Cocer Peptides fɛ 
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BƐƐRƐ KUNNAFONIW NI FƐRƐW KUNNAFONIW BƐƐ MIN BƐ NI WEBSITE KAN NA, U BƐ KUNNAFONIW FƆLƆ DƆRƆN NI KALANSENW YE.
Fɛn minnu bɛ di nin siti in kan, olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *glasi kɔnɔ*, o kɔrɔ ye gilasi kɔnɔ) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki ka dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.
Kuma bɛɛ lajɛlen
Kɔrɔyabana (GHD) ye bonya ni yiriwali bana ye min bɛ sɔrɔ bonya hormone (GH) bɔli dafabaliya fɛ walima a baarakɛbaliya fɛ. GH, n’o ye pepitiri ɔrimɔni ye min bɛ bɔ ɲɛgɛnɛsira ɲɛfɛla fɛ, o jɔyɔrɔ ka bon denmisɛnw ka bonya ni u ka yiriwali la. Pepitidi caman cili furakɛli, n’o ye GHD furakɛli fɔlɔ ye, o kɛra ka caya dɔgɔtɔrɔso la.
Jaa 1 Bonya hormone ni hormone wɛrɛw bɛ se ka nɔ min bila kolo la.
Bonya-hormone (banakisɛfagalan) ka farikolo-ɲɛnajɛ baarakɛcogo
(1) Bonya ni yiriwali sabatili
Kolow falenni : GH bɛ baara kɛ kolotugudaw la k’u ɲɛsin kolotugudaw bonya ma, ka kolotugudaw caya ni u danfara lawuli, ka kolotugudaw matirili labɛnni ni a kɛli sabati, o la, a bɛ kolotugudaw falenni nɔgɔya. Misali la, kolo janw falenni waati, GH bɛ kolotugudaw tila-tila ka taa a fɛ, ka dɔ fara kolotugudaw hakɛ kan, wa o bɛ kolo janya.
Farikolo yɔrɔw falenni : GH fana bɛ farikolo yɔrɔw ni farikolo yɔrɔ suguya caman falen farikolo fan bɛɛ la. A bɛ farikolokisɛw caya ni farikolojɔlifɛnw sɔrɔli lawuli, ka dɔ fara farikolo fanga kan; a bɛ kɔnɔnafɛnw falenni ni u yiriwa i n’a fɔ sugunɛ ni sugunɛ, k’u ka baara kɛcogo ɲuman sabati. Misali la, farikolo yɔrɔw la, GH bɛ jamu nafamaw jiracogo kɔrɔta, ka farikolo yɔrɔw falenni ni u caya caya.
(2) Fɛnɲɛnɛmafagalanw ka baarakɛcogo ɲɛnabɔli
Sukaro sɛnɛcogo : GH ka sukaro sɛnɛcogo ɲɛnabɔli ka gɛlɛn kosɛbɛ. A bɛ se ka farikolo yɔrɔw ka sukaro tali ni a baara bali, o bɛ na ni sukaro hakɛ caya ye joli la; a bɛ se fana ka sugunɛbilenni sumaya tiɲɛni sabati, ka dɔ fara joli sukaro hakɛ kan ka taa a fɛ. GH ka baara kuntaalajan bɛ se ka inisɔndiya hakɛ caya cogo la min tɛ ɲɛ, ni a bɛ inisɔndiya ɲɔgɔnna bonyalan-1 (IGF-1) bɔli sabati, o la, a bɛ joli sukaro hakɛ dɔgɔya.
Tumu sɛnɛcogo : GH bɛ tulumafɛnw tiɲɛni sabati, ka dɔ fara tulumafɛnw bɔli kan walasa ka fanga di farikolo ma. A bɛ dɔ bɔ fana tulumafɛnw dalajɛli la, o bɛ dɛmɛ ka farikolo tulumafɛnw tilatilali cogo bɛnnen na. Kalan dɔw la, denmisɛn minnu ka bonyali hormone (GHD) bɛ u la, olu farikolo tulumafɛnw hakɛ dɔgɔyara kosɛbɛ GH nɔnabila furakɛli kɔfɛ, o min ni GH jɔyɔrɔ bɛ tali kɛ ɲɔgɔn na kosɛbɛ tulumafɛnw falenfalenni sabatili la.
