Cocer Peptides ye 
ŋlɔe ɣleti 1 enye sia
NYATAKAKAWO KPLE NUSIWO WOTSƆ ƑE NYATAKAKA SIWO KAtã WOÐO LE NYATAKAKADZRAÐOƑE SIA ME LA KPLE NYATAKAKAWO kaka KPLEE NUFIAFIA ƑE TAÐOÐOWO KO.
Wotrɔ asi le atike siwo wona le nyatakakadzraɖoƒe sia ŋu na numekuku le vitro ɖeɖeko. Wowɔa numekuku le vitro (Latingbe me: *le ahuhɔ̃e me*, si gɔmee nye le ahuhɔ̃e me) le amegbetɔ ƒe ŋutilã godo. Atike siawo menye atikewo o, United States ƒe Nuɖuɖu Kple Atike Ŋuti Dɔwɔƒe (FDA) meda asi ɖe wo dzi o, eye mele be woazã wo atsɔ axe mɔ ɖe atikewɔwɔ, dɔléle, alo dɔléle aɖeke nu, adae, alo adae o. Se de se vevie be woatsɔ atike siawo ade amegbetɔ alo lãwo ƒe ŋutilã me le mɔ ɖesiaɖe nu.
Kpɔɖeŋu bliboa
Nyati sia ku nu me tso mɔnu siwo dzi lãmenugbagbevi siwo le tsitsim tona kpena ɖe Alzheimer ƒe dɔléle (AD) ƒe gɔmedzedze kple eƒe ŋgɔyiyi ŋu. Alzheimer ƒe dɔlélea nye ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie si bɔ si dzea ame tsitsiwo koŋ dzi, si ƒe dzesi enye be woƒe susu ƒe dɔwɔwɔ meganɔa dɔ wɔm nyuie o vivivi eye woƒe nuwɔna megawɔa dɔ nyuie o. Esi xexeame katã ƒe amewo le tsitsim la, AD ƒe dzɔdzɔ yi edzi le dzidzim ɖe edzi ƒe sia ƒe, si le agba gã aɖe dam ɖe hadomegbenɔnɔ kple ƒomewo dzi. Togbɔ be wowɔ ŋgɔyiyi ɖedzesi aɖe le AD ŋuti numekuku me hã la, nusi tututu gbɔ wòtso kple dɔlélea ƒe dzɔdzɔ me mekɔ haɖe o. Abe nusiwo koŋ gbɔ AD ƒe afɔku le dometɔ ɖeka ene la, lãmenugbagbeviwo ƒe tsitsi va le susu hem yi edzi le ƒe ʋɛ siwo va yi me le akpa si wòwɔna le AD ƒe dɔléle dzɔdzɔ me ta. Lãmenugbagbevi siwo le tsitsim ƒe ƒuƒoƒo ɖe ŋutilãa me do ƒome kplikplikpli kple dɔléle vovovo siwo do ƒome kple tsitsi ƒe gɔmedzedze kple woƒe ŋgɔyiyi. Lãmenugbagbevi siwo tsina wɔa akpa vevi aɖe le AD ƒe dɔlélenutsiŋutete me, eye woƒe dɔwɔwɔ ƒe mɔnuwo me kɔ nyuie le vevie ŋutɔ na AD ƒe atike yeyewo toto vɛ.
Nɔnɔmetata 1. Alzheimer dɔlélea ƒe dɔlékuiwo ƒe proteinwo kpena ɖe ahɔhɔ̃menugbagbeviwo ƒe tsitsi ŋu. (a) Ahɔhɔ̃ me lãmenugbagbevi siwo le tsitsim kple amyloid-kpewo kple tau si hea dɔlékuiwo dome kadodoa ŋuti nyatakaka kpui aɖe. (b–e) Lãmenugbagbevi ƒomevi ɖesiaɖe kple tsitsi ƒe nɔnɔme siwo ŋu woka nya ta le le agbalẽwo me ƒe nukpɔkpɔ tsitotsito: (b) ahɔhɔ̃meka, (c) microglia, (d) oligodendrocyte/oligodendrocyte precursor cell, (e) astrocyte, kple (f) ʋu-ahɔhɔ̃ ƒe mɔxenu (BBB) si me endothelial cells, pericytes, kple astrocytes le, si le eɖem fia si gblẽ nu le BBB ƒe fɔmaɖimaɖi ŋu le AD.
