Los ntawm Cocer Peptides 
1 month ago
Tag nrho cov kab lus thiab cov ntaub ntawv ntawm cov khoom lag luam muab rau ntawm lub vev xaib no tsuas yog rau cov ntaub ntawv tshaj tawm kev tshaj tawm thiab cov hom phiaj kev kawm.
Cov khoom muab rau hauv lub vev xaib no yog npaj tshwj xeeb rau kev tshawb fawb hauv vitro. Kev tshawb fawb hauv vitro (Latin: * hauv iav *, lub ntsiab lus hauv iav) yog ua los ntawm tib neeg lub cev. Cov khoom no tsis yog tshuaj, tsis tau txais kev pom zoo los ntawm US Food and Drug Administration (FDA), thiab yuav tsum tsis txhob siv los tiv thaiv, kho, lossis kho txhua yam mob, kab mob, lossis mob. Nws raug txwv nruj raws li txoj cai los qhia cov khoom no rau hauv tib neeg lossis tsiaj lub cev hauv txhua daim ntawv.
Hauv kev tshawb fawb txog kev ua neej, kev laus ib txwm yog lub ntsiab lus tseem ceeb ntawm kev tshawb fawb. Raws li kev tshawb fawb rau hauv cov txheej txheem ntawm kev laus txuas ntxiv mus tob zuj zus, lub luag haujlwm ntawm nicotinamide adenine dinucleotide (NAD +) hauv cov txheej txheem tiv thaiv kev laus tau txais kev saib xyuas ntxiv. Raws li cov coenzyme koom nrog ntau cov txheej txheem physiological tseem ceeb hauv cov hlwb, NAD + tau pom tias muaj kev cuam tshuam zoo rau cov txheej txheem kev laus.
Daim duab 1 Biological functions ntawm NAD. NAD tswj hwm lub zog sib npaug, kev ntxhov siab, thiab cellular homeostasis los ntawm sirtuins, PARPs, thiab ntau yam redox enzymes.
Txheej txheem cej luam ntawm Physiological Functions ntawm NAD +
NAD + yog coenzyme dav dav hauv cov hlwb, koom nrog ntau yam txheej txheem physiological tseem ceeb. Nws feem ntau muaj nyob rau hauv ob daim ntawv hauv hlwb: daim ntawv oxidized (NAD +) thiab daim ntawv txo (NADH), uas tuaj yeem hloov pauv. Qhov kev sib npaug dynamic no yog qhov tseem ceeb rau kev tswj cov cellular metabolism thiab ua haujlwm.
1. Lub zog metabolism: NAD + ua lub luag haujlwm tseem ceeb hauv kev ua pa ntawm tes. Nyob rau hauv lub zog metabolism txoj hauv kev xws li glycolysis, lub voj voog tricarboxylic acid, thiab oxidative phosphorylation, NAD + ua raws li cov khoom siv hluav taws xob, tau txais cov hluav taws xob tso tawm thaum lub sij hawm oxidation ntawm metabolic substrates los tsim NADH. Tom qab ntawd, NADH hloov electrons mus rau mitochondrial respiratory saw, qhov twg oxidative phosphorylation generates adenosine triphosphate (ATP), muab lub zog rau lub cell. Cov txheej txheem no ua kom cov hlwb tsis tu ncua kom tau txais lub zog txaus los tswj lawv cov haujlwm ntawm lub cev, xws li kev loj hlob ntawm tes, faib, thiab kho.
Thaum lub sij hawm glycolysis, 3-phosphoglycerate hloov hydrogen atoms rau NAD + raws li kev ua ntawm 3-phosphoglycerate dehydrogenase, tsim NADH thiab 1,3-diphosphoglycerate. Tom qab ntawd, NADH hloov hluav taws xob mus rau oxygen los ntawm cov kab mob ua pa hauv mitochondria, thaum kawg tsim cov dej thiab sib txuas ATP synthesis. Qhov no qhia tau hais tias NAD + yog ib qho tseem ceeb ntawm cov cellular zog metabolism, thiab kev hloov hauv nws cov concentration ncaj qha cuam tshuam rau kev ua tau zoo ntawm lub zog tsim.