Protéines metabolism : GH ye protéines (banakisɛfagalanw) sɔrɔli ɲɛnabɔbaga nafama ye. A bɛ asidi aminikiw don farikolo la, ka farikolojɔlifɛnw sɔrɔli teliya, ani ka farikolojɔli dumuniw tiɲɛni bali, o bɛ dɔ fara farikolo farikolojɔli dumuniw hakɛ kan. Denmisɛnninw ka bonya ni u ka yiriwali waati, o nɔ bɛ dɛmɛ ka farikolo yɔrɔw falencogo ni u dilancogo ɲuman sabati i n’a fɔ farikolo ni kolotugudaw.
Denmisɛnw ka bonya hormone (banakisɛfagalanw) dɛsɛ
(1) Banakisɛw sɔrɔcogo
Fɛn minnu bɛ sɔrɔ bangekɔlɔsi fɛ: GHD banabagatɔ dɔw bɛ sɔrɔ jamu fɛ. Jɛnɛya caman caman cili bɛ se ka nɔ bila GH sɔrɔli la, a bɔli la, walima a kɛcogo la. Jamu nafama minnu ka teli ka sɔrɔ, olu dɔw ye fɛn caman cili ye bonya hormone gène (GH1) la, o bɛ se ka kɛ sababu ye ka GH sɛnɛcogo tiɲɛ; fɛn falenw jamu minnu bɛ tali kɛ sɔgɔsɔgɔninjɛ yiriwali la, i n’a fɔ PROP1 ani POU1F1, olu bɛ se ka nɔ bila ɲɛgɛnɛsira ɲɛfɛla yiriwali la cogo bɛnnen na, o bɛ na ni GH bɔli ye min tɛ se ka kɛ.
Fɛn minnu bɛ sɔrɔ : Fɛn minnu bɛ sɔrɔ i n’a fɔ kunsɛmɛnasumaya, banakisɛw, ani joginda, olu fana bɛ se ka GHD bila mɔgɔ la. Sugunɛbilenniw, i n’a fɔ kunsɛmɛnasumaya, olu bɛ se ka pituitaire gland walima hypothalamus degun, ka nɔ bila GH bɔli la; kunsɛmɛnasumaya i n’a fɔ kunsɛmɛnasumaya walima kunsɛmɛnasumaya bɛ se ka ɲɛgɛnɛsiralabanaw walima ɲɛgɛnɛsiralabanaw tiɲɛ, o bɛ na ni GH bɔli ye cogo la min tɛ bɛn; kunkolo joginni, kɛrɛnkɛrɛnnenya la minnu bɛ kɛ ni tiɲɛni ye pituitaire (pituitaire) walima hypothalamus la, o fana bɛ se ka GH bɔli ɲɛnabɔli siraw tiɲɛ, o bɛ na ni GHD ye.
Kɔnɔnatumuw : GHD banabagatɔw yɔrɔ dɔ sababu tɛ se ka dɔn, wa u bɛ jate ko GHD banakɔtaa bɛ u la. Nin banabagatɔ ninnu bɛ se ka kɛ ni fɛn misɛnniw ye minnu bɛ kɛ ni hipotalamu-pituitaire baarakɛcogo ye, nka o fɛn jugumanw man jugu fo ka se ka kɛ sababu ye ka bana sɛgɛsɛgɛ tigitigi. Sisan, a dalen b’a la ko GHD idiopathique bɛ se ka kɛ sababu ye ka hypothalamus neurotransmitter walima neuro-regulatory function tiɲɛniw sɔrɔ.
(2) Kɛnɛyaso taamasiɲɛw
Bonya kɔtigɛbaliya : Nin ye GHD taamasiɲɛ ye min ka bon kosɛbɛ kɛnɛyaso la. Den janya bɛ dɔgɔya kosɛbɛ ka tɛmɛ a tɔɲɔgɔnw ta kan, a ka ca a la a bonya hakɛ bɛ se santimɛtɛrɛ 5 ma san kɔnɔ. Ni den bɛ kɔrɔbaya, danfara min bɛ a ni a tɔɲɔgɔnw cɛ, o bɛ bonya dɔɔni dɔɔni, wa a janya surunya bɛ ye ka taa a fɛ. Misali la, hali ni denmisɛn kɛnɛmanw bɛ bonya santimɛtɛrɛ 5–7 ɲɔgɔn san kɔnɔ sani u ka cɛya, GHD banabagatɔw bɛ se ka bonya santimɛtɛrɛ 2–3 dɔrɔn.
