Ghrp-2 miligaramu 10

▎ GHRP-2 ka baarakɛcogo

Sɔrɔyɔrɔ: PubChem

A kɛcogo: AXAWFK Formula molekilɛri: C 45H 55N 9O6 Molecules girinya: 817,98 g/mol CAS nimɔrɔ:158861-67-7 PubChem CID:6918245. Bamako, Mali Kɔrɔɲɔgɔnmaw: Pralmorelin;pralmoreline;KP-102;pralmoreline

▎ GHRP-2  Sɛgɛsɛgɛli

GHRP-2 ka ɲininiw kɛcogo ye mun ye?

Bonya hormone jɔyɔrɔ ka bon hadamaden ka bonya, a yiriwali ani farikoloɲɛnajɛ balansi la. Dɔnniyakɛlaw ye fɛnw ɲini kabini tuma jan minnu bɛ se k’a bɔli ɲɛnabɔ ka ɲɛ. Bonya-hormone-releasing peptides (GHRPs), oligopeptide sintetiki kulu dɔ min bɛ bonya hormone bɔli lawuli, o bɔra kɛnɛ kan ka kɛ ɲininiw sinsinnan ye.

GHRP-2 bɛ grelin ka baara ladege a kɛtɔ ka a siri grelin minɛbaga la, ka taamasiɲɛw siraw baara walasa ka GH bɔli lawuli ka ɲɛ. A bɛ se jira ka ɲɛsin bonya hormone dɛsɛ sɛgɛsɛgɛli n’a furakɛli ma, ka don dumunikɛbaliya la, ani ka farikolo yɔrɔw tanga, o bɛ ɲinini juguw kɛ a kɛcogo n’a kɛcogo kan.

GHRP-2 ka baarakɛcogo ye mun ye?

Kɔrɔya-hormone (banakisɛfagalan) bɔli ɲɛnabɔli

Ka baara kɛ ni Hypothalamic-Pituitary Axis ye:

GHRP-2 bɛ bonya hormone (GH) bɔli lawuli ni wale fila ye min ɲɔgɔn tɛ, min bɛ kɛ sababu ye ka hypothalamus ni pituitary gland (Bowers CY) fila bɛɛ laɲini. Pituitaire ta fan fɛ, GHRP-2 bɛ siri bonya hormone-releasing hormone receptor (GHS-R) la. Ni a sirilen don GHS-R la, GHRP-2 bɛ taamasiɲɛw kɛli daminɛ selilɛri kɔnɔ. Misali la, a bɛ fosifolipazi C (PLC) baara, o min bɛ fosifatidilinɔsitɔli-4,5-bisifosifati (PIP2) jilama kɛ selilɛri kan ka kɛ inositɔli trisfosifati (IP3) ani diasiligilisɛrɔli (DAG) ye. IP3 bɛ kalisiyɔmu ion bɔli sabati endoplasmique reticulum kɔnɔ, ka sɔrɔ DAG bɛ protein kinase C (PKC) baara, o laban bɛ na ni GH bɔli ye (Roh SG,). Kalan dɔ la min kɛra ni misiw ka ɲɛgɛnɛsiralabanaw ye, GHRP-2 hakɛ suguya caman na (10−⊃1;⊃3; ka se 10−7 M ma) ye dɔ fara kosɛbɛ GH bɔli kan (P < 0,05), o b’a jira ko GHRP-2 bɛ se ka GH bɔli nɔ tilennen bila sɔgɔsɔgɔninjɛ ^la.