2. Kev kho DNA: NAD+ yog lub substrate rau poly (ADP-ribose) polymerase (PARP) tsev neeg. Tom qab PARP lees paub thiab khi rau qhov chaw DNA puas lawm, nws siv NAD + ua lub substrate hloov ADP-ribose pawg rau nws tus kheej los yog lwm yam proteins, tsim poly (ADP-ribose) (PAR) chains. Cov PAR chains no tuaj yeem nrhiav thiab qhib ntau cov proteins koom nrog hauv DNA kho, xws li DNA ligase thiab DNA polymerase, yog li pib txheej txheem kho DNA. Thaum cov hlwb raug cuam tshuam rau DNA kev puas tsuaj los ntawm yam xws li hluav taws xob ultraviolet lossis tshuaj lom neeg, PARP-NAD + system teb sai sai los kho DNA puas thiab tswj cov genomic stability. Yog tias NAD + qib tsis txaus, PARP kev ua haujlwm raug cuam tshuam, ua rau txo qis DNA kho lub peev xwm, nce genomic instability, thiab ceev cellular aging thiab kab mob pib.
3. Kev hloov pauv tom qab kev hloov pauv ntawm cov proteins: NAD + kuj koom nrog cov tshuaj tiv thaiv catalytic ntawm sirtuin tsev neeg cov proteins. Sirtuins yog ib chav kawm ntawm NAD +-nyob deacetylases uas tuaj yeem tshem tawm cov kev hloov pauv acetyl los ntawm lysine residues ntawm cov proteins. Qhov kev hloov kho deacetylation no tswj cov kev ua, kev ruaj ntseg, thiab subcellular localization ntawm ntau cov proteins, yog li cuam tshuam cov cellular metabolism, kev ntxhov siab, kev laus, thiab lwm yam txheej txheem physiological. Piv txwv li, SIRT1 tuaj yeem tswj hwm cov haujlwm ntawm cov khoom siv hloov pauv xws li p53 thiab FOXO los ntawm kev hloov kho deacetylation, yog li cuam tshuam rau lub voj voog ntawm tes, apoptosis, thiab cov txheej txheem kev ntxhov siab antioxidant. Thaum cov hlwb muaj kev ntxhov siab, SIRT1 deacetylates p53 los ntawm kev noj NAD +, yog li inhibiting p53's transcriptional kev ua, txo qhov tshwm sim ntawm apoptosis, thiab txhim kho cellular ciaj sia taus.
Hloov hauv NAD + Qib Thaum Laus
Cov kev tshawb fawb tau pom tias nrog lub hnub nyoog, NAD + qib maj mam txo qis hauv ntau cov ntaub so ntswg thiab hlwb ntawm lub cev. Qhov kev poob qis no tau pom nyob hauv ntau hom, suav nrog cov tsiaj txhu, nematodes, thiab yoov txiv hmab txiv ntoo, qhia tias txo NAD + qib yuav yog qhov tshwm sim ntawm kev txuag hauv kev laus.
1. Cov kev hloov pauv ntawm cov ntaub so ntswg: Qhov ntau thiab cov txheej txheem ntawm NAD + qib poob nrog lub hnub nyoog yuav txawv ntawm cov ntaub so ntswg sib txawv. Hauv cov leeg pob txha, kev laus yog nrog los ntawm kev txo qis ntawm cov enzymes tseem ceeb hauv NAD + biosynthetic txoj hauv kev, ua rau txo NAD + synthesis. Kev qhia thiab kev ua ntawm NAD + kev noj cov enzymes xws li CD38 nce, ua kom NAD + degradation thiab thaum kawg ua rau txo qis NAD + qib hauv cov leeg pob txha. Hauv daim siab, ntxiv rau cov kev hloov pauv tau hais los saum toj no hauv kev sib txuas thiab kev ua kom tsis zoo, kev laus kuj tseem tuaj yeem cuam tshuam rau NAD + kev thauj mus los, ua rau muaj kev tsis txaus ntseeg hauv intracellular NAD + kev faib tawm thiab ntxiv txo nws cov concentration.