Hali Farikolo jɔcogo ɲɔgɔn fɛ : ni GHD bɛ denmisɛn minnu na, olu janya ka surun, a ka c’a la, u farikolo jɔcogo bɛ bɛn ɲɔgɔn ma. O ni denbaya ka surunya tɛ kelen ye, denmisɛnw bɛ se ka u senw janya jira min tɛ bɛn ɲɔgɔn ma. GHD bɛ denmisɛn minnu na, olu ɲɛda ka teli ka kɛ i n’a fɔ denmisɛnninw, u kunkolo ka bon kosɛbɛ, o tɛ bɛn u farikolo bonya ma. GHD bɛ denmisɛn dɔw fana na, farikoloɲɛnajɛ bɛ se ka kɛ u la, i n’a fɔ farikolo tulu hakɛ cayalenba ani farikolo fanga dɔgɔyali; dɔw bɛ se ka cɛnimusoya yiriwali kɔfɛ, o min bɛ sɔrɔ cɛya ni musoya daminɛni kɔfɛ ani cɛnimusoya kɛcogo filananw yiriwali kɔfɛ; ka fara o kan, GHD bɛ denmisɛn minnu na, olu bɛ se ka hakiliɲagami gɛlɛyaw sɔrɔ i n’a fɔ kalan gɛlɛyaw ani hakilijagabɔbaliya, o minnu bɛ tali kɛ bonya hormone nɔfɛkow la hakiliɲagami yiriwali la.
(3) Fɛɛrɛw
Laboratowari ka sɛgɛsɛgɛliw
Bonya hormone stimulation test : Ikomi GH bɛ bɔ sɔgɔsɔgɔninjɛ la, joli tacogo gansan walasa ka GH hakɛ jateminɛ, o tɛ se k’a bɔli cogoya jira ka ɲɛ. O la, bonya hormone stimulation test ka kan ka kɛ. Fura minnu bɛ kɛ ka mɔgɔw bila ka wuli, olu ye inisɔndiya, arijini ani kulonidini ye. Ni aw ye wuli fura di, GH bɔli jaabi bɛ kɔlɔsi. A ka ca a la, GH hakɛ min bɛ 10 μg/L duguma, o bɛ GH dɛsɛ yɔrɔ dɔ jira, ani GH hakɛ min bɛ 5 μg/L duguma, o bɛ GH dɛsɛ dafalen jira.
Insuline-like Growth Factor-1 (IGF-1) ani Insulin-like Growth Factor Binding Protein-3 (IGFBP-3) Sumanikɛlan: IGF-1 ni IGFBP-3 hakɛw bɛ tali kɛ GH bɔli la kosɛbɛ, wa u bɛ sabati kosɛbɛ, u tɛ nɔ bila pulsatile bɔli la. GHD bɛ denmisɛn minnu na, a ka ca a la, IGF-1 ni IGFBP-3 hakɛ bɛ dɔgɔya u si hakɛ la. IGF-1 hakɛ fana bɛ nɔ bila fɛnw na i n’a fɔ si hakɛ ani balocogo, o la, olu ka kan ka jateminɛ kosɛbɛ bana sɛgɛsɛgɛli waati.
Pepitidi caman cili furakɛli
Fura sugandili ka ɲɛsin bonya hormone sinsinni furakɛli ma
Adamadenw ka bonya hormone (rhGH) faralen ɲɔgɔn kan (rhGH): rhGH ye pepitiri fura ye min bɛ kɛ ka caya sisan GHD furakɛli la kɛnɛyaso la. A bɛ dilan ni jamu fɛɛrɛ ye, ni asidi aminiki sinsinni ye min ni GH nafama ta bɛ kelen ye. rhGH bɛ sɔrɔ fura suguya caman na, i n’a fɔ mugu pikiri minnu bɛ kɛ nɛnɛ na ani pikiri minnu bɛ kɛ ni ji ye. Kalan dɔw la, hadamadenw ka bonya hormone jilama minnu bɛ fara ɲɔgɔn kan kokura, olu tali GHD bɛ denmisɛn minnu na, o ye furakɛli ɲuman sɔrɔ, ni dɔ farala kosɛbɛ banabagatɔw janya bonya hakɛ kan.
Bonya hormone min bɛ baara kɛ waati jan kɔnɔ: Walasa ka banabagatɔ ka sariya labatoli ɲɛ, bonya hormone min bɛ baara kɛ waati jan kɔnɔ, o labɛnna. Bonya hormones minnu bɛ baara kɛ waati jan kɔnɔ, olu bɛ sɔrɔ ni rhGH caman cili ye kemikɛli fɛ walasa k’a tilancɛ janya farikolo la, o la, pikiri kɛcogo bɛ dɔgɔya. Hadamaden ka bonya hormone recombinant poliéthylène glycol (PEG-rhGH) bɛ pikiri kelen dɔrɔn de wajibiya dɔgɔkun kɔnɔ, o bɛ dɔ bɔ kosɛbɛ pikiri doni na banabagatɔw kan. PEG-rhGH bɛ a jira ko a nafa ni a lakanani bɛ tali kɛ don o don rhGH pikiri la GHD bɛ denmisɛn minnu na.