Baarakɛɲɔgɔnya ni bonya hormone-releasing hormone (GHRH) ye:

GHRP-2 bɛ jɛɲɔgɔnya nɔ jira ni GHRH ye GH bɔli lawulili la. Ni u bɛ kɛ ɲɔgɔn fɛ pituitaire selilɛriw la, u bɛ baara kɛ taamasiɲɛw sira danfaralenw fɛ minnu laban bɛ ɲɔgɔn sɔrɔ walasa ka GH bɔli sabati. Kɔlɔsiliw y’a jira ko GHRH bɛ adenilati siklazi (AC) baara fɔlɔ, ka cAMP hakɛ kɔrɔta selilɛri kɔnɔ walasa ka kɔfɛ ka poroteyini kinase A (PKA) baara, o la, a bɛ GH jamu sɛbɛnni ni GH dilanni/bɔli sabati. O kɔfɛ, GHRP-2 b’a nɔ bila PLC-IP3/DAG-PKC sira fɛ min ɲɛfɔlen don sanfɛ. U ka jɛɲɔgɔnya bɛ dɔ fara GH bɔli kan kosɛbɛ. Sagaw ka pituitary cellules k’a lajɛ, GHRH (10 nM) ni GHRP-2 (100 nM) fila bɛɛ kelen-kelen ye dɔ fara GH mRNA hakɛ kan ani GH bɔli cogo la min bɛ tali kɛ waati la sanga 0,5–2 kɔnɔ o nɔ in bonyalen don kosɛbɛ ni u farala ɲɔgɔn kan ^{[2] .}.

Bonya hormone bɔli ɲɛnabɔli:

GHRP-2 bɛ bonya hormone (GH) bɔli lawuli ni wale fila ye min ɲɔgɔn tɛ, min bɛ kɛ sababu ye ka hypothalamus ni pituitary gland (Bowers CY) laɲini waati kelen na. Pituitaire ta fan fɛ, GHRP-2 bɛ siri bonya hormone-releasing hormone receptor (GHS-R) la. Ni a sirilen don GHS-R la, GHRP-2 bɛ taamasiɲɛw kɛli daminɛ selilɛri kɔnɔ. Misali la, a bɛ fosfolipazi C (PLC) baara, o min bɛ fosifatidilinɔsitɔli 4,5-bisifositɛri (PIP2) jilama kɛ selilɛri kan ka kɛ inositɔli trisfosifati (IP3) ani diasiligilisirɔli (DAG) ye. IP3 bɛ kalisiyɔmu ion bɔli sabati endoplasmique reticulum kɔnɔ, ka sɔrɔ DAG bɛ protein kinase C (PKC) baara, o laban bɛ na ni GH bɔli ye (Roh SG,). Kalan dɔ la min kɛra ni misiw ka ɲɛgɛnɛsiralabanaw ye, GHRP-2 hakɛ suguya caman na (10−⊃1;⊃3; ka se 10−7 M ma) ye dɔ fara kosɛbɛ GH bɔli kan (P < 0,05), o b’a jira ko GHRP-2 bɛ se ka GH bɔli nɔ tilennen bila sɔgɔsɔgɔninjɛ ^la.

Furakɛli nɔ minnu bɛ dumunikɛbaliya la:

Banabagatɔ minnu ka dumunikɛbaliya bɛ u la, GHRP-2 tali nugu fɛ, o bɛ dɔ fara kɔngɔ ni dumuni dunni kan, ka dɔ bɔ fasa joona la, ani ka sukarodunbana taamasiɲɛw ɲɛ. GHRP-2 tali kalo 14 kɔfɛ, banabagatɔw farikolo girinya bɛ kilogaramu 6,7 caya dɔɔni dɔɔni. O fɛɛrɛ bɛ se ka kɛ GHRP-2 ka kɛ i n’a fɔ ghrelin minɛbaga agoniste walasa ka ghrelin nɔw ladege, o la, a bɛ dumuni nege yɔrɔ caman sɛmɛntiya ani ka banabagatɔw ka dumunikɛcogo ni u balocogo ^ɲɛ.