2. Kev koom nrog cov kab mob uas muaj hnub nyoog: Cov qib NAD + txo qis yog cuam tshuam nrog kev pib thiab kev loj hlob ntawm ntau yam kab mob uas muaj hnub nyoog. Hauv cov kab mob plawv, qhov poob ntawm myocardial cell NAD + theem tshwm sim los ntawm kev laus ua rau lub zog metabolism tsis zoo, nce oxidative kev nyuaj siab, thiab myocardial cell apoptosis, yog li ua rau lub plawv tsis ua haujlwm. Hauv cov kab mob neurodegenerative xws li Alzheimer's kab mob thiab Parkinson tus kab mob, qhov txo qis hauv neuronal NAD + qib cuam tshuam rau DNA kho thiab protein homeostasis, txhawb kev sib sau ntawm neurotoxic proteins thiab neuronal tuag. Cov kab mob metabolic xws li ntshav qab zib kuj tseem cuam tshuam nrog txo qis NAD + qib, vim NAD + tsis txaus ua rau txo qis cov tshuaj insulin thiab insulin rhiab heev, ua rau cov ntshav qabzib txawv txav.
Mechanisms uas txo NAD + qib txhawb kev laus
1. **Energy metabolism disorders**: NAD+ plays lub luag haujlwm tseem ceeb hauv cellular zog metabolism. Raws li hnub nyoog nce, txo NAD + qib ua rau muaj kev cuam tshuam lub zog metabolism hauv txoj hauv kev thiab txo qis ATP ntau lawm. Qhov no tsis tsuas yog cuam tshuam rau lub cev lub cev ntawm lub cev, tab sis kuj ua rau muaj cov lus teb rau cov lus teb, xws li kev loj hlob ntawm mitochondrial ntau dhau thiab kev ua haujlwm tsis zoo. Mitochondria yog lub cellular powerhouses; Thaum NAD + tsis txaus, mitochondrial respiratory saw muaj nuj nqi yog qhov tsis zoo, ua rau muaj kev tsim cov pa oxygen ntau ntxiv (ROS) thaum thauj hluav taws xob. ROS ntau dhau tuaj yeem tua mitochondrial DNA, cov proteins, thiab lipids, ntxiv cuam tshuam cov qauv mitochondrial thiab kev ua haujlwm, tsim kom muaj lub voj voog tsis zoo uas ua rau cov cellular aging.
Daim duab 2 Npaj cov txheej txheem ntawm kev laus li cas cuam tshuam rau NAD metabolism. Kev laus cuam tshuam qhov sib npaug ntawm NAD synthesis thiab degradation, ua rau txo NAD qib hauv ntau cov ntaub so ntswg.
2. Kev puas tsuaj ntawm DNA: Raws li lub substrate rau PARP, txo NAD + qib tsis muaj zog kho DNA. Thaum DNA kev puas tsuaj tsis tuaj yeem kho tau zoo raws sijhawm, nws ua rau genomic instability, accumulating ib tug loj tus naj npawb ntawm kev hloov thiab chromosomal txawv txav. Cov kev puas tsuaj ntawm caj ces cuam tshuam nrog kev ua haujlwm ntawm cellular physiological, cuam tshuam rau cell proliferation, sib txawv, thiab apoptosis, yog li txhawb kev laus ntawm cellular. DNA kev puas tsuaj kuj ua rau muaj kev cuam tshuam txog kev laus hauv cov hlwb, xws li p53-p21 thiab p16INK4a-Rb txoj hauv kev, ntxiv inducing qhov tshwm sim ntawm cellular aging.