Lãmenugbagbevi Siwo Tsitsi Ŋuti Nyatakaka Kpuie
(1) Lãmenugbagbevi siwo Tsitsi ƒe Gɔmesese Kple Nɔnɔmewo
Senescence fia lãmenugbagbeviwo ƒe tsitsi ƒe nuléle si womate ŋu atrɔ o ne woto mama xexlẽme aɖe me alo wodo go nuteɖeamedzinu vovovowo (abe oxidative stress, DNA ƒe gbegblẽ, telomere ƒe kpuiƒe, kple bubuawo ene). Lãmenugbagbevi siwo tsi la ɖea nɔnɔme tɔxɛwo fiana, siwo dometɔ aɖewoe nye lãmenugbagbeviwo ƒe lolome ƒe dzidziɖedzi, woƒe gbadzaƒe, kple β-galactosidase (β-gal) ƒe dɔwɔwɔ si dzina ɖe edzi, si nye nugbagbeŋutinunya ƒe dzesi si wozãna zi geɖe tsɔ dea dzesi lãmenugbagbevi siwo tsi. Tsɔ kpe ɖe eŋu la, lãmenugbagbevi siwo tsi la ɖea kinase mɔxenu siwo nɔa te ɖe cyclin dzi (abe p16INK4a kple p21Cip1 ene) ƒe dziyiyi fiana, siwo xea mɔ na lãmenugbagbeviwo ƒe tsatsam ƒe ŋgɔyiyi, si wɔnɛ be lãmenugbagbeviwo léna le G1 ƒe akpa alo G2/M ƒe akpaa me eye wòtoa esia me xea mɔ na mama bubuwo.
Mɔnu Siwo Dzi Lãmenugbagbevi Siwo Le Tsitsiwo Wɔm
1. Oxidative Stress kple DNA ƒe Gbegblẽ: Oxidative stress nye nu vevi aɖe si nana lãmenugbagbeviwo tsina. Le ŋutilã ƒe nɔnɔme siwo sɔ me la, oxygen ƒomevi siwo wɔa dɔ (ROS) ƒe wɔwɔ kple wo ɖeɖeɖa le lãmenugbagbeviwo me nɔa dadasɔ si me ŋusẽ le me. Gake ne ame tsi alo le dɔléle ƒe nɔnɔme aɖewo me la, ROS ƒe dzidziɖedzi hea DNA ƒe gbegblẽ vɛ. Ne DNA ƒe gbegblẽ ƒo ƒu va ɖo afi aɖe eye womate ŋu adzrae ɖo nyuie o la, dzesimɔ siwo kplɔ wo nɔewo ɖo, abe p53-p21 kple p16-Rb dzesimɔwo ene, wɔa dɔ, si wɔnɛ be lãmenugbagbeviwo gena ɖe tsitsi ƒe nɔnɔme me. Le ahɔhɔ̃meka siwo tso Alzheimer-dɔlélawo gbɔ me la, oxidative stress ƒe agbɔsɔsɔ dzina ɖe edzi ŋutɔ, si wɔnɛ be DNA ƒe gbegblẽ le ahɔhɔ̃mekawo kple glial cells me dzina ɖe edzi, si hã nana lãmenugbagbeviwo tsina.
2. Telomere ƒe kpuiƒe: Telomere nye DNA ƒe ɖoɖo siwo gbugbɔna le domenyiŋusẽfianu ƒe nuwuwu siwo nɔa kpuie vivivi ne lãmenugbagbeviwo ma. Ne telomerewo le kpuie va ɖo didime aɖe la, woʋãa tsitsi ƒe dzesiwo. Le ahɔhɔ̃mekawo me la, telomere ƒe kpuiƒe do ƒome kplikplikpli kple tsitsi ƒe gɔmedzedze, si ate ŋu agblẽ nu le ahɔhɔ̃mekawo ƒe lãmenugbagbeviwo ƒe wo ɖokui yeyewɔwɔ kple vovototodedeameme ŋutete ŋu, si ana wòakpɔ ŋusẽ ɖe lãmekawo ƒe tsitsi kple dɔwɔwɔ nyuie dzi.