Jaa 1 (A) Yɛlɛma minnu bɛ don farikolo girinya la, farikolo girinya la, ani tulumafɛnw na furakɛli kɔfɛ ni pepitiri-2 (GHRP-2) bɔli ye bonya hormone la. Fasa ni farikolo girinya jateminɛna ni biyo-impédance fɛɛrɛ ye. Paramɛtiriw bɛɛ cayara dɔɔni dɔɔni, farikolo girinya ni don o don fanga hakɛ cayara ni kilogaramu −1,5 ye ka se kilogaramu 2,4 ma ani 12% ka se 36% ma, grelini pikiri kɔfɛ. (B) Yɛlɛma donna bonya hormone (GH) ni insuline-like growth factor 1 (IGF-1) hakɛ la GHRP-2 furakɛli kɔfɛ. GH dɔgɔyara ka sɔrɔ IGF-1 cayara kalo 12 kɔfɛ. (C) Yɛlɛma donna balocogo la. Retinol sirili furakisɛ (RBP) ni farikolojɔli dumuni bɛɛ lajɛlen (TP) wulila joona, ni albumin (Alb) cayara kalo 4 kɔfɛ. O paramɛtɛrɛw cayara ka t’a fɛ kalo 12 tɛmɛnen kɔ. (D) Yɛlɛma donna asili grelini (AG) ni de-asili grelini (DAG) hakɛ la GHRP-2 tali kɔfɛ. Sunɔgɔ DAG ni AG cayara, ani DAG/AG hakɛ dɔgɔyara kalo 10 kɔfɛ. BW; farikolo girinya.

Source: PubMed ^{[3] Ɲɛjirali dɔw.}

GHRP-2 bɛ kɛ cogo jumɛn na furakɛli la?

Bonya hormone bɔli dɛsɛ sɛgɛsɛgɛli : GHRP-2 bɛ kɛ kɛnɛyaso la i n’a fɔ bonya hormone dɛsɛ sɛgɛsɛgɛli fura. Ni balikuw ka bonya hormone dɛsɛ, diɲɛ kɔnɔ sɛgɛsɛgɛli fɔlɔ min bɛ kɛ, o ye inisɔndiya muɲuni sɛgɛsɛgɛli ye (ITT). Nka, ka da a kan a bɛ se ka kɔlɔlɔ jugumanw lase mɔgɔ ma, a man ɲi banabagatɔ dɔw ma. Kɔlɔsili dɔw y’a jira ko GHRP-2 bɛ kɛ ka balikuw ka bonya hormone (GHD) sɛgɛsɛgɛ. Nin ɲinini in ye mɔgɔ kɛnɛman 77 ni banabagatɔ 58 tɔgɔ sɛbɛn minnu ka GH hakɛ cayalenba < 3 μg/L i n’a fɔ ITT y’a jira cogo min na. Mɔgɔ bɛɛ ye GHRP-2 miligaramu 100 pikiri kɛ joli la, o kɔfɛ, joli ta kɛra lɛri 2 nataw kɔnɔ. GH hakɛw jateminɛna ni immunoradiometric assay ye. Jateminɛw y’a jira ko mɔgɔ bɛɛ ye GH hakɛ cayalenba jira joli la miniti 60 kɔnɔ GHRP-2 tali kɔfɛ. GH ka jaabi GHRP-2 ma, o ma nɔ bila cɛya ni musoya la. Hali ni jaabiw tun ka dɔgɔn dɔɔni mɔgɔkɔrɔbaw ni mɔgɔ fasalenw na, o ma GHD sɛgɛsɛgɛli tiɲɛ. Segin-ka-bɔnyew y’a jira ko nin fɛɛrɛ in bɛ se ka segin ka kɛ cogo ɲuman na. Ni aw bɛ GHRP-2 kɛ ka GHD sɛgɛsɛgɛ, ni tigɛda hakɛ ye 15 μg/L ye, o bɛ bɛn sɛgɛsɛgɛli hakɛ ma min ye 3 μg/L ye ITT kɔnɔ, o b’a jira ko ni aw ye GH hakɛ tigɛcogo bɛnnen kɛ joli la, o bɛ bonya hormone dɛsɛ jugumanba sɛgɛsɛgɛ ni dannaya ^ye.

