Retatrutidi (GLP-3) miligaramu 10

▎ GLP-3 sigicogo

▎ Molecules (Molecules) ka ɲɛfɔli

GLP-3 (LY3437943) ye sɛgɛsɛgɛli pepitiri ye min ɲɛfɔlen don i n’a fɔ agoniste saba minɛbaga ye glucagon-like peptide-1 receptor (GLP-1R), glucose-dependent insulinotropic polypeptide receptor (GIPR), ani glucagon receptor (GCGR) la.

Jaa1. GLP-3 tali sira saba minnu kofɔlen don, olu jiracogo sɛgɛsɛgɛli la, seginnkanni kofɔlen kɔnɔ.[1]

Ɲininikalan ɲɛtaa

Coskun, Tamer ani a baarakɛɲɔgɔnw ye GLP-3 sɛgɛsɛgɛ C57/Bl6 dumuni fasa (DIO) sogow la. Sɛbɛnnikɛlaw ye fɛn dɔ fɔ ka kɛɲɛ ni fura tata hakɛ yeli ye farikolo girinya la, kalori hakɛ la, farikolo hakɛ la, joli sukaro la, inisɔndiya la, ALT la, ani sugunɛ triglycérides la. Kɔrɔbɔli wɛrɛw kɛra o kalan kelen in na walasa ka GCGR, GIPR ani GLP-1R taamasiɲɛw dɛmɛni sɛgɛsɛgɛ jaabiw kɔlɔsili la minnu kɛra ka kɔn kɛnɛyaso ɲɛ.[2]

Jaa2. Farikolo girinya, kalori hakɛ, farikolo labɛncogo, ani farikoloɲɛnajɛ labanyɔrɔw fɔra LY3437943 kan sogo fasalenw na minnu bɛ dumuni kɛ.[2]

Sogo fasalenw minnu ye dumuni kɛ, olu ye LY3437943 hakɛ cayalenba sɔrɔ siɲɛ kelen don o don (QD) tile 21 kɔnɔ nin sɛgɛsɛgɛli kofɔlen in na.

(A) Yɛlɛma donna farikolo girinya kɛmɛsarada la waati kɔnɔ.

(B) Kalori hakɛ caman dunni waati kɔnɔ.

(C – F) Farikolo labɛncogo yeli garamu la kalan laban na: farikolo girinya (C), tuluma hakɛ (D), tuluma hakɛ (E), ani tulumafɛnw/tulu hakɛ hakɛ (F).

(G – J) Farikoloɲɛnajɛ taamasiɲɛw kalan laban na: joli sukaro (G), inisɔndiya (H), ALT (I), ani sugunɛ triglycérides (J).

(K) LY3437943 ni GLP-2 sumalen don a tata hakɛ la min fɔra kalan kɔnɔ walasa ka farikolo girinya caman yeli kɛmɛsarada la waati kɔnɔ.

(L) LY3437943 ni GLP-2 sumalen don a tata hakɛ la min fɔra kalan fɛ kalori hakɛ la waati kɔnɔ.

Kunnafoni bɛ jira ni cɛmancɛ ± SEM ye ni n = 6 (A – L) ye. Jateminɛ sɛgɛsɛgɛli kɛra (C) – (K) kɔnɔ ni sira kelen ANOVA ye ni bolifɛn ye, ni nafa ɲɛfɔra p < 0,05. ∗ p < 0,05, ∗∗ p < 0,01, ∗∗∗ p < 0,001, ∗∗∗∗ p < 0,0001 ni bolifɛn, p < 0,05 ni GLP-2 ye. ALT, alanini aminotransferase, o ye alanini aminotransferase ye; LY, LY3437943 ye baara kɛ; SEM, fili standard de la moyenne.+

Li, Wenzhuo, ani mɔgɔ wɛrɛw. baara kɛra ni cryo-électron microscopie ye walasa ka GLP-3 sɛgɛsɛgɛ min sirilen bɛ GLP-1R, GIPR ani GCGR la. Sɛbɛnnikɛlaw y’a jira ko pepitiri ka N-terminal yɔrɔ bɛ ɲɔgɔn sɔrɔ ni receptor transmembrane binding pocket ye, k’a sɔrɔ C-terminal yɔrɔ bɛ kɛ sababu ye ka jɛɲɔgɔnyaw kɛ ni extracellular receptor yɔrɔw ye. Nin ɲinini in ye ɲɔgɔndan maralenw ni sɔrɔyɔrɔ kɛrɛnkɛrɛnnenw bɛɛ jira minɛbaga saba kɔnɔ.[3]