3. Dysregulation of senescence-related signaling pathways: NAD+-dependent sirtuin tsev neeg cov proteins ua lub luag haujlwm tseem ceeb hauv kev tswj hwm senescence-txog kev taw qhia txoj hauv kev. Raws li NAD + qib poob qis, sirtuin kev ua haujlwm yog inhibited, ua rau txo qis deacetylation hloov pauv ntawm cov dej hauv qab lub hom phiaj. Kev txo qis SIRT1 ua rau p53 nyob rau hauv lub xeev acetylated heev, txhim kho p53 qhov kev hloov pauv, ua rau lub voj voog ntawm tes raug ntes thiab apoptosis; Tib lub sijhawm, tsis muaj zog deacetylation ntawm FOXO kev hloov pauv hloov pauv los ntawm SIRT1 cuam tshuam rau lub cell lub zog tiv thaiv kev ntxhov siab thiab kev tswj cov metabolism. Tsis tas li ntawd, kev hloov pauv hauv kev ua haujlwm ntawm lwm tus neeg hauv tsev neeg xws li SIRT3 thiab SIRT6 kuj cuam tshuam rau kev ua haujlwm mitochondrial, genomic stability, thiab inflammatory teb, sib sau ua ke kev loj hlob ntawm cellular senescence.
Cov tswv yim tiv thaiv kev laus kom nce qib NAD +
Muab kev sib raug zoo ntawm kev txo qis NAD + qib thiab kev laus, cov tswv yim kom ncua kev laus los ntawm kev nce qib NAD + tau dhau los ua qhov kev tshawb fawb hotspot.
1. Ntxiv NAD + Precursors: Ntxiv NAD + precursors yog ib txoj hauv kev los nce NAD + ntau ntau. Feem ntau NAD + precursors suav nrog nicotinamide (NAM), nicotinamide mononucleotide (NMN), thiab nicotinamide riboside (NR). Cov precursors no tuaj yeem hloov mus rau hauv NAD + los ntawm cov txheej txheem metabolic hauv cov hlwb, yog li nce nws qib.
Nicotinamide (NAM): NAM yog ib daim ntawv ntawm vitamin B3 uas tuaj yeem hloov mus rau nicotinamide mononucleotide (NMN) los ntawm kev ua ntawm nicotinamide phosphoribosyltransferase (NAMPT), uas yog siv los ua ke NAD +. Kev noj tshuaj ntau ntxiv NAM tuaj yeem tawm tswv yim inhibit NAMPT kev ua, txwv nws lub peev xwm nce NAD + qib. Kev siv tshuaj NAM ntev ntev tuaj yeem ua rau muaj kev phiv xws li tawv nqaij, tab sis ntawm cov koob tshuaj uas tsim nyog, NAM tuaj yeem ua rau muaj txiaj ntsig zoo ntawm NAD + qib, txhim kho cov metabolism hauv lub zog, thiab txhim kho DNA kho cov haujlwm.
Nicotinamide mononucleotide (NMN): NMN yog qhov ncaj qha ua ntej hauv NAD + txoj kev biosynthetic. Cov kev tshawb fawb tau pom tias qhov ncauj NMN tau nqus sai thiab hloov mus rau hauv NAD +, ua kom NAD + ntau ntau hauv ntau cov ntaub so ntswg. Hauv kev sim tsiaj, NMN supplementation tau pom tias muaj kev txhim kho tseem ceeb hauv cov hnub nyoog ntsig txog cov kab mob metabolic, plawv plawv tsis ua haujlwm, thiab cov kab mob neurodegenerative. Piv txwv li, hauv cov nas muaj hnub nyoog, NMN supplementation txhim kho lub peev xwm locomotor, txhim kho insulin rhiab heev, txo cov hnub nyoog ntsig txog kev hloov pauv hauv lub plawv, thiab txhim kho kev txawj ntse. Tsis tas li ntawd, NMN tau pom tias txhawb nqa mitochondrial biogenesis, txhim kho mitochondrial muaj nuj nqi, thiab txo oxidative kev nyuaj siab vim kev puas tsuaj.