Lãmenugbagbevi Siwo Tsitsi ƒe Dɔwɔwɔ Le Alzheimer Dɔléle Me
(1) Ahɔhɔ̃mekawo ƒe Dɔdzẽ ƒe Dɔwɔwɔ
1. Akpa si Senescence-Associated Secretory Phenotype (SASP) Wɔna: Lãmenugbagbevi siwo le tsitsim ɖea adzame ƒe nɔnɔme tɔxɛ aɖe si woyɔna be senescence-associated secretory phenotype (SASP) fiana. SASP nye cytokines, chemokines, tsitsinu, kple protease vovovowo, abe interleukin-6 (IL-6), interleukin-8 (IL-8), kple tumor necrosis factor-α (TNF-α) ene. Le Alzheimer-dɔlélawo ƒe ahɔhɔ̃mekawo me la, glial lãmenugbagbeviwo kple ahɔhɔ̃meka siwo le tsitsim la ɖea SASP-nu gbogbo aɖewo ɖe go, si ate ŋu ana dɔlélenutsiŋutete ƒe lãmenugbagbevi siwo ƒo xlãe nawɔ dɔ eye wòahe dɔdzẽ ƒe ŋuɖoɖo siwo nɔa anyi didi vɛ. IL-6 kple TNF-α doa microglia ƒe dɔwɔwɔ ɖe ŋgɔ, si wɔnɛ be wotrɔna tso nɔnɔme si me wozi ɖoɖoe me yia nɔnɔme si doa alɔ dɔdzẽ me, si wɔnɛ be domenɔla siwo doa dzo na dɔdzẽ geɖe wu dona eye wògagblẽa nu le ahɔhɔ̃mekawo ƒe dɔdzẽ ŋu. Dzoxɔxɔ ƒe nɔnɔme sia si nɔa anyi didi gblẽa nu le ahɔhɔ̃mekawo ŋu, egblẽa nu le ahɔhɔ̃mekawo ƒe dɔwɔwɔ ŋu, eye wòhea susu ƒe dɔmawɔmawɔ nyuie vɛ.
2. Ŋusẽkpɔɖeamedzi ɖe glial lãmenugbagbeviwo dzi: Astrocytes kple microglia ƒe tsitsi wɔa akpa vevi aɖe le AD ahɔhɔ̃mekawo ƒe dɔdzẽ me. Ɣletivimenugbagbevi tsitsiwo ɖea SASP nusiwo doa β-amyloid (Aβ) ƒe ƒuƒoƒo kple eƒe ƒuƒu ɖe ŋgɔ esime woxea mɔ na eƒe ʋuʋu. Microglia ƒe tsitsi ɖea woƒe ŋutete be woaɖu Aβ dzi kpɔtɔna, si xea mɔ na Aβ ƒe kpeƒekpeƒewo ɖeɖeɖa nyuie le ahɔhɔ̃a me. Ke boŋ woɖea nusiwo naa dɔdzẽ geɖe wu ɖe go, si wɔnɛ be tsatsam vɔ̃ɖi aɖe si nana ahɔhɔ̃mekawo ƒe dɔdzẽ kple ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie gagblẽna ɖe edzi.
Nɔnɔmetata 2 Lãmenugbagbeviwo ƒe tsitsi ƒe dzesiwo dzina ɖe edzi le hTau mice modeling tauopathy of AD ƒe ahɔhɔ̃wo me.
(2) Ahɔhɔ̃mekawo ƒe Dɔmawɔmawɔ nyuie Dodo Ðe Ŋgɔ
1. Nu gblẽ le ahɔhɔ̃mekawo ŋu tẽ: Cytokines kple protease aɖewo siwo lãmenugbagbevi siwo le tsitsim ɖena ɖe go ate ŋu agblẽ nu le ahɔhɔ̃mekawo ŋu tẽ. Matrix metalloproteinases (MMPs) nye senescence-associated secretome (SASP) ƒe akpa ɖeka, si ate ŋu agblẽ nu le lãmenugbagbeviwo godo ƒe matriki kple protein siwo do ƒome kple ahɔhɔ̃mekawo ƒe dɔwɔwɔ ŋu, si agblẽ ahɔhɔ̃mekawo ƒe wɔwɔme kple dɔwɔwɔ me. ROS si lãmenugbagbevi siwo le tsitsim wɔna hã ate ŋu agblẽ nu le ahɔhɔ̃mekawo ŋu le oxidative me, si ana ahɔhɔ̃mekawo naku eye woaku. Le AD dɔnɔwo ƒe ahɔhɔ̃mekawo me la, ahɔhɔ̃mekawo ƒe tsitsi do ƒome kplikplikpli kple lãmenugbagbeviwo ƒe ku, si ate ŋu anye nu vevi siwo hea susu ƒe dɔmawɔmawɔ nyuie vɛ la dometɔ ɖeka.