Joachim Neumann n’a baarakɛɲɔgɔnw ye GLP-3 sɛgɛsɛgɛ hadamaden kininbolo ɲɛda labɛncogo danfaralenw na minnu sɔrɔla dusukun opereli senfɛ. Sɛbɛnnikɛlaw ye fɛn dɔw fɔ minnu bɛ bɔ a hakɛ ni waati la, fɛn minnu bɛ kɛ ka fɛnw sɔgɔsɔgɔ fanga la, ani ka baara kɛ ni furakisɛw ye minnu bɛ se ka fɛnw minɛ walasa ka GCGR, GIPR ani GLP-1R sendoncogo sɛgɛsɛgɛ. U ye taamasiɲɛw kɛcogo dɔ labɛn min bɛ tali kɛ cAMP la, nin ex vivo kalan in cogoyaw la.[4]

Coskun ni a ɲɔgɔnnaw. fana ye dusukun ni jolisiraw lakanani sɛgɛsɛgɛliw fɔ minnu tɛ kɛnɛyaso ye sinomɔli sonsanninw kan. Sɛgɛsɛgɛli min kɛra ni fura tata hakɛ kelen ye, dusukun tantanni tun ka ca ni a kɛcogo kelen ye LY3437943 tali kɔfɛ, ni sɛgɛsɛgɛli tata hakɛ min ka bon, o ye dɔ faraliba lase. Kalo wɔɔrɔ segin-ka-bɔnye sɛgɛsɛgɛli la, dusukun tantanni caman kɛra fura tali waati la, wa a ɲɛfɔra ko a bɛ bɔ fura tata hakɛ la; fɛn minnu bɛ tansiyɔn sistoliki ni diastoliki la, olu fana fɔra.[2] O kɔlɔsiliw Kɛra 'kɔnɔnafiliko minnu tɛ hadamadenw ye, olu ka kàlan cogoyaw la.

Ɲininikalan Danyɔrɔw

Baganw ka misaliw bɛ kunnafoniw di kɔrɔbɔli cogoya ɲɛfɔlenw kɔnɔ nka u tɛ se ka hadamaden farikolo-ɲɛnajɛ gɛlɛyaw lasegin ka dafa. Danfara minnu bɛ sɔrɔ minɛbagaw ka ɲɛnamayako la, farikoloɲɛnajɛw ladamuni na, u tali kuntaala, ani jiginɛ taamasiɲɛw bɛ se ka nɔ bila bamanankan bamanankan na suguyaw ni ɲɔgɔn cɛ. O la, fɛn minnu sɔrɔla furakɛlikɛlaw ka sɛgɛsɛgɛliw la, u jɔcogo sɛgɛsɛgɛliw la, hadamaden farikolo yɔrɔw danfaralenw na, ani baganw ka misaliw la, olu ka kan ka faamuya misali kɛlen kɔnɔ, wa u man kan ka jate i n’a fɔ kɛnɛyaso lakanani walima a nafa daliluw.

COCER Peptides bɛ GLP-3 di laboratuwari ɲininiw dɔrɔn de kama, a tɛ kɛ hadamadenw walima baganw ka baara kama. Nin ɲɛ in kan, kunnafoni minnu bɛ sɔrɔ, olu bɛ fɛnw lajɛ minnu fɔra mɔgɔ wɛrɛw ka sɛbɛnw kɔnɔ minnu kofɔlen don, wa u tɛ kuma fɔ kɛnɛyaso nafa kan, a lakanani, a sɛgɛsɛgɛli, a furakɛli, a kunbɛnni, walima a kɛcogo wɛrɛw kan.

▎ Sɛbɛn minnu bɛ tali kɛ o la

[1] KAUR M, MISRA S. Sɛgɛsɛgɛli fura dɔ seginnkanni GLP-3, o ye agoniste saba fura kura ye fasa furakɛli kama[J]. Erɔpu ka furakɛli gafe, 2024,80(5):669-676.