Nicotinamide riboside (NR): NR yog lwm qhov ua tau zoo NAD + ua ntej uas tuaj yeem hloov mus rau NMN los ntawm phosphorylation los ntawm nicotinamide riboside kinase (NRK), uas yog siv los ua ke NAD +. Zoo ib yam li NMN, kev ntxiv nrog NR tuaj yeem nce qib hauv cov cellular NAD +, txhim kho metabolic muaj nuj nqi, thiab ncua kev laus. Hauv cov nas muaj hnub nyoog, NR ntxiv tuaj yeem kho cov txheej txheem metabolic thiab kev ntxhov siab, txhim kho cov chromatin-binding peev xwm ntawm circadian moos noob BMAL1, rov ua kom mitochondrial respiratory rhythms thiab circadian ua haujlwm, thiab ib nrab rov qab kho lub cev ntawm cov nas laus rau cov nas yau.
Daim duab 3 Tus qauv piav qhia txog NAD + txoj kev khaws cia thiab nicotinamide riboside (NR) hloov mus rau NAD +.
2. Kev tswj ntawm NAD + metabolic enzymes:
Kev ua kom NAD + synthase: NAMPT yog tus nqi txwv enzyme hauv NAD + biosynthetic txoj hauv kev, thiab nce kev ua haujlwm tuaj yeem txhawb nqa NAD + synthesis. Qee cov khoom siv ntuj tsim, xws li resveratrol thiab apigenin, tau pom los ua kom NAMPT, yog li nce NAD + ntau lawm. Resveratrol yog ib qho tshuaj polyphenolic muaj nyob rau hauv cov tawv nqaij txiv hmab txiv ntoo, caw liab, thiab lwm yam nroj tsuag. Nws tuaj yeem cuam tshuam ncaj qha rau NAMPT kev qhia los ntawm kev ua kom SIRT1-PGC-1α txoj kev taw qhia, yog li nce NAD + qib. Kev kho Resveratrol txhim kho cov metabolism hauv lub zog, txo oxidative kev nyuaj siab puas tsuaj, thiab txuas ntxiv lub neej ntawm cov nas muaj hnub nyoog.
Inhibiting NAD + noj enzymes: CD38 yog ib qho tseem ceeb NAD + noj enzyme uas nws qhia thiab kev ua si nce nrog lub hnub nyoog, ua kom NAD + degradation. Inhibiting CD38 kev ua ub no txo NAD + noj thiab tswj cov qib NAD + intracellular. Qee cov tshuaj me me, xws li 78c thiab apigenin, tau tshaj tawm tias inhibit CD38 kev ua haujlwm. Kev siv CD38 inhibitors tuaj yeem nce qib NAD + thiab txhim kho lub hnub nyoog ntsig txog lub cev tsis ua haujlwm, xws li txhim kho lub plawv thiab txhim kho cov kab mob metabolic.
3. Kev cuam tshuam txog kev ua neej nyob: Cov yam ntxwv ntawm kev ua neej kuj tseem cuam tshuam rau qib NAD+.
Kev tawm dag zog: Kev tawm dag zog ib txwm txhawb nqa NAD + txoj hauv kev biosynthetic thiab nce NAD + qib. Ob leeg aerobic ce thiab kev cob qhia lub zog tuaj yeem ua rau kom muaj kev qhia thiab kev ua haujlwm ntawm NAMPT hauv cov leeg pob txha, txhawb nqa NAD + synthesis. Kev tawm dag zog kuj tseem tuaj yeem tswj cov kev qhia ntawm NAD + cov tshuaj metabolism hauv cov noob, txhim kho mitochondrial muaj nuj nqi, thiab txhim kho cellular antioxidant muaj peev xwm. Hauv cov neeg laus, kev tawm dag zog nruab nrab tuaj yeem ua rau muaj txiaj ntsig NAD + cov ntsiab lus hauv cov leeg, txhim kho cov leeg nqaij thiab lub cev muaj zog, thiab ua rau cov txheej txheem laus zuj zus.