Dumunikɛbaliya furakɛli : Banabagatɔ minnu ka dumunikɛbaliya bɛ u la kabini tuma jan, GHRP-2 bɛ se ka kɛ furakɛli fɛɛrɛ ye min bɛ layidu ta. Kalan dɔ ye GHRP-2 kɛ nugu la sani dumuni kelen-kelen bɛɛ ka kɛ san kelen kɔnɔ banabagatɔ dɔ la, dumunikɛbaliya bɛ min na kabini san 20. Sani furakɛli ka kɛ, hali ni banabagatɔ ka dumuni siran ni a ka farin nege tun dɔgɔyara furakɛli tɛmɛnenw fɛ, kɔnɔbara basigilen ye dumuni dunta caya ni a girinya bali. A taamasiɲɛw tun ye dumuni kɔfɛ fɔɔnɔ, kɔnɔboli, banakɔtaa jukɔrɔla balili ani sukarodunbana. GHRP-2 tali kɔfɛ, kɔngɔ ni dumuni dunta cayara banabagatɔ la, a fasa joona dɔgɔyara, sukarodunbana taamasiɲɛw ɲɛnabɔra, ani farikolo girinya cayara dɔɔni dɔɔni ni kilogaramu 6,7 ye (ka bɔ kilogaramu 21,1 na ka se kilogaramu 27,8 ma) kalo 14 kɔnɔ furakɛli daminɛ kɔfɛ. Sɛgɛn ni farikolo fanga bonyalen don, farikolo ni hakili baara cayara, wa kɔlɔlɔba si ma ye ni a tali kuntaalajan ye nugu kɔnɔ. O b’a jira ko GHRP-2 bɛ se ka kɛ furakɛli fɛɛrɛ ɲuman ye banabagatɔw ma minnu ka dumunikɛbaliya basigilen jugumanba bɛ u la ^{[3] .}.

Jeninida ka baarakɛbaliya nɔgɔyali : Jeninida jugumanw kɔfɛ, ka dɔ fara kataboliki ɔrimɔni ni funubanakisɛw bɔli kan ka fara anaboliki ɔrimɔni hakɛ dɔgɔyali kan, o bɛ na ni farikoloɲɛnajɛ caya kojugu ye, farikolo girinya dɔgɔyali, ani farikolo tiɲɛni. Hali ni furakɛli suguya caman kɛra i n’a fɔ farikoloɲɛnajɛ ani farikolojidɛsɛ furaw (insuline, croissance hormone, IGF-I, walima stéroïdes) tali, u nɔ bɛ to ka ɲɛ. Kɔrɔbɔliw jaabiw y’a jira ko kakɛsi kɛlɛli pepitiri kura min bɔra ɲɔgɔn na, n’o ye ghrelin ye, o bɛ jigin sosow la minnu jeni kɔfɛ. Gɛrɛlini kɛnɛma bɛ se ka farikolo girinya segin a cogo kɔrɔ la ni a bɛ dɔ fara dumuni dunta kan ani ka farikolo fanga bonya sosow la. A fana bɛ dɔ bɔ kosɛbɛ kolotugudaw la farikolojɔli dumuniw tiɲɛni na sogo jenilenw na, a kɛtɔ ka E3 ubiquitin ligase, MuRF1 ani MAFbx farikolo mRNA jirali kɛ cogo la. Gɛrɛlini tilancɛ waati kunkurunnin bɛ dan sigi a tali la kɛnɛyaso la. O ni hexapeptide sintetiki bonya hormone-releasing peptide 2 (GHRP-2) ye GHRP minɛbaga agoniste sabatilen ni barikama ye min bɛ dɔ fara farikolo girinya kan sosow la, ka funu kɛlɛli nɔ jira jolidɛsɛbanatɔw la, ani ka catabolic metabolism ɲɛ banabagatɔ jugumanw na. GHRP-2 bɛ nɔ ɲuman bila farikolo girinya la, dumuni dunta la, ani kolotugudaw la farikolojɔli dumuniw tiɲɛni na soso jenilenw na, ka jeninida ka baarakɛbaliya nɔgɔya

Kuncɛli

GHRP-2 bɛ bonya hormone bɔli baara kɛ ni taamasiɲɛ siraw lawulili ye minnu bɛ tali kɛ a la a ka wale fɛ GHS-R kan hipotalamu-pituitaire axis kɔnɔ. Furakɛcogo la, a bɛ se ka bonya hormones dɛsɛ sɛgɛsɛgɛ ani ka banaw furakɛ i n’a fɔ dumunikɛbaliya, sugunɛ joginni jugumanba, ani jeninida kɔfɛ baarakɛbaliya, ka sɔrɔ fana a bɛ dimimada ni farikolo tangalanw jira.