DOI:10.1007/s00228-024-03646-0. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew

[2] COSKUN T, URVA S, ROELL WC, ani a ɲɔgɔnnaw. LY3437943, glucagon saba, GIP ani GLP-1 minɛbaga agoniste kura ye sukarodunbana kunbɛnni ni farikolo girinya dɔgɔyali kama: K’a ta sɔrɔli la ka se hakilina daliluw ma kɛnɛyaso la[J]. Jabɛtibana selilɛriw, 2022,34(9):1234-1247.e9.

DOI:10.1016/j.cmet.2022.07.013. Bamako, Mali

[3] LI W, ZHOU Q, CONG Z, ani a ɲɔgɔnnaw. Jateminɛw sigicogo kan agonisme saba kan GLP-1R, GIPR ani GCGR la minnu bɛ jira GLP-3 fɛ[J]. Selilu sɔrɔli, 2024,10:77.

DOI:10.1038/s41421-024-00700-0. Bamako, Mali

[4] NEUMANN J, AHLREP U, HOFMANN B, ani a ɲɔgɔnnaw. GLP-3 ka inotropi nɔw hadamadenw ka ɲɛgɛnɛsira labɛncogo danfaralenw na[J]. Naunyn-Schmiedeberg ka furakɛli sɛbɛnw, 2026,399(1):317-327.

DOI:10.1007/s00210-025-04421-3. Bamako, Mali

[5] LUTZ T A. Baganw ka sukarodunbana misaliw, ni u sinsinnen don sukarodunbana suguya 2 kan[J]. Sigida lajɛw Endocrinologie, 2023,19(6):350-360.

DOI:10.1038/s41574-023-00818-3. Bamako, Mali

[6] TU Q, LIU G, LIU X, ani a ɲɔgɔnnaw. Hakilila min bɛ baara kɛ ni fɛnɲɛnamaw ye minnu tɛ hadamadenw ye Exposome ɲininiw na[J]. Ecotoxicologie ani sigida lakanani, 2024,286:117199. DOI:10.1016/j.ecoenv.2024.117199. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew.

FƐƐRƐW, ƝƐFƆLIW, FƐƐRƐW, FƐRƐW ƝƐFƆLIW, ANI KUNNAFONI WƐRƐW BƐƐ MIN BƐ DI ƝƐSIN ƝƐNABƆLI ƝƐNABƆLI MA, KUNNAFONIW ANI KALANSENW DƆRƆN MA. 

Cocer Peptides bɛ fura minnu di, olu dabɔra dɔrɔn ka kɛ in vitro ani laboratuwari ɲininiw kama, wa u ma dabɔ hadamadenw walima baganw ka baara kama, hadamadenw ka dumuni, kɛnɛyaso, bana sɛgɛsɛgɛli, furakɛli, ka u fara ɲɔgɔn kan, ka u yɛrɛ ta, ka u pikiri, walima ka u di hadamadenw walima baganw ma cogo wɛrɛ la. Nin fura ninnu ma dabɔ ka bana walima furakɛli cogoya si sɛgɛsɛgɛ, k’a furakɛ, k’a furakɛ, k’a nɔgɔya, walima k’a bali, wa u ma dabɔ fana ka nɔ bila hadamaden walima bagan farikolo jɔcogo walima a baara la. Fo ni a fɔra cogo wɛrɛ la, fɛn minnu bɛ dilan nin siti in kan, olu ma jateminɛ walima ka sɔn u ma Ameriki dumuniko ni furako ɲɛmɔgɔso fɛ (FDA) hadamadenw walima baganw ka baara kama. Fɛn o fɛn bɛ tali kɛ kalan bɔlenw na, biyokimiki siraw, molekiyɔmuw ka fɛɛrɛw, walima kɔrɔbɔli sɔrɔlenw kan, olu bɛ di dɔnniya baro ni ɲininiw dɔrɔn de kama, wa u tɛ kɛ furakɛli ladilikanw ye, furakɛli kumaw, fura tata hakɛ ɲɛfɔli, walima baarakɛcogo cikanw ye. Sannikɛlaw dɔrɔn de ka kan k’a lajɛ ko fɛn bɛɛ bɛ sɔrɔ, ka minɛ, ka mara, ka baara kɛ ni u ye, ani ka fili ka kɛɲɛ ni sariyaw, sariyakolow, sigida ka wajibiw ani laboratuwari lakanani sariyaw ye minnu bɛ sirataama.