Kev txwv kev noj zaub mov: kev txwv kev noj zaub mov, xws li kev txwv calories (CR) thiab kev yoo mov tsis sib xws (IF), tau lees paub tias yog cov tswv yim zoo rau kev laus qeeb. Cov qauv kev noj haus no siv lawv cov kev tiv thaiv kev laus los ntawm kev tswj hwm NAD + cov metabolism. CR thiab IF qhib sirtuin tsev neeg cov proteins xws li SIRT1, txhawb NAD + synthesis thiab siv. Kev txwv kev noj zaub mov kuj tseem tuaj yeem txo cov kev ntxhov siab oxidative, txhim kho cov metabolism, thiab txo cov kev pheej hmoo ntawm cov kab mob uas muaj hnub nyoog. Hauv kev sim tsiaj, kev txwv tsis pub calorie ntau ntau tuaj yeem nce qib NAD + thiab txuas ntxiv lub neej ntawm ntau hom.
Los tiv thaiv kev laus los ntawm nce NAD + qib
1. Kev tiv thaiv kev laus hauv kev sim tsiaj: Ntau qhov kev sim tsiaj tau lees paub tias nce qib NAD + tuaj yeem ua rau qeeb ntawm kev laus thiab txhim kho lub hnub nyoog ntsig txog lub cev tsis ua haujlwm.
Txhim kho Metabolic Function: Hauv cov nas muaj hnub nyoog, ntxiv nrog NMN lossis NR tuaj yeem txhim kho insulin rhiab heev, tswj cov ntshav qabzib, thiab txhim kho lipid metabolism. NAD + precursor supplementation tuaj yeem ua rau cov roj ntsha oxidation hauv cov ntaub so ntswg adipose, txo cov rog, thiab txo cov kev pheej hmoo ntawm kev rog rog. Kev nce qib NAD + tuaj yeem txhim kho daim siab metabolic muaj nuj nqi, txhim kho lub siab lub peev xwm detoxification rau tshuaj thiab co toxins, thiab tswj lub siab lub cev ua haujlwm.
Kev Tiv Thaiv Kab Mob Ntshav Qab Zib: Thaum lub sijhawm kev laus, cov kab mob plawv tau hloov pauv cov qauv thiab kev ua haujlwm, xws li myocardial hypertrophy thiab txo cov vascular elasticity. Ntxiv nrog rau NAD + precursors tuaj yeem txhim kho lub plawv contraction thiab so muaj nuj nqi, txo myocardial fibrosis, thiab txo oxidative kev nyuaj siab. Hauv cov qauv tsiaj, ntxiv nrog NMN lossis NR tuaj yeem txo cov ntshav siab, txhim kho vascular endothelial muaj nuj nqi, thiab txo qhov kev pheej hmoo ntawm cov kab mob plawv. Hauv cov qauv myocardial infarction, nce NAD + qib tuaj yeem txhawb nqa myocardial cell ciaj sia thiab kho, txo qhov loj me me, thiab txhim kho kev ua haujlwm plawv.
Neuroprotective Effects: Hauv cov qauv ntawm cov kab mob neurodegenerative, nce NAD + qib qhia pom cov teebmeem neuroprotective tseem ceeb. Cov kev tshawb fawb tau pom tias kev ntxiv nrog NMN lossis NR tuaj yeem txhim kho kev paub txog kev ua haujlwm, txo qis neuroinflammation, thiab txo qis kev sib sau ntawm cov proteins hauv neurotoxic. Hauv Alzheimer tus kab mob nas qauv, ntxiv nrog NAD + precursors tuaj yeem txo qis β-amyloid ntau lawm, inhibit phosphorylation ntawm tau protein ntau, tiv thaiv neurons los ntawm kev puas tsuaj, thiab yog li txhim kho kev kawm thiab kev nco muaj peev xwm.