A sɛbɛnbaga ko la

Fɛn minnu kofɔlen dòn san fɛ, olu bɛɛ ɲinini Kɛra, k’u Labɛn ani k’u Lajɛ Cocer Peptides fɛ.

Dɔnniya gafe sɛbɛnbaga

Haruta I ye dɔgɔtɔrɔ-dɔnniyakɛla ye min ni hakiliɲagami kɔnɔna furakɛli ɲɛmɔgɔso bɛ Kagoshima Iniwɛrisite ka furakɛli ni ɲinw dɔnniya kalanso la Zapɔn. A ka bamanankan bamanankan ɲininiw sinsinnen bɛ endokirini ni farikoloɲɛnajɛ kɛcogo kan dumunikɛbaliya jugumanba la. Haruta I tɔgɔ sɛbɛnnen bɛ citation (citation) ɲɛfɔli sɛbɛn kɔnɔ [3].

▎ Sɛbɛn minnu bɛ tali kɛ o la

[1] Roh SG, He ML, Matsunaga N, Hidaka S, Hidari H. Pepitiri-2 min bɛ bonya hormone bɔ, o ka baara kɛcogo misiw ka pituitaire selilɛriw la. Baganw ka dɔnniya gafe 1997; 75(10): 2744-2748.DOI: 10.2527/1997.75102744x.

[2] Yan M, Hernandez M, Xu R, Chen C. GHRH ni GHRP-2 furakɛli nɔ min bɛ sɔrɔ in vitro la GH bɔli la ani GH, pituitaire transcription facteur-1, GHRH-recepteur, GH-secretagogue-recepteur ani somatostatin receptor mRNAs hakɛw la misiw ka pituitaire selilɛriw kɔnɔ. Erɔpu jamanaw ka gafe min bɛ wele ko « Journal of Endocrinology » 2004; 150(2): 235-242.DOI: 10.1530/eje.0.1500235. Ɲɛgɛnɛsiraw ani mɔgɔ dogoyɔrɔw.

[3] Haruta I, Fuku Y, Kinoshita K, ani a ɲɔgɔnnaw. Pepitiri-2 min bɛ bonya hormone bɔ, o kɛli nugu la san kelen kɔnɔ, o bɛ farikolo girinya ni sukarodunbana ɲɛ ka taa a fɛ dumunikɛbaliya banabagatɔ la min farikolo dɔgɔyara kosɛbɛ. Journal of Cachexia Sarcopenie ani farikolo 2015; 6(3): 237-241.DOI: 10.1002/jcsm.12028. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew.

[4] Chihara K, Shimatsu A, Hizuka N, Tanaka T, Seino Y, Katofor Y. Sɛgɛsɛgɛli nɔgɔman min bɛ kɛ ni GH-releasing peptide-2 ye balikuw ka GH dɛsɛ la. Erɔpu jamanaw ka gafe min bɛ wele ko « Journal of Endocrinology » 2007; 157(1): 19-27.DOI: 10.1530/EJE-07-0066. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew.

[5] Balasubramaniam A, Joshi R, Teri L. A., James J. H., ani mɔgɔw ye baara kɛ ni u ye. GHRP-2 bɛ jeninida ka baarakɛbaliya dɔgɔya sosow la. Ɲɛtaa minnu kɛra furakɛli ni ɲɛnamayako kɔrɔbɔli la san 2009; 611: 571-572.DOI: 10.1007/978-0-387-73657-0_251.

BƐƐRƐ KUNNAFONIW NI FƐRƐW KUNNAFONIW BƐƐ MIN BƐ NI WEBSITE KAN NA, U BƐ KUNNAFONIW FƆLƆ DƆRƆN NI KALANSENW YE.  

Fɛn minnu bɛ di nin siti in kan, olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *glasi kɔnɔ*, o kɔrɔ ye gilasi kɔnɔ) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.