2. Nusiwo doa kplamatse ahɔhɔ̃mekawo ƒe kaka: Lãmenugbagbevi siwo le tsitsim ƒe anyinɔnɔ ate ŋu agblẽ nu le ahɔhɔ̃mekawo ƒe wɔwɔme, woƒe dodo, kple woƒe kaka ŋu hã. Dɔlékuiwutikewo ate ŋu axe mɔ ɖe acetylcholine, si nye ahɔhɔ̃mekawo ƒe dɔwɔwɔ si hiã vevie be woalé susu ƒe dɔwɔwɔ nyuie me ɖe asi la ƒe wɔwɔ nu. Tsɔ kpe ɖe eŋu la, nu aɖewo siwo lãmenugbagbevi siwo le tsitsim ɖena ɖe go ate ŋu akpɔ ŋusẽ ɖe ahɔhɔ̃mekawo ƒe dɔwɔwɔ ƒe dzesiwo ɖeɖefia kple dɔwɔwɔ dzi, si ana ahɔhɔ̃mekawo ƒe dzesi siwo mesɔ o nava, si ana kadodo kple nyatakakawo ƒe dɔwɔwɔ le ahɔhɔ̃mekawo dome nagblẽ ɖe edzi, eye wòato esia me ahe susu ƒe dɔmawɔmawɔ nyuie vɛ.
(3) Tɔtrɔ siwo va le lãmenugbagbeviwo dome kadodo me
1. Paracrine Signaling si Mesɔ O: Lãmenugbagbevi siwo le tsitsim la ɖoa dze kple lãmenugbagbevi siwo ƒo xlã wo to paracrine signaling dzi to SASP factors ɖeɖe ɖe go me. Nu siawo ate ŋu akpɔ ŋusẽ ɖe lãmenugbagbevi siwo te ɖe wo ŋu ƒe dɔwɔwɔ kple dzɔgbese dzi, si ana lãmenugbagbeviwo dome kadodomɔnu nagblẽ. Le AD dɔnɔwo ƒe ahɔhɔ̃mekawo me la, SASP nusiwo glial cells siwo tsi tsitsi ɖena ɖe go ate ŋu akpɔ ŋusẽ ɖe ahɔhɔ̃mekawo ƒe tsitsi, agbetsitsi, kple vovototodedeameme dzi, eye woakpɔ ŋusẽ ɖe ahɔhɔ̃mekawo ƒe lãmenugbagbeviwo ƒe nuto suewo hã dzi, si axe mɔ ɖe woƒe dzidziɖedzi kple vovototodedeameme nu, si ana woakpɔ ŋusẽ ɖe ahɔhɔ̃mekawo ƒe gbugbɔgadzɔ kple wo dzadzraɖo ƒe ɖoɖowo dzi.
2.Lãmenugbagbeviwo dome kadodowo ƒe tɔtɔ: Lãmenugbagbevi siwo tsi ate ŋu agblẽ lãmenugbagbeviwo dome kadodo ƒe wɔwɔmewo hã me, abe kadodo sesẽwo kple dometsotsowo ene. Le ʋu kple ahɔhɔ̃ ƒe mɔxenu me la, lãmenugbagbevi siwo le lãkusi me ƒe tsitsi nana be protein siwo ƒoa ƒu sesĩe ƒe ɖeɖefia dzi ɖena kpɔtɔna, si wɔnɛ be ʋu kple ahɔhɔ̃ ƒe mɔxenu la te ŋu gena ɖe lãme na ame geɖe wu eye wònana nusiwo gblẽa nu le ame ŋu gena ɖe ahɔhɔ̃mekawo me bɔbɔe wu, si wɔnɛ be ahɔhɔ̃mekawo ƒe dɔléle kple ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie gasẽna ɖe edzi. Dometsotso siwo le ahɔhɔ̃mekawo dome le vevie ŋutɔ na elektrikŋusẽ ƒe dzesiwo ƒe kaka kple lãmenugbagbeviwo ƒe dɔwɔwɔ ɖekae le ahɔhɔ̃mekawo dome. Nusiwo lãmenugbagbevi siwo le tsitsim ɖena ɖe go ate ŋu agblẽ dometsotso ƒe kadodowo ƒe dɔwɔwɔ me, si akpɔ ŋusẽ ɖe dɔwɔwɔ ɖekae kple nyatakakawo ƒe kaka le ahɔhɔ̃mekawo dome dzi.
(4) Ŋusẽ si wòkpɔna ɖe ahɔhɔ̃mekawo ƒe lãmenugbagbeviwo ƒe nuto suewo dzi
1. Mɔxexe ɖe ahɔhɔ̃mekawo ƒe dzidziɖedzi kple vovototodedeameme nu: Ahɔhɔ̃mekawo ƒe lãmenugbagbeviwo le lã tsitsi siwo naa no wo viwo ƒe ahɔhɔ̃ me eye ŋutete le wo si be woawɔ wo ɖokui yeyee ahato vovo azu ahɔhɔ̃mekawo, ɣletivimefakaka, kple oligodendrocytes. SASP nusiwo lãmenugbagbevi siwo le tsitsim ɖena ɖe go ate ŋu atrɔ ahɔhɔ̃mekawo ƒe lãmenugbagbeviwo ƒe nuto suewo, si axe mɔ ɖe woƒe dzidziɖedzi kple vovototodedeameme nu. Cytokines aɖewo siwo le SASP me ate ŋu adzi cyclin-dependent kinase inhibitors ƒe ɖeɖefia ɖe dzi, si ana ahɔhɔ̃mekawo nalé le lãmenugbagbeviwo ƒe tsatsam ƒe akpa aɖewo koŋ eye womate ŋu ato mama kple vovototodedeameme si sɔ me o. Dɔlékuiwutike siwo lãmenugbagbevi siwo le tsitsim ɖena ɖe go hã ate ŋu akpɔ ŋusẽ ɖe ahɔhɔ̃mekawo ƒe vovototodedeameme ƒe mɔfiame dzi, si ana woato vovo geɖe wu azu glial lãmenugbagbeviwo tsɔ wu ahɔhɔ̃mekawo, si ana woakpɔ ŋusẽ ɖe ahɔhɔ̃mekawo ƒe gbugbɔgadzɔ kple wo dzadzraɖo dzi.
2. Ŋusẽkpɔɖeamedzi ɖe ahɔhɔ̃mekawo ƒe lãmenugbagbeviwo ƒe ʋuʋu dzi: Ahɔhɔ̃mekawo ƒe lãmenugbagbeviwo ƒe ʋuʋu le vevie ŋutɔ na woƒe teƒe nyui nɔnɔ kple woƒe dɔwɔwɔ nyuie le ahɔhɔ̃a me. Nu aɖewo siwo lãmenugbagbevi siwo le tsitsim ɖena ɖe go ate ŋu ado kplamatse ahɔhɔ̃mekawo ƒe lãmenugbagbeviwo ƒe ʋuʋu, si ana womate ŋu aʋu ayi teƒe siwo wòle be woadzra ɖo o. Chemokines ƒe ɖeɖefia si mesɔ o ate ŋu atrɔ alesi ahɔhɔ̃mekawo ƒe ʋuʋu yi teƒe bubu, si ana be womate ŋu aɖo afisi woxɔ abi le be woadzra wo ɖo o, si ana lãmekawo ƒe ŋutete be woadzra wo ɖokui ɖo la nagblẽ.
Alzheimer-dɔléle dadamɔnu siwo wozãna tsɔ tɔa ŋku lãmenugbagbevi siwo le tsitsim
(1) Senolytics ƒe atikewo
1. Mɔnu si dzi wòtona wɔa dɔ: Senolytics nye atikewo ƒe hatsotso aɖe si ate ŋu atia lãmenugbagbevi siwo tsi. Woƒe dɔwɔwɔ ƒe mɔnuwo koŋue nye be woahe lãmenugbagbeviwo ƒe kuku vɛ eye woaxe mɔ ɖe lãmenugbagbeviwo ƒe tsitsi ƒe dzesimɔ siwo tsi tre ɖe apoptotic ŋu nu. Dasatinib kple quercetin ye nye senolytics ƒe ƒuƒoƒo siwo ŋu wosrɔ̃ nu tsoe wu fifia. Dasatinib ate ŋu axe mɔ na kinase ƒe dzesimɔ siwo wɔa dɔ akpa le lãmenugbagbevi siwo tsi, gake quercetin ya doa ŋusẽ dasatinib ƒe ŋusẽkpɔɖeamedzi. Ne wozã wo ɖekae la, woate ŋu atiae be lãmenugbagbevi siwo le tsitsim la naku eye woaɖe woƒe ƒoƒo ɖe ŋutilã me dzi akpɔtɔ.