Kev ncua sij hawm ntev: Hauv ntau hom kab mob, nce NAD + qib tau pom tias txuas ntxiv txoj sia. Hauv nematodes thiab txiv hmab txiv ntoo yoov, nce NAD + qib los ntawm kev tswj cov caj ces lossis ntxiv nrog NAD + precursors tuaj yeem txuas ntxiv lawv txoj sia. Hauv kev sim nas, kev ntxiv mus sij hawm ntev nrog NMN lossis NR kuj tau pom qhov sib txawv ntawm kev ua neej ntev, txawm hais tias qhov txiaj ntsig no yuav txawv ntawm cov kev tshawb fawb sib txawv. Zuag qhia tag nrho, cov kev tshawb pom no qhia txog qhov zoo ntawm kev nce NAD + qib ntawm kev ua neej nyob.
Xaus
Raws li cov coenzyme tseem ceeb hauv cov hlwb, NAD + ua lub luag haujlwm tseem ceeb hauv cov txheej txheem physiological tseem ceeb xws li lub zog metabolism, kho DNA, thiab kev hloov pauv tom qab hloov pauv ntawm cov protein. Raws li lub hnub nyoog nce, qhov poob ntawm NAD + qib yog ze rau cov txheej txheem kev laus thiab qhov pib thiab kev loj hlob ntawm ntau yam kab mob uas muaj hnub nyoog. Cov tswv yim txhawm rau nce qib NAD +, xws li ntxiv NAD + precursors, tswj NAD + metabolic enzymes, thiab kev cuam tshuam hauv kev ua neej, tau pom muaj txiaj ntsig zoo los tiv thaiv kev laus hauv cov tsiaj sim, suav nrog kev txhim kho metabolic, tiv thaiv kab mob plawv thiab paj hlwb, thiab txuas ntxiv lub neej.
Qhov chaw
[1] Chubanava S, Treebak J T. Kev tawm dag zog tsis tu ncua muaj txiaj ntsig tiv thaiv kev laus-txo qis hauv cov leeg pob txha NAD cov ntsiab lus [J]. Experimental Gerontology, 2023,173:112109.DOI:10.1016/j.exger.2023.112109.
[2] Soma M, Lalam S K. Lub luag haujlwm ntawm nicotinamide mononucleotide (NMN) hauv kev tiv thaiv kev laus, kev ua neej ntev, thiab nws lub peev xwm los kho cov mob ntev [J]. Molecular Biology Reports, 2022,49(10):9737-9748.DOI:10.1007/s11033-022-07459-1.
[3] Curry A, White D, Cen Y. Me Molecule Regulators Targeting NAD(+) Biosynthetic Enzymes[J]. Tam sim no Medicinal Chemistry, 2022,29(10):1718-1738.DOI:10.2174/0929867328666210531144629.
[4] Yuan Y, Li B, Li X, et al. Targeting NAD +: Nws puas yog ib lub tswv yim zoo los ncua kev laus lub plawv?[J]. Cell Tuag Discovery, 2022, 8. https://api.semanticscholar.org/CorpusID:248393418
[5] Levine DC, Hong H, Weidemann BJ, et al. NAD(+) Tswj Circadian Reprogramming los ntawm PER2 Nuclear Translocation rau Counter Aging[J]. Molecular Cell, 2020,78(5):835-849.DOI:10.1016/j.molcel.2020.04.010.
[6] Fang EF, Hou Y, Lautrup S, et al. NAD (+) augmentation restores mitophagy thiab txwv ceev kev laus hauv Werner syndrome [J]. Nature Communications, 2019,10(1):5284.DOI:10.1038/s41467-019-13172-8.
[7] Yaku K, Okabe K, Nakagawa T. NAD metabolism: cuam tshuam rau kev laus thiab kev ua neej ntev[J]. Kev Tshawb Fawb Txog Kev Laus, 2018,47:1-17.DOI:10.1016/j.arr.2018.05.006.
[8] Chaturvedi P, Tyagi S. C. NAD(+) : Ib tug loj neeg uas ua ntawv nyob rau hauv lub plawv thiab skeletal nqaij remodeling thiab aging[J]. Phau ntawv Journal of Cellular Physiology, 2018,233(3):1895-1896.DOI:10.1002/jcp.26014.
Cov khoom muaj rau kev tshawb fawb siv nkaus xwb:
