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1 kits (10 Vials)
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▎ GHRP-2 Tsarin
Source: PubChem |
Jerin: AXAWFK Tsarin kwayoyin halitta: C 45H 55N 9O6 Nauyin Kwayoyin Halitta: 817.98 g/mol Lambar CAS: 158861-67-7 Saukewa: 6918245 Synonyms: Pralmorelin; pralmorelina; KP-102; pralmoreline |
▎ GHRP-2 Bincike
Menene asalin bincike na GHRP-2?
Hormone na girma yana taka muhimmiyar rawa a cikin haɓakar ɗan adam, haɓakawa, da daidaiton rayuwa. Masana kimiyya sun dade suna neman abubuwan da za su iya sarrafa yadda ya kamata. peptides masu sakin hormone girma (GHRPs), wani nau'in oligopeptides na roba wanda ke ƙarfafa sakin hormone girma, ya fito a matsayin mayar da hankali kan bincike.
GHRP-2 yana kwaikwayon aikin ghrelin ta hanyar ɗaure ga mai karɓar ghrelin, kunna hanyoyin sigina don haɓaka sakin GH daidai. Yana nuna yuwuwar ganowa da magance ƙarancin haɓakar hormone girma, shiga tsakani a cikin anorexia, da kuma kariya daga lalacewar gabobin jiki, tuƙi zurfin bincike cikin hanyoyin sa da aikace-aikacen sa.
Menene tsarin aiki don GHRP-2?
Ka'idojin Sirin Hormone na Girma
Yin aiki akan Hypothalamic-Pituitary Axis:
GHRP-2 yana ƙarfafa sakin hormone girma (GH) ta hanyar aiki na musamman na biyu-dual wanda ke nufin duka hypothalamus da glandan pituitary (Bowers CY). A matakin pituitary, GHRP-2 yana ɗaure ga mai karɓar hormone mai sakin hormone girma (GHS-R). Bayan an ɗaure ga GHS-R, GHRP-2 yana ƙaddamar da abubuwan da suka faru na siginar ciki. Misali, yana kunna phospholipase C (PLC), wanda ke haifar da hydrolysis na phosphatidylinositol-4,5-bisphosphate (PIP2) akan membrane cell zuwa inositol trisphosphate (IP3) da diacylglycerol (DAG). IP3 yana haɓaka sakin calcium ion daga endoplasmic reticulum, yayin da DAG yana kunna furotin kinase C (PKC), a ƙarshe yana haifar da sakin GH (Roh SG,). A cikin binciken da aka yi amfani da sel pituitary bovine, GHRP-2 a daban-daban maida hankali (10⁻⊃1;⊃3; zuwa 10⁻⁷ M) ya karu da yawa GH secretion (P <0.05), yana nuna wani tasiri mai tasiri kai tsaye na GHRP-2 akan ɓoyewar GH ta ƙwayoyin pituitary [1].
Ayyukan Haɗin kai tare da Hormone-Sakin Hormone (GHRH):
GHRP-2 yana nuna tasirin haɗin gwiwa tare da GHRH a cikin ƙaddamar da sakin GH. Lokacin da aka haɗa tare da ƙwayoyin pituitary, suna aiki ta hanyoyi daban-daban na sigina waɗanda a ƙarshe ke haɗuwa don haɓaka siginar GH. Nazarin ya nuna cewa GHRH da farko yana kunna adenylate cyclase (AC), yana haɓaka matakan cAMP na ciki don kunna furotin kinase A (PKA), ta haka yana haɓaka rubutun GH da haɗin GH. Sabanin haka, GHRP-2 yana yin tasirin sa ta hanyar PLC-IP3/DAG-PKC da aka kwatanta a sama. Haɗin gwiwar haɗin gwiwar su yana ƙaruwa sosai da sakin GH. A cikin gwaje-gwajen ƙwayoyin tumaki na pituitary, duka GHRH (10 nM) da GHRP-2 (100 nM) ɗaya-daya sun haɓaka matakan GH mRNA da sakin GH a cikin hanyar dogaro da lokaci a cikin sa'o'i 0.5-2; An inganta wannan tasiri sosai lokacin da aka haɗa [2].
Dokokin Sirin Hormone na Girma:
GHRP-2 yana ƙarfafa sakin hormone girma (GH) ta hanyar aiki na musamman na biyu-nau'i-nau'i, tare da niyya ga hypothalamus da glandan pituitary (Bowers CY). A matakin pituitary, GHRP-2 yana ɗaure ga mai karɓar hormone mai sakin hormone girma (GHS-R). Bayan an ɗaure ga GHS-R, GHRP-2 yana ƙaddamar da abubuwan da suka faru na siginar ciki. Misali, yana kunna phospholipase C (PLC), wanda ke haifar da hydrolysis na phosphatidylinositol 4,5-bisphosphate (PIP2) akan membrane cell zuwa inositol trisphosphate (IP3) da diacylglycerol (DAG). IP3 yana haɓaka sakin calcium ion daga endoplasmic reticulum, yayin da DAG yana kunna furotin kinase C (PKC), a ƙarshe yana haifar da sakin GH (Roh SG,). A cikin binciken da aka yi amfani da sel pituitary bovine, GHRP-2 a daban-daban maida hankali (10⁻⊃1;⊃3; zuwa 10⁻⁷ M) ya karu da yawa GH secretion (P <0.05), yana nuna wani tasiri mai tasiri kai tsaye na GHRP-2 akan ɓoyewar GH ta ƙwayoyin pituitary [1].
Hanyoyin warkewa akan Anorexia:
Ga marasa lafiya tare da anorexia, gudanar da GHRP-2 a cikin hanci yana ƙara jin yunwa da cin abinci, yana rage jin daɗi da wuri, kuma yana inganta alamun hypoglycemia. Bayan watanni 14 na gwamnatin GHRP-2, marasa lafiya a hankali sun sami kilogiram 6.7 a cikin nauyin jiki. Tsarin na iya haɗawa da GHRP-2 aiki azaman mai karɓar mai karɓar ghrelin don yin kwaikwayon tasirin ghrelin, ta haka ne ke daidaita cibiyar ci da haɓaka halayen cin abinci na marasa lafiya da matsayin abinci mai gina jiki [3].
Hoto 1 (A) Canje-canje a cikin nauyin jiki, ƙwayar tsoka, da kitsen mai bayan jiyya tare da haɓakar hormone girma peptide-2 (GHRP-2). An kimanta kitse da ƙwayar tsoka ta amfani da hanyar bio-impedance. Duk sigogi a hankali sun karu, tare da nauyin jiki da yawan kuzarin yau da kullun yana tashi da -1.5 zuwa 2.4 kg da 12% zuwa 36%, bi da bi, bayan jiko na ghrelin. (B) Canje-canje a cikin hormone girma (GH) da insulin-like girma factor 1 (IGF-1) matakan bin GHRP-2 jiyya. GH ya ragu yayin da IGF-1 ya karu bayan watanni 12. (C) Canje-canje a yanayin abinci mai gina jiki. Retinol daure protein (RBP) da jimillar furotin (TP) sun tashi da sauri, tare da albumin (Alb) yana ƙaruwa bayan watanni 4. Waɗannan sigogi sun ƙara ƙaruwa bayan watanni 12. (D) Canje-canje a cikin matakan acyl ghrelin (AG) da des-acyl ghrelin (DAG) bayan gwamnatin GHRP-2. Azumi DAG da AG sun karu, kuma rabon DAG/AG ya ragu bayan watanni 10. BW; nauyin jiki.
Source: PubMed [3]
Menene aikace-aikacen likita na GHRP-2?
Ganewar ƙarancin haɓakar haɓakar haɓakar hormone girma: GHRP-2 ana amfani da shi azaman wakili na asibiti don ƙarancin ƙarancin hormone girma. Don ƙarancin girma na hormone girma, gwajin gwajin layin farko na duniya shine gwajin haƙuri na insulin (ITT). Duk da haka, saboda yuwuwar sa na haifar da mummunan al'amura masu haɗari, an hana shi ga wasu marasa lafiya. Nazarin ya ba da shawarar yin amfani da GHRP-2 don tantance ƙarancin girma na hormone girma (GHD). Binciken ya yi rajistar batutuwan lafiya na 77 da marasa lafiya 58 tare da GH <3 μg/L mafi girma kamar yadda ITT ta ƙaddara. Dukkan batutuwa sun sami allura ta 100 μg GHRP-2 na cikin jini, sannan samfurin jini ya biyo baya a cikin sa'o'i 2 masu zuwa. An auna matakan GH ta amfani da gwajin immunoradiometric. Sakamako ya nuna cewa duk batutuwa sun baje kolin maganin GH a cikin mintuna 60 bayan gudanarwar GHRP-2. Amsar GH ga GHRP-2 bai shafi jinsi ba. Kodayake martanin ya ɗan ragu kaɗan a cikin batutuwan da suka tsufa da kuma mutane masu kiba, wannan bai lalata cutar ta GHD ba. Gwajin maimaitawa ya nuna kyakkyawan sake fasalin wannan hanyar. Lokacin amfani da GHRP-2 don bincikar GHD, ƙimar yankewa na 15 μg/L yayi daidai da ƙimar bincike na 3 μg/L a cikin ITT, yana nuna cewa saita matakin yanke ƙwayar ƙwayar cuta mai dacewa ta GH yana bincikar ƙarancin ƙarancin girma na hormone [4].
