƒe dɔwɔwɔ dzi ene dzi. Ƒomedodo sesẽ aɖe le telomeres kple autophagy dome le ɖoɖowo dome. Telomeres ateŋu aɖɔ autophagy ɖo to dzesimɔwo abe mTOR kple p53 dzi, gake autophagy ya kpɔa telomere ƒe liƒo ta to lãmenugbagbeviwo me nutome ƒe homeostasis me léle ɖe asi me. Numekuku siwo wowɔ tsɔ tsi tre ɖe tsitsi ŋu si wotu ɖe telomere ƒe nufiafia dzi, abe telomerase ƒe dɔwɔwɔ ƒe mɔnuwo, autophagy ƒe ɖoɖowɔwɔ ƒe mɔnuwo, kple nudede nyawo me ƒe mɔnuwo ƒokpli ene, na mɔkpɔkpɔ gbadzawo be woahe tsitsi ɖe megbe ahada dɔléle siwo do ƒome kple tsitsi.
Dzɔtsoƒewo
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