Sɛgɛsɛgɛliw kɛra ka ɲɛ pepitiri fura wɛrɛw kan: Ka fara rhGH n’a furakɛcogo kan minnu bɛ baara kɛ waati jan kɔnɔ, pepitiri fura kura caman bɛ ka labɛn sisan. Misali la, pepitiri fɛn dɔw minnu bɛ GH bɔli sabati walima ka GH baara caya, olu bɛ se ka bɔ kɛnɛ kan ka kɛ furakɛli suguya kura ye GHD la.
(2) Furakɛli kɔlɔlɔw
Kɔrɔya bonya : Kɔrɔya bonya ye taamasiɲɛ tilennen ye min bɛ se ka kɛ sababu ye ka bonya hormone (banakisɛfagalan) falen furakɛli nafa jateminɛ. Ni aw bɛ to ka den janya suman, ka a janya bonya hakɛ jateminɛ, ka a suma ni a hakɛw ye sani furakɛli ka kɛ. A ka ca a la, furakɛli kalo 6–12 fɔlɔ kɔnɔ, a janya bɛ teliya kosɛbɛ, o kɔfɛ, a bɛ sabati dɔɔni dɔɔni. Kalanw kɔnɔ, GHD banabagatɔ minnu furakɛra ni bonya hormone ye kalo 6 kɔnɔ, olu janya bonya hakɛ cayara ka bɔ santimɛtɛrɛ 3 la san kɔnɔ sani furakɛli ka kɛ ka se santimɛtɛrɛ 8 ma san kɔnɔ.
Kolow si hakɛ yeli : Kolow si hakɛ ye kolotugudaw kɔgɔli taamasiɲɛ nafama ye. Bonya furakɛli bɛ se ka nɔ dɔ bila kolo si hakɛ la. Furakɛli waati la, kolo si hakɛ ka kan ka jateminɛ tuma bɛɛ walasa ka kolo kɔrɔ bonya hakɛ kɔlɔsi. Kolow si hakɛ bonya ka kan ka bɛn ni janya bonya ye walasa ka kolo kɔrɔbayali bali ka kɔn a waati ɲɛ min bɛ na ni bonya platiw datuguli ye joona, o bɛ se ka nɔ bila balikuw janya laban na.
IGF-1 hakɛ : IGF-1 hakɛ ye biyokimiki taamasiɲɛ nafama ye walasa ka bonya furakɛli nafa jateminɛ. Bonya furakɛli kɔfɛ, a ka ca a la, IGF-1 hakɛ bɛ bonya, wa a ni furakɛli nafa bɛ tali kɛ ɲɔgɔn na kosɛbɛ. A ka ca a la, ni IGF-1 hakɛ tora a hakɛ danma sanfɛla la walima ka tɛmɛ a hakɛ danma kan dɔɔni, o b’a jira ko furakɛli nafa ka bon.
Ka fara farikolo taamasiɲɛw caman yeli kan, bonya furakɛli bɛ se ka nɔ min bila den ka ɲɛnamaya kɛcogo la, o fana ka kan ka jateminɛ. O ye den hakili cogoya ye, a ka sigidamɔgɔw ka sekow, ani a ka kalan kɛcogo. Furakɛcogo ɲuman kɔfɛ ni bonya hormone ye, den ka yɛrɛdɔn bɛ ɲɛ, a ka sigida baara bɛ bonya, a ka kalan kɛcogo bɛ ɲɛ, ani a ka ɲɛnamaya kɛcogo bɛ bonya kosɛbɛ.
Kuncɛli
Denmisɛnw ka bonya hormone dɛsɛ ye bana jugumanba ye min bɛ nɔba bila u ka bonya ni u ka yiriwali la, a kɛcogo gɛlɛnw bɛ a kɔnɔ ani a taamasiɲɛ suguya caman bɛ kɛnɛyaso la. Pepitidi caman cili furakɛli, kɛrɛnkɛrɛnnenya la, bonya hormone caman cili furakɛli, o kɛra GHD furakɛli fɔlɔ ye.
Sosow (Sɔrɔyɔrɔw).
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