Jiyya na Anorexia: Ga marasa lafiya tare da dogon tarihin anorexia, GHRP-2 na iya wakiltar wakili na warkewa mai ban sha'awa. Ɗaya daga cikin binciken da aka gudanar da GHRP-2 a cikin ciki kafin kowane abinci na shekara guda ga mara lafiya tare da tarihin shekaru 20 na anorexia. Kafin a yi magani, ko da yake tsoron mai haƙuri na cin abinci da sha'awar zama bakin ciki ya ragu ta hanyar hanyoyin kwantar da hankali na baya, rashin aikin gastrointestinal ya hana karuwar cin abinci da nauyin nauyi. Alamomin sun haɗa da amai bayan cin abinci, maƙarƙashiya, toshewar hanji, da hypoglycemia. Bayan gudanar da GHRP-2, mai haƙuri ya sami karuwar yunwa da cin abinci, rage jin daɗi da wuri, alamun hypoglycemia sun inganta, kuma a hankali nauyin jiki ya karu da 6.7 kg (daga 21.1 kg zuwa 27.8 kg) a cikin watanni 14 na farawa magani. Rashin gajiya da ƙarfin tsoka ya inganta, aikin jiki da tunani ya karu, kuma babu wani tasiri mai mahimmanci da aka samu tare da kulawar intranasal na dogon lokaci. Wannan yana nuna GHRP-2 na iya zama ingantacciyar hanyar warkewa ga marasa lafiya tare da matsanancin anorexia na yau da kullun [3].
Rage raunin da ya haifar da ƙonawa: Bayan ƙonawa mai tsanani, ƙara yawan samar da hormones na catabolic da cytokines masu kumburi tare da rage yawan matakan hormone anabolic yana haifar da hyperactivity na rayuwa, rage yawan ƙwayar jiki, da zubar da tsoka. Ko da yake an ba da shawarar ko amfani da hanyoyin kwantar da hankali daban-daban kamar motsa jiki da kuma amfani da hormones anabolic (insulin, hormone girma, IGF-I, ko steroids) ko amfani da su, tasirin su ya kasance mara kyau. Sakamakon gwaji ya nuna cewa sabon keɓewar anti-cachexia peptide ghrelin an rage shi a cikin berayen da suka kone. Exogenous ghrelin na iya dawo da asarar nauyi ta hanyar ƙara yawan abinci da haɓaka ƙwayar tsoka a cikin mice. Har ila yau yana da mahimmanci rage raguwar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta ta ta ta hanyar daidaita maganganun mRNA na tsoka na E3 ubiquitin ligase, MuRF1, da MAFbx. Shortarancin rabin rayuwar ghrelin yana iyakance aikace-aikacen sa na asibiti. Sabanin haka, ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta (GHRP-2 GHRP-2) ta kasance mai ƙarfi kuma mai ƙarfi ta GHRP agonist wanda ke kara yawan nauyin jiki a cikin rodents, yana nuna tasirin anti-mai kumburi a cikin berayen arthritic, kuma yana inganta metabolism na catabolic a cikin marasa lafiya marasa lafiya. GHRP-2 yana da tasiri mai tasiri akan nauyin jiki, cin abinci, da raunin furotin na tsoka a cikin konewar rodents, yana rage rashin aiki mai haifar da ƙonewa [5].
Kammalawa
GHRP-2 yana kunna haɓakar haɓakar hormone girma ta hanyar haɓaka hanyoyin siginar da suka dace ta hanyar aikinta akan GHS-R a cikin axis hypothalamic-pituitary. A likitance, yana iya tantance raunin hormone girma da kuma kula da yanayi kamar anorexia, raunin koda mai tsanani, da rashin aiki bayan ƙonawa, yayin da yake nuna tasirin analgesic da antioxidant.
Game da Marubuci
Abubuwan da aka ambata a sama duk bincike ne, gyara su kuma Cocer Peptides ne suka haɗa su.
Mawallafin Jaridar Kimiyya
Haruta I masanin kimiya ne da ke da alaƙa da Sashen Nazarin Magungunan Ciki na Psychosomatic a Makarantar Graduate of Medical and Dental Sciences na Jami'ar Kagoshima a Japan. Binciken fassarar ta yana mai da hankali kan tsarin endocrin da ayyukan rayuwa a cikin matsanancin rashin jin daɗi. An jera Haruta I a cikin ambaton ambato [3].