2.Ŋgɔyiyi le lãwo dodokpɔwo kple dɔdamɔnu ŋuti numekukuwo me: Le lãwo dodokpɔwo me la, atikewɔwɔ na AD kpɔɖeŋu mice kple senescent cell clearance agents ɖe senescent cells ƒe xexlẽme dzi kpɔtɔ ŋutɔ le ahɔhɔ̃a me, eɖe ahɔhɔ̃mekawo ƒe dɔdzẽ ƒe agbɔsɔsɔ dzi kpɔtɔ, eye wòna susu ƒe dɔwɔwɔ nyo ɖe edzi. Numekukuwo ɖee fia be esi wodo dasatinib kple quercetin ƒokpli ƒe atike na AD ƒe kpɔɖeŋu mice vɔ la, Aβ-kpe siwo le ahɔhɔ̃a me dzi ɖe kpɔtɔ, ahɔhɔ̃mekawo ƒe gbegblẽ dzi ɖe kpɔtɔ, eye teƒeteƒewo sɔsrɔ̃ kple ŋkuɖoɖonudzi ŋutetewo nyo ɖe edzi.
Nɔnɔmetata 3 Lãmenugbagbeviwo ƒe tsitsi abe tsitsi le lãmesẽ me kple AD ƒe akpa aɖe ene.
(2) Adzame ƒe nɔnɔme ƒe tɔtrɔ siwo do ƒome kple tsitsi (Senomorphics) .
1. Dɔwɔwɔ ƒe mɔnu: Senomorphics ƒe taɖodzinue nye be woaɖɔ SASP factors ƒe dodo ɖe lãmenugbagbevi siwo le tsitsim dzi, si aɖe woƒe ŋusẽkpɔɖeamedzi gbegblẽ ɖe lãmenugbagbevi siwo ƒo xlã wo dzi dzi akpɔtɔ. Atike aɖewo siwo tsia dɔdzẽ nu ate ŋu axe mɔ na dɔdzẽ ƒe nusiwo woɖena fiana kple wo dodo le SASP me, si aɖe ahɔhɔ̃mekawo ƒe dɔdzẽ dzi akpɔtɔ. Nu suesuesue aɖewo ate ŋu aɖɔ lãmenugbagbevi siwo le tsitsim ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe mɔnuwo ɖo, si atrɔ SASP ƒe wɔwɔme be wòagbɔdzɔ eƒe ŋusẽkpɔɖeamedzi gbegblẽ ɖe lãmenugbagbevi siwo ƒo xlãe dzi.
2.Potential Application Prospects: Viɖe si le senescence-associated secretory phenotype modulators le woƒe ŋutete be woana lãmenugbagbeviwo ƒe microenvironment nanyo ɖe edzi to senescent cells ƒe secretory dɔwɔwɔ dzi kpɔkpɔ me tsɔ wu be woaɖe wo ɖa tẽ. Esia ate ŋu aƒo asa na afɔku aɖewo siwo ate ŋu ado ƒome kple lãmenugbagbeviwo ɖeɖeɖa ƒe atikewo, abe nusiwo megblẽna le lãmenugbagbevi siwo sɔ ŋu o. Eyata, senescence-associated secretory phenotype modulators léa dɔwɔwɔ ƒe mɔkpɔkpɔ gbadzawo ɖe asi eye ate ŋu ado abe atikewɔwɔmɔnu yeye na AD ene.
Nyanuwuwuw
Lãmenugbagbevi siwo tsina wɔa akpa vovovowo le Alzheimer ƒe dɔlélea ƒe gɔmedzedze kple eƒe ŋgɔyiyi me. To mɔnuwo abe ahɔhɔ̃mekawo ƒe dɔdzẽ dodo ɖe ŋgɔ, ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie dodo ɖe ŋgɔ, lãmenugbagbeviwo dome kadodo tɔtrɔ, kple ŋusẽkpɔkpɔ ɖe ahɔhɔ̃mekawo ƒe lãmenugbagbeviwo ƒe nuto suewo dzi dzi la, lãmenugbagbevi siwo tsina la nana AD ƒe dɔlélenutsiŋutete gasẽna ɖe edzi. Atikewɔwɔmɔnu siwo woɖo taɖodzinu na lãmenugbagbevi siwo le tsitsim, abe lãmenugbagbeviwo ɖeɖeɖa ƒe atikewo kple tsitsi ƒe adzame ƒe nɔnɔme ƒe tɔtrɔ siwo do ƒome kple tsitsi ene, nye tiatia yeyewo hena AD dada.
Dzɔtsoƒewo
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